SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5zhz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K6C_B_MK1B902_2
(POL POLYPROTEIN)		 5zhz PROBABLE
ENDONUCLEASE 4
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 227
ALA A 228
ASP A 188
THR A 163
VAL A 190
 None
 0.99A 1k6cB-5zhzA:
undetectable		 1k6cB-5zhzA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE2_A_CUA502_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 5zhz PROBABLE
ENDONUCLEASE 4
(Mycobacterium
tuberculosis) 		3 / 3 GLU A 129
HIS A 165
HIS A  96
 ZN  A 304 (-2.3A)
ZN  A 306 ( 3.2A)
ZN  A 304 ( 3.1A)
 0.51A 1oe2A-5zhzA:
undetectable		 1oe2A-5zhzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QL8_A_BEZA143_0
(PUTATIVE REDOX
PROTEIN)		 5zhz PROBABLE
ENDONUCLEASE 4
(Mycobacterium
tuberculosis) 		4 / 7 THR A  81
ALA A  84
PRO A  58
ARG A  40
 None
 0.99A 2ql8A-5zhzA:
undetectable
2ql8B-5zhzA:
undetectable		 2ql8A-5zhzA:
undetectable
2ql8B-5zhzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM7_A_ACAA502_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 5zhz PROBABLE
ENDONUCLEASE 4
(Mycobacterium
tuberculosis) 		5 / 10 ALA A 207
ASP A 162
HIS A 206
GLY A 212
ILE A 214
 None
ZN  A 305 ( 3.1A)
ZN  A 306 ( 3.2A)
None
None
 1.21A 2zm7A-5zhzA:
undetectable		 2zm7A-5zhzA:
10.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B2R_B_VDNB1_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 5zhz PROBABLE
ENDONUCLEASE 4
(Mycobacterium
tuberculosis) 		5 / 11 ILE A 157
LEU A 148
ALA A 146
ILE A 145
ILE A 187
 None
 1.13A 3b2rB-5zhzA:
undetectable		 3b2rB-5zhzA:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BUF_A_AEGA394_0
(BETA-SECRETASE 1)		 5zhz PROBABLE
ENDONUCLEASE 4
(Mycobacterium
tuberculosis) 		4 / 5 LEU A 148
ILE A 106
ILE A 145
GLY A  97
 None
 0.94A 3bufA-5zhzA:
undetectable		 3bufA-5zhzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GGU_B_017B201_1
(PROTEASE)		 5zhz PROBABLE
ENDONUCLEASE 4
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 227
ALA A 228
ASP A 188
THR A 163
VAL A 190
 None
 0.95A 3gguA-5zhzA:
undetectable		 3gguA-5zhzA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LJG_A_HAEA301_1
(MACROPHAGE
METALLOELASTASE)		 5zhz PROBABLE
ENDONUCLEASE 4
(Mycobacterium
tuberculosis) 		4 / 5 ILE A 231
HIS A 165
GLU A 129
HIS A 206
 None
ZN  A 306 ( 3.2A)
ZN  A 304 (-2.3A)
ZN  A 306 ( 3.2A)
 1.03A 3ljgA-5zhzA:
undetectable		 3ljgA-5zhzA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDT_A_VORA506_1
(CHOLESTEROL
24-HYDROXYLASE)		 5zhz PROBABLE
ENDONUCLEASE 4
(Mycobacterium
tuberculosis) 		5 / 9 LEU A 161
PHE A 159
ILE A 145
ALA A 139
ALA A 132
 None
 1.17A 3mdtA-5zhzA:
undetectable		 3mdtA-5zhzA:
9.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROZ_A_NCAA266_0
(APOLIPOPROTEIN
A-I-BINDING PROTEIN)		 5zhz PROBABLE
ENDONUCLEASE 4
(Mycobacterium
tuberculosis) 		4 / 6 LEU A 161
ALA A 132
ASP A 204
THR A 166
 None
None
ZN  A 306 ( 1.9A)
None
 1.10A 3rozA-5zhzA:
undetectable		 3rozA-5zhzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_C_CLQC303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5zhz PROBABLE
ENDONUCLEASE 4
(Mycobacterium
tuberculosis) 		4 / 8 ASN A 193
HIS A   6
GLN A  25
ILE A  94
 ZN  A 305 ( 4.9A)
None
None
None
 0.78A 4fglD-5zhzA:
undetectable		 4fglD-5zhzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1A_A_AB1A101_1
(MDR769 HIV-1
PROTEASE)		 5zhz PROBABLE
ENDONUCLEASE 4
(Mycobacterium
tuberculosis) 		5 / 11 GLY A 227
ALA A 228
ASP A 188
THR A 163
VAL A 190
 None
 1.00A 4l1aA-5zhzA:
undetectable		 4l1aA-5zhzA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6S_B_DAHB305_1
(TYROSINASE)		 5zhz PROBABLE
ENDONUCLEASE 4
(Mycobacterium
tuberculosis) 		4 / 7 HIS A 191
HIS A 165
ASN A 130
HIS A  96
 ZN  A 305 (-3.2A)
ZN  A 306 ( 3.2A)
None
ZN  A 304 ( 3.1A)
 0.96A 4p6sB-5zhzA:
undetectable		 4p6sB-5zhzA:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_A_MMSA511_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 5zhz PROBABLE
ENDONUCLEASE 4
(Mycobacterium
tuberculosis) 		4 / 7 HIS A 191
HIS A 165
ASN A 130
HIS A  96
 ZN  A 305 (-3.2A)
ZN  A 306 ( 3.2A)
None
ZN  A 304 ( 3.1A)
 1.01A 5m8rA-5zhzA:
undetectable		 5m8rA-5zhzA:
10.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NCD_D_ACTD301_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 5zhz PROBABLE
ENDONUCLEASE 4
(Mycobacterium
tuberculosis) 		4 / 4 ASP A 162
HIS A 165
HIS A  96
HIS A 191
 ZN  A 305 ( 3.1A)
ZN  A 306 ( 3.2A)
ZN  A 304 ( 3.1A)
ZN  A 305 (-3.2A)
 1.03A 5ncdD-5zhzA:
3.9		 5ncdD-5zhzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEL_C_ACTC302_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 5zhz PROBABLE
ENDONUCLEASE 4
(Mycobacterium
tuberculosis) 		4 / 6 ASP A 162
HIS A 165
HIS A  96
HIS A 191
 ZN  A 305 ( 3.1A)
ZN  A 306 ( 3.2A)
ZN  A 304 ( 3.1A)
ZN  A 305 (-3.2A)
 1.01A 5nelB-5zhzA:
3.9
5nelC-5zhzA:
4.1		 5nelB-5zhzA:
undetectable
5nelC-5zhzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0G_B_DAHB98_0
(MELC
TYROSINASE)		 5zhz PROBABLE
ENDONUCLEASE 4
(Mycobacterium
tuberculosis) 		5 / 11 HIS A  56
HIS A 206
ASN A 193
HIS A 165
HIS A 191
 ZN  A 304 ( 3.3A)
ZN  A 306 ( 3.2A)
ZN  A 305 ( 4.9A)
ZN  A 306 ( 3.2A)
ZN  A 305 (-3.2A)
 1.42A 5z0gA-5zhzA:
undetectable
5z0gB-5zhzA:
undetectable		 5z0gA-5zhzA:
21.28
5z0gB-5zhzA:
20.99