SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5zwp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MSK_A_SAMA1301_0
(COBALAMIN-DEPENDENT
METHIONINE SYNTHASE)		 5zwp GLUTATHIONE
S-TRANSFERASE 1
(Musca
domestica) 		5 / 10 ASP A 100
ARG A  66
TYR A 113
PRO A 114
TYR A 112
 None
GSH  A 301 (-3.4A)
FMT  A 302 (-4.4A)
None
None
 1.44A 1mskA-5zwpA:
undetectable		 1mskA-5zwpA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTF_A_2TNA201_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 5zwp GLUTATHIONE
S-TRANSFERASE 1
(Musca
domestica) 		4 / 5 LEU A  30
ILE A  52
SER A   9
GLY A   8
 None
GSH  A 301 (-4.2A)
GSH  A 301 ( 4.5A)
None
 0.94A 2otfA-5zwpA:
undetectable		 2otfA-5zwpA:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BPX_A_SALA257_1
(TRANSCRIPTIONAL
REGULATOR)		 5zwp GLUTATHIONE
S-TRANSFERASE 1
(Musca
domestica) 		4 / 8 SER A  65
ARG A  66
ALA A  10
THR A 165
 GSH  A 301 (-2.6A)
GSH  A 301 (-3.4A)
None
None
 0.93A 3bpxA-5zwpA:
undetectable
3bpxB-5zwpA:
undetectable		 3bpxA-5zwpA:
22.22
3bpxB-5zwpA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROD_A_NCAA302_0
(NICOTINAMIDE
N-METHYLTRANSFERASE)		 5zwp GLUTATHIONE
S-TRANSFERASE 1
(Musca
domestica) 		5 / 8 LEU A  97
ASP A 100
ALA A 158
SER A  14
SER A  65
 None
None
None
None
GSH  A 301 (-2.6A)
 1.39A 3rodA-5zwpA:
undetectable		 3rodA-5zwpA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROD_B_NCAB302_0
(NICOTINAMIDE
N-METHYLTRANSFERASE)		 5zwp GLUTATHIONE
S-TRANSFERASE 1
(Musca
domestica) 		5 / 9 LEU A  97
ASP A 100
ALA A 158
SER A  14
SER A  65
 None
None
None
None
GSH  A 301 (-2.6A)
 1.46A 3rodB-5zwpA:
undetectable		 3rodB-5zwpA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_G_377G401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5zwp GLUTATHIONE
S-TRANSFERASE 1
(Musca
domestica) 		4 / 6 ARG A  13
GLU A 167
TYR A 183
LEU A 160
 None
 1.40A 4twdF-5zwpA:
2.2
4twdG-5zwpA:
undetectable		 4twdF-5zwpA:
14.13
4twdG-5zwpA:
14.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NR3_A_95EA401_0
(DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3B)		 5zwp GLUTATHIONE
S-TRANSFERASE 1
(Musca
domestica) 		4 / 7 PHE A 127
ASP A 172
LYS A 175
SER A 170
 None
 1.44A 5nr3A-5zwpA:
undetectable		 5nr3A-5zwpA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BM5_A_SAMA1301_0
(METHIONINE SYNTHASE)		 5zwp GLUTATHIONE
S-TRANSFERASE 1
(Musca
domestica) 		5 / 11 ASP A 100
ARG A  66
TYR A 113
PRO A 114
TYR A 112
 None
GSH  A 301 (-3.4A)
FMT  A 302 (-4.4A)
None
None
 1.45A 6bm5A-5zwpA:
undetectable		 6bm5A-5zwpA:
undetectable