SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5zqz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AM6_A_HAEA555_1
(CARBONIC ANHYDRASE)		 5zqz TRIFUNCTIONAL ENZYME
SUBUNIT ALPHA,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 HIS A 498
LEU A 551
THR A 548
THR A 547
 None
 0.82A 1am6A-5zqzA:
undetectable		 1am6A-5zqzA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CIL_A_ETSA263_1
(CARBONIC ANHYDRASE
II)		 5zqz TRIFUNCTIONAL ENZYME
SUBUNIT ALPHA,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 HIS A 498
VAL A 591
LEU A 551
THR A 548
THR A 547
 None
 1.17A 1cilA-5zqzA:
undetectable		 1cilA-5zqzA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EIZ_A_SAMA301_1
(FTSJ)		 5zqz TRIFUNCTIONAL ENZYME
SUBUNIT ALPHA,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 ASP A 567
ASP A 572
ASP A 653
 None
 0.63A 1eizA-5zqzA:
5.8		 1eizA-5zqzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EJ0_A_SAMA301_1
(FTSJ)		 5zqz TRIFUNCTIONAL ENZYME
SUBUNIT ALPHA,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 ASP A 567
ASP A 572
ASP A 653
 None
 0.62A 1ej0A-5zqzA:
5.7		 1ej0A-5zqzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQW_A_RTLA135_0
(CELLULAR
RETINOL-BINDING
PROTEIN)		 5zqz TRIFUNCTIONAL ENZYME
SUBUNIT ALPHA,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 ILE A  91
VAL A 127
LEU A  90
LEU A  64
ILE A  99
 None
 1.25A 1kqwA-5zqzA:
undetectable		 1kqwA-5zqzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VPO_H_TESH1010_1
(ANTI-TESTOSTERONE
(HEAVY CHAIN)
ANTI-TESTOSTERONE
(LIGHT CHAIN))		 5zqz TRIFUNCTIONAL ENZYME
SUBUNIT ALPHA,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 TYR A 546
ALA A 552
GLY A 612
LEU A 603
PHE A 607
 None
 1.22A 1vpoH-5zqzA:
undetectable
1vpoL-5zqzA:
undetectable		 1vpoH-5zqzA:
18.52
1vpoL-5zqzA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AW1_A_COXA264_1
(CARBONIC ANHYDRASE
II)		 5zqz TRIFUNCTIONAL ENZYME
SUBUNIT ALPHA,
MITOCHONDRIAL
(Homo
sapiens) 		6 / 12 HIS A 498
LEU A 587
VAL A 591
LEU A 551
THR A 548
THR A 547
 None
 1.30A 2aw1A-5zqzA:
undetectable		 2aw1A-5zqzA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTT_C_H4BC1002_1
(HYPOTHETICAL PROTEIN
PH0634)		 5zqz TRIFUNCTIONAL ENZYME
SUBUNIT ALPHA,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 6 ASP A 541
PHE A 545
THR A 547
GLU A 510
 None
 1.26A 2dttB-5zqzA:
undetectable
2dttC-5zqzA:
undetectable		 2dttB-5zqzA:
18.75
2dttC-5zqzA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_K_BO2K1402_1
(PROTEASOME COMPONENT
PRE2
PROTEASOME COMPONENT
C5)		 5zqz TRIFUNCTIONAL ENZYME
SUBUNIT ALPHA,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 10 THR A 162
ALA A 140
ALA A 153
ALA A 139
GLY A 143
 None
 1.05A 2f16K-5zqzA:
undetectable
2f16L-5zqzA:
undetectable		 2f16K-5zqzA:
14.62
2f16L-5zqzA:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_Y_BO2Y1403_1
(PROTEASOME COMPONENT
PRE2
PROTEASOME COMPONENT
C5)		 5zqz TRIFUNCTIONAL ENZYME
SUBUNIT ALPHA,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 10 THR A 162
ALA A 140
ALA A 153
ALA A 139
GLY A 143
 None
 1.05A 2f16Y-5zqzA:
undetectable
2f16Z-5zqzA:
undetectable		 2f16Y-5zqzA:
14.62
2f16Z-5zqzA:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_D_SAMD603_0
(HYPOTHETICAL PROTEIN)		 5zqz TRIFUNCTIONAL ENZYME
SUBUNIT ALPHA,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 ILE A 376
GLY A 368
ALA A 377
ALA A 392
VAL A 448
 None
 0.95A 2yvlD-5zqzA:
6.8		 2yvlD-5zqzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_B_D2VB602_1
(CYTOCHROME P450 2R1)		 5zqz TRIFUNCTIONAL ENZYME
SUBUNIT ALPHA,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 THR A 167
ALA A 153
ALA A 212
VAL A  89
ILE A  91
 None
 1.03A 3czhB-5zqzA:
undetectable		 3czhB-5zqzA:
10.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DAZ_A_MZMA263_1
(CARBONIC ANHYDRASE 2)		 5zqz TRIFUNCTIONAL ENZYME
SUBUNIT ALPHA,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 10 HIS A 498
VAL A 591
LEU A 551
THR A 548
THR A 547
 None
 1.12A 3dazA-5zqzA:
undetectable		 3dazA-5zqzA:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCS_A_MZMA263_1
(CARBONIC ANHYDRASE 2)		 5zqz TRIFUNCTIONAL ENZYME
SUBUNIT ALPHA,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 10 HIS A 498
VAL A 591
LEU A 551
THR A 548
THR A 547
 None
 1.12A 3dcsA-5zqzA:
undetectable		 3dcsA-5zqzA:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DD0_A_EZLA301_1
(CARBONIC ANHYDRASE 2)		 5zqz TRIFUNCTIONAL ENZYME
SUBUNIT ALPHA,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 10 HIS A 498
VAL A 591
LEU A 551
THR A 548
THR A 547
 None
 1.10A 3dd0A-5zqzA:
undetectable		 3dd0A-5zqzA:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DL9_A_V2HA602_1
(CYTOCHROME P450 2R1)		 5zqz TRIFUNCTIONAL ENZYME
SUBUNIT ALPHA,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 5 ASN A 615
LEU A 603
GLY A 608
THR A 745
 None
 0.96A 3dl9A-5zqzA:
undetectable		 3dl9A-5zqzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS4_A_AZMA701_1
(CARBONIC ANHYDRASE 2)		 5zqz TRIFUNCTIONAL ENZYME
SUBUNIT ALPHA,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 11 HIS A 498
VAL A 591
LEU A 551
THR A 548
THR A 547
 None
 1.18A 3hs4A-5zqzA:
undetectable		 3hs4A-5zqzA:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ML5_A_AZMA264_1
(CARBONIC ANHYDRASE 7)		 5zqz TRIFUNCTIONAL ENZYME
SUBUNIT ALPHA,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 11 HIS A 498
VAL A 591
LEU A 551
THR A 548
THR A 547
 None
 1.10A 3ml5A-5zqzA:
undetectable		 3ml5A-5zqzA:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_C_SAMC300_0
(PUTATIVE
METHYLTRANSFERASE)		 5zqz TRIFUNCTIONAL ENZYME
SUBUNIT ALPHA,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 GLN A 314
GLY A 319
GLY A 311
SER A 324
ALA A 318
 None
 1.36A 3t7sC-5zqzA:
5.8		 3t7sC-5zqzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V2J_A_AZMA302_1
(CARBONIC ANHYDRASE 2)		 5zqz TRIFUNCTIONAL ENZYME
SUBUNIT ALPHA,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 11 HIS A 498
VAL A 591
LEU A 551
THR A 548
THR A 547
 None
 1.13A 3v2jA-5zqzA:
undetectable		 3v2jA-5zqzA:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_D_ZPCD1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5zqz TRIFUNCTIONAL ENZYME
SUBUNIT ALPHA,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 GLU A 238
ILE A 237
HIS A  40
VAL A  75
 None
 1.06A 4a97D-5zqzA:
undetectable		 4a97D-5zqzA:
12.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIL_A_RBFA401_2
(MEMBRANE LIPOPROTEIN
TPN38(B))		 5zqz TRIFUNCTIONAL ENZYME
SUBUNIT ALPHA,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 PRO A 195
VAL A 194
GLN A 280
ILE A 275
 None
 0.94A 4iilA-5zqzA:
2.6		 4iilA-5zqzA:
13.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K0S_A_AZMA302_1
(CARBONIC ANHYDRASE 2)		 5zqz TRIFUNCTIONAL ENZYME
SUBUNIT ALPHA,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 11 HIS A 498
VAL A 591
LEU A 551
THR A 548
THR A 547
 None
 1.10A 4k0sA-5zqzA:
undetectable		 4k0sA-5zqzA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K0Z_A_MZMA308_1
(CARBONIC ANHYDRASE 2)		 5zqz TRIFUNCTIONAL ENZYME
SUBUNIT ALPHA,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 HIS A 498
VAL A 591
LEU A 551
THR A 548
THR A 547
 None
 1.07A 4k0zA-5zqzA:
undetectable		 4k0zA-5zqzA:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K13_A_ETSA304_1
(CARBONIC ANHYDRASE 2)		 5zqz TRIFUNCTIONAL ENZYME
SUBUNIT ALPHA,
MITOCHONDRIAL
(Homo
sapiens) 		6 / 12 HIS A 498
LEU A 587
VAL A 591
LEU A 551
THR A 548
THR A 547
 None
 1.28A 4k13A-5zqzA:
undetectable		 4k13A-5zqzA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2W_A_ETSA302_1
(CARBONIC ANHYDRASE 2)		 5zqz TRIFUNCTIONAL ENZYME
SUBUNIT ALPHA,
MITOCHONDRIAL
(Homo
sapiens) 		6 / 12 HIS A 498
LEU A 587
VAL A 591
LEU A 551
THR A 548
THR A 547
 None
 1.27A 4m2wA-5zqzA:
undetectable		 4m2wA-5zqzA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NPT_A_017A401_1
(PROTEASE)		 5zqz TRIFUNCTIONAL ENZYME
SUBUNIT ALPHA,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 9 ALA A 244
GLY A 250
ILE A 256
ILE A 137
VAL A  89
 None
 1.11A 4nptA-5zqzA:
undetectable		 4nptA-5zqzA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLM_A_198A1001_2
(ANDROGEN RECEPTOR)		 5zqz TRIFUNCTIONAL ENZYME
SUBUNIT ALPHA,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 6 MET A 215
ILE A 304
ILE A 305
VAL A 308
 None
 1.01A 4olmA-5zqzA:
undetectable		 4olmA-5zqzA:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_C_RBFC201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 5zqz TRIFUNCTIONAL ENZYME
SUBUNIT ALPHA,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 9 THR A 167
LEU A 221
VAL A 243
LEU A 240
ILE A 160
 None
 1.24A 4r38C-5zqzA:
undetectable		 4r38C-5zqzA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UOV_B_AZMB299_1
(CARBONATE
DEHYDRATASE)		 5zqz TRIFUNCTIONAL ENZYME
SUBUNIT ALPHA,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 11 HIS A 498
VAL A 591
LEU A 551
THR A 548
THR A 547
 None
 1.16A 4uovB-5zqzA:
undetectable		 4uovB-5zqzA:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UOV_C_AZMC299_1
(CARBONATE
DEHYDRATASE)		 5zqz TRIFUNCTIONAL ENZYME
SUBUNIT ALPHA,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 11 HIS A 498
VAL A 591
LEU A 551
THR A 548
THR A 547
 None
 1.14A 4uovC-5zqzA:
undetectable		 4uovC-5zqzA:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UOV_D_AZMD299_1
(CARBONATE
DEHYDRATASE)		 5zqz TRIFUNCTIONAL ENZYME
SUBUNIT ALPHA,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 11 HIS A 498
VAL A 591
LEU A 551
THR A 548
THR A 547
 None
 1.15A 4uovD-5zqzA:
undetectable		 4uovD-5zqzA:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UOV_E_AZME299_1
(CARBONATE
DEHYDRATASE)		 5zqz TRIFUNCTIONAL ENZYME
SUBUNIT ALPHA,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 11 HIS A 498
VAL A 591
LEU A 551
THR A 548
THR A 547
 None
 1.14A 4uovE-5zqzA:
undetectable		 4uovE-5zqzA:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UOV_F_AZMF299_1
(CARBONATE
DEHYDRATASE)		 5zqz TRIFUNCTIONAL ENZYME
SUBUNIT ALPHA,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 11 HIS A 498
VAL A 591
LEU A 551
THR A 548
THR A 547
 None
 1.13A 4uovF-5zqzA:
undetectable		 4uovF-5zqzA:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XIW_B_AZMB402_1
(CARBONIC ANHYDRASE,
ALPHA TYPE)		 5zqz TRIFUNCTIONAL ENZYME
SUBUNIT ALPHA,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 HIS A 498
VAL A 591
LEU A 551
THR A 548
THR A 547
 None
 1.16A 4xiwB-5zqzA:
undetectable
4xiwE-5zqzA:
undetectable		 4xiwB-5zqzA:
14.23
4xiwE-5zqzA:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XIW_H_AZMH402_1
(CARBONIC ANHYDRASE,
ALPHA TYPE)		 5zqz TRIFUNCTIONAL ENZYME
SUBUNIT ALPHA,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 11 HIS A 498
VAL A 591
LEU A 551
THR A 548
THR A 547
 None
 1.11A 4xiwH-5zqzA:
undetectable		 4xiwH-5zqzA:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YGF_E_AZME303_1
(ALPHA-CARBONIC
ANHYDRASE)		 5zqz TRIFUNCTIONAL ENZYME
SUBUNIT ALPHA,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 HIS A 498
GLU A 510
VAL A 599
LEU A 551
THR A 547
 None
 1.21A 4ygfE-5zqzA:
undetectable		 4ygfE-5zqzA:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_H_MZMH303_1
(ALPHA-CARBONIC
ANHYDRASE)		 5zqz TRIFUNCTIONAL ENZYME
SUBUNIT ALPHA,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 10 HIS A 498
GLU A 510
VAL A 599
LEU A 551
THR A 547
 None
 1.13A 4yhaH-5zqzA:
undetectable		 4yhaH-5zqzA:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_X_BEZX801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 5zqz TRIFUNCTIONAL ENZYME
SUBUNIT ALPHA,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 5 ILE A 445
GLY A 368
ILE A 376
LEU A 367
 None
 0.82A 5dzki-5zqzA:
8.4
5dzkj-5zqzA:
8.4
5dzkx-5zqzA:
undetectable		 5dzki-5zqzA:
undetectable
5dzkj-5zqzA:
undetectable
5dzkx-5zqzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_Z_BEZZ801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 5zqz TRIFUNCTIONAL ENZYME
SUBUNIT ALPHA,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 4 ILE A 445
GLY A 368
ILE A 376
LEU A 367
 None
 0.82A 5dzkl-5zqzA:
8.4
5dzkz-5zqzA:
undetectable		 5dzkl-5zqzA:
undetectable
5dzkz-5zqzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JN9_D_EZLD302_1
(CARBONIC ANHYDRASE 4)		 5zqz TRIFUNCTIONAL ENZYME
SUBUNIT ALPHA,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 10 HIS A 498
VAL A 591
LEU A 551
THR A 548
THR A 547
 None
 1.11A 5jn9D-5zqzA:
undetectable		 5jn9D-5zqzA:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JNC_A_6LHA302_0
(CARBONIC ANHYDRASE 4)		 5zqz TRIFUNCTIONAL ENZYME
SUBUNIT ALPHA,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 11 HIS A 498
VAL A 591
LEU A 551
THR A 548
THR A 547
 None
 1.12A 5jncA-5zqzA:
undetectable		 5jncA-5zqzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JNC_B_6LHB302_0
(CARBONIC ANHYDRASE 4)		 5zqz TRIFUNCTIONAL ENZYME
SUBUNIT ALPHA,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 10 HIS A 498
VAL A 591
LEU A 551
THR A 548
THR A 547
 None
 1.18A 5jncB-5zqzA:
undetectable		 5jncB-5zqzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPR_A_PAUA404_0
(PANTOTHENATE KINASE
3)		 5zqz TRIFUNCTIONAL ENZYME
SUBUNIT ALPHA,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 5 GLU A 684
GLY A 608
ARG A 680
GLY A 614
 None
 0.98A 5kprA-5zqzA:
0.8		 5kprA-5zqzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JNH_A_ASCA202_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 5zqz TRIFUNCTIONAL ENZYME
SUBUNIT ALPHA,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 ASN A 352
PRO A 357
GLN A 358
 None
 0.80A 6jnhA-5zqzA:
4.3		 6jnhA-5zqzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JNH_A_ASCA202_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 5zqz TRIFUNCTIONAL ENZYME
SUBUNIT ALPHA,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 ASN A 683
PRO A 746
GLN A 748
 None
 0.85A 6jnhA-5zqzA:
4.3		 6jnhA-5zqzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JOG_A_ASCA202_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 5zqz TRIFUNCTIONAL ENZYME
SUBUNIT ALPHA,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 ASN A 352
PRO A 357
GLN A 358
 None
 0.82A 6jogA-5zqzA:
4.3		 6jogA-5zqzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JOG_A_ASCA202_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 5zqz TRIFUNCTIONAL ENZYME
SUBUNIT ALPHA,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 ASN A 683
PRO A 746
GLN A 748
 None
 0.83A 6jogA-5zqzA:
4.3		 6jogA-5zqzA:
undetectable