SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5zya'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BX4_A_ADNA355_1
(PROTEIN (ADENOSINE
KINASE))		 5zya SPLICING FACTOR 3B
SUBUNIT 1
(Homo
sapiens) 		5 / 12 GLY C 880
ILE C 872
GLY C 845
ALA C 847
ILE C 850
 None
 0.92A 1bx4A-5zyaC:
undetectable		 1bx4A-5zyaC:
12.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_G_SAMG199_0
(METHIONINE REPRESSOR)		 5zya SPLICING FACTOR 3B
SUBUNIT 1
(Homo
sapiens) 		5 / 10 ALA C 706
LEU C 731
PRO C 730
ALA C 749
GLY C 751
 None
 1.29A 1mjqG-5zyaC:
undetectable
1mjqH-5zyaC:
undetectable		 1mjqG-5zyaC:
undetectable
1mjqH-5zyaC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N6C_A_SAMA402_0
(SET
DOMAIN-CONTAINING
PROTEIN 7)		 5zya SPLICING FACTOR 3B
SUBUNIT 1
(Homo
sapiens) 		5 / 11 ALA C 841
GLY C 845
GLU C 848
LYS C 807
GLU C 839
 None
 1.39A 1n6cA-5zyaC:
undetectable		 1n6cA-5zyaC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBC_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		 5zya SPLICING FACTOR 3B
SUBUNIT 1
(Homo
sapiens) 		5 / 10 VAL C 936
LEU C 974
LEU C 978
TYR C 981
ALA C 951
 None
 1.26A 1pbcA-5zyaC:
undetectable		 1pbcA-5zyaC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VQ1_A_SAMA301_0
(N5-GLUTAMINE
METHYLTRANSFERASE,
HEMK)		 5zya SPLICING FACTOR 3B
SUBUNIT 1
(Homo
sapiens) 		5 / 12 ALA C 999
ILE C1000
VAL C 989
GLU C 984
ALA C 951
 None
 1.22A 1vq1A-5zyaC:
undetectable		 1vq1A-5zyaC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VQ1_A_SAMA301_0
(N5-GLUTAMINE
METHYLTRANSFERASE,
HEMK)		 5zya SPLICING FACTOR 3B
SUBUNIT 1
(Homo
sapiens) 		5 / 12 GLY C 995
ALA C 999
ILE C1000
VAL C 989
GLU C 984
 None
 1.33A 1vq1A-5zyaC:
undetectable		 1vq1A-5zyaC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_A_9CRA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5zya SPLICING FACTOR 3B
SUBUNIT 1
(Homo
sapiens) 		5 / 12 ALA C 672
GLN C 669
LEU C 712
ALA C 711
CYH C 652
 None
 1.14A 1xdkA-5zyaC:
undetectable		 1xdkA-5zyaC:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_A_9CRA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5zya SPLICING FACTOR 3B
SUBUNIT 1
(Homo
sapiens) 		5 / 12 ALA C 672
GLN C 669
LEU C 712
ALA C 711
LEU C 644
 None
 1.13A 1xdkA-5zyaC:
undetectable		 1xdkA-5zyaC:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XIU_A_9CRA201_1
(RXR-LIKE PROTEIN)		 5zya SPLICING FACTOR 3B
SUBUNIT 1
(Homo
sapiens) 		5 / 12 ALA C 672
GLN C 669
LEU C 712
ALA C 711
LEU C 644
 None
 1.00A 1xiuA-5zyaC:
undetectable		 1xiuA-5zyaC:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XVA_B_ACTB294_0
(GLYCINE
N-METHYLTRANSFERASE)		 5zya SPLICING FACTOR 3B
SUBUNIT 1
(Homo
sapiens) 		4 / 6 ALA C 749
TYR C 765
ILE C 754
LEU C 731
 None
 1.04A 1xvaA-5zyaC:
undetectable
1xvaB-5zyaC:
undetectable		 1xvaA-5zyaC:
undetectable
1xvaB-5zyaC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FT9_A_CHDA131_0
(FATTY ACID-BINDING
PROTEIN 2, LIVER)		 5zya SPLICING FACTOR 3B
SUBUNIT 1
(Homo
sapiens) 		5 / 11 LEU C 560
LEU C 600
PRO C 530
ASN C 533
ARG C 524
 None
 1.26A 2ft9A-5zyaC:
undetectable		 2ft9A-5zyaC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_B_SAMB500_1
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 5zya SPLICING FACTOR 3B
SUBUNIT 1
(Homo
sapiens) 		4 / 6 THR C 612
ASP C 616
THR C 628
ASP C 621
 None
 1.14A 2okcB-5zyaC:
undetectable		 2okcB-5zyaC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_A_CHDA2_0
(FERROCHELATASE)		 5zya SPLICING FACTOR 3B
SUBUNIT 1
(Homo
sapiens) 		4 / 6 ARG C 684
PRO C 755
GLY C 720
MET C 757
 None
 1.46A 3aqiA-5zyaC:
undetectable		 3aqiA-5zyaC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_B_CHDB6_0
(FERROCHELATASE)		 5zya SPLICING FACTOR 3B
SUBUNIT 1
(Homo
sapiens) 		5 / 12 LEU C 753
LEU C 731
ILE C 721
VAL C 695
VAL C 687
 None
 1.32A 3aqiB-5zyaC:
undetectable		 3aqiB-5zyaC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZY_A_9CRA463_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5zya SPLICING FACTOR 3B
SUBUNIT 1
(Homo
sapiens) 		5 / 12 ALA C 672
GLN C 669
LEU C 712
ALA C 711
CYH C 652
 None
 1.02A 3dzyA-5zyaC:
undetectable		 3dzyA-5zyaC:
9.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZY_A_9CRA463_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5zya SPLICING FACTOR 3B
SUBUNIT 1
(Homo
sapiens) 		5 / 12 ALA C 672
GLN C 669
LEU C 712
ALA C 711
LEU C 644
 None
 1.05A 3dzyA-5zyaC:
undetectable		 3dzyA-5zyaC:
9.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IX9_B_MTXB200_1
(DIHYDROFOLATE
REDUCTASE)		 5zya SPLICING FACTOR 3B
SUBUNIT 1
(Homo
sapiens) 		5 / 12 ILE C 667
ALA C 636
LEU C 645
LYS C 649
VAL C 668
 None
 1.11A 3ix9B-5zyaC:
undetectable		 3ix9B-5zyaC:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U7S_A_017A202_2
(POL POLYPROTEIN)		 5zya SPLICING FACTOR 3B
SUBUNIT 1
(Homo
sapiens) 		5 / 9 GLY C 605
ALA C 604
ASP C 564
LEU C 575
VAL C 571
 None
 0.98A 3u7sB-5zyaC:
undetectable		 3u7sB-5zyaC:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BKJ_B_STIB1000_2
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 5zya SPLICING FACTOR 3B
SUBUNIT 1
(Homo
sapiens) 		4 / 5 LEU C 747
TYR C 761
MET C 757
ARG C 702
 None
 1.46A 4bkjB-5zyaC:
undetectable		 4bkjB-5zyaC:
12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IOM_A_FOLA608_0
(FORMATE--TETRAHYDROF
OLATE LIGASE)		 5zya SPLICING FACTOR 3B
SUBUNIT 1
(Homo
sapiens) 		4 / 7 ALA C 716
PRO C 718
LEU C 680
LEU C 683
 None
 1.06A 4iomA-5zyaC:
undetectable		 4iomA-5zyaC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_B_ESTB600_1
(ESTROGEN RECEPTOR
BETA)		 5zya SPLICING FACTOR 3B
SUBUNIT 1
(Homo
sapiens) 		5 / 12 LEU C 501
LEU C 500
ILE C 535
ILE C 556
LEU C 551
 None
 1.21A 4j24B-5zyaC:
undetectable		 4j24B-5zyaC:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_A_GCSA303_1
(CHITOSANASE)		 5zya SPLICING FACTOR 3B
SUBUNIT 1
(Homo
sapiens) 		4 / 6 ILE C 556
ASP C 557
GLY C 593
VAL C 634
 None
 1.08A 4oltA-5zyaC:
undetectable		 4oltA-5zyaC:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PST_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 5zya PHD FINGER-LIKE
DOMAIN-CONTAINING
PROTEIN 5A
(Homo
sapiens) 		3 / 3 ILE D  88
ASP D  34
ARG D  12
 None
 0.69A 4pstA-5zyaD:
undetectable		 4pstA-5zyaD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYQ_A_3CJA607_1
(LACTOPEROXIDASE)		 5zya SPLICING FACTOR 3B
SUBUNIT 1
(Homo
sapiens) 		3 / 3 GLN C 737
HIS C 738
ARG C 702
 None
 1.16A 4qyqA-5zyaC:
undetectable		 4qyqA-5zyaC:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYQ_B_3CJB607_1
(LACTOPEROXIDASE)		 5zya SPLICING FACTOR 3B
SUBUNIT 1
(Homo
sapiens) 		3 / 3 GLN C 737
HIS C 738
ARG C 702
 None
 1.13A 4qyqB-5zyaC:
undetectable		 4qyqB-5zyaC:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R21_B_STRB601_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 5zya SPLICING FACTOR 3B
SUBUNIT 1
(Homo
sapiens) 		5 / 9 ALA C 745
ILE C 690
VAL C 687
ALA C 710
VAL C 727
 None
 1.01A 4r21B-5zyaC:
undetectable		 4r21B-5zyaC:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5O_A_IPHA906_0
(PROTEIN ARGONAUTE-2)		 5zya SPLICING FACTOR 3B
SUBUNIT 1
(Homo
sapiens) 		4 / 5 PHE C 532
PRO C 569
VAL C 567
ALA C 528
 None
 1.30A 4w5oA-5zyaC:
undetectable		 4w5oA-5zyaC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 5zya SPLICING FACTOR 3B
SUBUNIT 1
(Homo
sapiens) 		4 / 5 PHE C 532
PRO C 569
VAL C 567
ALA C 528
 None
 1.33A 4z4cA-5zyaC:
undetectable		 4z4cA-5zyaC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4D_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 5zya SPLICING FACTOR 3B
SUBUNIT 1
(Homo
sapiens) 		4 / 5 PHE C 532
PRO C 569
VAL C 567
ALA C 528
 None
 1.30A 4z4dA-5zyaC:
undetectable		 4z4dA-5zyaC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4E_A_IPHA906_0
(PROTEIN ARGONAUTE-2)		 5zya SPLICING FACTOR 3B
SUBUNIT 1
(Homo
sapiens) 		4 / 5 PHE C 532
PRO C 569
VAL C 567
ALA C 528
 None
 1.30A 4z4eA-5zyaC:
undetectable		 4z4eA-5zyaC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE2_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5zya SPLICING FACTOR 3B
SUBUNIT 1
(Homo
sapiens) 		5 / 12 GLY C1089
TYR C1165
LEU C1129
ILE C1166
GLY C1159
 None
 1.17A 4ze2A-5zyaC:
1.0		 4ze2A-5zyaC:
10.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWY_E_010E6_0
(N-[(5-METHYLISOXAZOL
-3-YL)CARBONYL]ALANY
L-L-VALYL-N~1~-((1R,
2Z)-4-(BENZYLOXY)-4-
OXO-1-{[(3R)-2-OXOPY
RROLIDIN-3-YL]METHYL
}BUT-2-ENYL)-L-LEUCI
NAMIDE
MAIN PROTEASE)		 5zya SPLICING FACTOR 3B
SUBUNIT 1
(Homo
sapiens) 		4 / 4 THR C1187
LEU C1148
HIS C1184
GLY C1146
 None
 0.98A 5gwyA-5zyaC:
undetectable		 5gwyA-5zyaC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IWU_A_ACTA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 5zya SPLICING FACTOR 3B
SUBUNIT 1
(Homo
sapiens) 		4 / 6 PHE C 647
VAL C 651
ILE C 617
ASP C 618
 None
 1.17A 5iwuA-5zyaC:
undetectable		 5iwuA-5zyaC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UAN_A_9CRA503_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5zya SPLICING FACTOR 3B
SUBUNIT 1
(Homo
sapiens) 		5 / 12 ALA C 672
GLN C 669
LEU C 712
ALA C 711
LEU C 644
 None
 1.00A 5uanA-5zyaC:
undetectable		 5uanA-5zyaC:
11.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AF6_A_GLYA507_0
(L-PROLYL-[PEPTIDYL-C
ARRIER PROTEIN]
DEHYDROGENASE)		 5zya SPLICING FACTOR 3B
SUBUNIT 1
(Homo
sapiens) 		3 / 3 TYR C1136
HIS C1184
MET C1178
 None
 1.22A 6af6A-5zyaC:
undetectable		 6af6A-5zyaC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_C_EU7C101_0
(MATRIX PROTEIN 2)		 5zya SPLICING FACTOR 3B
SUBUNIT 1
(Homo
sapiens) 		5 / 9 ALA C 601
VAL C 634
ALA C 636
SER C 637
GLY C 640
 None
 1.16A 6bklA-5zyaC:
undetectable
6bklB-5zyaC:
undetectable
6bklC-5zyaC:
undetectable
6bklD-5zyaC:
undetectable		 6bklA-5zyaC:
undetectable
6bklB-5zyaC:
undetectable
6bklC-5zyaC:
undetectable
6bklD-5zyaC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_D_AQ4D602_0
(CYTOCHROME P450 1A1)		 5zya SPLICING FACTOR 3B
SUBUNIT 1
(Homo
sapiens) 		5 / 12 ILE C 872
GLY C 880
ALA C 881
ASP C 883
LEU C 888
 None
 1.05A 6dwnD-5zyaC:
undetectable		 6dwnD-5zyaC:
23.33