SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5zgb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JNO_A_DVAA6_0
(GRAMICIDIN A)		 5zgb LHCR3
(Cyanidioschyzon
merolae) 		3 / 3 ALA 3 114
VAL 3 119
TRP 3  47
 None
None
CLA  3 208 (-3.4A)
 0.87A 1jnoA-5zgb3:
undetectable		 1jnoA-5zgb3:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JNO_B_DVAB6_0
(GRAMICIDIN A)		 5zgb LHCR3
(Cyanidioschyzon
merolae) 		3 / 3 ALA 3 114
VAL 3 119
TRP 3  47
 None
None
CLA  3 208 (-3.4A)
 0.86A 1jnoB-5zgb3:
undetectable		 1jnoB-5zgb3:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAG_A_DVAA6_0
(GRAMICIDIN A)		 5zgb LHCR3
(Cyanidioschyzon
merolae) 		3 / 3 ALA 3 114
VAL 3 119
TRP 3  47
 None
None
CLA  3 208 (-3.4A)
 0.92A 1magA-5zgb3:
undetectable		 1magA-5zgb3:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAG_B_DVAB6_0
(GRAMICIDIN A)		 5zgb LHCR3
(Cyanidioschyzon
merolae) 		3 / 3 ALA 3 114
VAL 3 119
TRP 3  47
 None
None
CLA  3 208 (-3.4A)
 0.92A 1magB-5zgb3:
undetectable		 1magB-5zgb3:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NG8_A_DVAA6_0
(GRAMICIDIN A)		 5zgb LHCR3
(Cyanidioschyzon
merolae) 		3 / 3 ALA 3 114
VAL 3 119
TRP 3  47
 None
None
CLA  3 208 (-3.4A)
 0.91A 1ng8A-5zgb3:
undetectable		 1ng8A-5zgb3:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NG8_B_DVAB6_0
(GRAMICIDIN A)		 5zgb LHCR3
(Cyanidioschyzon
merolae) 		3 / 3 ALA 3 114
VAL 3 119
TRP 3  47
 None
None
CLA  3 208 (-3.4A)
 0.90A 1ng8B-5zgb3:
undetectable		 1ng8B-5zgb3:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NRM_A_DVAA6_0
(GRAMICIDIN A)		 5zgb LHCR3
(Cyanidioschyzon
merolae) 		3 / 3 ALA 3 114
VAL 3 119
TRP 3  47
 None
None
CLA  3 208 (-3.4A)
 0.93A 1nrmA-5zgb3:
undetectable		 1nrmA-5zgb3:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NRM_B_DVAB6_0
(GRAMICIDIN A)		 5zgb LHCR3
(Cyanidioschyzon
merolae) 		3 / 3 ALA 3 114
VAL 3 119
TRP 3  47
 None
None
CLA  3 208 (-3.4A)
 0.92A 1nrmB-5zgb3:
undetectable		 1nrmB-5zgb3:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NRU_A_DVAA6_0
(GRAMICIDIN A)		 5zgb LHCR3
(Cyanidioschyzon
merolae) 		3 / 3 ALA 3 114
VAL 3 119
TRP 3  47
 None
None
CLA  3 208 (-3.4A)
 0.85A 1nruA-5zgb3:
undetectable		 1nruA-5zgb3:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NRU_B_DVAB6_0
(GRAMICIDIN A)		 5zgb LHCR3
(Cyanidioschyzon
merolae) 		3 / 3 ALA 3 114
VAL 3 119
TRP 3  47
 None
None
CLA  3 208 (-3.4A)
 0.85A 1nruB-5zgb3:
undetectable		 1nruB-5zgb3:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_I_FUAI707_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5zgb PSAL
(Cyanidioschyzon
merolae) 		3 / 3 VAL L 126
ALA L 125
HIS L  54
 None
None
BCR  L 205 (-3.9A)
 0.57A 1q23G-5zgbL:
undetectable		 1q23G-5zgbL:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_K_FUAK712_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5zgb PSAL
(Cyanidioschyzon
merolae) 		3 / 3 VAL L 126
ALA L 125
HIS L  54
 None
None
BCR  L 205 (-3.9A)
 0.68A 1q23L-5zgbL:
undetectable		 1q23L-5zgbL:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_L_FUAL710_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5zgb PSAL
(Cyanidioschyzon
merolae) 		3 / 3 VAL L 126
ALA L 125
HIS L  54
 None
None
BCR  L 205 (-3.9A)
 0.58A 1q23J-5zgbL:
undetectable		 1q23J-5zgbL:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QHY_A_CLMA888_0
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE)		 5zgb LHCR3
(Cyanidioschyzon
merolae) 		4 / 6 PRO 3  17
LYS 3  13
GLU 3  31
GLU 3  33
 None
None
None
CLA  3 203 (-3.2A)
 1.16A 1qhyA-5zgb3:
undetectable		 1qhyA-5zgb3:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T9W_A_NFNA6001_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 5zgb PSAF
(Cyanidioschyzon
merolae) 		3 / 3 SER F 170
GLY F 171
ARG F 126
 None
 0.58A 1t9wA-5zgbF:
2.8		 1t9wA-5zgbF:
5.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVS_B_MK1B902_1
(POL POLYPROTEIN)		 5zgb PSAL
(Cyanidioschyzon
merolae) 		5 / 12 LEU L  89
GLY L  51
ALA L 125
GLY L 130
ILE L  86
 BCR  L 205 (-3.7A)
None
None
None
None
 0.88A 2avsA-5zgbL:
undetectable		 2avsA-5zgbL:
25.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GLU_B_SAMB302_0
(YCGJ)		 5zgb PSAK
(Cyanidioschyzon
merolae) 		5 / 12 GLY K  24
GLY K  20
ALA K  38
THR K  34
ALA K  27
 None
None
BCR  K 101 (-3.8A)
None
BCR  K 101 ( 3.7A)
 1.00A 2gluB-5zgbK:
undetectable		 2gluB-5zgbK:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H9T_H_SVRH301_1
(THROMBIN)		 5zgb LHCR1
(Cyanidioschyzon
merolae) 		5 / 11 PRO 1  13
ARG 1  29
VAL 1  36
GLN 1  40
GLU 1 113
 None
None
None
CLA  1 602 (-4.0A)
None
 1.30A 2h9tH-5zgb1:
undetectable		 2h9tH-5zgb1:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS1_A_017A201_2
(HIV-1 PROTEASE)		 5zgb PSAL
(Cyanidioschyzon
merolae) 		5 / 12 LEU L  89
GLY L  51
ALA L 125
ILE L  83
ILE L  86
 BCR  L 205 (-3.7A)
None
None
None
None
 0.82A 2hs1B-5zgbL:
undetectable		 2hs1B-5zgbL:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9C_A_ACTA1121_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 5zgb LHCR1
PSAF
(Cyanidioschyzon
merolae;
Cyanidioschyzon
merolae) 		4 / 5 SER F 156
VAL F 124
VAL 1 107
SER F 127
 None
CLA  F 302 ( 4.8A)
None
None
 1.34A 2j9cA-5zgbF:
undetectable
2j9cB-5zgbF:
undetectable
2j9cC-5zgbF:
undetectable		 2j9cA-5zgbF:
undetectable
2j9cB-5zgbF:
undetectable
2j9cC-5zgbF:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RKF_A_AB1A501_1
(PROTEASE RETROPEPSIN)		 5zgb PSAL
(Cyanidioschyzon
merolae) 		5 / 12 LEU L  89
GLY L  51
ALA L 125
ILE L  83
ILE L  86
 BCR  L 205 (-3.7A)
None
None
None
None
 0.81A 2rkfA-5zgbL:
undetectable		 2rkfA-5zgbL:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RKG_B_AB1B501_2
(PROTEASE RETROPEPSIN)		 5zgb PSAL
(Cyanidioschyzon
merolae) 		5 / 12 LEU L  89
GLY L  51
ALA L 125
ILE L  83
ILE L  86
 BCR  L 205 (-3.7A)
None
None
None
None
 0.90A 2rkgB-5zgbL:
undetectable		 2rkgB-5zgbL:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU4_B_478B401_2
(PROTEASE)		 5zgb PSAL
(Cyanidioschyzon
merolae) 		5 / 9 LEU L  89
GLY L  51
ALA L 125
ILE L  83
ILE L  86
 BCR  L 205 (-3.7A)
None
None
None
None
 0.87A 3nu4B-5zgbL:
undetectable		 3nu4B-5zgbL:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHN_A_ACTA108_0
(PROTEIN P-30)		 5zgb LHCR3
(Cyanidioschyzon
merolae) 		3 / 3 THR 3 118
SER 3 122
ARG 3 124
 None
 0.80A 3phnA-5zgb3:
undetectable		 3phnA-5zgb3:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PS9_A_SAMA670_1
(TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC)		 5zgb PSAF
(Cyanidioschyzon
merolae) 		4 / 6 TYR F 131
THR F 132
LEU F 129
GLU F 134
 None
None
CLA  F 301 (-3.9A)
None
 1.00A 3ps9A-5zgbF:
undetectable		 3ps9A-5zgbF:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9V_B_DXCB323_0
(INVASIN IPAD)		 5zgb PSAK
(Cyanidioschyzon
merolae) 		4 / 7 ILE K  12
VAL K  51
LEU K  54
SER K  55
 None
 0.67A 3r9vA-5zgbK:
undetectable
3r9vB-5zgbK:
undetectable		 3r9vA-5zgbK:
undetectable
3r9vB-5zgbK:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S43_A_478A401_2
(PROTEASE)		 5zgb PSAL
(Cyanidioschyzon
merolae) 		5 / 10 LEU L  89
GLY L  51
ALA L 125
ILE L  83
ILE L  86
 BCR  L 205 (-3.7A)
None
None
None
None
 0.86A 3s43B-5zgbL:
undetectable		 3s43B-5zgbL:
24.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S45_B_478B201_2
(PROTEASE)		 5zgb PSAL
(Cyanidioschyzon
merolae) 		5 / 11 LEU L  89
GLY L  51
ALA L 125
ILE L  83
ILE L  86
 BCR  L 205 (-3.7A)
None
None
None
None
 0.84A 3s45B-5zgbL:
undetectable		 3s45B-5zgbL:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UZZ_B_ASDB501_1
(3-OXO-5-BETA-STEROID
4-DEHYDROGENASE)		 5zgb PSAL
(Cyanidioschyzon
merolae) 		4 / 8 TYR L  37
LEU L 117
MET L  93
TRP L 114
 None
None
BCR  L 205 (-3.4A)
None
 1.16A 3uzzB-5zgbL:
undetectable		 3uzzB-5zgbL:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VN2_A_TLSA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5zgb PSAD
(Cyanidioschyzon
merolae) 		5 / 12 ILE D  78
TYR D  81
LEU D  59
MET D  30
HIS D  96
 None
 1.39A 3vn2A-5zgbD:
undetectable		 3vn2A-5zgbD:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VN2_A_TLSA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5zgb PSAD
(Cyanidioschyzon
merolae) 		5 / 12 TYR D  81
LEU D  72
LEU D  59
MET D  30
HIS D  96
 None
 1.47A 3vn2A-5zgbD:
undetectable		 3vn2A-5zgbD:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_F_GAIF411_0
(PROTEIN (ARGINASE))		 5zgb PSAF
(Cyanidioschyzon
merolae) 		4 / 6 ARG F 102
GLU F 106
LEU F  86
ASP F 100
 None
None
None
CLA  F 303 (-4.1A)
 1.45A 4cevE-5zgbF:
undetectable
4cevF-5zgbF:
undetectable		 4cevE-5zgbF:
undetectable
4cevF-5zgbF:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNU_A_QDNA602_1
(CYTOCHROME P450 2D6)		 5zgb LHCR1
LHCR2
(Cyanidioschyzon
merolae) 		5 / 11 LEU 1   6
PHE 1  30
GLY 2 121
LEU 2 122
PHE 2 118
 CLA  1 601 (-4.0A)
CLA  1 602 ( 3.7A)
None
CLA  2 607 ( 4.8A)
None
 1.09A 4wnuA-5zgb1:
undetectable		 4wnuA-5zgb1:
10.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNU_C_QDNC602_1
(CYTOCHROME P450 2D6)		 5zgb LHCR1
LHCR2
(Cyanidioschyzon
merolae) 		5 / 11 LEU 1   6
PHE 1  30
GLY 2 121
LEU 2 122
PHE 2 118
 CLA  1 601 (-4.0A)
CLA  1 602 ( 3.7A)
None
CLA  2 607 ( 4.8A)
None
 1.07A 4wnuC-5zgb1:
undetectable		 4wnuC-5zgb1:
10.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNU_C_QDNC602_1
(CYTOCHROME P450 2D6)		 5zgb LHCR1
LHCR2
(Cyanidioschyzon
merolae) 		5 / 11 PHE 1  30
GLY 2 121
LEU 2 122
ASP 1  26
PHE 2 118
 CLA  1 602 ( 3.7A)
None
CLA  2 607 ( 4.8A)
CLA  1 602 ( 3.2A)
None
 1.35A 4wnuC-5zgb1:
undetectable		 4wnuC-5zgb1:
10.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZDY_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5zgb PSAD
(Cyanidioschyzon
merolae) 		3 / 3 ALA D  29
TYR D  28
PRO D  88
 None
 0.65A 4zdyA-5zgbD:
undetectable		 4zdyA-5zgbD:
9.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E5J_A_017A201_1
(PROTEASE)		 5zgb PSAL
(Cyanidioschyzon
merolae) 		5 / 12 LEU L  89
GLY L  51
ALA L 125
ILE L  83
ILE L  86
 BCR  L 205 (-3.7A)
None
None
None
None
 0.83A 5e5jA-5zgbL:
undetectable		 5e5jA-5zgbL:
24.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E5K_B_017B201_2
(HIV-1 PROTEASE)		 5zgb PSAL
(Cyanidioschyzon
merolae) 		5 / 12 LEU L  89
GLY L  51
ALA L 125
ILE L  83
ILE L  86
 BCR  L 205 (-3.7A)
None
None
None
None
 0.86A 5e5kB-5zgbL:
undetectable		 5e5kB-5zgbL:
24.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J6H_A_NCAA402_0
(H-2 CLASS I
HISTOCOMPATIBILITY
ANTIGEN, Q10 ALPHA
CHAIN)		 5zgb LHCR2
(Cyanidioschyzon
merolae) 		3 / 3 PRO 2 135
ARG 2 133
GLU 2  53
 None
 0.70A 5j6hA-5zgb2:
undetectable		 5j6hA-5zgb2:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T8H_B_478B401_1
(PROTEASE)		 5zgb PSAL
(Cyanidioschyzon
merolae) 		5 / 12 LEU L  89
GLY L  51
ALA L 125
ILE L  83
ILE L  86
 BCR  L 205 (-3.7A)
None
None
None
None
 0.83A 5t8hA-5zgbL:
undetectable		 5t8hA-5zgbL:
24.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_E_CVIE301_1
(REGULATORY PROTEIN
TETR)		 5zgb PSAD
(Cyanidioschyzon
merolae) 		4 / 7 GLN D  75
GLN D 105
TYR D 104
ASP D  35
 None
 0.97A 5vlmE-5zgbD:
undetectable		 5vlmE-5zgbD:
undetectable