SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6a8m'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A7Y_A_DVAA8_0
(ACTINOMYCIN D)		 6a8m -
(-) 		3 / 3 THR A  63
THR A  64
PRO A  62
 None
 0.85A 1a7yA-6a8mA:
undetectable		 1a7yA-6a8mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_A_DVAA8_0
(GRAMICIDIN A)		 6a8m -
(-) 		3 / 3 VAL A 176
TRP A 174
TRP A  55
 None
 1.24A 1c4dA-6a8mA:
undetectable
1c4dB-6a8mA:
undetectable		 1c4dA-6a8mA:
undetectable
1c4dB-6a8mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_B_CCSB381_0
(ESTROGEN RECEPTOR)		 6a8m -
(-) 		3 / 3 GLU A  71
ALA A 128
SER A  31
 None
 0.70A 1errB-6a8mA:
undetectable		 1errB-6a8mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JGS_A_SALA256_1
(MULTIPLE ANTIBIOTIC
RESISTANCE PROTEIN
MARR)		 6a8m -
(-) 		4 / 7 VAL A  34
THR A  49
LEU A  52
VAL A  75
 None
 0.86A 1jgsA-6a8mA:
undetectable		 1jgsA-6a8mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW3_A_SAMA500_1
(HISTONE
METHYLTRANSFERASE
DOT1L)		 6a8m -
(-) 		4 / 4 THR A 424
GLN A 422
GLU A 181
ASP A   8
 None
 1.47A 1nw3A-6a8mA:
undetectable		 1nw3A-6a8mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QFI_A_DVAA8_0
(ACTINOMYCIN X2)		 6a8m -
(-) 		3 / 3 THR A  63
THR A  64
PRO A  62
 None
 0.84A 1qfiA-6a8mA:
undetectable		 1qfiA-6a8mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U18_A_HSMA401_1
(NITROPHORIN 1)		 6a8m -
(-) 		4 / 4 ASP A  21
LEU A  16
LEU A  19
LEU A  17
 None
 1.32A 1u18A-6a8mA:
undetectable		 1u18A-6a8mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_F_DVAF8_0
(7-AMINO-ACTINOMYCIN
D)		 6a8m -
(-) 		3 / 3 THR A  63
THR A  64
PRO A  62
 None
 0.86A 1unjF-6a8mA:
undetectable		 1unjF-6a8mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YVP_A_ACTA2001_0
(60-KDA SS-A/RO
RIBONUCLEOPROTEIN)		 6a8m -
(-) 		4 / 5 TYR A 258
SER A 303
SER A 290
ASN A 396
 None
 1.11A 1yvpA-6a8mA:
undetectable		 1yvpA-6a8mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8D_A_BEZA1002_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 6a8m -
(-) 		5 / 10 LEU A 399
GLY A 366
LEU A 380
LEU A 332
ILE A 328
 None
 1.06A 2f8dA-6a8mA:
undetectable		 2f8dA-6a8mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8D_B_BEZB1003_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 6a8m -
(-) 		5 / 10 LEU A 399
GLY A 366
LEU A 380
LEU A 332
ILE A 328
 None
 1.06A 2f8dB-6a8mA:
undetectable		 2f8dB-6a8mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OGY_B_C2FB4000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 6a8m -
(-) 		5 / 12 ILE A 226
LEU A 232
GLY A 191
SER A 189
ILE A 293
 None
 1.09A 2ogyB-6a8mA:
undetectable		 2ogyB-6a8mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_A_ASDA1223_1
(GLUTATHIONE
S-TRANSFERASE A2)		 6a8m -
(-) 		4 / 8 GLY A  72
ARG A  20
LEU A  96
PHE A  12
 None
 0.70A 2vctA-6a8mA:
undetectable		 2vctA-6a8mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_B_ASDB1223_1
(GLUTATHIONE
S-TRANSFERASE A2)		 6a8m -
(-) 		4 / 8 GLY A  72
ARG A  20
LEU A  96
PHE A  12
 None
 0.69A 2vctB-6a8mA:
undetectable		 2vctB-6a8mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_D_ASDD1223_1
(GLUTATHIONE
S-TRANSFERASE A2)		 6a8m -
(-) 		4 / 7 GLY A  72
ARG A  20
LEU A  96
PHE A  12
 None
 0.73A 2vctD-6a8mA:
undetectable		 2vctD-6a8mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XF3_A_J01A600_1
(ORF12)		 6a8m -
(-) 		5 / 11 SER A 188
THR A 420
SER A 300
TYR A 258
GLY A 191
 None
 1.32A 2xf3A-6a8mA:
undetectable		 2xf3A-6a8mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XF3_B_J01B600_1
(ORF12)		 6a8m -
(-) 		5 / 11 SER A 188
THR A 420
SER A 300
TYR A 258
GLY A 191
 None
 1.33A 2xf3B-6a8mA:
undetectable		 2xf3B-6a8mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XH9_A_J01A1437_1
(ORF12)		 6a8m -
(-) 		5 / 11 SER A 188
THR A 420
SER A 300
TYR A 258
GLY A 191
 None
 1.35A 2xh9A-6a8mA:
undetectable		 2xh9A-6a8mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XH9_B_J01B1437_1
(ORF12)		 6a8m -
(-) 		5 / 10 SER A 188
THR A 420
SER A 300
TYR A 258
GLY A 191
 None
 1.32A 2xh9B-6a8mA:
undetectable		 2xh9B-6a8mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YCJ_A_C2FA3000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 6a8m -
(-) 		5 / 12 ILE A 226
LEU A 232
GLY A 191
SER A 189
ILE A 293
 None
 1.16A 2ycjA-6a8mA:
undetectable		 2ycjA-6a8mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_E_SVRE510_2
(PHOSPHOLIPASE A2)		 6a8m -
(-) 		4 / 6 VAL A 421
GLN A 186
GLY A 191
LEU A 254
 None
 1.06A 3bjwE-6a8mA:
undetectable		 3bjwE-6a8mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_D_MTXD164_2
(DIHYDROFOLATE
REDUCTASE)		 6a8m -
(-) 		3 / 3 ARG A 271
ILE A 261
THR A 214
 None
 0.65A 3ia4D-6a8mA:
undetectable		 3ia4D-6a8mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_M_TFPM201_1
(PROTEIN S100-A4)		 6a8m -
(-) 		4 / 7 GLY A 366
PHE A 361
GLY A 400
PHE A 401
 None
 0.96A 3ko0M-6a8mA:
undetectable
3ko0P-6a8mA:
undetectable		 3ko0M-6a8mA:
undetectable
3ko0P-6a8mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_D_VIBD223_1
(THIAMINE
PYROPHOSPHOKINASE)		 6a8m -
(-) 		4 / 8 LEU A 415
LEU A 307
CYH A 286
SER A 264
 None
 0.99A 3lm8B-6a8mA:
3.6
3lm8D-6a8mA:
undetectable		 3lm8B-6a8mA:
undetectable
3lm8D-6a8mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA505_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 6a8m -
(-) 		3 / 3 THR A  50
ASN A  54
GLU A  60
 None
 0.68A 3v4tA-6a8mA:
undetectable
3v4tC-6a8mA:
undetectable		 3v4tA-6a8mA:
undetectable
3v4tC-6a8mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7A_B_RGZB601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 6a8m -
(-) 		5 / 12 LEU A  57
LEU A  56
ILE A 102
ILE A  66
PHE A  23
 None
 1.08A 4a7aB-6a8mA:
undetectable		 4a7aB-6a8mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DR5_A_SRYA1860_1
(16S RRNA
30S RIBOSOMAL
PROTEIN S12)		 6a8m -
(-) 		3 / 3 LYS A 180
PRO A 244
LYS A 296
 None
 1.31A 4dr5L-6a8mA:
undetectable		 4dr5L-6a8mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DR6_A_SRYA1956_1
(16S RRNA
30S RIBOSOMAL
PROTEIN S12)		 6a8m -
(-) 		3 / 3 LYS A 180
PRO A 244
LYS A 296
 None
 1.25A 4dr6L-6a8mA:
undetectable		 4dr6L-6a8mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DV7_A_SRYA1601_1
(16S RRNA
RIBOSOMAL PROTEIN
S12)		 6a8m -
(-) 		3 / 3 LYS A 180
PRO A 244
LYS A 296
 None
 1.12A 4dv7L-6a8mA:
undetectable		 4dv7L-6a8mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0V_A_MIXA1301_1
(DNA TOPOISOMERASE
2-BETA)		 6a8m -
(-) 		4 / 7 GLY A 370
ILE A  51
GLU A 372
GLN A 422
 None
 1.08A 4g0vA-6a8mA:
undetectable		 4g0vA-6a8mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_A_20JA601_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 6a8m -
(-) 		4 / 8 PHE A 373
ARG A 374
ALA A 418
SER A 303
 None
 1.18A 4lv9A-6a8mA:
undetectable
4lv9B-6a8mA:
undetectable		 4lv9A-6a8mA:
undetectable
4lv9B-6a8mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M6K_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 6a8m -
(-) 		5 / 12 LEU A  85
PHE A  12
THR A  64
ILE A  66
LEU A  52
 None
 1.08A 4m6kA-6a8mA:
undetectable		 4m6kA-6a8mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_C_ACTC202_0
(RETINOL-BINDING
PROTEIN 2)		 6a8m -
(-) 		4 / 6 TYR A 298
THR A  11
TRP A 174
LEU A 371
 None
 1.34A 4qzuC-6a8mA:
undetectable		 4qzuC-6a8mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G5G_B_ACTB1321_0
(PUTATIVE XANTHINE
DEHYDROGENASE YAGR
MOLYBDENUM-BINDING
SU SUBUNIT)		 6a8m -
(-) 		3 / 3 THR A 214
ASP A 215
ALA A 216
 None
 0.09A 5g5gB-6a8mA:
undetectable		 5g5gB-6a8mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEO_A_VDYA206_2
(CDL2.3A)		 6a8m -
(-) 		4 / 8 ILE A 308
MET A 196
LEU A 218
ILE A 262
 None
 1.01A 5ieoA-6a8mA:
1.8		 5ieoA-6a8mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NM5_B_LOCB502_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 6a8m -
(-) 		4 / 4 ASN A 162
SER A  29
ALA A 131
VAL A 132
 None
 1.23A 5nm5A-6a8mA:
undetectable		 5nm5A-6a8mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH8_A_ACTA302_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 6a8m -
(-) 		3 / 3 CYH A 286
MET A 314
ASN A 317
 None
 1.09A 5qh8A-6a8mA:
undetectable		 5qh8A-6a8mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZJI_A_PQNA844_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 6a8m -
(-) 		5 / 10 MET A 369
PHE A 373
SER A 367
GLY A 366
PHE A 231
 None
 1.45A 5zjiA-6a8mA:
undetectable
5zjiJ-6a8mA:
undetectable		 5zjiA-6a8mA:
undetectable
5zjiJ-6a8mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BZO_C_FI8C1201_2
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
RNA POLYMERASE SIGMA
FACTOR SIGA)		 6a8m -
(-) 		4 / 4 LEU A 270
ASP A 269
GLN A 263
VAL A 421
 None
 1.45A 6bzoF-6a8mA:
undetectable		 6bzoF-6a8mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BZO_C_FI8C1201_2
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
RNA POLYMERASE SIGMA
FACTOR SIGA)		 6a8m -
(-) 		4 / 4 LEU A 270
ASP A 269
GLN A 263
VAL A 430
 None
 1.38A 6bzoF-6a8mA:
undetectable		 6bzoF-6a8mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_B_BEZB502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 6a8m -
(-) 		4 / 6 PHE A  12
VAL A  68
LEU A  52
LEU A  56
 None
 0.92A 6e43B-6a8mA:
undetectable		 6e43B-6a8mA:
undetectable