SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5zm4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UOB_A_PNNA1311_0
(DEACETOXYCEPHALOSPOR
IN C SYNTHETASE)		 5zm4 DIOXYGENASE ANDA
(Aspergillus
stellatus) 		5 / 12 LEU A 205
HIS A 135
ASP A 137
SER A 179
PHE A 207
 None
FE  A 301 ( 3.4A)
FE  A 301 (-2.5A)
None
None
 1.48A 1uobA-5zm4A:
10.8		 1uobA-5zm4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_C_STIC600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5zm4 DIOXYGENASE ANDA
(Aspergillus
stellatus) 		4 / 6 VAL A  54
MET A  55
ILE A 225
MET A  73
 None
None
None
9FU  A 303 ( 4.5A)
 1.17A 2hyyC-5zm4A:
undetectable		 2hyyC-5zm4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VJ1_A_BEZA1303_0
(SARS CORONAVIRUS
MAIN PROTEINASE)		 5zm4 DIOXYGENASE ANDA
(Aspergillus
stellatus) 		3 / 3 HIS A  79
MET A  73
MET A 125
 AKG  A 302 (-4.2A)
9FU  A 303 ( 4.5A)
AKG  A 302 ( 4.7A)
 1.42A 2vj1A-5zm4A:
undetectable		 2vj1A-5zm4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AI8_A_HNQA255_1
(CATHEPSIN B)		 5zm4 DIOXYGENASE ANDA
(Aspergillus
stellatus) 		4 / 7 GLN A 132
GLY A 215
HIS A  74
HIS A  79
 AKG  A 302 (-3.1A)
AKG  A 302 (-3.5A)
None
AKG  A 302 (-4.2A)
 1.16A 3ai8A-5zm4A:
undetectable		 3ai8A-5zm4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJD_A_C2FA315_0
(UNCHARACTERIZED
PROTEIN)		 5zm4 DIOXYGENASE ANDA
(Aspergillus
stellatus) 		5 / 11 THR A 160
ILE A  47
PHE A 166
VAL A 201
ILE A  39
 None
 1.44A 3ijdA-5zm4A:
undetectable		 3ijdA-5zm4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I13_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 5zm4 DIOXYGENASE ANDA
(Aspergillus
stellatus) 		3 / 3 ASP A 281
ARG A 247
THR A 265
 None
 0.85A 4i13A-5zm4A:
undetectable		 4i13A-5zm4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKX_A_198A1002_2
(ANDROGEN RECEPTOR)		 5zm4 DIOXYGENASE ANDA
(Aspergillus
stellatus) 		4 / 6 LEU A  83
MET A  55
LEU A 163
ILE A  43
 None
 1.16A 4okxA-5zm4A:
undetectable		 4okxA-5zm4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P3R_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 5zm4 DIOXYGENASE ANDA
(Aspergillus
stellatus) 		3 / 3 ASP A 281
ARG A 247
THR A 265
 None
 0.85A 4p3rA-5zm4A:
undetectable		 4p3rA-5zm4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QCK_A_ASDA404_1
(3-KETOSTEROID-9-ALPH
A-MONOOXYGENASE
OXYGENASE SUBUNIT)		 5zm4 DIOXYGENASE ANDA
(Aspergillus
stellatus) 		5 / 12 LEU A 123
ALA A 230
MET A 156
ASN A 158
GLY A 214
 AKG  A 302 ( 3.6A)
9FU  A 303 (-3.5A)
9FU  A 303 ( 4.0A)
9FU  A 303 (-4.3A)
AKG  A 302 ( 3.9A)
 1.09A 4qckA-5zm4A:
undetectable		 4qckA-5zm4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_X_BEZX801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 5zm4 DIOXYGENASE ANDA
(Aspergillus
stellatus) 		4 / 5 ARG A  13
ILE A  11
GLY A 172
ILE A  34
 None
 0.82A 5dzki-5zm4A:
undetectable
5dzkj-5zm4A:
undetectable
5dzkx-5zm4A:
undetectable		 5dzki-5zm4A:
undetectable
5dzkj-5zm4A:
undetectable
5dzkx-5zm4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIK_A_SAMA301_0
(GLYCINE SARCOSINE
N-METHYLTRANSFERASE)		 5zm4 DIOXYGENASE ANDA
(Aspergillus
stellatus) 		5 / 12 GLY A 234
ASN A 275
GLY A 113
SER A 112
GLY A 262
 None
 1.07A 5hikA-5zm4A:
undetectable		 5hikA-5zm4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_B_GLYB709_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 5zm4 DIOXYGENASE ANDA
(Aspergillus
stellatus) 		4 / 5 GLY A 171
ASN A 170
ASP A 169
ARG A 167
 None
 1.35A 6dwdB-5zm4A:
undetectable
6dwdD-5zm4A:
undetectable		 6dwdB-5zm4A:
undetectable
6dwdD-5zm4A:
undetectable