SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5zvt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4S_A_TPVA201_1
(PROTEIN (HIV-1
PROTEASE))		 5zvt C-TERMINUS OF OUTER
CAPSID PROTEIN VP5
(Aquareovirus
C) 		5 / 10 LEU B 597
ALA B 573
VAL B 604
ILE B 525
GLY B 522
 None
 1.26A 1d4sA-5zvtB:
undetectable		 1d4sA-5zvtB:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EE2_A_CHDA1150_0
(ALCOHOL
DEHYDROGENASE)		 5zvt N-TERMINUS OF OUTER
CAPSID PROTEIN VP5
C-TERMINUS OF OUTER
CAPSID PROTEIN VP5
(Aquareovirus
C;
Aquareovirus
C) 		5 / 11 LEU B 163
LEU B 187
MET B 167
LEU B 218
ILE A  13
 None
MYR  A 101 (-4.2A)
MYR  A 101 (-3.6A)
None
MYR  A 101 (-4.7A)
 1.36A 1ee2A-5zvtB:
undetectable		 1ee2A-5zvtB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EE2_B_CHDB1250_1
(ALCOHOL
DEHYDROGENASE)		 5zvt N-TERMINUS OF OUTER
CAPSID PROTEIN VP5
C-TERMINUS OF OUTER
CAPSID PROTEIN VP5
(Aquareovirus
C;
Aquareovirus
C) 		5 / 11 LEU B 163
LEU B 187
MET B 167
LEU B 218
ILE A  13
 None
MYR  A 101 (-4.2A)
MYR  A 101 (-3.6A)
None
MYR  A 101 (-4.7A)
 1.41A 1ee2B-5zvtB:
undetectable		 1ee2B-5zvtB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_B_RALB600_1
(ESTROGEN RECEPTOR)		 5zvt C-TERMINUS OF OUTER
CAPSID PROTEIN VP5
(Aquareovirus
C) 		5 / 12 THR B 442
LEU B 351
LEU B 349
ILE B 307
LEU B 358
 None
 1.09A 1errB-5zvtB:
undetectable		 1errB-5zvtB:
14.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MIC_A_DVAA6_0
(GRAMICIDIN A)		 5zvt CORE PROTEIN VP6
(Aquareovirus
C) 		3 / 3 ALA U 262
VAL U 161
TRP U 210
 None
 0.90A 1micA-5zvtU:
undetectable
1micB-5zvtU:
undetectable		 1micA-5zvtU:
undetectable
1micB-5zvtU:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NSI_A_H4BA600_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 5zvt C-TERMINUS OF OUTER
CAPSID PROTEIN VP5
(Aquareovirus
C) 		4 / 6 ARG B 292
ILE B 299
TRP B 306
GLU B 497
 None
 1.29A 1nsiA-5zvtB:
undetectable
1nsiB-5zvtB:
undetectable		 1nsiA-5zvtB:
10.45
1nsiB-5zvtB:
10.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NSI_B_H4BB601_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 5zvt C-TERMINUS OF OUTER
CAPSID PROTEIN VP5
(Aquareovirus
C) 		4 / 6 TRP B 306
GLU B 497
ARG B 292
ILE B 299
 None
 1.25A 1nsiA-5zvtB:
undetectable
1nsiB-5zvtB:
undetectable		 1nsiA-5zvtB:
10.45
1nsiB-5zvtB:
10.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NSI_C_H4BC602_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 5zvt C-TERMINUS OF OUTER
CAPSID PROTEIN VP5
(Aquareovirus
C) 		4 / 6 ARG B 292
ILE B 299
TRP B 306
GLU B 497
 None
 1.25A 1nsiC-5zvtB:
undetectable
1nsiD-5zvtB:
undetectable		 1nsiC-5zvtB:
10.45
1nsiD-5zvtB:
10.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NSI_D_H4BD603_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 5zvt C-TERMINUS OF OUTER
CAPSID PROTEIN VP5
(Aquareovirus
C) 		4 / 6 TRP B 306
GLU B 497
ARG B 292
ILE B 299
 None
 1.22A 1nsiC-5zvtB:
undetectable
1nsiD-5zvtB:
undetectable		 1nsiC-5zvtB:
10.45
1nsiD-5zvtB:
10.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQ5_A_PAUA6001_0
(PANTOTHENATE KINASE)		 5zvt CORE PROTEIN VP6
(Aquareovirus
C) 		5 / 9 LEU U  51
GLY U  49
HIS U 276
TYR U 362
ASN U 242
 None
 1.34A 1sq5A-5zvtU:
undetectable		 1sq5A-5zvtU:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQ5_C_PAUC6002_0
(PANTOTHENATE KINASE)		 5zvt CORE PROTEIN VP6
(Aquareovirus
C) 		5 / 9 LEU U  51
GLY U  49
HIS U 276
TYR U 362
ASN U 242
 None
 1.34A 1sq5C-5zvtU:
undetectable		 1sq5C-5zvtU:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQ5_D_PAUD6004_0
(PANTOTHENATE KINASE)		 5zvt CORE PROTEIN VP6
(Aquareovirus
C) 		5 / 10 LEU U  51
GLY U  49
HIS U 276
TYR U 362
ASN U 242
 None
 1.31A 1sq5D-5zvtU:
undetectable		 1sq5D-5zvtU:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXQ_A_IMNA2001_1
(SERUM ALBUMIN)		 5zvt C-TERMINUS OF OUTER
CAPSID PROTEIN VP5
(Aquareovirus
C) 		5 / 10 ALA B 572
PHE B 576
ALA B 583
LEU B 584
LEU B 514
 None
 1.03A 2bxqA-5zvtB:
undetectable		 2bxqA-5zvtB:
8.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G78_A_REAA200_1
(CELLULAR RETINOIC
ACID-BINDING PROTEIN
2)		 5zvt C-TERMINUS OF OUTER
CAPSID PROTEIN VP5
(Aquareovirus
C) 		5 / 12 PHE B 417
LEU B 358
ILE B 405
ALA B 404
LEU B 351
 None
 1.14A 2g78A-5zvtB:
undetectable		 2g78A-5zvtB:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G78_A_REAA200_1
(CELLULAR RETINOIC
ACID-BINDING PROTEIN
2)		 5zvt CORE PROTEIN VP6
(Aquareovirus
C) 		5 / 12 ILE U 208
VAL U 290
VAL U 161
LEU U 406
MET U 410
 None
 1.06A 2g78A-5zvtU:
undetectable		 2g78A-5zvtU:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_J_TACJ5888_1
(ELONGATION FACTOR
EF-TU)		 5zvt CORE PROTEIN VP6
(Aquareovirus
C) 		4 / 6 THR U  38
ASP U 141
SER U 289
VAL U 293
 None
 1.28A 2hdnI-5zvtU:
undetectable
2hdnJ-5zvtU:
undetectable
2hdnL-5zvtU:
undetectable		 2hdnI-5zvtU:
17.11
2hdnJ-5zvtU:
14.02
2hdnL-5zvtU:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_L_TACL6888_1
(ELONGATION FACTOR
EF-TU)		 5zvt CORE PROTEIN VP6
(Aquareovirus
C) 		4 / 6 SER U 289
VAL U 293
THR U  38
ASP U 141
 None
 1.25A 2hdnJ-5zvtU:
undetectable
2hdnK-5zvtU:
undetectable
2hdnL-5zvtU:
undetectable		 2hdnJ-5zvtU:
14.02
2hdnK-5zvtU:
17.11
2hdnL-5zvtU:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NSI_A_H4BA600_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 5zvt C-TERMINUS OF OUTER
CAPSID PROTEIN VP5
(Aquareovirus
C) 		4 / 7 ARG B 292
ILE B 299
TRP B 306
GLU B 497
 None
 1.22A 2nsiA-5zvtB:
undetectable
2nsiB-5zvtB:
undetectable		 2nsiA-5zvtB:
10.45
2nsiB-5zvtB:
10.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NSI_B_H4BB601_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 5zvt C-TERMINUS OF OUTER
CAPSID PROTEIN VP5
(Aquareovirus
C) 		4 / 7 TRP B 306
GLU B 497
ARG B 292
ILE B 299
 None
 1.22A 2nsiA-5zvtB:
undetectable
2nsiB-5zvtB:
undetectable		 2nsiA-5zvtB:
10.45
2nsiB-5zvtB:
10.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_B_SAMB300_1
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 5zvt CORE PROTEIN VP6
(Aquareovirus
C) 		4 / 5 SER U 151
GLY U 154
HIS U 158
ASP U 327
 None
 0.99A 2oxtB-5zvtU:
undetectable		 2oxtB-5zvtU:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WUZ_A_TPFA1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE
, PUTATIVE)		 5zvt CORE PROTEIN VP6
(Aquareovirus
C) 		5 / 10 TYR U 359
TYR U 362
ALA U 237
ALA U 246
LEU U 219
 None
 1.41A 2wuzA-5zvtU:
undetectable		 2wuzA-5zvtU:
13.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WUZ_B_TPFB1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE
, PUTATIVE)		 5zvt CORE PROTEIN VP6
(Aquareovirus
C) 		5 / 10 TYR U 359
TYR U 362
ALA U 237
ALA U 246
LEU U 219
 None
 1.39A 2wuzB-5zvtU:
undetectable		 2wuzB-5zvtU:
13.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WV2_A_TPFA1_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 5zvt CORE PROTEIN VP6
(Aquareovirus
C) 		5 / 9 TYR U 359
TYR U 362
ALA U 237
ALA U 246
LEU U 219
 None
 1.50A 2wv2A-5zvtU:
undetectable		 2wv2A-5zvtU:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGO_A_PCFA1213_1
(WNT INHIBITORY
FACTOR 1)		 5zvt CORE PROTEIN VP6
(Aquareovirus
C) 		4 / 6 ILE U  66
ARG U  40
MET U 145
VAL U 111
 None
 0.96A 2ygoA-5zvtU:
undetectable		 2ygoA-5zvtU:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_B_2FAB500_2
(ADENOSYLHOMOCYSTEINA
SE)		 5zvt CORE PROTEIN VP6
(Aquareovirus
C) 		4 / 5 LEU U 296
GLN U 288
THR U 291
THR U 316
 None
 1.23A 2zj0B-5zvtU:
undetectable		 2zj0B-5zvtU:
10.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_C_2FAC500_2
(ADENOSYLHOMOCYSTEINA
SE)		 5zvt CORE PROTEIN VP6
(Aquareovirus
C) 		4 / 5 LEU U 296
GLN U 288
THR U 291
THR U 316
 None
 1.34A 2zj0C-5zvtU:
undetectable		 2zj0C-5zvtU:
10.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_D_2FAD500_2
(ADENOSYLHOMOCYSTEINA
SE)		 5zvt CORE PROTEIN VP6
(Aquareovirus
C) 		4 / 4 LEU U 296
GLN U 288
THR U 291
THR U 316
 None
 1.26A 2zj0D-5zvtU:
undetectable		 2zj0D-5zvtU:
10.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_B_ADNB500_2
(ADENOSYLHOMOCYSTEINA
SE)		 5zvt CORE PROTEIN VP6
(Aquareovirus
C) 		4 / 5 LEU U 296
GLN U 288
THR U 291
THR U 316
 None
 1.33A 3ce6B-5zvtU:
undetectable		 3ce6B-5zvtU:
10.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E23_A_SAMA221_0
(UNCHARACTERIZED
PROTEIN RPA2492)		 5zvt C-TERMINUS OF OUTER
CAPSID PROTEIN VP5
(Aquareovirus
C) 		5 / 12 PHE B 111
LEU B 108
GLY B  77
SER B  83
LEU B 145
 None
 1.16A 3e23A-5zvtB:
undetectable		 3e23A-5zvtB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 5zvt C-TERMINUS OF OUTER
CAPSID PROTEIN VP5
(Aquareovirus
C) 		4 / 7 ARG B 292
ILE B 299
TRP B 306
GLU B 497
 None
 1.26A 3e7gA-5zvtB:
undetectable
3e7gB-5zvtB:
undetectable		 3e7gA-5zvtB:
10.61
3e7gB-5zvtB:
10.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_B_H4BB1902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 5zvt C-TERMINUS OF OUTER
CAPSID PROTEIN VP5
(Aquareovirus
C) 		4 / 7 TRP B 306
GLU B 497
ARG B 292
ILE B 299
 None
 1.27A 3e7gA-5zvtB:
undetectable
3e7gB-5zvtB:
undetectable		 3e7gA-5zvtB:
10.61
3e7gB-5zvtB:
10.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_D_H4BD3902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 5zvt C-TERMINUS OF OUTER
CAPSID PROTEIN VP5
(Aquareovirus
C) 		4 / 8 TRP B 306
GLU B 497
ARG B 292
ILE B 299
 None
 1.31A 3e7gC-5zvtB:
undetectable
3e7gD-5zvtB:
undetectable		 3e7gC-5zvtB:
10.61
3e7gD-5zvtB:
10.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_D_ROCD201_4
(HIV-1 PROTEASE)		 5zvt C-TERMINUS OF OUTER
CAPSID PROTEIN VP5
(Aquareovirus
C) 		3 / 3 ARG B 567
VAL B 527
THR B 536
 None
 0.82A 3k4vD-5zvtB:
undetectable		 3k4vD-5zvtB:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Z_A_FLPA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 5zvt C-TERMINUS OF OUTER
CAPSID PROTEIN VP5
(Aquareovirus
C) 		5 / 12 VAL B 353
LEU B 444
GLY B 401
ALA B 400
LEU B 422
 None
 1.02A 3n8zA-5zvtB:
undetectable		 3n8zA-5zvtB:
9.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXC_A_ROCA401_2
(PROTEASE)		 5zvt C-TERMINUS OF OUTER
CAPSID PROTEIN VP5
(Aquareovirus
C) 		3 / 3 ARG B 154
LEU B 158
THR B  99
 None
 0.72A 3oxcA-5zvtB:
undetectable		 3oxcA-5zvtB:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_A_FLPA701_1
(CYCLOOXYGENASE-2)		 5zvt C-TERMINUS OF OUTER
CAPSID PROTEIN VP5
(Aquareovirus
C) 		5 / 12 VAL B 353
LEU B 444
GLY B 401
ALA B 400
LEU B 422
 None
 1.07A 3pghA-5zvtB:
undetectable		 3pghA-5zvtB:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_B_SALB404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 5zvt CORE PROTEIN VP6
(Aquareovirus
C) 		4 / 7 ASN U 329
PRO U 332
TYR U 359
ALA U 363
 None
 1.08A 3twpB-5zvtU:
undetectable		 3twpB-5zvtU:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_C_SALC404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 5zvt CORE PROTEIN VP6
(Aquareovirus
C) 		4 / 7 ASN U 329
PRO U 332
TYR U 359
ALA U 363
 None
 1.07A 3twpC-5zvtU:
undetectable		 3twpC-5zvtU:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_D_SALD404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 5zvt CORE PROTEIN VP6
(Aquareovirus
C) 		4 / 5 ASN U 329
PRO U 332
TYR U 359
ALA U 363
 None
 1.09A 3twpD-5zvtU:
undetectable		 3twpD-5zvtU:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U8Q_A_NPUA7231_1
(LACTOTRANSFERRIN)		 5zvt C-TERMINUS OF OUTER
CAPSID PROTEIN VP5
(Aquareovirus
C) 		4 / 5 GLY B 413
PRO B 415
ASN B 410
TYR B 360
 None
 1.27A 3u8qA-5zvtB:
undetectable		 3u8qA-5zvtB:
11.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V5W_A_8PRA701_2
(G-PROTEIN COUPLED
RECEPTOR KINASE 2)		 5zvt CORE PROTEIN VP6
(Aquareovirus
C) 		3 / 3 LEU U 132
MET U 135
ASP U 141
 None
 0.86A 3v5wA-5zvtU:
undetectable		 3v5wA-5zvtU:
7.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 5zvt C-TERMINUS OF OUTER
CAPSID PROTEIN VP5
(Aquareovirus
C) 		4 / 8 TRP B 306
GLU B 497
ARG B 292
ILE B 299
 None
 1.18A 4cx7A-5zvtB:
undetectable
4cx7B-5zvtB:
undetectable		 4cx7A-5zvtB:
10.45
4cx7B-5zvtB:
10.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_C_H4BC600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 5zvt C-TERMINUS OF OUTER
CAPSID PROTEIN VP5
(Aquareovirus
C) 		4 / 8 ARG B 292
ILE B 299
TRP B 306
GLU B 497
 None
 1.16A 4cx7C-5zvtB:
undetectable
4cx7D-5zvtB:
undetectable		 4cx7C-5zvtB:
10.45
4cx7D-5zvtB:
10.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DT8_B_ADNB401_1
(APH(2'')-ID)		 5zvt C-TERMINUS OF OUTER
CAPSID PROTEIN VP5
(Aquareovirus
C) 		5 / 10 SER B 500
ALA B 304
ILE B 299
LEU B 464
ILE B 339
 None
 1.06A 4dt8B-5zvtB:
undetectable		 4dt8B-5zvtB:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KQ8_A_ASDA602_1
(CYTOCHROME P450 19A1)		 5zvt C-TERMINUS OF OUTER
CAPSID PROTEIN VP5
(Aquareovirus
C) 		5 / 10 ILE B 507
ALA B 506
ASP B 505
THR B 474
VAL B 480
 None
 1.28A 4kq8A-5zvtB:
undetectable		 4kq8A-5zvtB:
9.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LHM_A_AZZA510_1
(THYMIDINE
PHOSPHORYLASE)		 5zvt C-TERMINUS OF OUTER
CAPSID PROTEIN VP5
(Aquareovirus
C) 		5 / 11 LEU B 280
ILE B 274
SER B 598
PHE B 285
LEU B 514
 None
 1.35A 4lhmA-5zvtB:
undetectable		 4lhmA-5zvtB:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_STRA301_1
(ANCESTRAL STEROID
RECEPTOR 2)		 5zvt C-TERMINUS OF OUTER
CAPSID PROTEIN VP5
(Aquareovirus
C) 		5 / 12 LEU B 514
ASN B 515
LEU B 517
ALA B 518
LEU B 582
 None
 1.02A 4ltwA-5zvtB:
undetectable		 4ltwA-5zvtB:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NOS_D_H4BD3011_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 5zvt C-TERMINUS OF OUTER
CAPSID PROTEIN VP5
(Aquareovirus
C) 		4 / 6 TRP B 306
GLU B 497
ARG B 292
ILE B 299
 None
 1.35A 4nosC-5zvtB:
undetectable
4nosD-5zvtB:
undetectable		 4nosC-5zvtB:
10.54
4nosD-5zvtB:
10.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_A_IPHA101_0
(INSULIN)		 5zvt C-TERMINUS OF OUTER
CAPSID PROTEIN VP5
(Aquareovirus
C) 		5 / 10 LEU B 280
ALA B 276
HIS B 513
LEU B 514
LEU B 273
 None
 1.24A 4p65A-5zvtB:
undetectable
4p65B-5zvtB:
undetectable
4p65F-5zvtB:
undetectable
4p65H-5zvtB:
undetectable		 4p65A-5zvtB:
undetectable
4p65B-5zvtB:
undetectable
4p65F-5zvtB:
undetectable
4p65H-5zvtB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVM_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 5zvt CORE PROTEIN VP6
(Aquareovirus
C) 		5 / 9 THR U  85
ALA U 115
GLY U  82
GLY U  81
ALA U  80
 None
 1.08A 4qvmK-5zvtU:
undetectable
4qvmL-5zvtU:
undetectable		 4qvmK-5zvtU:
15.57
4qvmL-5zvtU:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 5zvt CORE PROTEIN VP6
(Aquareovirus
C) 		5 / 10 THR U  85
ALA U 115
GLY U  82
GLY U  81
ALA U  80
 None
 1.05A 4qvpK-5zvtU:
undetectable
4qvpL-5zvtU:
undetectable		 4qvpK-5zvtU:
15.57
4qvpL-5zvtU:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 5zvt CORE PROTEIN VP6
(Aquareovirus
C) 		5 / 10 THR U  85
ALA U 115
GLY U  82
GLY U  81
ALA U  80
 None
 1.04A 4qvpY-5zvtU:
undetectable
4qvpZ-5zvtU:
undetectable		 4qvpY-5zvtU:
15.57
4qvpZ-5zvtU:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 5zvt CORE PROTEIN VP6
(Aquareovirus
C) 		5 / 10 THR U  85
ALA U 115
GLY U  82
GLY U  81
ALA U  80
 None
 1.06A 4qw1Y-5zvtU:
undetectable
4qw1Z-5zvtU:
undetectable		 4qw1Y-5zvtU:
16.51
4qw1Z-5zvtU:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW3_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 5zvt CORE PROTEIN VP6
(Aquareovirus
C) 		5 / 10 THR U  85
ALA U 115
GLY U  82
GLY U  81
ALA U  80
 None
 1.07A 4qw3K-5zvtU:
undetectable
4qw3L-5zvtU:
undetectable		 4qw3K-5zvtU:
16.51
4qw3L-5zvtU:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW3_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 5zvt CORE PROTEIN VP6
(Aquareovirus
C) 		5 / 10 THR U  85
ALA U 115
GLY U  82
GLY U  81
ALA U  80
 None
 1.07A 4qw3Y-5zvtU:
undetectable
4qw3Z-5zvtU:
undetectable		 4qw3Y-5zvtU:
16.51
4qw3Z-5zvtU:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_D_ACTD201_0
(RETINOL-BINDING
PROTEIN 2)		 5zvt C-TERMINUS OF OUTER
CAPSID PROTEIN VP5
(Aquareovirus
C) 		3 / 3 ASP B 229
HIS B 233
LYS B 219
 None
 0.99A 4qzuD-5zvtB:
undetectable		 4qzuD-5zvtB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_F_MN9F401_0
(N-ACETYLNEURAMINATE
LYASE)		 5zvt CORE PROTEIN VP6
(Aquareovirus
C) 		4 / 5 LEU U 211
TYR U 177
LEU U 174
THR U 188
 None
 1.18A 4wozF-5zvtU:
undetectable
4wozH-5zvtU:
undetectable		 4wozF-5zvtU:
undetectable
4wozH-5zvtU:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H8T_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 5zvt C-TERMINUS OF OUTER
CAPSID PROTEIN VP5
(Aquareovirus
C) 		5 / 12 LEU B 366
ALA B 404
ILE B 394
ILE B 445
LEU B 440
 None
 1.17A 5h8tA-5zvtB:
undetectable		 5h8tA-5zvtB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5zvt C-TERMINUS OF OUTER
CAPSID PROTEIN VP5
(Aquareovirus
C) 		5 / 12 VAL B 353
SER B 369
GLY B 401
ALA B 400
LEU B 422
 None
 1.07A 5iktA-5zvtB:
undetectable		 5iktA-5zvtB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5zvt C-TERMINUS OF OUTER
CAPSID PROTEIN VP5
(Aquareovirus
C) 		5 / 12 VAL B 353
LEU B 444
GLY B 401
ALA B 400
LEU B 422
 None
 1.08A 5iktB-5zvtB:
undetectable		 5iktB-5zvtB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MTH_A_ACTA301_0
(ANTIBODY FAB HEAVY
CHAIN)		 5zvt C-TERMINUS OF OUTER
CAPSID PROTEIN VP5
(Aquareovirus
C) 		4 / 4 THR B 350
VAL B 348
PRO B 291
THR B 467
 None
 1.32A 5mthA-5zvtB:
undetectable
5mthH-5zvtB:
undetectable		 5mthA-5zvtB:
undetectable
5mthH-5zvtB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE8_B_08JB602_1
(CYTOCHROME P450 3A4)		 5zvt C-TERMINUS OF OUTER
CAPSID PROTEIN VP5
(Aquareovirus
C) 		4 / 8 ALA B 607
ILE B 263
ALA B 262
LEU B 259
 None
 0.79A 5te8B-5zvtB:
undetectable		 5te8B-5zvtB:
10.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_G_CVIG301_0
(REGULATORY PROTEIN
TETR)		 5zvt CORE PROTEIN VP6
(Aquareovirus
C) 		5 / 12 MET U 410
GLN U 263
ALA U 262
LEU U 406
ASP U 301
 None
 1.25A 5vlmG-5zvtU:
undetectable		 5vlmG-5zvtU:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_G_CVIG301_0
(REGULATORY PROTEIN
TETR)		 5zvt CORE PROTEIN VP6
(Aquareovirus
C) 		5 / 12 MET U 410
GLN U 263
LEU U 406
ILE U 267
ASP U 301
 None
 1.30A 5vlmG-5zvtU:
undetectable		 5vlmG-5zvtU:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZWR_A_9KLA402_0
(EST-Y29)		 5zvt C-TERMINUS OF OUTER
CAPSID PROTEIN VP5
(Aquareovirus
C) 		5 / 12 TYR B 322
LEU B 459
GLY B 401
ALA B 400
LEU B 420
 None
 1.21A 5zwrA-5zvtB:
undetectable		 5zwrA-5zvtB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNR_B_6J3B201_0
(TRANSTHYRETIN)		 5zvt C-TERMINUS OF OUTER
CAPSID PROTEIN VP5
(Aquareovirus
C) 		4 / 4 LYS B 191
LEU B 187
ALA B 190
LEU B 186
 MYR  A 101 (-2.4A)
MYR  A 101 (-4.2A)
MYR  A 101 ( 3.7A)
None
 1.29A 6gnrB-5zvtB:
undetectable		 6gnrB-5zvtB:
undetectable