SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5zzk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IEP_A_STIA201_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 5zzk MONOFUNCTIONAL
GLYCOSYLTRANSFERASE
(Staphylococcus
aureus) 		4 / 6 VAL A 223
VAL A 242
ILE A 231
MET A 264
 None
 1.13A 1iepA-5zzkA:
undetectable		 1iepA-5zzkA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_B_STIB600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5zzk MONOFUNCTIONAL
GLYCOSYLTRANSFERASE
(Staphylococcus
aureus) 		4 / 6 VAL A 223
VAL A 242
ILE A 231
MET A 264
 None
 1.11A 2hyyB-5zzkA:
undetectable		 2hyyB-5zzkA:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYX_A_ROCA201_4
(HIV-1 PROTEASE)		 5zzk MONOFUNCTIONAL
GLYCOSYLTRANSFERASE
(Staphylococcus
aureus) 		4 / 4 LEU A 157
ASP A  68
VAL A 163
THR A 135
 None
 1.10A 3cyxB-5zzkA:
undetectable		 3cyxB-5zzkA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K5V_A_STIA2_2
(TYROSINE-PROTEIN
KINASE ABL1)		 5zzk MONOFUNCTIONAL
GLYCOSYLTRANSFERASE
(Staphylococcus
aureus) 		4 / 6 VAL A 223
VAL A 242
ILE A 231
MET A 264
 None
 1.11A 3k5vA-5zzkA:
undetectable		 3k5vA-5zzkA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K5V_B_STIB2_2
(TYROSINE-PROTEIN
KINASE ABL1)		 5zzk MONOFUNCTIONAL
GLYCOSYLTRANSFERASE
(Staphylococcus
aureus) 		4 / 6 VAL A 223
VAL A 242
ILE A 231
MET A 264
 None
 1.14A 3k5vB-5zzkA:
undetectable		 3k5vB-5zzkA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MS9_B_STIB1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 5zzk MONOFUNCTIONAL
GLYCOSYLTRANSFERASE
(Staphylococcus
aureus) 		4 / 7 VAL A 223
VAL A 242
ILE A 231
MET A 264
 None
 1.16A 3ms9B-5zzkA:
undetectable		 3ms9B-5zzkA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_A_STIA1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 5zzk MONOFUNCTIONAL
GLYCOSYLTRANSFERASE
(Staphylococcus
aureus) 		4 / 6 VAL A 223
VAL A 242
ILE A 231
MET A 264
 None
 1.10A 3mssA-5zzkA:
undetectable		 3mssA-5zzkA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_C_STIC1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 5zzk MONOFUNCTIONAL
GLYCOSYLTRANSFERASE
(Staphylococcus
aureus) 		4 / 6 VAL A 223
VAL A 242
ILE A 231
MET A 264
 None
 1.11A 3mssC-5zzkA:
undetectable		 3mssC-5zzkA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K17_B_OHBB701_0
(LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 16A)		 5zzk MONOFUNCTIONAL
GLYCOSYLTRANSFERASE
(Staphylococcus
aureus) 		4 / 5 GLU A  77
SER A  84
ARG A  74
SER A 174
 None
 1.42A 4k17B-5zzkA:
undetectable		 4k17B-5zzkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_B_8LXB501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5zzk MONOFUNCTIONAL
GLYCOSYLTRANSFERASE
(Staphylococcus
aureus) 		5 / 12 GLN A 136
ILE A 172
LEU A 173
ILE A 180
HIS A 107
 None
 1.08A 5y2tB-5zzkA:
undetectable		 5y2tB-5zzkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G9B_B_IXXB705_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN
ENVELOPE
GLYCOPROTEIN)		 5zzk MONOFUNCTIONAL
GLYCOSYLTRANSFERASE
(Staphylococcus
aureus) 		4 / 5 ALA A  95
TYR A  91
GLN A 215
ILE A 211
 None
 1.41A 6g9bA-5zzkA:
undetectable
6g9bB-5zzkA:
undetectable		 6g9bA-5zzkA:
18.82
6g9bB-5zzkA:
21.18