SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6a91'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_C_FUAC701_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 6a91 -
(-) 		5 / 12 SER A 870
LEU A 962
VAL A 965
PHE A1304
VAL A1308
 None
 1.39A 1q23C-6a91A:
undetectable		 1q23C-6a91A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_I_FUAI707_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 6a91 -
(-) 		5 / 11 SER A 870
LEU A 962
VAL A 965
PHE A1304
VAL A1308
 None
 1.37A 1q23I-6a91A:
undetectable		 1q23I-6a91A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_J_FUAJ711_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 6a91 -
(-) 		5 / 11 SER A 870
LEU A 962
VAL A 965
PHE A1304
VAL A1308
 None
 1.38A 1q23J-6a91A:
undetectable		 1q23J-6a91A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z95_A_198A501_1
(ANDROGEN RECEPTOR)		 6a91 -
(-) 		5 / 12 LEU A 698
GLY A 728
VAL A 644
MET A 645
ILE A 411
 None
 1.05A 1z95A-6a91A:
undetectable		 1z95A-6a91A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA2_A_SCKA901_1
(ACETYLCHOLINESTERASE)		 6a91 -
(-) 		4 / 8 ASP A 708
TRP A 682
TYR A 667
HIS A 689
 None
 1.48A 2ha2A-6a91A:
undetectable		 2ha2A-6a91A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA2_B_SCKB951_1
(ACETYLCHOLINESTERASE)		 6a91 -
(-) 		4 / 8 ASP A 708
TRP A 682
TYR A 667
HIS A 689
 None
 1.47A 2ha2B-6a91A:
undetectable		 2ha2B-6a91A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HJH_A_NCAA900_0
(NAD-DEPENDENT
HISTONE DEACETYLASE
SIR2)		 6a91 -
(-) 		4 / 5 ILE A1479
PRO A1480
PHE A1488
ILE A1448
 None
 1.11A 2hjhA-6a91A:
undetectable		 2hjhA-6a91A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OD9_A_NCAA3721_0
(NAD-DEPENDENT
DEACETYLASE HST2)		 6a91 -
(-) 		3 / 3 PHE A1339
PHE A1311
PHE A1307
 None
 0.81A 2od9A-6a91A:
undetectable		 2od9A-6a91A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q7L_A_TESA155_1
(ANDROGEN RECEPTOR)		 6a91 -
(-) 		5 / 12 LEU A 733
LEU A 698
GLY A 728
VAL A 644
MET A 645
 None
 1.10A 2q7lA-6a91A:
undetectable		 2q7lA-6a91A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQG_A_NCAA3721_0
(NAD-DEPENDENT
DEACETYLASE HST2)		 6a91 -
(-) 		3 / 3 PHE A1339
PHE A1311
PHE A1307
 None
 0.81A 2qqgA-6a91A:
undetectable		 2qqgA-6a91A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VAV_F_CSCF1383_2
(ACETYL-COA--DEACETYL
CEPHALOSPORIN C
ACETYLTRANSFERASE)		 6a91 -
(-) 		3 / 3 LEU A 688
MET A 692
MET A 665
 None
 1.03A 2vavF-6a91A:
2.1		 2vavF-6a91A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFH_A_CL6A1413_1
(ERYTHROMYCIN B/D
C-12 HYDROXYLASE)		 6a91 -
(-) 		4 / 6 ALA A1291
ALA A1295
THR A1298
PHE A1115
 None
 1.03A 2xfhA-6a91A:
undetectable		 2xfhA-6a91A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7W_C_SALC1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 6a91 -
(-) 		4 / 7 THR A 553
ILE A 557
GLY A 554
PHE A 535
 None
 0.58A 2y7wC-6a91A:
undetectable		 2y7wC-6a91A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDV_A_CL6A506_1
(CHOLESTEROL
24-HYDROXYLASE)		 6a91 -
(-) 		5 / 9 LEU A1345
PHE A1336
LEU A1391
ILE A1362
ALA A1361
 None
 1.12A 3mdvA-6a91A:
undetectable		 3mdvA-6a91A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ONN_A_ACTA270_0
(PROTEIN SSM1)		 6a91 -
(-) 		4 / 5 LEU A 383
SER A 387
LEU A 284
PRO A 351
 None
 0.95A 3onnA-6a91A:
undetectable		 3onnA-6a91A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P5N_A_RBFA190_1
(RIBOFLAVIN UPTAKE
PROTEIN)		 6a91 -
(-) 		5 / 12 THR A1059
ASP A1356
GLY A1354
ALA A1353
LEU A 374
 None
9SL  A1610 (-2.8A)
9SL  A1610 (-3.3A)
9SL  A1610 ( 3.9A)
None
 1.07A 3p5nA-6a91A:
1.6		 3p5nA-6a91A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_A_SUEA1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 6a91 -
(-) 		4 / 4 PHE A 695
TYR A1089
ILE A 654
LEU A 650
 None
 1.34A 3sudA-6a91A:
undetectable		 3sudA-6a91A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_B_CLMB221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 6a91 -
(-) 		5 / 12 SER A 870
LEU A 962
VAL A 965
PHE A1304
VAL A1308
 None
 1.43A 3u9fB-6a91A:
undetectable
3u9fC-6a91A:
undetectable		 3u9fB-6a91A:
undetectable
3u9fC-6a91A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_E_CLME221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 6a91 -
(-) 		5 / 10 SER A 870
LEU A 962
VAL A 965
PHE A1304
VAL A1308
 None
 1.42A 3u9fE-6a91A:
undetectable		 3u9fE-6a91A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_I_CLMI221_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 6a91 -
(-) 		5 / 10 SER A 870
LEU A 962
VAL A 965
PHE A1304
VAL A1308
 None
 1.40A 3u9fI-6a91A:
undetectable		 3u9fI-6a91A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_N_CLMN221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 6a91 -
(-) 		5 / 11 SER A 870
LEU A 962
VAL A 965
PHE A1304
VAL A1308
 None
 1.43A 3u9fN-6a91A:
undetectable
3u9fO-6a91A:
undetectable		 3u9fN-6a91A:
undetectable
3u9fO-6a91A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_R_CLMR221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 6a91 -
(-) 		5 / 10 SER A 870
LEU A 962
VAL A 965
PHE A1304
VAL A1308
 None
 1.43A 3u9fR-6a91A:
undetectable		 3u9fR-6a91A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_S_CLMS221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 6a91 -
(-) 		5 / 12 SER A 870
LEU A 962
VAL A 965
PHE A1304
VAL A1308
 None
 1.36A 3u9fP-6a91A:
undetectable
3u9fS-6a91A:
undetectable		 3u9fP-6a91A:
undetectable
3u9fS-6a91A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BLV_B_SAMB1281_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 6a91 -
(-) 		5 / 12 HIS A 392
GLY A 329
GLY A 389
LEU A 344
GLY A 346
 None
 1.15A 4blvB-6a91A:
undetectable		 4blvB-6a91A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FIA_A_0U9A601_1
(CHOLESTEROL
24-HYDROXYLASE)		 6a91 -
(-) 		5 / 12 PHE A1501
VAL A1500
ARG A1131
THR A1426
GLU A1419
 None
 1.24A 4fiaA-6a91A:
undetectable		 4fiaA-6a91A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FIA_A_198A602_1
(CHOLESTEROL
24-HYDROXYLASE)		 6a91 -
(-) 		5 / 12 PHE A1501
VAL A1500
ARG A1131
THR A1426
GLU A1419
 None
 1.24A 4fiaA-6a91A:
undetectable		 4fiaA-6a91A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G19_D_ACTD302_0
(GLUTATHIONE
TRANSFERASE GTE1)		 6a91 -
(-) 		3 / 3 TYR A 562
PHE A 623
ARG A 619
 None
 1.17A 4g19D-6a91A:
undetectable		 4g19D-6a91A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_A_ACTA303_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 6a91

(;
) 		3 / 3 TYR B  16
HIS A1077
ARG B  55
 None
 1.05A 4htfA-6a91B:
undetectable		 4htfA-6a91B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_A_SASA806_1
(SEPIAPTERIN
REDUCTASE)		 6a91 -
(-) 		5 / 12 LEU A1496
PHE A1433
TYR A1430
ALA A1146
ASP A1441
 None
 1.25A 4j7xA-6a91A:
undetectable		 4j7xA-6a91A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB0_B_ACTB401_0
(UNCHARACTERIZED
PROTEIN)		 6a91 -
(-) 		4 / 5 VAL A 731
LEU A 258
VAL A 262
PHE A 726
 None
 0.89A 4lb0B-6a91A:
undetectable		 4lb0B-6a91A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_B_CHDB502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 6a91 -
(-) 		4 / 6 PHE A 142
ILE A 146
ARG A 236
VAL A 181
 None
 1.42A 4mk4B-6a91A:
undetectable		 4mk4B-6a91A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKB_A_198A1002_1
(ANDROGEN RECEPTOR)		 6a91 -
(-) 		5 / 12 LEU A 698
GLY A 728
VAL A 644
MET A 645
ILE A 411
 None
 1.05A 4okbA-6a91A:
undetectable		 4okbA-6a91A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKT_A_198A1001_1
(ANDROGEN RECEPTOR)		 6a91 -
(-) 		5 / 12 LEU A 698
GLY A 728
VAL A 644
MET A 645
ILE A 411
 None
 0.99A 4oktA-6a91A:
undetectable		 4oktA-6a91A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKT_A_198A1001_1
(ANDROGEN RECEPTOR)		 6a91 -
(-) 		5 / 12 LEU A 733
LEU A 698
GLY A 728
VAL A 644
MET A 645
 None
 1.09A 4oktA-6a91A:
undetectable		 4oktA-6a91A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QC6_B_KANB201_2
(BIFUNCTIONAL AAC/APH)		 6a91 -
(-) 		3 / 3 LEU A 891
ASP A 894
TYR A 895
 None
 0.63A 4qc6B-6a91A:
undetectable		 4qc6B-6a91A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_A_DGXA1107_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 6a91 -
(-) 		5 / 12 LEU A1345
LEU A1055
GLY A1357
ALA A1329
ARG A1384
 None
PC1  A1609 ( 4.3A)
None
None
PC1  A1609 (-3.1A)
 1.18A 4retA-6a91A:
undetectable		 4retA-6a91A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_C_DGXC2005_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 6a91 -
(-) 		5 / 12 LEU A1345
LEU A1055
GLY A1357
ALA A1329
ARG A1384
 None
PC1  A1609 ( 4.3A)
None
None
PC1  A1609 (-3.1A)
 1.18A 4retC-6a91A:
2.9		 4retC-6a91A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4H_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 6a91 -
(-) 		4 / 5 ARG A 883
GLN A 882
PRO A 881
ASP A 877
 None
 1.24A 4z4hA-6a91A:
undetectable		 4z4hA-6a91A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8I_C_FK5C201_2
(CALCINEURIN SUBUNIT
B, VARIANT
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 6a91 -
(-) 		4 / 4 LEU A 736
MET A 645
VAL A 644
ASN A 643
 None
 1.01A 5b8iB-6a91A:
1.5		 5b8iB-6a91A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HPU_A_IPHA101_0
(INSULIN, CHAIN A
INSULIN, CHAIN B)		 6a91 -
(-) 		4 / 4 CYH A 406
LEU A1299
LEU A1292
ALA A1295
 None
 0.90A 5hpuA-6a91A:
undetectable
5hpuB-6a91A:
undetectable		 5hpuA-6a91A:
undetectable
5hpuB-6a91A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_A_SAMA306_1
(METHYLTRANSFERASE)		 6a91 -
(-) 		4 / 7 LEU A 662
PHE A 663
SER A 690
ILE A 668
 None
 0.89A 5n5dA-6a91A:
undetectable		 5n5dA-6a91A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_A_8LXA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 6a91 -
(-) 		5 / 12 PHE A 992
GLY A1099
TYR A 744
LEU A 740
LEU A 627
 None
 1.24A 5y2tA-6a91A:
undetectable		 5y2tA-6a91A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AJI_A_AY6A1001_0
(DRUG EXPORTERS OF
THE RND
SUPERFAMILY-LIKE
PROTEIN,ENDOLYSIN)		 6a91 -
(-) 		5 / 12 VAL A 995
ILE A 990
VAL A1047
ALA A1050
LEU A1054
 None
 1.16A 6ajiA-6a91A:
undetectable		 6ajiA-6a91A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BZO_C_FI8C1201_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 6a91 -
(-) 		5 / 12 ILE A 152
THR A 149
THR A 237
VAL A 238
VAL A 241
 None
 1.25A 6bzoC-6a91A:
undetectable		 6bzoC-6a91A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN8_A_HFGA603_0
(UNCHARACTERIZED
PROTEIN)		 6a91

(;
) 		5 / 12 LEU B  43
GLU B  19
VAL B  53
SER A 607
GLY A 605
 None
 1.32A 6mn8A-6a91B:
undetectable		 6mn8A-6a91B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 6a91 -
(-) 		4 / 5 LEU A1346
GLN A1348
PHE A1347
PHE A1339
 None
 1.04A 6nmpP-6a91A:
5.3
6nmpW-6a91A:
undetectable		 6nmpP-6a91A:
undetectable
6nmpW-6a91A:
undetectable