SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5zkq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S3Z_B_RIOB501_0
(AMINOGLYCOSIDE
6'-N-ACETYLTRANSFERA
SE)		 5zkq PLATELET-ACTIVATING
FACTOR
RECEPTOR,ENDOLYSIN,E
NDOLYSIN,PLATELET-AC
TIVATING FACTOR
RECEPTOR
(Homo
sapiens;
Escherichia
virus
T4) 		4 / 8 TYR A  15
VAL A 170
GLU A  12
ASP A 163
 None
 1.10A 1s3zA-5zkqA:
undetectable
1s3zB-5zkqA:
undetectable		 1s3zA-5zkqA:
undetectable
1s3zB-5zkqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HJH_A_NCAA900_0
(NAD-DEPENDENT
HISTONE DEACETYLASE
SIR2)		 5zkq PLATELET-ACTIVATING
FACTOR
RECEPTOR,ENDOLYSIN,E
NDOLYSIN,PLATELET-AC
TIVATING FACTOR
RECEPTOR
(Homo
sapiens;
Escherichia
virus
T4) 		4 / 5 ILE A 242
PHE A 195
PHE A 245
ILE A 202
 None
 1.14A 2hjhA-5zkqA:
undetectable		 2hjhA-5zkqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_A_IMNA2_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5zkq PLATELET-ACTIVATING
FACTOR
RECEPTOR,ENDOLYSIN,E
NDOLYSIN,PLATELET-AC
TIVATING FACTOR
RECEPTOR
(Escherichia
virus
T4;
Homo
sapiens) 		4 / 6 ILE A  99
ILE A  25
TYR A  22
PHE A  98
 None
None
9EU  A 501 (-4.7A)
OLC  A 502 ( 4.8A)
 0.75A 3adsA-5zkqA:
undetectable		 3adsA-5zkqA:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6PAH_A_DAHA600_1
(PHENYLALANINE
4-MONOOXYGENASE)		 5zkq PLATELET-ACTIVATING
FACTOR
RECEPTOR,ENDOLYSIN,E
NDOLYSIN,PLATELET-AC
TIVATING FACTOR
RECEPTOR
(Escherichia
virus
T4;
Homo
sapiens) 		4 / 6 LEU A 279
HIS A   8
HIS A 268
GLU A 259
 9EU  A 501 (-4.5A)
ZN  A 506 (-3.9A)
ZN  A 506 (-3.2A)
ZN  A 506 (-2.4A)
 1.04A 6pahA-5zkqA:
undetectable		 6pahA-5zkqA:
13.52