SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5zic'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRK_B_TFPB201_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 5zic -
(-) 		5 / 10 GLU A 429
ALA A 252
MET A 612
LEU A 613
SER A 302
 None
 1.41A 1wrkA-5zicA:
undetectable
1wrkB-5zicA:
undetectable		 1wrkA-5zicA:
undetectable
1wrkB-5zicA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOM_B_CIOB601_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 5zic -
(-) 		5 / 12 LEU A 377
THR A 306
ILE A 305
PHE A 235
MET A 238
 None
 1.40A 1xomB-5zicA:
undetectable		 1xomB-5zicA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O5Y_H_STRH249_1
(CHIMERIC ANTIBODY
FAB 1E9-DB3)		 5zic -
(-) 		4 / 7 ASN A 421
GLY A 381
THR A 556
SER A 712
 None
 1.23A 2o5yH-5zicA:
undetectable
2o5yL-5zicA:
undetectable		 2o5yH-5zicA:
undetectable
2o5yL-5zicA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6R_B_CTCB1385_0
(TETX2 PROTEIN)		 5zic -
(-) 		4 / 8 GLN A 300
ARG A 558
PHE A 415
GLY A 425
 None
 0.94A 2y6rB-5zicA:
undetectable		 2y6rB-5zicA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_B_SAMB801_0
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 5zic -
(-) 		5 / 12 THR A 548
GLY A 516
ASP A 580
LEU A 581
ASN A 582
 None
 0.85A 2zw9B-5zicA:
undetectable		 2zw9B-5zicA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_C_486C4_1
(GLUCOCORTICOID
RECEPTOR)		 5zic -
(-) 		5 / 12 LEU A 324
GLY A 355
TRP A 301
LEU A 374
PHE A 359
 None
 1.47A 3h52C-5zicA:
undetectable		 3h52C-5zicA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q5P_A_TACA7101_1
(MULTIDRUG-EFFLUX
TRANSPORTER 1
REGULATOR)		 5zic -
(-) 		5 / 12 PRO A 604
ILE A 571
PHE A 415
TYR A 566
GLU A 606
 None
 1.20A 3q5pA-5zicA:
undetectable		 3q5pA-5zicA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q5R_A_KANA2002_1
(MULTIDRUG-EFFLUX
TRANSPORTER 1
REGULATOR)		 5zic -
(-) 		5 / 11 PRO A 604
ILE A 571
PHE A 415
TYR A 566
GLU A 606
 None
 1.29A 3q5rA-5zicA:
undetectable		 3q5rA-5zicA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F3T_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 5zic -
(-) 		4 / 6 LEU A 450
TYR A 452
LEU A 506
GLU A 526
 None
 1.17A 4f3tA-5zicA:
undetectable		 4f3tA-5zicA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O4D_A_ACTA406_0
(INOSITOL
HEXAKISPHOSPHATE
KINASE)		 5zic -
(-) 		4 / 7 ASP A 696
PHE A 695
SER A 694
HIS A 720
 None
 0.97A 4o4dA-5zicA:
undetectable		 4o4dA-5zicA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_H_377H402_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5zic -
(-) 		4 / 5 TYR A 602
GLU A 606
TYR A 566
PHE A 607
 None
 1.35A 4twdH-5zicA:
undetectable
4twdI-5zicA:
undetectable		 4twdH-5zicA:
undetectable
4twdI-5zicA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWA_A_GCSA301_1
(CHITOSANASE)		 5zic -
(-) 		4 / 8 GLN A 614
GLY A 611
THR A 608
LEU A 256
 None
 0.91A 5hwaA-5zicA:
undetectable		 5hwaA-5zicA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IK1_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 5zic -
(-) 		4 / 5 PHE A 235
LEU A 276
GLY A 275
ILE A 317
 None
 1.02A 5ik1A-5zicA:
undetectable		 5ik1A-5zicA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VM8_B_SAMB301_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 5zic -
(-) 		5 / 10 VAL A 427
GLY A 425
LEU A 310
ILE A 616
LEU A 613
 None
 1.05A 5vm8B-5zicA:
2.4		 5vm8B-5zicA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA504_1
(CYTOCHROME P450 2C9)		 5zic -
(-) 		4 / 8 ILE A 353
PHE A 411
ASN A 421
THR A 399
 NAG  A1003 ( 4.4A)
None
None
None
 1.17A 5x23A-5zicA:
undetectable		 5x23A-5zicA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HLP_A_GAWA1501_0
(SUBSTANCE-P
RECEPTOR,SUBSTANCE-P
RECEPTOR)		 5zic -
(-) 		5 / 12 PRO A 488
ILE A 487
VAL A 479
THR A 478
PRO A 524
 None
 0.75A 6hlpA-5zicA:
5.0		 6hlpA-5zicA:
undetectable