SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5zw4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FML_B_RTLB501_0
(RETINOL DEHYDRATASE)		 5zw4 PUTATIVE
O-METHYLTRANSFERASE
YRRM
(Bacillus
subtilis) 		5 / 12 ILE A 186
TYR A 189
LEU A 193
LEU A 162
ILE A 203
 None
 1.08A 1fmlB-5zw4A:
undetectable		 1fmlB-5zw4A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG4_A_SAMA500_1
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 5zw4 PUTATIVE
O-METHYLTRANSFERASE
YRRM
(Bacillus
subtilis) 		4 / 8 GLU A  60
GLY A  62
GLU A  85
ASP A 113
 SAM  A 302 (-3.9A)
SAM  A 302 (-3.4A)
SAM  A 302 (-2.7A)
SAM  A 302 (-3.3A)
 0.35A 1jg4A-5zw4A:
12.6		 1jg4A-5zw4A:
28.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJL_A_SAMA200_0
(METHIONINE REPRESSOR
PROTEIN METJ)		 5zw4 PUTATIVE
O-METHYLTRANSFERASE
YRRM
(Bacillus
subtilis) 		5 / 11 GLU A  27
ARG A  71
GLU A  44
ALA A  41
LEU A  16
 None
 1.20A 1mjlA-5zw4A:
undetectable
1mjlB-5zw4A:
undetectable		 1mjlA-5zw4A:
undetectable
1mjlB-5zw4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RH3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 5zw4 PUTATIVE
O-METHYLTRANSFERASE
YRRM
(Bacillus
subtilis) 		5 / 12 ILE A  58
MET A  43
ILE A  70
LEU A 103
ARG A 106
 None
 1.34A 1rh3A-5zw4A:
2.3		 1rh3A-5zw4A:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RMT_D_ADND1504_1
(CLASS B ACID
PHOSPHATASE)		 5zw4 PUTATIVE
O-METHYLTRANSFERASE
YRRM
(Bacillus
subtilis) 		4 / 8 PHE A 143
TYR A 189
LEU A 193
TRP A 192
 None
 1.09A 1rmtD-5zw4A:
3.7		 1rmtD-5zw4A:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVD_A_SAMA501_0
(CATECHOL-O-METHYLTRA
NSFERASE)		 5zw4 PUTATIVE
O-METHYLTRANSFERASE
YRRM
(Bacillus
subtilis) 		6 / 12 MET A  38
GLY A  62
TYR A  67
SER A  68
ALA A 114
ALA A 134
 None
SAM  A 302 (-3.4A)
None
SAM  A 302 (-2.7A)
SAM  A 302 (-3.7A)
SAM  A 302 (-3.4A)
 0.73A 2avdA-5zw4A:
24.7		 2avdA-5zw4A:
28.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVD_B_SAMB601_0
(CATECHOL-O-METHYLTRA
NSFERASE)		 5zw4 PUTATIVE
O-METHYLTRANSFERASE
YRRM
(Bacillus
subtilis) 		6 / 12 MET A  38
GLY A  62
TYR A  67
ALA A 114
ASP A 133
ALA A 134
 None
SAM  A 302 (-3.4A)
None
SAM  A 302 (-3.7A)
SAM  A 302 (-3.6A)
SAM  A 302 (-3.4A)
 0.94A 2avdB-5zw4A:
24.5		 2avdB-5zw4A:
28.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_B_SAMB301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 5zw4 PUTATIVE
O-METHYLTRANSFERASE
YRRM
(Bacillus
subtilis) 		5 / 12 GLU A  60
GLY A  62
ASP A 133
ALA A 134
ALA A 135
 SAM  A 302 (-3.9A)
SAM  A 302 (-3.4A)
SAM  A 302 (-3.6A)
SAM  A 302 (-3.4A)
SAM  A 302 (-3.3A)
 1.09A 2br4B-5zw4A:
14.3		 2br4B-5zw4A:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_F_SAMF301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 5zw4 PUTATIVE
O-METHYLTRANSFERASE
YRRM
(Bacillus
subtilis) 		5 / 12 GLY A  62
ASP A 113
ASP A 133
ALA A 134
ALA A 135
 SAM  A 302 (-3.4A)
SAM  A 302 (-3.3A)
SAM  A 302 (-3.6A)
SAM  A 302 (-3.4A)
SAM  A 302 (-3.3A)
 1.11A 2br4F-5zw4A:
13.9		 2br4F-5zw4A:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_F_SAMF301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 5zw4 PUTATIVE
O-METHYLTRANSFERASE
YRRM
(Bacillus
subtilis) 		5 / 12 GLY A  62
SER A  68
ASP A 113
ASP A 133
ALA A 134
 SAM  A 302 (-3.4A)
SAM  A 302 (-2.7A)
SAM  A 302 (-3.3A)
SAM  A 302 (-3.6A)
SAM  A 302 (-3.4A)
 0.85A 2br4F-5zw4A:
13.9		 2br4F-5zw4A:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZTH_A_SAMA305_1
(CATECHOL
O-METHYLTRANSFERASE)		 5zw4 PUTATIVE
O-METHYLTRANSFERASE
YRRM
(Bacillus
subtilis) 		3 / 3 SER A  68
GLU A  85
ASP A 133
 SAM  A 302 (-2.7A)
SAM  A 302 (-2.7A)
SAM  A 302 (-3.6A)
 0.22A 2zthA-5zw4A:
22.1		 2zthA-5zw4A:
27.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_B_VDYB6178_1
(VITAMIN D
HYDROXYLASE)		 5zw4 PUTATIVE
O-METHYLTRANSFERASE
YRRM
(Bacillus
subtilis) 		5 / 12 PRO A  55
MET A  72
LEU A  50
VAL A 206
LEU A 210
 None
 1.31A 3a51B-5zw4A:
undetectable		 3a51B-5zw4A:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A7E_A_SAMA216_1
(CATECHOL
O-METHYLTRANSFERASE)		 5zw4 PUTATIVE
O-METHYLTRANSFERASE
YRRM
(Bacillus
subtilis) 		5 / 6 GLY A  62
SER A  68
ILE A  84
GLU A  85
ASP A 133
 SAM  A 302 (-3.4A)
SAM  A 302 (-2.7A)
SAM  A 302 ( 4.7A)
SAM  A 302 (-2.7A)
SAM  A 302 (-3.6A)
 0.29A 3a7eA-5zw4A:
23.5		 3a7eA-5zw4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWM_A_SAMA301_1
(CATECHOL
O-METHYLTRANSFERASE)		 5zw4 PUTATIVE
O-METHYLTRANSFERASE
YRRM
(Bacillus
subtilis) 		3 / 3 SER A  68
GLU A  85
ASP A 133
 SAM  A 302 (-2.7A)
SAM  A 302 (-2.7A)
SAM  A 302 (-3.6A)
 0.19A 3bwmA-5zw4A:
22.7		 3bwmA-5zw4A:
29.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWY_A_SAMA301_1
(COMT PROTEIN)		 5zw4 PUTATIVE
O-METHYLTRANSFERASE
YRRM
(Bacillus
subtilis) 		3 / 3 SER A  68
GLU A  85
ASP A 133
 SAM  A 302 (-2.7A)
SAM  A 302 (-2.7A)
SAM  A 302 (-3.6A)
 0.18A 3bwyA-5zw4A:
22.3		 3bwyA-5zw4A:
29.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DXY_A_SAMA1_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 5zw4 PUTATIVE
O-METHYLTRANSFERASE
YRRM
(Bacillus
subtilis) 		6 / 11 GLU A  60
GLY A  62
ILE A  84
GLU A  85
ASP A 113
ALA A 114
 SAM  A 302 (-3.9A)
SAM  A 302 (-3.4A)
SAM  A 302 ( 4.7A)
SAM  A 302 (-2.7A)
SAM  A 302 (-3.3A)
SAM  A 302 (-3.7A)
 0.59A 3dxyA-5zw4A:
12.7		 3dxyA-5zw4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GRY_A_SAMA300_0
(DIMETHYLADENOSINE
TRANSFERASE)		 5zw4 PUTATIVE
O-METHYLTRANSFERASE
YRRM
(Bacillus
subtilis) 		5 / 12 GLU A  60
GLY A  62
GLU A  85
ASP A 113
ALA A 114
 SAM  A 302 (-3.9A)
SAM  A 302 (-3.4A)
SAM  A 302 (-2.7A)
SAM  A 302 (-3.3A)
SAM  A 302 (-3.7A)
 0.41A 3gryA-5zw4A:
14.3		 3gryA-5zw4A:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ID6_C_SAMC301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 5zw4 PUTATIVE
O-METHYLTRANSFERASE
YRRM
(Bacillus
subtilis) 		6 / 12 GLY A  62
ALA A  64
GLU A  85
ASP A 113
ALA A 114
ASP A 133
 SAM  A 302 (-3.4A)
SAM  A 302 (-3.6A)
SAM  A 302 (-2.7A)
SAM  A 302 (-3.3A)
SAM  A 302 (-3.7A)
SAM  A 302 (-3.6A)
 0.46A 3id6C-5zw4A:
14.5		 3id6C-5zw4A:
26.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MB5_A_SAMA301_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 5zw4 PUTATIVE
O-METHYLTRANSFERASE
YRRM
(Bacillus
subtilis) 		4 / 4 GLY A  62
GLU A  85
ASP A 113
ASP A 133
 SAM  A 302 (-3.4A)
SAM  A 302 (-2.7A)
SAM  A 302 (-3.3A)
SAM  A 302 (-3.6A)
 0.37A 3mb5A-5zw4A:
18.7		 3mb5A-5zw4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NMU_F_SAMF228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
NOP5/NOP56 RELATED
PROTEIN)		 5zw4 PUTATIVE
O-METHYLTRANSFERASE
YRRM
(Bacillus
subtilis) 		6 / 12 GLY A  62
ALA A  64
GLU A  85
ASP A 113
ALA A 114
ASP A 133
 SAM  A 302 (-3.4A)
SAM  A 302 (-3.6A)
SAM  A 302 (-2.7A)
SAM  A 302 (-3.3A)
SAM  A 302 (-3.7A)
SAM  A 302 (-3.6A)
 0.60A 3nmuA-5zw4A:
undetectable
3nmuF-5zw4A:
12.0		 3nmuA-5zw4A:
23.48
3nmuF-5zw4A:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NMU_J_SAMJ228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
NOP5/NOP56 RELATED
PROTEIN)		 5zw4 PUTATIVE
O-METHYLTRANSFERASE
YRRM
(Bacillus
subtilis) 		6 / 11 GLY A  62
ALA A  64
ILE A  84
GLU A  85
ALA A 114
ASP A 133
 SAM  A 302 (-3.4A)
SAM  A 302 (-3.6A)
SAM  A 302 ( 4.7A)
SAM  A 302 (-2.7A)
SAM  A 302 (-3.7A)
SAM  A 302 (-3.6A)
 0.71A 3nmuB-5zw4A:
undetectable
3nmuJ-5zw4A:
14.5		 3nmuB-5zw4A:
undetectable
3nmuJ-5zw4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NVK_I_SAMI228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 5zw4 PUTATIVE
O-METHYLTRANSFERASE
YRRM
(Bacillus
subtilis) 		6 / 12 GLY A  62
ALA A  64
ILE A  84
ASP A 113
ALA A 114
ASP A 133
 SAM  A 302 (-3.4A)
SAM  A 302 (-3.6A)
SAM  A 302 ( 4.7A)
SAM  A 302 (-3.3A)
SAM  A 302 (-3.7A)
SAM  A 302 (-3.6A)
 0.73A 3nvkI-5zw4A:
15.3		 3nvkI-5zw4A:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NVK_J_SAMJ228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
NOP5/NOP56 RELATED
PROTEIN)		 5zw4 PUTATIVE
O-METHYLTRANSFERASE
YRRM
(Bacillus
subtilis) 		6 / 12 GLY A  62
ALA A  64
GLU A  85
ASP A 113
ALA A 114
ASP A 133
 SAM  A 302 (-3.4A)
SAM  A 302 (-3.6A)
SAM  A 302 (-2.7A)
SAM  A 302 (-3.3A)
SAM  A 302 (-3.7A)
SAM  A 302 (-3.6A)
 0.74A 3nvkF-5zw4A:
undetectable
3nvkJ-5zw4A:
15.3		 3nvkF-5zw4A:
23.48
3nvkJ-5zw4A:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S68_A_SAMA228_0
(CATECHOL
O-METHYLTRANSFERASE)		 5zw4 PUTATIVE
O-METHYLTRANSFERASE
YRRM
(Bacillus
subtilis) 		5 / 10 GLU A  60
GLY A  62
SER A  68
GLU A  85
ASP A 133
 SAM  A 302 (-3.9A)
SAM  A 302 (-3.4A)
SAM  A 302 (-2.7A)
SAM  A 302 (-2.7A)
SAM  A 302 (-3.6A)
 0.34A 3s68A-5zw4A:
22.8		 3s68A-5zw4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BLV_A_SAMA1281_1
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 5zw4 PUTATIVE
O-METHYLTRANSFERASE
YRRM
(Bacillus
subtilis) 		4 / 6 SER A  68
GLU A  85
ASP A 113
ASP A 133
 SAM  A 302 (-2.7A)
SAM  A 302 (-2.7A)
SAM  A 302 (-3.3A)
SAM  A 302 (-3.6A)
 0.93A 4blvA-5zw4A:
12.0		 4blvA-5zw4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_A_SAMA301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 5zw4 PUTATIVE
O-METHYLTRANSFERASE
YRRM
(Bacillus
subtilis) 		5 / 12 GLY A  62
ALA A  64
ASP A 113
ALA A 114
ASP A 133
 SAM  A 302 (-3.4A)
SAM  A 302 (-3.6A)
SAM  A 302 (-3.3A)
SAM  A 302 (-3.7A)
SAM  A 302 (-3.6A)
 0.47A 4df3A-5zw4A:
16.3		 4df3A-5zw4A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_B_SAMB301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 5zw4 PUTATIVE
O-METHYLTRANSFERASE
YRRM
(Bacillus
subtilis) 		5 / 12 GLY A  62
ALA A  64
ASP A 113
ALA A 114
ASP A 133
 SAM  A 302 (-3.4A)
SAM  A 302 (-3.6A)
SAM  A 302 (-3.3A)
SAM  A 302 (-3.7A)
SAM  A 302 (-3.6A)
 0.50A 4df3B-5zw4A:
16.2		 4df3B-5zw4A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MI4_B_SPMB201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 5zw4 PUTATIVE
O-METHYLTRANSFERASE
YRRM
(Bacillus
subtilis) 		4 / 7 GLU A  31
GLU A  27
GLU A  13
ARG A  19
 None
 1.00A 4mi4B-5zw4A:
undetectable
4mi4C-5zw4A:
undetectable		 4mi4B-5zw4A:
17.59
4mi4C-5zw4A:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_B_SPMB201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 5zw4 PUTATIVE
O-METHYLTRANSFERASE
YRRM
(Bacillus
subtilis) 		4 / 8 GLU A  31
GLU A  27
GLU A  13
ARG A  19
 None
 1.00A 4mj8B-5zw4A:
undetectable
4mj8C-5zw4A:
undetectable		 4mj8B-5zw4A:
16.57
4mj8C-5zw4A:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_C_AERC601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 5zw4 PUTATIVE
O-METHYLTRANSFERASE
YRRM
(Bacillus
subtilis) 		5 / 12 ASN A  97
ILE A  70
ILE A  98
ALA A  64
VAL A 109
 None
None
PO4  A 301 ( 4.3A)
SAM  A 302 (-3.6A)
PO4  A 301 (-4.3A)
 1.05A 4nkvC-5zw4A:
undetectable		 4nkvC-5zw4A:
11.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_A_STRA601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 5zw4 PUTATIVE
O-METHYLTRANSFERASE
YRRM
(Bacillus
subtilis) 		5 / 12 ASN A  97
ILE A  70
ILE A  98
ALA A  64
VAL A 109
 None
None
PO4  A 301 ( 4.3A)
SAM  A 302 (-3.6A)
PO4  A 301 (-4.3A)
 1.02A 4nkxA-5zw4A:
undetectable		 4nkxA-5zw4A:
11.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNU_D_QDND602_1
(CYTOCHROME P450 2D6)		 5zw4 PUTATIVE
O-METHYLTRANSFERASE
YRRM
(Bacillus
subtilis) 		5 / 10 GLY A 112
GLU A 116
PHE A 110
ALA A 120
ASP A 119
 None
 1.27A 4wnuD-5zw4A:
undetectable		 4wnuD-5zw4A:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUD_A_SAMA303_1
(CATECHOL
O-METHYLTRANSFERASE)		 5zw4 PUTATIVE
O-METHYLTRANSFERASE
YRRM
(Bacillus
subtilis) 		3 / 3 SER A  68
GLU A  85
ASP A 133
 SAM  A 302 (-2.7A)
SAM  A 302 (-2.7A)
SAM  A 302 (-3.6A)
 0.16A 4xudA-5zw4A:
22.3		 4xudA-5zw4A:
29.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUE_A_SAMA303_1
(CATECHOL
O-METHYLTRANSFERASE)		 5zw4 PUTATIVE
O-METHYLTRANSFERASE
YRRM
(Bacillus
subtilis) 		5 / 5 GLY A  62
TYR A  67
SER A  68
GLU A  85
ASP A 133
 SAM  A 302 (-3.4A)
None
SAM  A 302 (-2.7A)
SAM  A 302 (-2.7A)
SAM  A 302 (-3.6A)
 0.38A 4xueA-5zw4A:
22.9		 4xueA-5zw4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YMG_B_SAMB1001_0
(PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE)		 5zw4 PUTATIVE
O-METHYLTRANSFERASE
YRRM
(Bacillus
subtilis) 		6 / 12 GLY A  62
TYR A  67
SER A  68
ALA A 114
ASP A 133
ALA A 134
 SAM  A 302 (-3.4A)
None
SAM  A 302 (-2.7A)
SAM  A 302 (-3.7A)
SAM  A 302 (-3.6A)
SAM  A 302 (-3.4A)
 0.39A 4ymgB-5zw4A:
25.8		 4ymgB-5zw4A:
26.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERG_B_SAMB401_1
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61)		 5zw4 PUTATIVE
O-METHYLTRANSFERASE
YRRM
(Bacillus
subtilis) 		4 / 7 GLY A  62
GLU A  85
ASP A 113
ASP A 133
 SAM  A 302 (-3.4A)
SAM  A 302 (-2.7A)
SAM  A 302 (-3.3A)
SAM  A 302 (-3.6A)
 0.41A 5ergB-5zw4A:
16.9		 5ergB-5zw4A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_A_SAMA301_0
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 5zw4 PUTATIVE
O-METHYLTRANSFERASE
YRRM
(Bacillus
subtilis) 		6 / 12 GLU A  60
GLY A  62
TYR A  67
ALA A 114
ASP A 133
ALA A 134
 SAM  A 302 (-3.9A)
SAM  A 302 (-3.4A)
None
SAM  A 302 (-3.7A)
SAM  A 302 (-3.6A)
SAM  A 302 (-3.4A)
 0.65A 5kvaA-5zw4A:
25.9		 5kvaA-5zw4A:
25.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_B_SAMB301_0
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 5zw4 PUTATIVE
O-METHYLTRANSFERASE
YRRM
(Bacillus
subtilis) 		6 / 12 GLU A  60
GLY A  62
TYR A  67
ALA A 114
ASP A 133
ALA A 134
 SAM  A 302 (-3.9A)
SAM  A 302 (-3.4A)
None
SAM  A 302 (-3.7A)
SAM  A 302 (-3.6A)
SAM  A 302 (-3.4A)
 0.65A 5kvaB-5zw4A:
25.8		 5kvaB-5zw4A:
25.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LSA_A_SAMA303_1
(CATECHOL
O-METHYLTRANSFERASE)		 5zw4 PUTATIVE
O-METHYLTRANSFERASE
YRRM
(Bacillus
subtilis) 		4 / 4 TYR A  67
SER A  68
GLU A  85
ASP A 133
 None
SAM  A 302 (-2.7A)
SAM  A 302 (-2.7A)
SAM  A 302 (-3.6A)
 0.40A 5lsaA-5zw4A:
22.8		 5lsaA-5zw4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_A_SAMA306_0
(METHYLTRANSFERASE)		 5zw4 PUTATIVE
O-METHYLTRANSFERASE
YRRM
(Bacillus
subtilis) 		6 / 12 GLU A  60
GLY A  62
TYR A  67
ALA A 114
PHE A 131
ALA A 134
 SAM  A 302 (-3.9A)
SAM  A 302 (-3.4A)
None
SAM  A 302 (-3.7A)
None
SAM  A 302 (-3.4A)
 0.49A 5n5dA-5zw4A:
25.0		 5n5dA-5zw4A:
28.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_A_SAMA306_1
(METHYLTRANSFERASE)		 5zw4 PUTATIVE
O-METHYLTRANSFERASE
YRRM
(Bacillus
subtilis) 		4 / 7 SER A  68
ILE A  84
GLU A  85
ASP A 133
 SAM  A 302 (-2.7A)
SAM  A 302 ( 4.7A)
SAM  A 302 (-2.7A)
SAM  A 302 (-3.6A)
 0.15A 5n5dA-5zw4A:
25.0		 5n5dA-5zw4A:
28.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_B_SAMB303_0
(METHYLTRANSFERASE)		 5zw4 PUTATIVE
O-METHYLTRANSFERASE
YRRM
(Bacillus
subtilis) 		6 / 12 GLU A  60
TYR A  67
ILE A  84
ALA A 114
PHE A 131
ALA A 134
 SAM  A 302 (-3.9A)
None
SAM  A 302 ( 4.7A)
SAM  A 302 (-3.7A)
None
SAM  A 302 (-3.4A)
 0.55A 5n5dB-5zw4A:
24.5		 5n5dB-5zw4A:
28.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_B_SAMB303_1
(METHYLTRANSFERASE)		 5zw4 PUTATIVE
O-METHYLTRANSFERASE
YRRM
(Bacillus
subtilis) 		4 / 7 GLY A  62
SER A  68
GLU A  85
ASP A 133
 SAM  A 302 (-3.4A)
SAM  A 302 (-2.7A)
SAM  A 302 (-2.7A)
SAM  A 302 (-3.6A)
 0.19A 5n5dB-5zw4A:
24.5		 5n5dB-5zw4A:
28.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ZW4_A_SAMA302_0
(PUTATIVE
O-METHYLTRANSFERASE
YRRM)		 5zw4 PUTATIVE
O-METHYLTRANSFERASE
YRRM
(Bacillus
subtilis) 		7 / 12 ILE A  65
GLU A  60
GLY A  62
ALA A 114
ALA A 134
ALA A 135
PHE A 142
 None
SAM  A 302 (-3.9A)
SAM  A 302 (-3.4A)
SAM  A 302 (-3.7A)
SAM  A 302 (-3.4A)
SAM  A 302 (-3.3A)
SAM  A 302 (-4.8A)
 1.41A 5zw4A-5zw4A:
41.4		 5zw4A-5zw4A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ZW4_A_SAMA302_0
(PUTATIVE
O-METHYLTRANSFERASE
YRRM)		 5zw4 PUTATIVE
O-METHYLTRANSFERASE
YRRM
(Bacillus
subtilis) 		12 / 12 PRO A  36
ILE A  37
MET A  38
GLU A  60
GLY A  62
ALA A  64
TYR A  67
ASN A  87
ALA A 114
ALA A 134
ALA A 135
PHE A 142
 U  D  34 ( 4.2A)
SAM  A 302 (-4.3A)
None
SAM  A 302 (-3.9A)
SAM  A 302 (-3.4A)
SAM  A 302 (-3.6A)
None
None
SAM  A 302 (-3.7A)
SAM  A 302 (-3.4A)
SAM  A 302 (-3.3A)
SAM  A 302 (-4.8A)
 0.01A 5zw4A-5zw4A:
41.4		 5zw4A-5zw4A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ZW4_A_SAMA302_1
(PUTATIVE
O-METHYLTRANSFERASE
YRRM)		 5zw4 PUTATIVE
O-METHYLTRANSFERASE
YRRM
(Bacillus
subtilis) 		4 / 6 GLU A  85
ARG A  86
ARG A  90
ASP A 113
 SAM  A 302 (-2.7A)
None
U  D  34 (-2.9A)
SAM  A 302 (-3.3A)
 1.12A 5zw4A-5zw4A:
41.4		 5zw4A-5zw4A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ZW4_A_SAMA302_1
(PUTATIVE
O-METHYLTRANSFERASE
YRRM)		 5zw4 PUTATIVE
O-METHYLTRANSFERASE
YRRM
(Bacillus
subtilis) 		5 / 6 SER A  68
GLU A  85
ARG A  90
ASP A 113
ASP A 133
 SAM  A 302 (-2.7A)
SAM  A 302 (-2.7A)
U  D  34 (-2.9A)
SAM  A 302 (-3.3A)
SAM  A 302 (-3.6A)
 0.00A 5zw4A-5zw4A:
41.4		 5zw4A-5zw4A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EMU_B_SAMB301_0
(TRNA
(GUANINE(9)-/ADENINE
(9)-N1)-METHYLTRANSF
ERASE)		 5zw4 PUTATIVE
O-METHYLTRANSFERASE
YRRM
(Bacillus
subtilis) 		5 / 12 LEU A  59
ILE A 157
ILE A  84
ASP A 133
ILE A  61
 None
None
SAM  A 302 ( 4.7A)
SAM  A 302 (-3.6A)
None
 1.07A 6emuB-5zw4A:
2.6		 6emuB-5zw4A:
20.90