SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5zib'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NSI_A_H4BA600_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 5zib -
(-) 		4 / 6 ARG A 500
ILE A 437
PHE A 504
GLU A 442
 NAG  A1001 ( 4.0A)
None
None
None
 1.31A 1nsiA-5zibA:
undetectable
1nsiB-5zibA:
undetectable		 1nsiA-5zibA:
undetectable
1nsiB-5zibA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NSI_B_H4BB601_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 5zib -
(-) 		4 / 6 PHE A 504
GLU A 442
ARG A 500
ILE A 437
 None
None
NAG  A1001 ( 4.0A)
None
 1.35A 1nsiA-5zibA:
undetectable
1nsiB-5zibA:
undetectable		 1nsiA-5zibA:
undetectable
1nsiB-5zibA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NSI_C_H4BC602_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 5zib -
(-) 		4 / 6 ARG A 500
ILE A 437
PHE A 504
GLU A 442
 NAG  A1001 ( 4.0A)
None
None
None
 1.38A 1nsiC-5zibA:
undetectable
1nsiD-5zibA:
undetectable		 1nsiC-5zibA:
undetectable
1nsiD-5zibA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NSI_D_H4BD603_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 5zib -
(-) 		4 / 6 PHE A 504
GLU A 442
ARG A 500
ILE A 437
 None
None
NAG  A1001 ( 4.0A)
None
 1.36A 1nsiC-5zibA:
undetectable
1nsiD-5zibA:
undetectable		 1nsiC-5zibA:
undetectable
1nsiD-5zibA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRK_B_TFPB201_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 5zib -
(-) 		5 / 10 GLU A 429
ALA A 252
MET A 612
LEU A 613
SER A 302
 None
 1.39A 1wrkA-5zibA:
0.7
1wrkB-5zibA:
1.0		 1wrkA-5zibA:
undetectable
1wrkB-5zibA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOM_A_CIOA603_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 5zib -
(-) 		5 / 12 ILE A 317
MET A 229
PHE A 235
MET A 238
SER A 302
 None
 1.26A 1xomA-5zibA:
undetectable		 1xomA-5zibA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOM_B_CIOB601_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 5zib -
(-) 		5 / 12 ILE A 317
MET A 229
PHE A 235
MET A 238
SER A 302
 None
 1.25A 1xomB-5zibA:
undetectable		 1xomB-5zibA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XR2_B_C2FB1201_0
(5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE)		 5zib -
(-) 		4 / 8 LYS A 337
SER A 169
ARG A 168
GLU A 193
 None
 1.32A 1xr2B-5zibA:
undetectable		 1xr2B-5zibA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9C_C_ACTC1120_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 5zib -
(-) 		3 / 3 LYS A 337
TYR A 188
PRO A 339
 None
 1.13A 2j9cC-5zibA:
undetectable		 2j9cC-5zibA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NSI_A_H4BA600_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 5zib -
(-) 		4 / 7 ARG A 500
ILE A 437
PHE A 504
GLU A 442
 NAG  A1001 ( 4.0A)
None
None
None
 1.28A 2nsiA-5zibA:
undetectable
2nsiB-5zibA:
undetectable		 2nsiA-5zibA:
undetectable
2nsiB-5zibA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NSI_B_H4BB601_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 5zib -
(-) 		4 / 7 PHE A 504
GLU A 442
ARG A 500
ILE A 437
 None
None
NAG  A1001 ( 4.0A)
None
 1.31A 2nsiA-5zibA:
undetectable
2nsiB-5zibA:
undetectable		 2nsiA-5zibA:
undetectable
2nsiB-5zibA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NSI_C_H4BC602_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 5zib -
(-) 		4 / 7 ARG A 500
ILE A 437
PHE A 504
GLU A 442
 NAG  A1001 ( 4.0A)
None
None
None
 1.31A 2nsiC-5zibA:
undetectable
2nsiD-5zibA:
undetectable		 2nsiC-5zibA:
undetectable
2nsiD-5zibA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NSI_D_H4BD603_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 5zib -
(-) 		4 / 7 PHE A 504
GLU A 442
ARG A 500
ILE A 437
 None
None
NAG  A1001 ( 4.0A)
None
 1.31A 2nsiC-5zibA:
undetectable
2nsiD-5zibA:
undetectable		 2nsiC-5zibA:
undetectable
2nsiD-5zibA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_A_DIFA1373_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 5zib -
(-) 		4 / 8 VAL A 703
TYR A 391
PHE A 711
ASN A 669
 None
 1.24A 2wekA-5zibA:
2.5		 2wekA-5zibA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_B_DIFB1373_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 5zib -
(-) 		4 / 8 VAL A 703
TYR A 391
PHE A 711
ASN A 669
 None
 1.25A 2wekB-5zibA:
3.7		 2wekB-5zibA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6R_B_CTCB1385_0
(TETX2 PROTEIN)		 5zib -
(-) 		4 / 8 GLN A 300
ARG A 558
PHE A 415
GLY A 425
 None
 0.89A 2y6rB-5zibA:
2.3		 2y6rB-5zibA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 5zib -
(-) 		4 / 7 ARG A 500
ILE A 437
PHE A 504
GLU A 442
 NAG  A1001 ( 4.0A)
None
None
None
 1.31A 3e7gA-5zibA:
undetectable
3e7gB-5zibA:
undetectable		 3e7gA-5zibA:
undetectable
3e7gB-5zibA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_B_H4BB1902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 5zib -
(-) 		4 / 7 PHE A 504
GLU A 442
ARG A 500
ILE A 437
 None
None
NAG  A1001 ( 4.0A)
None
 1.36A 3e7gA-5zibA:
undetectable
3e7gB-5zibA:
undetectable		 3e7gA-5zibA:
undetectable
3e7gB-5zibA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_C_H4BC2902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 5zib -
(-) 		4 / 7 ARG A 500
ILE A 437
PHE A 504
GLU A 442
 NAG  A1001 ( 4.0A)
None
None
None
 1.32A 3e7gC-5zibA:
undetectable
3e7gD-5zibA:
undetectable		 3e7gC-5zibA:
undetectable
3e7gD-5zibA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_D_H4BD3902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 5zib -
(-) 		4 / 8 PHE A 504
GLU A 442
ARG A 500
ILE A 437
 None
None
NAG  A1001 ( 4.0A)
None
 1.37A 3e7gC-5zibA:
undetectable
3e7gD-5zibA:
undetectable		 3e7gC-5zibA:
undetectable
3e7gD-5zibA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_C_486C4_1
(GLUCOCORTICOID
RECEPTOR)		 5zib -
(-) 		5 / 12 LEU A 324
GLY A 355
TRP A 301
LEU A 374
PHE A 359
 None
 1.47A 3h52C-5zibA:
undetectable		 3h52C-5zibA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 5zib -
(-) 		4 / 8 PHE A 504
GLU A 442
ARG A 500
ILE A 437
 None
None
NAG  A1001 ( 4.0A)
None
 1.35A 4cx7A-5zibA:
undetectable
4cx7B-5zibA:
undetectable		 4cx7A-5zibA:
undetectable
4cx7B-5zibA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_D_H4BD600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 5zib -
(-) 		4 / 7 PHE A 504
GLU A 442
ARG A 500
ILE A 437
 None
None
NAG  A1001 ( 4.0A)
None
 1.36A 4cx7C-5zibA:
undetectable
4cx7D-5zibA:
undetectable		 4cx7C-5zibA:
undetectable
4cx7D-5zibA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F3T_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 5zib -
(-) 		4 / 6 LEU A 450
TYR A 452
LEU A 506
GLU A 526
 None
 1.07A 4f3tA-5zibA:
undetectable		 4f3tA-5zibA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NOS_D_H4BD3011_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 5zib -
(-) 		4 / 6 PHE A 504
GLU A 442
ARG A 500
ILE A 437
 None
None
NAG  A1001 ( 4.0A)
None
 1.44A 4nosC-5zibA:
undetectable
4nosD-5zibA:
undetectable		 4nosC-5zibA:
undetectable
4nosD-5zibA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_A_377A401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5zib -
(-) 		4 / 5 GLU A 606
TYR A 566
PHE A 607
TYR A 602
 None
 1.40A 4twdA-5zibA:
undetectable
4twdE-5zibA:
undetectable		 4twdA-5zibA:
undetectable
4twdE-5zibA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_C_377C402_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5zib -
(-) 		4 / 5 TYR A 602
GLU A 606
TYR A 566
PHE A 607
 None
 1.39A 4twdC-5zibA:
undetectable
4twdD-5zibA:
undetectable		 4twdC-5zibA:
undetectable
4twdD-5zibA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_H_377H401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5zib -
(-) 		4 / 6 TYR A 602
GLU A 606
TYR A 566
PHE A 607
 None
 1.38A 4twdG-5zibA:
undetectable
4twdH-5zibA:
undetectable		 4twdG-5zibA:
undetectable
4twdH-5zibA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_H_377H402_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5zib -
(-) 		4 / 5 TYR A 602
GLU A 606
TYR A 566
PHE A 607
 None
 1.37A 4twdH-5zibA:
undetectable
4twdI-5zibA:
undetectable		 4twdH-5zibA:
undetectable
4twdI-5zibA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4G_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 5zib -
(-) 		4 / 6 LEU A 581
LYS A 538
PRO A 537
GLU A 586
 None
 1.22A 4z4gA-5zibA:
2.5		 4z4gA-5zibA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZO1_X_T3X500_1
(THYROID HORMONE
RECEPTOR BETA)		 5zib -
(-) 		5 / 12 ALA A 529
ARG A 445
LEU A 506
ASN A 530
HIS A 564
 None
 1.20A 4zo1X-5zibA:
undetectable		 4zo1X-5zibA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWA_A_GCSA301_1
(CHITOSANASE)		 5zib -
(-) 		4 / 8 GLN A 614
GLY A 611
THR A 608
LEU A 256
 None
 0.80A 5hwaA-5zibA:
undetectable		 5hwaA-5zibA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HLP_A_GAWA1501_0
(SUBSTANCE-P
RECEPTOR,SUBSTANCE-P
RECEPTOR)		 5zib -
(-) 		5 / 12 PRO A 488
ILE A 487
VAL A 479
THR A 478
PRO A 524
 None
 0.72A 6hlpA-5zibA:
10.5		 6hlpA-5zibA:
undetectable