SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5zu5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_A_DVAA8_0
(GRAMICIDIN A)		 5zu5 ALGINATE LYASE
(Vibrio
splendidus) 		3 / 4 VAL A 132
TRP A 129
TRP A  40
 None
 0.98A 1gmkA-5zu5A:
undetectable
1gmkB-5zu5A:
undetectable		 1gmkA-5zu5A:
undetectable
1gmkB-5zu5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_C_NCAC339_0
(ADP-RIBOSYL CYCLASE)		 5zu5 ALGINATE LYASE
(Vibrio
splendidus) 		3 / 3 GLU A  47
ASN A 130
TRP A  40
 None
 1.16A 1r15C-5zu5A:
undetectable		 1r15C-5zu5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_D_NCAD349_0
(ADP-RIBOSYL CYCLASE)		 5zu5 ALGINATE LYASE
(Vibrio
splendidus) 		3 / 3 GLU A  47
ASN A 130
TRP A  40
 None
 1.14A 1r15D-5zu5A:
undetectable		 1r15D-5zu5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_E_NCAE359_0
(ADP-RIBOSYL CYCLASE)		 5zu5 ALGINATE LYASE
(Vibrio
splendidus) 		3 / 3 GLU A  47
ASN A 130
TRP A  40
 None
 1.18A 1r15E-5zu5A:
undetectable		 1r15E-5zu5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_F_NCAF369_0
(ADP-RIBOSYL CYCLASE)		 5zu5 ALGINATE LYASE
(Vibrio
splendidus) 		3 / 3 GLU A  47
ASN A 130
TRP A  40
 None
 1.21A 1r15F-5zu5A:
undetectable		 1r15F-5zu5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_B_SAMB302_1
(HEMK PROTEIN)		 5zu5 ALGINATE LYASE
(Vibrio
splendidus) 		3 / 3 ASP A  77
PHE A 106
ASN A 130
 None
 0.84A 1sg9B-5zu5A:
undetectable		 1sg9B-5zu5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C49_B_ADNB1301_1
(SUGAR KINASE MJ0406)		 5zu5 ALGINATE LYASE
(Vibrio
splendidus) 		4 / 7 ALA A 265
ASP A 267
GLY A 268
GLY A 269
 None
 0.77A 2c49B-5zu5A:
undetectable		 2c49B-5zu5A:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JC9_A_ADNA1497_1
(CYTOSOLIC PURINE
5'-NUCLEOTIDASE)		 5zu5 ALGINATE LYASE
(Vibrio
splendidus) 		4 / 7 ASP A  35
THR A 133
ILE A 101
ASN A  70
 None
 1.23A 2jc9A-5zu5A:
undetectable		 2jc9A-5zu5A:
10.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_A_DIFA1375_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 5zu5 ALGINATE LYASE
(Vibrio
splendidus) 		3 / 3 LEU A 252
TYR A 256
GLN A 257
 None
 0.68A 2wekA-5zu5A:
undetectable		 2wekA-5zu5A:
13.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CCF_B_BEZB261_0
(CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE)		 5zu5 ALGINATE LYASE
(Vibrio
splendidus) 		4 / 8 HIS A 360
ILE A 355
TYR A 466
ARG A 289
 None
 1.01A 3ccfB-5zu5A:
undetectable		 3ccfB-5zu5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_A_SAMA220_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 5zu5 ALGINATE LYASE
(Vibrio
splendidus) 		4 / 8 TYR A 397
GLN A 468
GLU A 291
GLU A 365
 None
 1.17A 3dh0A-5zu5A:
undetectable		 3dh0A-5zu5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_A_THHA642_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 5zu5 ALGINATE LYASE
(Vibrio
splendidus) 		5 / 12 GLY A 134
VAL A 156
GLY A  69
SER A  67
ILE A 101
 None
 1.28A 3k13A-5zu5A:
undetectable		 3k13A-5zu5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_B_THHB643_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 5zu5 ALGINATE LYASE
(Vibrio
splendidus) 		5 / 12 GLY A 134
VAL A 156
GLY A  69
SER A  67
ILE A 101
 None
 1.28A 3k13B-5zu5A:
undetectable		 3k13B-5zu5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_C_THHC643_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 5zu5 ALGINATE LYASE
(Vibrio
splendidus) 		5 / 12 GLY A 134
VAL A 156
GLY A  69
SER A  67
ILE A 101
 None
 1.27A 3k13C-5zu5A:
undetectable		 3k13C-5zu5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_A_SALA3005_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 5zu5 ALGINATE LYASE
(Vibrio
splendidus) 		4 / 8 THR A 345
ALA A 342
SER A 478
HIS A 341
 None
 0.93A 3kp6A-5zu5A:
undetectable		 3kp6A-5zu5A:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_D_ACTD502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 5zu5 ALGINATE LYASE
(Vibrio
splendidus) 		3 / 3 GLY A 268
THR A 264
ASN A 219
 None
 0.70A 3v4tD-5zu5A:
undetectable		 3v4tD-5zu5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KJK_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 5zu5 ALGINATE LYASE
(Vibrio
splendidus) 		4 / 4 ASP A 473
LEU A 474
ARG A 280
THR A 345
 None
 1.39A 4kjkA-5zu5A:
undetectable		 4kjkA-5zu5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P3Q_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 5zu5 ALGINATE LYASE
(Vibrio
splendidus) 		4 / 5 ASP A 473
LEU A 474
ARG A 280
THR A 345
 None
 1.32A 4p3qA-5zu5A:
undetectable		 4p3qA-5zu5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE1_A_X2NA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5zu5 ALGINATE LYASE
(Vibrio
splendidus) 		4 / 5 TYR A 466
ILE A 356
PRO A 235
THR A 343
 None
 1.32A 4ze1A-5zu5A:
undetectable		 4ze1A-5zu5A:
10.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HS1_A_VORA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5zu5 ALGINATE LYASE
(Vibrio
splendidus) 		4 / 8 PHE A 236
THR A 290
LEU A 232
LEU A 252
 None
 0.83A 5hs1A-5zu5A:
undetectable		 5hs1A-5zu5A:
10.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_A_1GNA615_1
(PHIAB6 TAILSPIKE)		 5zu5 ALGINATE LYASE
(Vibrio
splendidus) 		3 / 3 TYR A 263
TYR A 477
GLN A 479
 None
 1.06A 5jsdA-5zu5A:
3.4
5jsdB-5zu5A:
3.6		 5jsdA-5zu5A:
7.54
5jsdB-5zu5A:
7.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB606_1
(PHIAB6 TAILSPIKE)		 5zu5 ALGINATE LYASE
(Vibrio
splendidus) 		3 / 3 TYR A 263
TYR A 477
GLN A 479
 None
 1.06A 5jsdB-5zu5A:
3.6
5jsdC-5zu5A:
1.6		 5jsdB-5zu5A:
7.54
5jsdC-5zu5A:
7.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L8D_B_ACTB601_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 5zu5 ALGINATE LYASE
(Vibrio
splendidus) 		3 / 3 THR A 281
PRO A 244
ASP A 246
 None
 0.84A 5l8dB-5zu5A:
undetectable		 5l8dB-5zu5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MWU_B_ACTB601_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 5zu5 ALGINATE LYASE
(Vibrio
splendidus) 		3 / 3 THR A 281
PRO A 244
ASP A 246
 None
 0.84A 5mwuB-5zu5A:
undetectable		 5mwuB-5zu5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NR3_A_95EA401_0
(DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3B)		 5zu5 ALGINATE LYASE
(Vibrio
splendidus) 		4 / 7 ILE A 359
PHE A 461
ASP A 330
LYS A 425
 None
 1.29A 5nr3A-5zu5A:
undetectable		 5nr3A-5zu5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_B_EY4B500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 5zu5 ALGINATE LYASE
(Vibrio
splendidus) 		4 / 6 VAL A 465
PRO A 235
ALA A 480
THR A 481
 None
 1.02A 6cduB-5zu5A:
undetectable
6cduC-5zu5A:
undetectable		 6cduB-5zu5A:
undetectable
6cduC-5zu5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GB9_A_ACTA508_0
(MOLYBDOPTERIN
BIOSYNTHESIS PROTEIN
CNX1)		 5zu5 ALGINATE LYASE
(Vibrio
splendidus) 		3 / 3 VAL A 271
ALA A 265
GLN A 479
 None
 0.69A 6gb9A-5zu5A:
undetectable		 6gb9A-5zu5A:
undetectable