SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5zvs'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DDR_B_MTXB200_1
(DIHYDROFOLATE
REDUCTASE)		 5zvs PUTATIVE CORE
PROTEIN NTPASE/VP5
(Aquareovirus
C) 		5 / 12 ALA 4 503
ASP 4 444
LEU 4 442
PHE 4 454
LEU 4 565
 None
 1.21A 1ddrB-5zvs4:
undetectable		 1ddrB-5zvs4:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4007_1
(SERUM ALBUMIN)		 5zvs PUTATIVE CORE
PROTEIN NTPASE/VP5
(Aquareovirus
C) 		4 / 8 LEU 4 685
PHE 4 683
LEU 4 607
LEU 4 634
 None
 0.84A 1e7cA-5zvs4:
undetectable		 1e7cA-5zvs4:
8.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_B_RALB600_2
(ESTROGEN RECEPTOR)		 5zvs VP2
(Aquareovirus
C) 		4 / 6 LEU 2 322
ASP 2 324
MET 2 290
LEU 2 793
 None
 1.05A 1errB-5zvs2:
undetectable		 1errB-5zvs2:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JNO_A_DVAA6_0
(GRAMICIDIN A)		 5zvs PUTATIVE CORE
PROTEIN NTPASE/VP5
(Aquareovirus
C) 		3 / 3 ALA 4 243
VAL 4 248
TRP 4 257
 None
 0.71A 1jnoA-5zvs4:
undetectable		 1jnoA-5zvs4:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JNO_B_DVAB6_0
(GRAMICIDIN A)		 5zvs PUTATIVE CORE
PROTEIN NTPASE/VP5
(Aquareovirus
C) 		3 / 3 ALA 4 243
VAL 4 248
TRP 4 257
 None
 0.71A 1jnoB-5zvs4:
undetectable		 1jnoB-5zvs4:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JO3_A_DVAA6_0
(GRAMICIDIN B)		 5zvs PUTATIVE CORE
PROTEIN NTPASE/VP5
(Aquareovirus
C) 		3 / 3 ALA 4 243
VAL 4 248
TRP 4 257
 None
 0.82A 1jo3A-5zvs4:
undetectable		 1jo3A-5zvs4:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JO3_B_DVAB6_0
(GRAMICIDIN B)		 5zvs PUTATIVE CORE
PROTEIN NTPASE/VP5
(Aquareovirus
C) 		3 / 3 ALA 4 243
VAL 4 248
TRP 4 257
 None
 0.81A 1jo3B-5zvs4:
undetectable		 1jo3B-5zvs4:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAG_A_DVAA6_0
(GRAMICIDIN A)		 5zvs PUTATIVE CORE
PROTEIN NTPASE/VP5
(Aquareovirus
C) 		3 / 3 ALA 4 243
VAL 4 248
TRP 4 257
 None
 0.80A 1magA-5zvs4:
undetectable		 1magA-5zvs4:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAG_B_DVAB6_0
(GRAMICIDIN A)		 5zvs PUTATIVE CORE
PROTEIN NTPASE/VP5
(Aquareovirus
C) 		3 / 3 ALA 4 243
VAL 4 248
TRP 4 257
 None
 0.80A 1magB-5zvs4:
undetectable		 1magB-5zvs4:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_B_AG2B7001_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 5zvs VP2
(Aquareovirus
C) 		4 / 6 ILE 2 349
GLU 2 255
LEU 2 241
LEU 2 263
 None
 1.03A 1mt1B-5zvs2:
undetectable
1mt1C-5zvs2:
undetectable		 1mt1B-5zvs2:
20.72
1mt1C-5zvs2:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_F_THAF6_1
(LIVER
CARBOXYLESTERASE I)		 5zvs VP2
(Aquareovirus
C) 		5 / 12 GLY 2 350
VAL 2 281
LEU 2 285
LEU 2 341
LEU 2 260
 None
 0.93A 1mx1F-5zvs2:
undetectable		 1mx1F-5zvs2:
9.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NG8_A_DVAA6_0
(GRAMICIDIN A)		 5zvs PUTATIVE CORE
PROTEIN NTPASE/VP5
(Aquareovirus
C) 		3 / 3 ALA 4 243
VAL 4 248
TRP 4 257
 None
 0.72A 1ng8A-5zvs4:
undetectable		 1ng8A-5zvs4:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NG8_B_DVAB6_0
(GRAMICIDIN A)		 5zvs PUTATIVE CORE
PROTEIN NTPASE/VP5
(Aquareovirus
C) 		3 / 3 ALA 4 243
VAL 4 248
TRP 4 257
 None
 0.72A 1ng8B-5zvs4:
undetectable		 1ng8B-5zvs4:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NRM_A_DVAA6_0
(GRAMICIDIN A)		 5zvs PUTATIVE CORE
PROTEIN NTPASE/VP5
(Aquareovirus
C) 		3 / 3 ALA 4 243
VAL 4 248
TRP 4 257
 None
 0.73A 1nrmA-5zvs4:
undetectable		 1nrmA-5zvs4:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NRM_B_DVAB6_0
(GRAMICIDIN A)		 5zvs PUTATIVE CORE
PROTEIN NTPASE/VP5
(Aquareovirus
C) 		3 / 3 ALA 4 243
VAL 4 248
TRP 4 257
 None
 0.73A 1nrmB-5zvs4:
undetectable		 1nrmB-5zvs4:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NRU_A_DVAA6_0
(GRAMICIDIN A)		 5zvs PUTATIVE CORE
PROTEIN NTPASE/VP5
(Aquareovirus
C) 		3 / 3 ALA 4 243
VAL 4 248
TRP 4 257
 None
 0.74A 1nruA-5zvs4:
undetectable		 1nruA-5zvs4:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NRU_B_DVAB6_0
(GRAMICIDIN A)		 5zvs PUTATIVE CORE
PROTEIN NTPASE/VP5
(Aquareovirus
C) 		3 / 3 ALA 4 243
VAL 4 248
TRP 4 257
 None
 0.74A 1nruB-5zvs4:
undetectable		 1nruB-5zvs4:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT5_A_DVAA6_0
(GRAMICIDIN A)		 5zvs PUTATIVE CORE
PROTEIN NTPASE/VP5
(Aquareovirus
C) 		3 / 3 ALA 4 243
VAL 4 248
TRP 4 257
 None
 0.88A 1nt5A-5zvs4:
undetectable		 1nt5A-5zvs4:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT5_B_DVAB6_0
(GRAMICIDIN A)		 5zvs PUTATIVE CORE
PROTEIN NTPASE/VP5
(Aquareovirus
C) 		3 / 3 ALA 4 243
VAL 4 248
TRP 4 257
 None
 0.88A 1nt5B-5zvs4:
undetectable		 1nt5B-5zvs4:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT6_A_DVAA6_0
(GRAMICIDIN C)		 5zvs PUTATIVE CORE
PROTEIN NTPASE/VP5
(Aquareovirus
C) 		3 / 3 ALA 4 243
VAL 4 248
TRP 4 257
 None
 0.82A 1nt6A-5zvs4:
undetectable		 1nt6A-5zvs4:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT6_B_DVAB6_0
(GRAMICIDIN C)		 5zvs PUTATIVE CORE
PROTEIN NTPASE/VP5
(Aquareovirus
C) 		3 / 3 ALA 4 243
VAL 4 248
TRP 4 257
 None
 0.82A 1nt6B-5zvs4:
undetectable		 1nt6B-5zvs4:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_C_DESC500_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 5zvs VP2
(Aquareovirus
C) 		5 / 12 LEU 2 235
LEU 2 238
LEU 2 241
ALA 2 242
GLU 2 255
 None
 1.06A 1s9pC-5zvs2:
undetectable		 1s9pC-5zvs2:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_B_VIBB504_1
(YKOF)		 5zvs PUTATIVE CORE
PROTEIN NTPASE/VP5
(Aquareovirus
C) 		4 / 6 PRO 4 409
PHE 4 342
LEU 4 350
ILE 4 543
 None
 1.21A 1sbrA-5zvs4:
undetectable
1sbrB-5zvs4:
undetectable		 1sbrA-5zvs4:
19.50
1sbrB-5zvs4:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VIF_A_FOLA1_0
(DIHYDROFOLATE
REDUCTASE)		 5zvs VP2
(Aquareovirus
C) 		3 / 3 GLN 2 441
ILE 2 442
TYR 2 554
 None
 0.70A 1vifA-5zvs2:
undetectable		 1vifA-5zvs2:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WOP_A_FFOA2888_0
(AMINOMETHYLTRANSFERA
SE)		 5zvs VP2
(Aquareovirus
C) 		5 / 10 LEU 21066
LEU 21263
ILE 21204
LEU 21233
MET 21229
 None
 1.23A 1wopA-5zvs2:
undetectable		 1wopA-5zvs2:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_D_BEZD2385_0
(CES1 PROTEIN)		 5zvs PUTATIVE CORE
PROTEIN NTPASE/VP5
(Aquareovirus
C) 		4 / 5 LEU 4 685
LEU 4 674
LEU 4 652
LEU 4 676
 None
 1.02A 1yajD-5zvs4:
undetectable		 1yajD-5zvs4:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_A_1FLA2003_1
(SERUM ALBUMIN)		 5zvs PUTATIVE CORE
PROTEIN NTPASE/VP5
(Aquareovirus
C) 		5 / 9 TYR 4 496
LEU 4 511
ARG 4 507
LEU 4 527
ALA 4 441
 None
 1.32A 2bxeA-5zvs4:
undetectable		 2bxeA-5zvs4:
8.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_B_1FLB2003_1
(SERUM ALBUMIN)		 5zvs PUTATIVE CORE
PROTEIN NTPASE/VP5
(Aquareovirus
C) 		5 / 10 LEU 4  27
PHE 4  37
LEU 4 209
ILE 4   4
ALA 4 243
 None
 0.91A 2bxeB-5zvs4:
undetectable		 2bxeB-5zvs4:
8.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXQ_A_P1ZA2002_1
(SERUM ALBUMIN)		 5zvs PUTATIVE CORE
PROTEIN NTPASE/VP5
(Aquareovirus
C) 		5 / 12 LEU 4  27
PHE 4  37
LEU 4 209
ILE 4   4
ALA 4 243
 None
 0.95A 2bxqA-5zvs4:
undetectable		 2bxqA-5zvs4:
8.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GVC_B_MMZB501_1
(MONOOXYGENASE)		 5zvs VP2
(Aquareovirus
C) 		3 / 3 ASN 2 227
TYR 2 233
SER 2  98
 None
 0.90A 2gvcB-5zvs2:
undetectable		 2gvcB-5zvs2:
11.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GVC_E_MMZE501_1
(MONOOXYGENASE)		 5zvs VP2
(Aquareovirus
C) 		3 / 3 ASN 2 227
TYR 2 233
SER 2  98
 None
 0.91A 2gvcE-5zvs2:
undetectable		 2gvcE-5zvs2:
11.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_A_RALA600_2
(ESTROGEN RECEPTOR)		 5zvs VP2
(Aquareovirus
C) 		4 / 5 LEU 2 322
ASP 2 324
MET 2 290
LEU 2 793
 None
 1.05A 2jfaA-5zvs2:
undetectable		 2jfaA-5zvs2:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LH8_A_VIBA1_1
(MAJOR PRION PROTEIN)		 5zvs VP2
(Aquareovirus
C) 		4 / 6 PRO 2 900
MET 2 899
ASP 21097
ASP 21098
 None
 1.39A 2lh8A-5zvs2:
undetectable		 2lh8A-5zvs2:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NMZ_B_ROCB401_2
(PROTEASE)		 5zvs PUTATIVE CORE
PROTEIN NTPASE/VP5
VP2
(Aquareovirus
C) 		3 / 3 ARG 2 418
VAL 4 536
THR 4 407
 None
 0.71A 2nmzA-5zvs2:
undetectable		 2nmzA-5zvs2:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NV4_A_SAMA201_0
(UPF0066 PROTEIN
AF_0241)		 5zvs VP2
PUTATIVE CORE
PROTEIN NTPASE/VP5
(Aquareovirus
C;
Aquareovirus
C) 		5 / 12 GLN 2 655
TYR 2 601
ASP 4 524
LEU 2 657
SER 4 574
 None
 1.32A 2nv4A-5zvs2:
undetectable		 2nv4A-5zvs2:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NV4_B_SAMB202_0
(UPF0066 PROTEIN
AF_0241)		 5zvs VP2
PUTATIVE CORE
PROTEIN NTPASE/VP5
(Aquareovirus
C;
Aquareovirus
C) 		5 / 12 GLN 2 655
TYR 2 601
ASP 4 524
LEU 2 657
SER 4 574
 None
 1.37A 2nv4B-5zvs2:
undetectable		 2nv4B-5zvs2:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_B_MTXB609_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 5zvs VP2
(Aquareovirus
C) 		5 / 12 ALA 2  33
LEU 2 162
SER 2 855
THR 2  45
LEU 2 151
 None
 1.26A 2oipB-5zvs2:
undetectable		 2oipB-5zvs2:
10.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_A_CHDA702_0
(FERROCHELATASE)		 5zvs PUTATIVE CORE
PROTEIN NTPASE/VP5
(Aquareovirus
C) 		3 / 3 LEU 4 239
PRO 4 240
ARG 4  36
 None
 0.60A 2qd5A-5zvs4:
undetectable		 2qd5A-5zvs4:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QXS_A_RALA600_2
(ESTROGEN RECEPTOR)		 5zvs VP2
(Aquareovirus
C) 		4 / 5 LEU 2 322
ASP 2 324
MET 2 290
LEU 2 793
 None
 1.03A 2qxsA-5zvs2:
undetectable		 2qxsA-5zvs2:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QXS_B_RALB600_2
(ESTROGEN RECEPTOR)		 5zvs VP2
(Aquareovirus
C) 		4 / 5 LEU 2 322
ASP 2 324
MET 2 290
LEU 2 793
 None
 1.05A 2qxsB-5zvs2:
undetectable		 2qxsB-5zvs2:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_D_KLND1499_1
(CYTOCHROME P450 3A4)		 5zvs VP2
(Aquareovirus
C) 		4 / 5 PHE 2 773
SER 2 598
PHE 2 708
ILE 2 599
 None
 1.37A 2v0mD-5zvs2:
undetectable		 2v0mD-5zvs2:
10.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		 5zvs VP2
(Aquareovirus
C) 		4 / 8 TYR 21116
SER 21222
LEU 21175
THR 21216
 None
 0.96A 2v0zO-5zvs2:
undetectable		 2v0zO-5zvs2:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VN1_A_FK5A501_2
(70 KDA
PEPTIDYLPROLYL
ISOMERASE)		 5zvs VP2
(Aquareovirus
C) 		4 / 6 LEU 2  17
SER 2 171
PHE 2 893
ASP 2 176
 None
 1.29A 2vn1B-5zvs2:
undetectable		 2vn1B-5zvs2:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WLK_B_SPMB1302_1
(ATP-SENSITIVE INWARD
RECTIFIER POTASSIUM
CHANNEL 10)		 5zvs VP2
(Aquareovirus
C) 		4 / 4 ALA 2 955
TYR 2 879
ALA 2 951
TYR 2 953
 None
 1.31A 2wlkA-5zvs2:
undetectable
2wlkB-5zvs2:
undetectable		 2wlkA-5zvs2:
13.47
2wlkB-5zvs2:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_B_QPSB1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 5zvs PUTATIVE CORE
PROTEIN NTPASE/VP5
(Aquareovirus
C) 		5 / 10 PHE 4  19
SER 4  13
TRP 4  14
GLY 4  43
ALA 4  41
 None
 1.18A 2x2iB-5zvs4:
undetectable		 2x2iB-5zvs4:
6.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YDO_A_ADNA400_1
(ADENOSINE RECEPTOR
A2A)		 5zvs VP2
(Aquareovirus
C) 		5 / 12 LEU 2 254
THR 2 257
PHE 2 370
LEU 2 285
ILE 2 354
 None
 1.49A 2ydoA-5zvs2:
undetectable		 2ydoA-5zvs2:
12.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_B_GW6B2_2
(GLUCOCORTICOID
RECEPTOR)		 5zvs VP2
(Aquareovirus
C) 		4 / 8 LEU 21236
ALA 21260
LEU 21263
ILE 21204
 None
 0.93A 3cldB-5zvs2:
undetectable		 3cldB-5zvs2:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_1
(CYTOCHROME P450 2R1)		 5zvs VP2
(Aquareovirus
C) 		5 / 12 VAL 2 654
ALA 2 658
VAL 2 551
VAL 2 633
ILE 2 414
 None
 1.11A 3czhA-5zvs2:
undetectable		 3czhA-5zvs2:
10.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D90_A_NOGA1001_1
(PROGESTERONE
RECEPTOR)		 5zvs VP2
(Aquareovirus
C) 		5 / 12 LEU 2 235
LEU 2 238
LEU 2 241
LEU 2  49
TYR 2  46
 None
 1.33A 3d90A-5zvs2:
undetectable		 3d90A-5zvs2:
13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D90_B_NOGB2001_1
(PROGESTERONE
RECEPTOR)		 5zvs VP2
(Aquareovirus
C) 		5 / 12 LEU 2 235
LEU 2 238
LEU 2 241
LEU 2  49
TYR 2  46
 None
 1.29A 3d90B-5zvs2:
undetectable		 3d90B-5zvs2:
13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DEU_B_SALB306_1
(TRANSCRIPTIONAL
REGULATOR SLYA)		 5zvs PUTATIVE CORE
PROTEIN NTPASE/VP5
VP2
(Aquareovirus
C) 		4 / 6 THR 2 652
ILE 2 515
SER 4 218
THR 2 631
 None
 0.78A 3deuB-5zvs2:
undetectable		 3deuB-5zvs2:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_B_SAMB300_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 5zvs PUTATIVE CORE
PROTEIN NTPASE/VP5
(Aquareovirus
C) 		5 / 12 LEU 4 588
VAL 4 536
GLN 4 535
ALA 4 435
LEU 4 511
 None
 1.00A 3dh0B-5zvs4:
undetectable		 3dh0B-5zvs4:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DL9_A_V2HA602_0
(CYTOCHROME P450 2R1)		 5zvs VP2
(Aquareovirus
C) 		5 / 12 VAL 2 654
ALA 2 658
GLU 2 614
VAL 2 633
ILE 2 414
 None
 1.17A 3dl9A-5zvs2:
undetectable		 3dl9A-5zvs2:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DL9_A_V2HA602_0
(CYTOCHROME P450 2R1)		 5zvs VP2
(Aquareovirus
C) 		5 / 12 VAL 2 654
ALA 2 658
VAL 2 551
VAL 2 633
ILE 2 414
 None
 1.14A 3dl9A-5zvs2:
undetectable		 3dl9A-5zvs2:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DL9_A_V2HA602_1
(CYTOCHROME P450 2R1)		 5zvs VP2
(Aquareovirus
C) 		5 / 5 ASN 2 358
ALA 2 284
LEU 2 341
GLY 2 350
THR 2 253
 None
 1.32A 3dl9A-5zvs2:
undetectable		 3dl9A-5zvs2:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_C_DXCC576_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2)		 5zvs VP2
(Aquareovirus
C) 		4 / 8 ALA 2 438
ALA 2 437
ILE 2 555
THR 2 703
 None
 0.84A 3dtuC-5zvs2:
undetectable
3dtuD-5zvs2:
undetectable		 3dtuC-5zvs2:
undetectable
3dtuD-5zvs2:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ERD_A_DESA600_1
(ESTROGEN RECEPTOR
ALPHA)		 5zvs VP2
(Aquareovirus
C) 		5 / 12 LEU 2   4
LEU 2 157
LEU 2 160
LEU 2 162
LEU 2  49
 None
 1.20A 3erdA-5zvs2:
undetectable		 3erdA-5zvs2:
14.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_B_ERYB195_1
(REPRESSOR PROTEIN
MPHR(A))		 5zvs PUTATIVE CORE
PROTEIN NTPASE/VP5
(Aquareovirus
C) 		4 / 7 TYR 4 413
ARG 4 553
HIS 4 371
ALA 4 370
 None
 1.06A 3frqB-5zvs4:
undetectable		 3frqB-5zvs4:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_A_BCZA1001_0
(NEURAMINIDASE)		 5zvs PUTATIVE CORE
PROTEIN NTPASE/VP5
(Aquareovirus
C) 		5 / 12 GLU 4 383
LEU 4 295
ARG 4 311
ALA 4 267
ARG 4 266
 None
 1.50A 3k39A-5zvs4:
undetectable		 3k39A-5zvs4:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_B_BCZB1001_0
(NEURAMINIDASE)		 5zvs PUTATIVE CORE
PROTEIN NTPASE/VP5
(Aquareovirus
C) 		5 / 12 GLU 4 383
LEU 4 295
ARG 4 311
ALA 4 267
ARG 4 266
 None
 1.50A 3k39B-5zvs4:
undetectable		 3k39B-5zvs4:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_H_BCZH1001_0
(NEURAMINIDASE)		 5zvs PUTATIVE CORE
PROTEIN NTPASE/VP5
(Aquareovirus
C) 		5 / 12 GLU 4 383
LEU 4 295
ARG 4 311
ALA 4 267
ARG 4 266
 None
 1.49A 3k39H-5zvs4:
undetectable		 3k39H-5zvs4:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_N_BCZN1001_0
(NEURAMINIDASE)		 5zvs PUTATIVE CORE
PROTEIN NTPASE/VP5
(Aquareovirus
C) 		5 / 12 GLU 4 383
LEU 4 295
ARG 4 311
ALA 4 267
ARG 4 266
 None
 1.50A 3k39N-5zvs4:
undetectable		 3k39N-5zvs4:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_D_ROCD201_4
(HIV-1 PROTEASE)		 5zvs PUTATIVE CORE
PROTEIN NTPASE/VP5
VP2
(Aquareovirus
C) 		3 / 3 ARG 2 418
VAL 4 536
THR 4 407
 None
 0.79A 3k4vD-5zvs2:
undetectable		 3k4vD-5zvs2:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_2
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		 5zvs VP2
(Aquareovirus
C) 		3 / 3 SER 2 630
SER 2 648
HIS 2 656
 None
 0.85A 3mzeA-5zvs2:
undetectable		 3mzeA-5zvs2:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NJZ_A_SALA370_1
(GENTISATE
1,2-DIOXYGENASE)		 5zvs VP2
(Aquareovirus
C) 		5 / 12 ARG 2 846
ALA 2 850
HIS 2 246
LEU 2 160
ILE 2 243
 None
 1.21A 3njzA-5zvs2:
undetectable		 3njzA-5zvs2:
12.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SP9_B_IL2B901_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR DELTA)		 5zvs VP2
(Aquareovirus
C) 		5 / 12 LEU 2 452
VAL 21127
THR 2 463
ILE 2 497
LEU 2 985
 None
 1.15A 3sp9B-5zvs2:
undetectable		 3sp9B-5zvs2:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5J_A_08HA1_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 5zvs VP2
(Aquareovirus
C) 		4 / 7 PRO 2 183
LEU 2 160
LEU 2 157
ILE 2  52
 None
 1.00A 3u5jA-5zvs2:
undetectable		 3u5jA-5zvs2:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_A_08JA1_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 5zvs VP2
(Aquareovirus
C) 		4 / 8 PRO 2 183
LEU 2 160
LEU 2 157
ILE 2  52
 None
 0.87A 3u5kA-5zvs2:
undetectable		 3u5kA-5zvs2:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_D_08JD4_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 5zvs VP2
(Aquareovirus
C) 		4 / 8 PRO 2 183
LEU 2 160
LEU 2 157
ILE 2  52
 None
 0.83A 3u5kD-5zvs2:
undetectable		 3u5kD-5zvs2:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_B_SAMB302_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 5zvs VP2
(Aquareovirus
C) 		4 / 5 TYR 2 233
SER 2 143
ASP 2  92
ILE 2  84
 None
 1.11A 3uj7B-5zvs2:
undetectable		 3uj7B-5zvs2:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_A_CHDA506_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5zvs PUTATIVE CORE
PROTEIN NTPASE/VP5
(Aquareovirus
C) 		4 / 4 PRO 4 686
LEU 4 685
ILE 4 679
ARG 4 655
 None
 1.42A 4f4dA-5zvs4:
undetectable		 4f4dA-5zvs4:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JKS_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 5zvs VP2
(Aquareovirus
C) 		4 / 4 SER 2 230
LEU 2 383
TYR 2 271
PRO 2 208
 None
 1.38A 4jksA-5zvs2:
undetectable		 4jksA-5zvs2:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JKS_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 5zvs VP2
(Aquareovirus
C) 		4 / 4 SER 2 230
LEU 2 383
TYR 2 271
PRO 2 208
 None
 1.39A 4jksB-5zvs2:
undetectable		 4jksB-5zvs2:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JKU_A_ADNA500_2
(PROBABLE SUGAR
KINASE PROTEIN)		 5zvs VP2
(Aquareovirus
C) 		4 / 4 SER 2 230
LEU 2 383
TYR 2 271
PRO 2 208
 None
 1.40A 4jkuA-5zvs2:
undetectable		 4jkuA-5zvs2:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8C_B_ADNB401_2
(SUGAR KINASE)		 5zvs VP2
(Aquareovirus
C) 		4 / 4 SER 2 230
LEU 2 383
TYR 2 271
PRO 2 208
 None
 1.36A 4k8cB-5zvs2:
undetectable		 4k8cB-5zvs2:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8K_A_ADNA401_2
(SUGAR KINASE)		 5zvs VP2
(Aquareovirus
C) 		4 / 4 SER 2 230
LEU 2 383
TYR 2 271
PRO 2 208
 None
 1.37A 4k8kA-5zvs2:
undetectable		 4k8kA-5zvs2:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8K_B_ADNB403_2
(SUGAR KINASE)		 5zvs VP2
(Aquareovirus
C) 		4 / 4 SER 2 230
LEU 2 383
TYR 2 271
PRO 2 208
 None
 1.38A 4k8kB-5zvs2:
undetectable		 4k8kB-5zvs2:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAL_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 5zvs VP2
(Aquareovirus
C) 		4 / 4 SER 2 230
LEU 2 383
TYR 2 271
PRO 2 208
 None
 1.39A 4kalB-5zvs2:
undetectable		 4kalB-5zvs2:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LCA_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 5zvs VP2
(Aquareovirus
C) 		4 / 4 SER 2 230
LEU 2 383
TYR 2 271
PRO 2 208
 None
 1.36A 4lcaA-5zvs2:
undetectable		 4lcaA-5zvs2:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LCA_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 5zvs VP2
(Aquareovirus
C) 		4 / 4 SER 2 230
LEU 2 383
TYR 2 271
PRO 2 208
 None
 1.36A 4lcaB-5zvs2:
undetectable		 4lcaB-5zvs2:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNW_A_T3A502_1
(THYROID HORMONE
RECEPTOR ALPHA)		 5zvs PUTATIVE CORE
PROTEIN NTPASE/VP5
(Aquareovirus
C) 		4 / 8 SER 4 475
ASP 4 482
VAL 4 488
THR 4 487
 None
 0.91A 4lnwA-5zvs4:
undetectable		 4lnwA-5zvs4:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNX_A_T44A501_1
(THYROID HORMONE
RECEPTOR ALPHA)		 5zvs PUTATIVE CORE
PROTEIN NTPASE/VP5
(Aquareovirus
C) 		4 / 6 GLN 4 587
VAL 4 687
THR 4 688
ARG 4 516
 None
 1.14A 4lnxA-5zvs4:
undetectable		 4lnxA-5zvs4:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1E_A_C2FA3000_1
(DIHYDROPTEROATE
SYNTHASE DHPS)		 5zvs VP2
(Aquareovirus
C) 		3 / 3 LYS 21234
ASN 2 911
ASP 21210
 None
 0.77A 4o1eA-5zvs2:
undetectable		 4o1eA-5zvs2:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLM_A_198A1001_2
(ANDROGEN RECEPTOR)		 5zvs PUTATIVE CORE
PROTEIN NTPASE/VP5
(Aquareovirus
C) 		4 / 6 MET 4 424
ILE 4 314
ILE 4 292
VAL 4 317
 None
 1.00A 4olmA-5zvs4:
undetectable		 4olmA-5zvs4:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XRG_B_AG2B502_1
(HOMOSPERMIDINE
SYNTHASE)		 5zvs VP2
(Aquareovirus
C) 		5 / 12 ALA 2 750
ASN 2 585
PRO 2 584
GLU 2 304
TYR 2 579
 None
 1.21A 4xrgB-5zvs2:
undetectable		 4xrgB-5zvs2:
11.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJ8_A_SUVA2001_2
(HUMAN OX1R FUSION
PROTEIN TO P.ABYSII
GLYCOGEN SYNTHASE)		 5zvs VP2
(Aquareovirus
C) 		4 / 6 TRP 2 875
ILE 2 909
HIS 2 932
ILE 2 918
 None
 0.95A 4zj8A-5zvs2:
undetectable		 4zj8A-5zvs2:
10.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5zvs VP2
(Aquareovirus
C) 		4 / 6 ILE 2 885
LEU 2 845
PHE 2 893
ARG 2 166
 None
 1.03A 5b1aN-5zvs2:
undetectable
5b1aW-5zvs2:
undetectable		 5b1aN-5zvs2:
undetectable
5b1aW-5zvs2:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BS8_H_MFXH101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 5zvs VP2
(Aquareovirus
C) 		4 / 7 ALA 2 658
ASP 2 635
ARG 2 637
GLY 2 412
 None
 0.90A 5bs8A-5zvs2:
undetectable
5bs8B-5zvs2:
undetectable
5bs8C-5zvs2:
undetectable		 5bs8A-5zvs2:
9.13
5bs8B-5zvs2:
15.81
5bs8C-5zvs2:
9.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTD_E_GFNE101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 5zvs VP2
(Aquareovirus
C) 		4 / 7 ALA 2 658
ASP 2 635
ARG 2 637
GLY 2 412
 None
 0.87A 5btdA-5zvs2:
undetectable
5btdB-5zvs2:
undetectable
5btdC-5zvs2:
undetectable		 5btdA-5zvs2:
9.13
5btdB-5zvs2:
15.81
5btdC-5zvs2:
9.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTD_G_GFNG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 5zvs VP2
(Aquareovirus
C) 		4 / 7 ALA 2 658
ASP 2 635
ARG 2 637
GLY 2 412
 None
 0.88A 5btdA-5zvs2:
undetectable
5btdC-5zvs2:
undetectable
5btdD-5zvs2:
undetectable		 5btdA-5zvs2:
9.13
5btdC-5zvs2:
9.13
5btdD-5zvs2:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_T_BEZT801_1
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 5zvs PUTATIVE CORE
PROTEIN NTPASE/VP5
(Aquareovirus
C) 		4 / 8 ALA 4 403
PRO 4 533
LEU 4 511
LEU 4 508
 None
 0.87A 5dzkF-5zvs4:
undetectable
5dzkT-5zvs4:
undetectable		 5dzkF-5zvs4:
undetectable
5dzkT-5zvs4:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EU8_B_010B6_0
(N-[(5-METHYLISOXAZOL
-3-YL)CARBONYL]ALANY
L-L-VALYL-N~1~-((1R,
2Z)-4-(BENZYLOXY)-4-
OXO-1-{[(3R)-2-OXOPY
RROLIDIN-3-YL]METHYL
}BUT-2-ENYL)-L-LEUCI
NAMIDE
MAIN PROTEASE)		 5zvs VP2
(Aquareovirus
C) 		4 / 5 LEU 21106
HIS 21207
THR 21250
CYH 21105
 None
 1.37A 5eu8A-5zvs2:
undetectable		 5eu8A-5zvs2:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EVY_X_SALX502_1
(SALICYLATE
HYDROXYLASE)		 5zvs VP2
(Aquareovirus
C) 		4 / 5 SER 2 286
MET 2 250
LEU 2 254
PHE 2 370
 None
 1.01A 5evyX-5zvs2:
undetectable		 5evyX-5zvs2:
10.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FF1_A_MMZA601_1
(LACTOPEROXIDASE)		 5zvs VP2
(Aquareovirus
C) 		4 / 5 GLN 2 164
ARG 2 181
GLU 2 843
LEU 2 160
 None
 1.49A 5ff1A-5zvs2:
undetectable		 5ff1A-5zvs2:
8.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FF1_A_MMZA602_1
(LACTOPEROXIDASE)		 5zvs VP2
(Aquareovirus
C) 		4 / 5 GLN 2 164
ARG 2 181
GLU 2 843
LEU 2 160
 None
 1.49A 5ff1A-5zvs2:
undetectable		 5ff1A-5zvs2:
8.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FF1_B_MMZB601_1
(LACTOPEROXIDASE)		 5zvs VP2
(Aquareovirus
C) 		4 / 5 GLN 2 164
ARG 2 181
GLU 2 843
LEU 2 160
 None
 1.49A 5ff1B-5zvs2:
undetectable		 5ff1B-5zvs2:
8.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FF1_B_MMZB613_1
(LACTOPEROXIDASE)		 5zvs VP2
(Aquareovirus
C) 		4 / 5 GLN 2 164
ARG 2 181
GLU 2 843
LEU 2 160
 None
 1.49A 5ff1B-5zvs2:
undetectable		 5ff1B-5zvs2:
8.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_A_VDYA201_2
(CDL2.2)		 5zvs VP2
(Aquareovirus
C) 		5 / 12 LEU 2 657
VAL 2 628
ILE 2 540
LEU 2 510
GLY 2 627
 None
 1.09A 5ienA-5zvs2:
undetectable		 5ienA-5zvs2:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_B_VDYB201_1
(CDL2.2)		 5zvs VP2
(Aquareovirus
C) 		5 / 10 TYR 21116
ILE 21191
PRO 21192
VAL 21248
LEU 21180
 None
 1.15A 5ienB-5zvs2:
undetectable		 5ienB-5zvs2:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKQ_A_JMSA602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5zvs VP2
(Aquareovirus
C) 		3 / 3 VAL 2 374
SER 2 289
MET 2 794
 None
 0.87A 5ikqA-5zvs2:
undetectable		 5ikqA-5zvs2:
10.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB603_1
(PHIAB6 TAILSPIKE)		 5zvs PUTATIVE CORE
PROTEIN NTPASE/VP5
(Aquareovirus
C) 		3 / 3 VAL 4 631
GLU 4 649
GLU 4 713
 None
 0.87A 5jsdB-5zvs4:
undetectable
5jsdC-5zvs4:
undetectable		 5jsdB-5zvs4:
10.33
5jsdC-5zvs4:
10.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_B_CELB602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5zvs VP2
(Aquareovirus
C) 		4 / 6 VAL 2 398
SER 2 684
ARG 2 666
PHE 2 681
 None
 0.97A 5jw1B-5zvs2:
undetectable		 5jw1B-5zvs2:
9.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_A_PFLA511_1
(PROTON-GATED ION
CHANNEL)		 5zvs VP2
(Aquareovirus
C) 		4 / 8 ILE 2 544
ILE 2 512
ALA 2 514
ILE 2 515
 None
 0.68A 5mvmA-5zvs2:
undetectable
5mvmB-5zvs2:
undetectable		 5mvmA-5zvs2:
20.99
5mvmB-5zvs2:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NU7_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 4)		 5zvs VP2
(Aquareovirus
C) 		4 / 8 ALA 2 699
TYR 2 554
GLN 2 441
HIS 2 558
 None
 0.83A 5nu7A-5zvs2:
undetectable		 5nu7A-5zvs2:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_B_SAMB501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 5zvs VP2
(Aquareovirus
C) 		5 / 9 LEU 21156
ILE 21159
GLY 21158
GLY 2 998
LEU 21139
 None
 1.02A 5o96A-5zvs2:
undetectable
5o96B-5zvs2:
undetectable		 5o96A-5zvs2:
undetectable
5o96B-5zvs2:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TT3_H_EZLH303_1
(ALPHA-CARBONIC
ANHYDRASE)		 5zvs VP2
(Aquareovirus
C) 		4 / 8 HIS 21206
HIS 21205
THR 21113
ALA 21112
 None
 0.85A 5tt3H-5zvs2:
undetectable		 5tt3H-5zvs2:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC3_A_486A801_2
(GLUCOCORTICOID
RECEPTOR)		 5zvs PUTATIVE CORE
PROTEIN NTPASE/VP5
(Aquareovirus
C) 		4 / 5 LEU 4 347
LEU 4 351
MET 4 424
GLN 4 337
 None
 1.13A 5uc3A-5zvs4:
undetectable		 5uc3A-5zvs4:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V1T_A_SAMA605_0
(RADICAL SAM)		 5zvs VP2
(Aquareovirus
C) 		5 / 12 LEU 2   4
ARG 2 846
SER 2 186
THR 2  56
GLU 2 843
 None
 1.37A 5v1tA-5zvs2:
undetectable		 5v1tA-5zvs2:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_B_8LXB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5zvs VP2
(Aquareovirus
C) 		4 / 8 PHE 2 686
SER 2 545
PHE 2 665
LEU 2 605
 None
 1.05A 5y2tB-5zvs2:
undetectable		 5y2tB-5zvs2:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YF0_A_SAMA505_1
(CARNOSINE
N-METHYLTRANSFERASE)		 5zvs VP2
(Aquareovirus
C) 		4 / 5 GLN 2 732
ARG 2 309
GLU 2 706
ASP 2 433
 None
 1.31A 5yf0A-5zvs2:
undetectable		 5yf0A-5zvs2:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA411_0
(UNCHARACTERIZED
PROTEIN KDOO)		 5zvs PUTATIVE CORE
PROTEIN NTPASE/VP5
(Aquareovirus
C) 		3 / 3 LYS 4 254
LEU 4 253
ARG 4 384
 None
 0.87A 5yw0A-5zvs4:
undetectable		 5yw0A-5zvs4:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B0I_B_TA1B502_1
(TUBULIN BETA CHAIN)		 5zvs VP2
(Aquareovirus
C) 		5 / 12 VAL 2 462
LEU 2 991
ASP 2 988
ALA 2 459
GLY 21025
 None
 1.04A 6b0iB-5zvs2:
undetectable		 6b0iB-5zvs2:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_B_SUEB1202_1
(NS3 PROTEASE)		 5zvs PUTATIVE CORE
PROTEIN NTPASE/VP5
(Aquareovirus
C) 		5 / 9 VAL 4 690
HIS 4 692
LEU 4 511
ALA 4 403
VAL 4 404
 None
 1.34A 6c2mB-5zvs4:
undetectable		 6c2mB-5zvs4:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_D_SUED1202_0
(NS3 PROTEASE)		 5zvs VP2
(Aquareovirus
C) 		5 / 12 GLY 2 649
VAL 2 633
ILE 2 540
GLY 2 627
ALA 2 514
 None
 0.99A 6c2mD-5zvs2:
undetectable		 6c2mD-5zvs2:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FTP_B_DM2B501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		 5zvs VP2
(Aquareovirus
C) 		5 / 9 LEU 2 985
PHE 2 986
GLU 2 983
LEU 21020
VAL 2 462
 None
 1.24A 6ftpA-5zvs2:
undetectable
6ftpB-5zvs2:
undetectable		 6ftpA-5zvs2:
23.46
6ftpB-5zvs2:
17.72