SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5zrx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UKB_A_BEZA1301_0
(2-HYDROXY-6-OXO-7-ME
THYLOCTA-2,4-DIENOAT
E HYDROLASE)		 5zrx PHOSPHATIDYLINOSITOL
3,4,5-TRISPHOSPHATE
5-PHOSPHATASE
2,EPHRIN TYPE-A
RECEPTOR 2
(Mus
musculus) 		4 / 6 LEU A1235
ALA A1238
LEU A1249
TRP A1221
 None
 0.87A 1ukbA-5zrxA:
undetectable		 1ukbA-5zrxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_A_ADNA401_1
(ADENOSINE KINASE)		 5zrx PHOSPHATIDYLINOSITOL
3,4,5-TRISPHOSPHATE
5-PHOSPHATASE
2,EPHRIN TYPE-A
RECEPTOR 2
(Mus
musculus) 		5 / 12 LEU A1255
GLY A1208
ALA A1206
THR A1252
GLY A1201
 None
 0.96A 4dc3A-5zrxA:
undetectable		 4dc3A-5zrxA:
13.61