SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5zry'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TQ8_A_TOPA2001_1
(DIHYDROFOLATE
REDUCTASE)		 5zry ANKYRIN REPEAT AND
SAM
DOMAIN-CONTAINING
PROTEIN 1A,EPHRIN
TYPE-A RECEPTOR 6
(Mus
musculus) 		5 / 9 ILE A 163
LEU A 129
SER A 177
ILE A 178
ILE A 160
 None
 1.21A 3tq8A-5zryA:
undetectable		 3tq8A-5zryA:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_H_ACTH502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 5zry ANKYRIN REPEAT AND
SAM
DOMAIN-CONTAINING
PROTEIN 1A,EPHRIN
TYPE-A RECEPTOR 6
(Mus
musculus) 		3 / 3 SER A 114
GLY A 113
GLN A 111
 None
EPE  A 206 ( 3.7A)
None
 0.34A 3v4tH-5zryA:
undetectable		 3v4tH-5zryA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_H_ACTH502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 5zry ANKYRIN REPEAT AND
SAM
DOMAIN-CONTAINING
PROTEIN 1A,EPHRIN
TYPE-A RECEPTOR 6
(Mus
musculus) 		3 / 3 SER A 115
GLY A 116
GLN A 111
 None
EPE  A 206 (-3.8A)
None
 0.51A 3v4tH-5zryA:
undetectable		 3v4tH-5zryA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAH_F_ACTF402_0
(ACTIN, ALPHA
SKELETAL MUSCLE)		 5zry ANKYRIN REPEAT AND
SAM
DOMAIN-CONTAINING
PROTEIN 1A,EPHRIN
TYPE-A RECEPTOR 6
(Mus
musculus) 		3 / 3 PHE A  58
ASP A  60
ARG A 173
 None
 0.84A 4eahF-5zryA:
undetectable		 4eahF-5zryA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAH_G_ACTG401_0
(ACTIN, ALPHA
SKELETAL MUSCLE)		 5zry ANKYRIN REPEAT AND
SAM
DOMAIN-CONTAINING
PROTEIN 1A,EPHRIN
TYPE-A RECEPTOR 6
(Mus
musculus) 		3 / 3 PHE A  58
ASP A  60
ARG A 173
 None
 0.84A 4eahG-5zryA:
undetectable		 4eahG-5zryA:
undetectable