SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5zh5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CD2_A_FOLA307_0
(DIHYDROFOLATE
REDUCTASE)		 5zh5 LYSINE--TRNA LIGASE
(Plasmodium
falciparum) 		5 / 12 ILE A 161
LEU A 122
PHE A 115
LEU A 133
ILE A 206
 None
 1.04A 1cd2A-5zh5A:
undetectable		 1cd2A-5zh5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P91_B_SAMB2401_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE A)		 5zh5 LYSINE--TRNA LIGASE
(Plasmodium
falciparum) 		5 / 12 LEU A 133
GLY A 156
GLY A 137
ILE A 110
LEU A 122
 None
 1.05A 1p91B-5zh5A:
undetectable		 1p91B-5zh5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WSV_A_THHA3001_0
(AMINOMETHYLTRANSFERA
SE)		 5zh5 LYSINE--TRNA LIGASE
(Plasmodium
falciparum) 		5 / 12 MET A 494
THR A 561
LEU A 564
ILE A 560
VAL A 501
 None
None
None
None
9CX  A 602 (-4.8A)
 1.35A 1wsvA-5zh5A:
undetectable		 1wsvA-5zh5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WSV_B_THHB4001_0
(AMINOMETHYLTRANSFERA
SE)		 5zh5 LYSINE--TRNA LIGASE
(Plasmodium
falciparum) 		5 / 12 MET A 494
THR A 561
LEU A 564
ILE A 560
VAL A 501
 None
None
None
None
9CX  A 602 (-4.8A)
 1.35A 1wsvB-5zh5A:
undetectable		 1wsvB-5zh5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_A_SALA1303_1
(LYSR-TYPE REGULATORY
PROTEIN)		 5zh5 LYSINE--TRNA LIGASE
(Plasmodium
falciparum) 		4 / 7 PRO A 418
ILE A 474
PRO A 486
GLY A 487
 None
 0.87A 2y7kA-5zh5A:
undetectable		 2y7kA-5zh5A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7W_C_SALC1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 5zh5 LYSINE--TRNA LIGASE
(Plasmodium
falciparum) 		4 / 7 THR A 211
ILE A 192
GLY A 191
ILE A 139
 None
 0.88A 2y7wC-5zh5A:
undetectable		 2y7wC-5zh5A:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_C_MTXC164_2
(DIHYDROFOLATE
REDUCTASE)		 5zh5 LYSINE--TRNA LIGASE
(Plasmodium
falciparum) 		4 / 4 ILE A 403
ARG A 559
ILE A 468
THR A 489
 None
9CX  A 602 (-3.3A)
None
None
 1.03A 3ia4C-5zh5A:
undetectable		 3ia4C-5zh5A:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_A_PFLA319_1
(GLR4197 PROTEIN)		 5zh5 LYSINE--TRNA LIGASE
(Plasmodium
falciparum) 		4 / 7 ILE A 258
LEU A 261
THR A 561
ILE A 560
 None
 0.87A 3p50A-5zh5A:
undetectable		 3p50A-5zh5A:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_B_PFLB319_1
(GLR4197 PROTEIN)		 5zh5 LYSINE--TRNA LIGASE
(Plasmodium
falciparum) 		4 / 7 ILE A 258
LEU A 261
THR A 561
ILE A 560
 None
 0.88A 3p50B-5zh5A:
undetectable		 3p50B-5zh5A:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_C_PFLC319_1
(GLR4197 PROTEIN)		 5zh5 LYSINE--TRNA LIGASE
(Plasmodium
falciparum) 		4 / 7 ILE A 258
LEU A 261
THR A 561
ILE A 560
 None
 0.88A 3p50C-5zh5A:
undetectable		 3p50C-5zh5A:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_D_PFLD320_1
(GLR4197 PROTEIN)		 5zh5 LYSINE--TRNA LIGASE
(Plasmodium
falciparum) 		4 / 7 ILE A 258
LEU A 261
THR A 561
ILE A 560
 None
 0.88A 3p50D-5zh5A:
undetectable		 3p50D-5zh5A:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_E_PFLE319_1
(GLR4197 PROTEIN)		 5zh5 LYSINE--TRNA LIGASE
(Plasmodium
falciparum) 		4 / 7 ILE A 258
LEU A 261
THR A 561
ILE A 560
 None
 0.90A 3p50E-5zh5A:
undetectable		 3p50E-5zh5A:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3THR_D_C2FD1200_0
(GLYCINE
N-METHYLTRANSFERASE)		 5zh5 LYSINE--TRNA LIGASE
(Plasmodium
falciparum) 		5 / 12 LEU A 372
HIS A 371
SER A 246
THR A 561
THR A 250
 None
 1.27A 3thrA-5zh5A:
undetectable
3thrB-5zh5A:
0.1
3thrC-5zh5A:
1.2
3thrD-5zh5A:
0.4		 3thrA-5zh5A:
undetectable
3thrB-5zh5A:
undetectable
3thrC-5zh5A:
undetectable
3thrD-5zh5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_CHDA1504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5zh5 LYSINE--TRNA LIGASE
(Plasmodium
falciparum) 		4 / 4 PRO A 196
LEU A 133
ILE A 135
ARG A 108
 None
 1.38A 3w1wA-5zh5A:
undetectable		 3w1wA-5zh5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPN_B_ZMRB700_1
(NEURAMINIDASE)		 5zh5 LYSINE--TRNA LIGASE
(Plasmodium
falciparum) 		5 / 12 GLU A 308
ARG A 304
GLU A 346
GLU A 324
TYR A 348
 LYS  A 601 (-3.1A)
None
LYS  A 601 (-3.1A)
None
LYS  A 601 (-4.3A)
 1.39A 4cpnB-5zh5A:
undetectable		 4cpnB-5zh5A:
10.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_D_NCTD501_1
(CYTOCHROME P450 2A6)		 5zh5 LYSINE--TRNA LIGASE
(Plasmodium
falciparum) 		4 / 7 PHE A 364
GLY A 554
ILE A 325
LEU A 265
 None
LYS  A 601 ( 3.8A)
None
None
 0.86A 4ejjD-5zh5A:
undetectable		 4ejjD-5zh5A:
11.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MWY_A_YNUA1101_1
(MINERALOCORTICOID
RECEPTOR)		 5zh5 LYSINE--TRNA LIGASE
(Plasmodium
falciparum) 		4 / 6 GLN A 367
ARG A 268
PHE A 364
PHE A 373
 None
 1.31A 5mwyA-5zh5A:
undetectable		 5mwyA-5zh5A:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6BNI_A_ADNA602_1
(LYSINE--TRNA LIGASE)		 5zh5 LYSINE--TRNA LIGASE
(Plasmodium
falciparum) 		6 / 10 HIS A 338
PHE A 342
GLU A 500
GLY A 556
ARG A 559
ILE A 570
 9CX  A 602 (-4.1A)
9CX  A 602 (-3.8A)
9CX  A 602 (-4.0A)
9CX  A 602 (-3.7A)
9CX  A 602 (-3.3A)
9CX  A 602 (-4.9A)
 0.40A 6bniA-5zh5A:
45.6		 6bniA-5zh5A:
33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6BNI_B_ADNB602_1
(LYSINE--TRNA LIGASE)		 5zh5 LYSINE--TRNA LIGASE
(Plasmodium
falciparum) 		6 / 10 HIS A 338
PHE A 342
GLU A 500
GLY A 556
ARG A 559
ILE A 570
 9CX  A 602 (-4.1A)
9CX  A 602 (-3.8A)
9CX  A 602 (-4.0A)
9CX  A 602 (-3.7A)
9CX  A 602 (-3.3A)
9CX  A 602 (-4.9A)
 0.40A 6bniB-5zh5A:
45.4		 6bniB-5zh5A:
33.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MVX_A_K4DA1304_0
(ION TRANSPORT
PROTEIN)		 5zh5 LYSINE--TRNA LIGASE
(Plasmodium
falciparum) 		4 / 6 MET A 562
THR A 561
LEU A 564
LEU A 261
 None
 1.12A 6mvxA-5zh5A:
undetectable
6mvxB-5zh5A:
undetectable
6mvxC-5zh5A:
undetectable		 6mvxA-5zh5A:
undetectable
6mvxB-5zh5A:
undetectable
6mvxC-5zh5A:
undetectable