SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5zkp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BDW_A_DVAA6_0
(GRAMICIDIN A)		 5zkp PLATELET-ACTIVATING
FACTOR
RECEPTOR,FLAVODOXIN,
PLATELET-ACTIVATING
FACTOR RECEPTOR
(Desulfovibrio
vulgaris;
Homo
sapiens) 		3 / 3 ALA A  41
VAL A  39
TRP A  38
 None
 0.79A 1bdwA-5zkpA:
undetectable
1bdwB-5zkpA:
undetectable		 1bdwA-5zkpA:
undetectable
1bdwB-5zkpA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BU5_A_RBFA301_1
(PROTEIN (FLAVODOXIN))		 5zkp PLATELET-ACTIVATING
FACTOR
RECEPTOR,FLAVODOXIN,
PLATELET-ACTIVATING
FACTOR RECEPTOR
(Desulfovibrio
vulgaris;
Homo
sapiens) 		6 / 7 THR A1011
ASN A1013
THR A1058
TRP A1059
GLY A1093
ASP A1094
 FMN  A1202 (-3.7A)
FMN  A1202 (-4.1A)
FMN  A1202 (-3.7A)
FMN  A1202 (-4.3A)
FMN  A1202 (-3.2A)
None
 0.56A 1bu5A-5zkpA:
30.3		 1bu5A-5zkpA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BU5_B_RBFB302_1
(PROTEIN (FLAVODOXIN))		 5zkp PLATELET-ACTIVATING
FACTOR
RECEPTOR,FLAVODOXIN,
PLATELET-ACTIVATING
FACTOR RECEPTOR
(Desulfovibrio
vulgaris;
Homo
sapiens) 		7 / 8 THR A1011
ASN A1013
THR A1058
TRP A1059
ASP A1061
GLY A1093
ASP A1094
 FMN  A1202 (-3.7A)
FMN  A1202 (-4.1A)
FMN  A1202 (-3.7A)
FMN  A1202 (-4.3A)
FMN  A1202 ( 4.2A)
FMN  A1202 (-3.2A)
None
 0.69A 1bu5B-5zkpA:
30.3		 1bu5B-5zkpA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_A_PFLA4002_1
(SERUM ALBUMIN)		 5zkp PLATELET-ACTIVATING
FACTOR
RECEPTOR,FLAVODOXIN,
PLATELET-ACTIVATING
FACTOR RECEPTOR
(Desulfovibrio
vulgaris;
Homo
sapiens) 		3 / 3 PHE A  18
LEU A  70
SER A 283
 9ER  A1201 ( 4.8A)
None
None
 0.90A 1e7aA-5zkpA:
undetectable		 1e7aA-5zkpA:
9.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_D_DVAD6_0
(GRAMICIDIN A)		 5zkp PLATELET-ACTIVATING
FACTOR
RECEPTOR,FLAVODOXIN,
PLATELET-ACTIVATING
FACTOR RECEPTOR
(Desulfovibrio
vulgaris;
Homo
sapiens) 		4 / 4 VAL A  36
TRP A  38
ALA A  41
VAL A  39
 None
 1.44A 1gmkC-5zkpA:
undetectable
1gmkD-5zkpA:
undetectable		 1gmkC-5zkpA:
undetectable
1gmkD-5zkpA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_B_URFB1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 5zkp PLATELET-ACTIVATING
FACTOR
RECEPTOR,FLAVODOXIN,
PLATELET-ACTIVATING
FACTOR RECEPTOR
(Desulfovibrio
vulgaris;
Homo
sapiens) 		4 / 6 ASN A  33
ASN A 285
SER A 104
ASN A 100
 None
 1.12A 1h7xB-5zkpA:
5.6		 1h7xB-5zkpA:
5.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_G_FUAG708_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5zkp PLATELET-ACTIVATING
FACTOR
RECEPTOR,FLAVODOXIN,
PLATELET-ACTIVATING
FACTOR RECEPTOR
(Desulfovibrio
vulgaris;
Homo
sapiens) 		5 / 11 PHE A1074
SER A1039
LEU A1004
VAL A1052
PHE A1046
 None
 1.09A 1q23G-5zkpA:
undetectable		 1q23G-5zkpA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E23_A_SAMA221_1
(UNCHARACTERIZED
PROTEIN RPA2492)		 5zkp PLATELET-ACTIVATING
FACTOR
RECEPTOR,FLAVODOXIN,
PLATELET-ACTIVATING
FACTOR RECEPTOR
(Desulfovibrio
vulgaris;
Homo
sapiens) 		3 / 3 TYR A  77
ASP A  10
HIS A 275
 9ER  A1201 (-4.5A)
None
9ER  A1201 (-4.5A)
 0.84A 3e23A-5zkpA:
undetectable		 3e23A-5zkpA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PO7_A_ZONA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 5zkp PLATELET-ACTIVATING
FACTOR
RECEPTOR,FLAVODOXIN,
PLATELET-ACTIVATING
FACTOR RECEPTOR
(Desulfovibrio
vulgaris;
Homo
sapiens) 		4 / 8 TYR A  76
LEU A 279
CYH A 280
TYR A  22
 None
9ER  A1201 (-4.8A)
None
9ER  A1201 (-4.6A)
 1.28A 3po7A-5zkpA:
2.4		 3po7A-5zkpA:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QPS_A_CHDA211_0
(CMER)		 5zkp PLATELET-ACTIVATING
FACTOR
RECEPTOR,FLAVODOXIN,
PLATELET-ACTIVATING
FACTOR RECEPTOR
(Desulfovibrio
vulgaris;
Homo
sapiens) 		5 / 10 LEU A  70
PHE A  26
GLY A  29
ILE A  25
PHE A  97
 None
None
None
None
9ER  A1201 (-3.9A)
 1.20A 3qpsA-5zkpA:
undetectable		 3qpsA-5zkpA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBS_A_DIFA502_1
(PENTALENIC ACID
SYNTHASE)		 5zkp PLATELET-ACTIVATING
FACTOR
RECEPTOR,FLAVODOXIN,
PLATELET-ACTIVATING
FACTOR RECEPTOR
(Desulfovibrio
vulgaris;
Homo
sapiens) 		5 / 9 LEU A  89
LEU A  65
THR A  69
LEU A  72
ILE A  68
 None
 1.27A 4ubsA-5zkpA:
1.3		 4ubsA-5zkpA:
10.68