SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5zzn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CEA_A_ACAA90_1
(PLASMINOGEN)		 5zzn -
(-) 		4 / 8 ASP V  53
TYR V  75
ARG V  66
THR V  58
 None
HEM  V 201 (-3.7A)
None
HEM  V 201 (-4.2A)
 1.18A 1ceaA-5zznV:
undetectable
1ceaB-5zznV:
undetectable		 1ceaA-5zznV:
undetectable
1ceaB-5zznV:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WG8_B_SAMB3141_0
(PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 5zzn -
(-) 		5 / 12 GLY V  43
GLY V  44
GLY V 132
GLN V  34
HIS V 118
 None
 1.07A 1wg8B-5zznV:
undetectable		 1wg8B-5zznV:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_A_ACHA301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 5zzn

(;
) 		4 / 7 THR V  63
TYR U  42
TYR V  82
ARG U  39
 None
None
HEM  V 201 (-4.6A)
None
 1.28A 3wipA-5zznV:
undetectable
3wipB-5zznV:
undetectable		 3wipA-5zznV:
undetectable
3wipB-5zznV:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_B_ACHB301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 5zzn

(;
) 		4 / 8 THR V  63
TYR U  42
TYR V  82
ARG U  39
 None
None
HEM  V 201 (-4.6A)
None
 1.26A 3wipB-5zznV:
undetectable
3wipC-5zznV:
undetectable		 3wipB-5zznV:
undetectable
3wipC-5zznV:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_C_ACHC301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 5zzn

(;
) 		4 / 8 THR V  63
TYR U  42
TYR V  82
ARG U  39
 None
None
HEM  V 201 (-4.6A)
None
 1.24A 3wipC-5zznV:
undetectable
3wipD-5zznV:
undetectable		 3wipC-5zznV:
undetectable
3wipD-5zznV:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_D_ACHD301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 5zzn

(;
) 		4 / 8 THR V  63
TYR U  42
TYR V  82
ARG U  39
 None
None
HEM  V 201 (-4.6A)
None
 1.27A 3wipD-5zznV:
undetectable
3wipE-5zznV:
undetectable		 3wipD-5zznV:
undetectable
3wipE-5zznV:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_E_ACHE301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 5zzn

(;
) 		4 / 8 ARG U  39
THR V  63
TYR U  42
TYR V  82
 None
None
None
HEM  V 201 (-4.6A)
 1.26A 3wipA-5zznU:
undetectable
3wipE-5zznU:
undetectable		 3wipA-5zznU:
undetectable
3wipE-5zznU:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_F_ACHF301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 5zzn

(;
) 		4 / 7 THR V  63
TYR U  42
TYR V  82
ARG U  39
 None
None
HEM  V 201 (-4.6A)
None
 1.32A 3wipF-5zznV:
undetectable
3wipG-5zznV:
undetectable		 3wipF-5zznV:
undetectable
3wipG-5zznV:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_G_ACHG301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 5zzn

(;
) 		4 / 8 THR V  63
TYR U  42
TYR V  82
ARG U  39
 None
None
HEM  V 201 (-4.6A)
None
 1.30A 3wipG-5zznV:
undetectable
3wipH-5zznV:
undetectable		 3wipG-5zznV:
undetectable
3wipH-5zznV:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_J_ACHJ301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 5zzn

(;
) 		4 / 8 ARG U  39
THR V  63
TYR U  42
TYR V  82
 None
None
None
HEM  V 201 (-4.6A)
 1.29A 3wipF-5zznU:
undetectable
3wipJ-5zznU:
undetectable		 3wipF-5zznU:
undetectable
3wipJ-5zznU:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QD3_A_5AEA201_1
(PEPTIDYL-TRNA
HYDROLASE)		 5zzn -
(-) 		5 / 9 LEU U  27
ASN U  78
VAL U  58
VAL U  61
LEU U  62
 None
 1.20A 4qd3A-5zznU:
undetectable		 4qd3A-5zznU:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_F_377F401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5zzn -
(-) 		4 / 7 LEU U  27
PHE U  35
TYR U  21
ARG U  97
 None
None
None
DMS  U 202 (-3.8A)
 1.18A 4twdF-5zznU:
undetectable
4twdJ-5zznU:
undetectable		 4twdF-5zznU:
undetectable
4twdJ-5zznU:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_G_377G401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5zzn -
(-) 		4 / 6 TYR U  21
ARG U  97
LEU U  27
PHE U  35
 None
DMS  U 202 (-3.8A)
None
None
 1.10A 4twdF-5zznU:
undetectable
4twdG-5zznU:
undetectable		 4twdF-5zznU:
undetectable
4twdG-5zznU:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UAC_A_ACRA501_2
(CARBOHYDRATE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, CUT1 FAMILY
(TC 3.A.1.1.-))		 5zzn -
(-) 		4 / 7 GLU V 109
TRP V 130
ASP V  53
THR V  46
 None
None
None
HEM  V 201 (-4.1A)
 0.88A 4uacA-5zznV:
undetectable		 4uacA-5zznV:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZDY_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5zzn -
(-) 		5 / 12 GLY V  84
PHE V  33
GLY V  44
LEU V  59
THR V  81
 None
None
None
HEM  V 201 (-4.9A)
None
 1.10A 4zdyA-5zznV:
undetectable		 4zdyA-5zznV:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE1_A_X2NA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5zzn -
(-) 		5 / 12 GLY V  84
PHE V  33
GLY V  44
LEU V  59
THR V  81
 None
None
None
HEM  V 201 (-4.9A)
None
 1.06A 4ze1A-5zznV:
undetectable		 4ze1A-5zznV:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE2_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5zzn -
(-) 		5 / 12 GLY V  84
PHE V  33
GLY V  44
LEU V  59
THR V  81
 None
None
None
HEM  V 201 (-4.9A)
None
 1.03A 4ze2A-5zznV:
undetectable		 4ze2A-5zznV:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WWS_A_SAMA501_0
(PUTATIVE
METHYLTRANSFERASE
NSUN6)		 5zzn -
(-) 		5 / 12 ALA U  53
PRO U  54
ASP U  60
LEU U  67
LEU U  75
 DMS  U 202 ( 3.5A)
HTG  U 203 (-3.9A)
HTG  U 203 (-4.3A)
None
None
 1.04A 5wwsA-5zznU:
undetectable		 5wwsA-5zznU:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E8Q_A_X2NA602_0
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5zzn -
(-) 		5 / 12 GLY V  84
PHE V  33
GLY V  44
LEU V  59
THR V  81
 None
None
None
HEM  V 201 (-4.9A)
None
 1.06A 6e8qA-5zznV:
undetectable		 6e8qA-5zznV:
undetectable