SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5znn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_P_TRPP81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 5znn SORTILIN
(Mus
musculus) 		5 / 11 GLY A 372
HIS A 362
HIS A 391
GLY A 398
THR A 400
 None
 1.15A 1c9sP-5znnA:
undetectable
1c9sQ-5znnA:
undetectable		 1c9sP-5znnA:
undetectable
1c9sQ-5znnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P91_A_SAMA1401_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE A)		 5znn SORTILIN
(Mus
musculus) 		5 / 11 GLY A 509
GLY A 484
ILE A 505
TYR A 504
HIS A 489
 None
 1.20A 1p91A-5znnA:
undetectable		 1p91A-5znnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZQ9_A_SAMA4000_0
(PROBABLE
DIMETHYLADENOSINE
TRANSFERASE)		 5znn SORTILIN
(Mus
musculus) 		5 / 12 GLY A 298
LEU A 282
LEU A 284
ASP A 278
VAL A 271
 None
 1.21A 1zq9A-5znnA:
undetectable		 1zq9A-5znnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1499_1
(CYTOCHROME P450 3A4)		 5znn SORTILIN
(Mus
musculus) 		4 / 7 ILE A 351
THR A 414
ILE A 325
GLY A 372
 None
 0.86A 2v0mB-5znnA:
undetectable		 2v0mB-5znnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDY_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 5znn SORTILIN
(Mus
musculus) 		5 / 12 SER A 478
VAL A 486
ILE A 413
SER A 415
HIS A 461
 None
 1.23A 2vdyA-5znnA:
undetectable		 2vdyA-5znnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BPX_A_SALA257_1
(TRANSCRIPTIONAL
REGULATOR)		 5znn SORTILIN
(Mus
musculus) 		4 / 8 ALA A 462
THR A 414
ILE A 413
THR A 403
 None
 0.98A 3bpxA-5znnA:
undetectable
3bpxB-5znnA:
undetectable		 3bpxA-5znnA:
undetectable
3bpxB-5znnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CL9_A_MTXA602_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE (DHFR-TS))		 5znn SORTILIN
(Mus
musculus) 		5 / 12 ALA A 353
MET A 358
THR A 428
LEU A 634
ARG A 409
 NAG  A 804 ( 3.7A)
None
None
None
NAG  A 805 (-4.9A)
 1.27A 3cl9A-5znnA:
undetectable		 3cl9A-5znnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBQ_B_URFB400_1
(URIDINE
PHOSPHORYLASE 1)		 5znn SORTILIN
(Mus
musculus) 		4 / 8 THR A 428
GLY A 410
LEU A 634
ILE A 716
 None
 0.84A 3nbqB-5znnA:
undetectable		 3nbqB-5znnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBQ_C_URFC400_1
(URIDINE
PHOSPHORYLASE 1)		 5znn SORTILIN
(Mus
musculus) 		4 / 8 THR A 428
GLY A 410
LEU A 634
ILE A 716
 None
 0.82A 3nbqC-5znnA:
undetectable		 3nbqC-5znnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU9_A_478A401_1
(PROTEASE)		 5znn SORTILIN
(Mus
musculus) 		4 / 8 ALA A 257
GLY A 260
ILE A 264
VAL A 239
 None
NA  A 809 (-3.1A)
NA  A 809 (-3.0A)
None
 0.75A 3nu9A-5znnA:
undetectable		 3nu9A-5znnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OEZ_A_STIA601_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5znn SORTILIN
(Mus
musculus) 		4 / 5 VAL A 483
ILE A 525
MET A 516
ARG A 653
 None
 1.47A 3oezA-5znnA:
undetectable		 3oezA-5znnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PYY_B_STIB4_2
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 5znn SORTILIN
(Mus
musculus) 		4 / 5 VAL A 483
ILE A 525
MET A 516
ARG A 653
 None
 1.47A 3pyyB-5znnA:
undetectable		 3pyyB-5znnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TI5_A_ZMRA1002_1
(NEURAMINIDASE)		 5znn SORTILIN
(Mus
musculus) 		5 / 12 GLU A 175
ASP A 117
SER A 528
GLU A 479
ASN A 481
 None
 1.41A 3ti5A-5znnA:
3.5		 3ti5A-5znnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U40_C_ADNC251_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 5znn SORTILIN
(Mus
musculus) 		5 / 12 ARG A 165
SER A 136
GLY A 188
VAL A 186
GLU A 185
 None
None
None
NA  A 808 (-3.7A)
NA  A 808 (-3.4A)
 1.42A 3u40B-5znnA:
undetectable
3u40C-5znnA:
undetectable		 3u40B-5znnA:
undetectable
3u40C-5znnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U40_D_ADND251_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 5znn SORTILIN
(Mus
musculus) 		5 / 11 ARG A 165
SER A 136
GLY A 188
VAL A 186
GLU A 185
 None
None
None
NA  A 808 (-3.7A)
NA  A 808 (-3.4A)
 1.43A 3u40D-5znnA:
undetectable
3u40E-5znnA:
undetectable		 3u40D-5znnA:
undetectable
3u40E-5znnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U40_E_ADNE251_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 5znn SORTILIN
(Mus
musculus) 		5 / 12 ARG A 165
SER A 136
GLY A 188
VAL A 186
GLU A 185
 None
None
None
NA  A 808 (-3.7A)
NA  A 808 (-3.4A)
 1.47A 3u40D-5znnA:
undetectable
3u40E-5znnA:
undetectable		 3u40D-5znnA:
undetectable
3u40E-5znnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_B_SAMB302_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 5znn SORTILIN
(Mus
musculus) 		4 / 5 TYR A 384
SER A 336
ASP A 378
ASP A 357
 None
 1.35A 3uj7B-5znnA:
undetectable		 3uj7B-5znnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AX8_A_SAMA1474_0
(WBDD)		 5znn SORTILIN
(Mus
musculus) 		5 / 12 GLY A 529
ILE A 531
ASN A 651
ILE A 532
ILE A 505
 None
 0.83A 4ax8A-5znnA:
undetectable		 4ax8A-5znnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7Q_B_ZMRB601_1
(NEURAMINIDASE)		 5znn SORTILIN
(Mus
musculus) 		5 / 12 GLU A 175
ASP A 117
SER A 528
GLU A 479
ASN A 481
 None
 1.39A 4b7qB-5znnA:
5.4		 4b7qB-5znnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_B_HCYB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 5znn SORTILIN
(Mus
musculus) 		5 / 12 SER A 478
VAL A 486
ILE A 413
SER A 415
HIS A 461
 None
 1.20A 4c49B-5znnA:
undetectable		 4c49B-5znnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_C_HCYC1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 5znn SORTILIN
(Mus
musculus) 		5 / 12 SER A 478
VAL A 486
ILE A 413
SER A 415
HIS A 461
 None
 1.39A 4c49C-5znnA:
undetectable		 4c49C-5znnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_D_HCYD1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 5znn SORTILIN
(Mus
musculus) 		5 / 12 SER A 478
VAL A 486
ILE A 413
SER A 415
HIS A 461
 None
 1.40A 4c49D-5znnA:
undetectable		 4c49D-5znnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CP3_B_RBTB1129_1
(B-CELL LYMPHOMA 6
PROTEIN)		 5znn SORTILIN
(Mus
musculus) 		4 / 7 ARG A 409
LEU A 408
GLY A 631
SER A 622
 NAG  A 805 (-4.9A)
None
None
None
 0.99A 4cp3A-5znnA:
undetectable
4cp3B-5znnA:
undetectable		 4cp3A-5znnA:
undetectable
4cp3B-5znnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJF_A_C2FA300_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 5znn SORTILIN
(Mus
musculus) 		5 / 12 GLU A 638
PHE A 640
ILE A 716
ASP A 670
GLY A 635
 None
 1.48A 4djfA-5znnA:
undetectable		 4djfA-5znnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_A_SHHA404_2
(HISTONE DEACETYLASE
8)		 5znn SORTILIN
(Mus
musculus) 		3 / 3 PRO A 727
MET A 725
TYR A 713
 None
 1.09A 4qa0B-5znnA:
undetectable		 4qa0B-5znnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_B_SHHB404_1
(HISTONE DEACETYLASE
8)		 5znn SORTILIN
(Mus
musculus) 		3 / 3 PRO A 727
MET A 725
TYR A 713
 None
 1.10A 4qa0A-5znnA:
undetectable		 4qa0A-5znnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RS0_A_IBPA706_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5znn SORTILIN
(Mus
musculus) 		5 / 9 VAL A 124
LEU A 112
SER A 111
GLY A 585
LEU A 106
 None
 1.12A 4rs0A-5znnA:
undetectable		 4rs0A-5znnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UAC_A_ACRA501_2
(CARBOHYDRATE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, CUT1 FAMILY
(TC 3.A.1.1.-))		 5znn SORTILIN
(Mus
musculus) 		4 / 7 PRO A 574
GLU A 175
SER A 113
THR A 127
 None
 1.09A 4uacA-5znnA:
undetectable		 4uacA-5znnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IH0_A_ACTA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 5znn SORTILIN
(Mus
musculus) 		4 / 6 PHE A  90
PRO A  88
THR A 549
ILE A 605
 None
 1.44A 5ih0A-5znnA:
2.5		 5ih0A-5znnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JHD_J_EDTJ301_0
(TCRBETA CHAIN)		 5znn SORTILIN
(Mus
musculus) 		4 / 5 TYR A 504
LYS A 515
GLU A 518
GLY A 519
 None
 1.01A 5jhdJ-5znnA:
undetectable		 5jhdJ-5znnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JHD_J_EDTJ301_0
(TCRBETA CHAIN)		 5znn SORTILIN
(Mus
musculus) 		4 / 5 TYR A 504
LYS A 515
GLU A 518
SER A 491
 None
 1.09A 5jhdJ-5znnA:
undetectable		 5jhdJ-5znnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA304_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 5znn SORTILIN
(Mus
musculus) 		4 / 4 ARG A 309
THR A 329
GLY A 381
PHE A 310
 None
 1.22A 5uunA-5znnA:
undetectable		 5uunA-5znnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNA_A_ACTA307_0
(THIOREDOXIN
REDUCTASE)		 5znn SORTILIN
(Mus
musculus) 		3 / 3 ARG A 197
LYS A 179
TYR A 220
 None
 1.38A 6gnaA-5znnA:
undetectable		 6gnaA-5znnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNB_A_ACTA307_0
(THIOREDOXIN
REDUCTASE)		 5znn SORTILIN
(Mus
musculus) 		3 / 3 ARG A 197
LYS A 179
TYR A 220
 None
 1.38A 6gnbA-5znnA:
undetectable		 6gnbA-5znnA:
undetectable