SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5zut'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_C_8MOC501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 5zut PROLIFERATING CELL
NUCLEAR ANTIGEN
(Saccharomyces
cerevisiae) 		5 / 10 ASN A 159
ILE A 158
ILE A 227
LEU A 229
PHE A 237
 None
 1.09A 1z11C-5zutA:
undetectable		 1z11C-5zutA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2D0K_B_FOLB2161_0
(DIHYDROFOLATE
REDUCTASE)		 5zut PROLIFERATING CELL
NUCLEAR ANTIGEN
(Saccharomyces
cerevisiae) 		6 / 12 ALA A 209
LEU A 250
PHE A 207
ILE A 227
LEU A 229
ILE A 160
 None
 1.36A 2d0kB-5zutA:
undetectable		 2d0kB-5zutA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_D_MTXD617_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 5zut PROLIFERATING CELL
NUCLEAR ANTIGEN
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 241
LEU A  11
PHE A  12
ILE A  35
LEU A  90
 None
 1.12A 2oipD-5zutA:
undetectable		 2oipD-5zutA:
9.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_E_MTXE621_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 5zut PROLIFERATING CELL
NUCLEAR ANTIGEN
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 241
LEU A  11
PHE A  12
ILE A  35
LEU A  90
 None
 1.10A 2oipE-5zutA:
undetectable		 2oipE-5zutA:
9.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QWX_A_ML1A233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5zut PROLIFERATING CELL
NUCLEAR ANTIGEN
(Saccharomyces
cerevisiae) 		4 / 8 ILE A 160
PHE A 237
PHE A 239
ILE A 182
 None
 0.86A 2qwxA-5zutA:
undetectable
2qwxB-5zutA:
undetectable		 2qwxA-5zutA:
16.14
2qwxB-5zutA:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5zut PROLIFERATING CELL
NUCLEAR ANTIGEN
(Saccharomyces
cerevisiae) 		4 / 5 ARG A 224
GLN A 238
PHE A 237
LEU A 139
 None
 1.21A 3ablC-5zutA:
undetectable
3ablJ-5zutA:
undetectable		 3ablC-5zutA:
undetectable
3ablJ-5zutA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOG_A_ML1A302_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5zut PROLIFERATING CELL
NUCLEAR ANTIGEN
(Saccharomyces
cerevisiae) 		4 / 8 ILE A 160
PHE A 237
PHE A 239
ILE A 182
 None
 0.83A 4qogA-5zutA:
undetectable
4qogB-5zutA:
undetectable		 4qogA-5zutA:
16.14
4qogB-5zutA:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UMJ_A_BFQA1298_1
(GERANYLTRANSTRANSFER
ASE)		 5zut PROLIFERATING CELL
NUCLEAR ANTIGEN
(Saccharomyces
cerevisiae) 		4 / 4 ILE A 128
PHE A 245
GLN A 238
ASP A 240
 None
 1.30A 4umjA-5zutA:
0.0		 4umjA-5zutA:
13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5zut PROLIFERATING CELL
NUCLEAR ANTIGEN
(Saccharomyces
cerevisiae) 		4 / 6 ARG A 224
GLN A 238
PHE A 237
LEU A 139
 None
 1.13A 5b1bC-5zutA:
undetectable
5b1bJ-5zutA:
undetectable		 5b1bC-5zutA:
undetectable
5b1bJ-5zutA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IK1_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 5zut PROLIFERATING CELL
NUCLEAR ANTIGEN
(Saccharomyces
cerevisiae) 		4 / 5 PHE A  12
LEU A  68
GLY A  69
ILE A  16
 None
 1.02A 5ik1A-5zutA:
undetectable		 5ik1A-5zutA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_C_CHDC305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 5zut PROLIFERATING CELL
NUCLEAR ANTIGEN
(Saccharomyces
cerevisiae) 		4 / 4 ARG A 224
GLN A 238
PHE A 237
LEU A 139
 None
 1.22A 6nmfC-5zutA:
undetectable		 6nmfC-5zutA:
undetectable