SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5zq4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_B_ACTB1868_0
(FPRA)		 5zq4 SIDE
(Legionella
pneumophila) 		3 / 3 ALA B 395
HIS B 396
VAL B 399
 None
 0.51A 1lqtB-5zq4B:
undetectable		 1lqtB-5zq4B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PNL_B_PACB559_0
(PENICILLIN
AMIDOHYDROLASE)		 5zq4 SIDE
(Legionella
pneumophila) 		4 / 8 PHE B 264
ALA B 556
ILE B 553
ASN B 560
 None
 1.19A 1pnlA-5zq4B:
undetectable
1pnlB-5zq4B:
undetectable		 1pnlA-5zq4B:
undetectable
1pnlB-5zq4B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V32_D_BEZD1221_0
(PEROXIREDOXIN 6)		 5zq4 SIDE
(Legionella
pneumophila) 		4 / 8 VAL B 315
PRO B 224
VAL B 223
SER B 222
 None
 1.00A 2v32C-5zq4B:
undetectable
2v32D-5zq4B:
undetectable		 2v32C-5zq4B:
undetectable
2v32D-5zq4B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A2Q_A_ACAA602_1
(6-AMINOHEXANOATE-CYC
LIC-DIMER HYDROLASE)		 5zq4 SIDE
(Legionella
pneumophila) 		4 / 7 ALA B 241
ALA B 240
ALA B 244
GLN B 327
 None
 0.88A 3a2qA-5zq4B:
undetectable		 3a2qA-5zq4B:
13.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU8_A_ACTA304_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 5zq4 SIDE
(Legionella
pneumophila) 		3 / 3 ARG B 549
HIS B 446
TYR B 449
 None
 0.93A 4fu8A-5zq4B:
undetectable		 4fu8A-5zq4B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU9_A_ACTA312_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 5zq4 SIDE
(Legionella
pneumophila) 		3 / 3 ARG B 549
HIS B 446
TYR B 449
 None
 1.03A 4fu9A-5zq4B:
undetectable		 4fu9A-5zq4B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAR_A_ERMA2001_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 1B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 5zq4 SIDE
(Legionella
pneumophila) 		4 / 7 ILE B 325
THR B 236
VAL B 399
PHE B 229
 None
 1.32A 4iarA-5zq4B:
undetectable		 4iarA-5zq4B:
10.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C06_D_FI8D1404_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 5zq4 SIDE
(Legionella
pneumophila) 		3 / 3 ARG B 351
LYS B 377
ARG B 310
 None
 1.12A 6c06D-5zq4B:
undetectable		 6c06D-5zq4B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_A_BEZA502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 5zq4 SIDE
(Legionella
pneumophila) 		4 / 6 PHE B 444
LEU B 566
LEU B 569
HIS B 573
 None
 0.59A 6e43A-5zq4B:
undetectable		 6e43A-5zq4B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_B_BEZB502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 5zq4 SIDE
(Legionella
pneumophila) 		4 / 6 PHE B 444
LEU B 566
LEU B 569
HIS B 573
 None
 0.56A 6e43B-5zq4B:
undetectable		 6e43B-5zq4B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_C_BEZC502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 5zq4 SIDE
(Legionella
pneumophila) 		4 / 6 PHE B 444
LEU B 566
LEU B 569
HIS B 573
 None
 0.62A 6e43C-5zq4B:
undetectable		 6e43C-5zq4B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_D_BEZD502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 5zq4 SIDE
(Legionella
pneumophila) 		4 / 6 PHE B 444
LEU B 566
LEU B 569
HIS B 573
 None
 0.53A 6e43D-5zq4B:
undetectable		 6e43D-5zq4B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GIQ_A_CUA601_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5zq4 SIDE
(Legionella
pneumophila) 		3 / 3 HIS B 403
HIS B 274
HIS B 278
 AMP  B 601 (-3.9A)
AMP  B 601 ( 4.9A)
None
 0.72A 6giqa-5zq4B:
undetectable		 6giqa-5zq4B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_2
(-)		 5zq4 SIDE
(Legionella
pneumophila) 		5 / 12 TYR B 421
HIS B 403
TYR B 285
VAL B 331
GLY B 275
 None
AMP  B 601 (-3.9A)
None
None
None
 1.43A 6gngA-5zq4B:
undetectable		 6gngA-5zq4B:
10.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_1
(-)		 5zq4 SIDE
(Legionella
pneumophila) 		5 / 12 TYR B 421
HIS B 403
TYR B 285
VAL B 331
GLY B 275
 None
AMP  B 601 (-3.9A)
None
None
None
 1.44A 6gngB-5zq4B:
undetectable		 6gngB-5zq4B:
10.05