SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5zfh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BCU_H_PRLH280_0
(ALPHA-THROMBIN)		 5zfh KALLIKREIN-7
(Mus
musculus) 		5 / 9 SER A 195
VAL A 213
TRP A 215
GLY A 216
GLY A 226
 None
 0.35A 1bcuH-5zfhA:
18.1		 1bcuH-5zfhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETR_H_MITH1_1
(EPSILON-THROMBIN)		 5zfh KALLIKREIN-7
(Mus
musculus) 		6 / 12 HIS A  57
SER A 195
VAL A 213
TRP A 215
GLY A 216
GLY A 226
 None
 0.47A 1etrH-5zfhA:
32.8		 1etrH-5zfhA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1F5L_A_AMRA301_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 5zfh KALLIKREIN-7
(Mus
musculus) 		4 / 8 SER A 195
VAL A 213
GLY A 216
GLY A 226
 None
 0.40A 1f5lA-5zfhA:
12.0		 1f5lA-5zfhA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_B_THAB2_1
(LIVER
CARBOXYLESTERASE I)		 5zfh KALLIKREIN-7
(Mus
musculus) 		5 / 11 LEU A 212
GLY A 196
LEU A  33
LEU A 209
LEU A  53
 None
 1.37A 1mx1B-5zfhA:
undetectable		 1mx1B-5zfhA:
9.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TNL_A_TPAA900_1
(TRYPSIN)		 5zfh KALLIKREIN-7
(Mus
musculus) 		4 / 6 SER A 195
VAL A 213
GLY A 216
GLY A 226
 None
 0.29A 1tnlA-5zfhA:
37.6		 1tnlA-5zfhA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTV_A_NCAA1301_0
(CATIONIC TRYPSIN)		 5zfh KALLIKREIN-7
(Mus
musculus) 		4 / 6 SER A 195
VAL A 213
GLY A 216
GLY A 226
 None
 0.37A 2otvA-5zfhA:
37.8		 2otvA-5zfhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_D_SAMD300_0
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 5zfh KALLIKREIN-7
(Mus
musculus) 		6 / 12 GLY A 142
GLY A  44
GLY A 196
GLY A 193
THR A  54
LEU A  53
 None
 1.38A 2oxtD-5zfhA:
undetectable		 2oxtD-5zfhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P16_A_GG2A298_1
(COAGULATION FACTOR X
(EC 3.4.21.6)
(STUART FACTOR)
(STUART-PROWER
FACTOR))		 5zfh KALLIKREIN-7
(Mus
musculus) 		6 / 12 SER A 195
VAL A 213
TRP A 215
GLY A 216
GLY A 226
TYR A 228
 None
 0.46A 2p16A-5zfhA:
33.5		 2p16A-5zfhA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W26_A_RIVA1001_1
(ACTIVATED FACTOR XA
HEAVY CHAIN)		 5zfh KALLIKREIN-7
(Mus
musculus) 		6 / 12 SER A 195
VAL A 213
TRP A 215
GLY A 216
GLY A 226
TYR A 228
 None
 0.39A 2w26A-5zfhA:
11.7		 2w26A-5zfhA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GY3_A_PNTA246_0
(CATIONIC TRYPSIN)		 5zfh KALLIKREIN-7
(Mus
musculus) 		5 / 11 HIS A  57
SER A 195
TRP A 215
GLY A 216
GLY A 226
 None
 0.40A 3gy3A-5zfhA:
37.1		 3gy3A-5zfhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RXF_A_4APA9_1
(CATIONIC TRYPSIN)		 5zfh KALLIKREIN-7
(Mus
musculus) 		5 / 6 SER A 195
VAL A 213
TRP A 215
GLY A 216
GLY A 226
 None
 0.30A 3rxfA-5zfhA:
15.6		 3rxfA-5zfhA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RN6_B_15UB301_1
(THROMBIN HEAVY CHAIN)		 5zfh KALLIKREIN-7
(Mus
musculus) 		5 / 12 HIS A  57
VAL A 213
TRP A 215
GLY A 216
GLY A 226
 None
 0.38A 4rn6B-5zfhA:
27.2		 4rn6B-5zfhA:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AJQ_A_DB8A800_2
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 5zfh KALLIKREIN-7
(Mus
musculus) 		4 / 4 VAL A 171
ILE A 163
ASN A 189
VAL A 227
 None
 1.21A 5ajqA-5zfhA:
undetectable		 5ajqA-5zfhA:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EIW_C_SAMC4000_0
(NS5
METHYLTRANSFERASE)		 5zfh KALLIKREIN-7
(Mus
musculus) 		6 / 12 GLY A 142
GLY A  44
GLY A 196
GLY A 193
THR A  54
VAL A  52
 None
 1.23A 5eiwC-5zfhA:
undetectable		 5eiwC-5zfhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_A_EY4A501_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 5zfh KALLIKREIN-7
(Mus
musculus) 		4 / 5 GLN A  30
VAL A  45
TRP A  29
THR A 208
 None
 1.39A 6cduA-5zfhA:
undetectable
6cduB-5zfhA:
undetectable		 6cduA-5zfhA:
undetectable
6cduB-5zfhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_I_EY4I500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 5zfh KALLIKREIN-7
(Mus
musculus) 		4 / 5 GLN A  30
VAL A  45
TRP A  29
THR A 208
 None
 1.41A 6cduI-5zfhA:
undetectable
6cduJ-5zfhA:
undetectable		 6cduI-5zfhA:
undetectable
6cduJ-5zfhA:
undetectable