SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6acd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_2
(DNA GYRASE SUBUNIT B)		 6acd -
(-) 		3 / 3 ASN A 119
PHE A 153
VAL A 124
 None
 0.84A 1kijA-6acdA:
undetectable		 1kijA-6acdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1H_A_GBNA502_1
(BRANCHED CHAIN
AMINOTRANSFERASE)		 6acd -
(-) 		4 / 8 THR A 773
GLY A 862
THR A 863
ALA A 864
 None
 0.79A 2a1hA-6acdA:
undetectable
2a1hB-6acdA:
undetectable		 2a1hA-6acdA:
undetectable
2a1hB-6acdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOF_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 6acd -
(-) 		4 / 5 GLY A 418
PRO A 399
ALA A 398
ILE A 397
 None
 0.91A 2aofA-6acdA:
undetectable		 2aofA-6acdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_B_SAMB301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 6acd -
(-) 		5 / 12 LEU A 986
LEU A 944
GLY A 839
ASP A 719
ASN A 838
 None
 1.14A 2bm9B-6acdA:
undetectable		 2bm9B-6acdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMZ_A_LDPA501_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE)		 6acd -
(-) 		4 / 7 GLU A 184
GLY A 212
PHE A  62
PHE A 262
 None
 1.01A 2qmzA-6acdA:
undetectable
2qmzB-6acdA:
undetectable		 2qmzA-6acdA:
undetectable
2qmzB-6acdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UVN_B_ECNB1406_1
(CYTOCHROME P450 130)		 6acd -
(-) 		5 / 11 PRO A 710
MET A 709
GLY A 928
LEU A 804
VAL A 808
 None
 1.38A 2uvnB-6acdA:
undetectable		 2uvnB-6acdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1161_1
(ALLERGEN ARG R 1)		 6acd -
(-) 		4 / 5 VAL A 496
TYR A 494
VAL A 394
ASP A 392
 None
 1.18A 2x45C-6acdA:
undetectable		 2x45C-6acdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZBU_D_ADND504_1
(UNCHARACTERIZED
CONSERVED PROTEIN)		 6acd -
(-) 		3 / 3 PHE A  22
ASN A 135
PHE A  76
 None
 0.93A 2zbuD-6acdA:
undetectable		 2zbuD-6acdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZBU_D_ADND504_1
(UNCHARACTERIZED
CONSERVED PROTEIN)		 6acd -
(-) 		3 / 3 PHE A 529
ASN A 530
PHE A 551
 None
 1.03A 2zbuD-6acdA:
undetectable		 2zbuD-6acdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZV_A_AZMA263_1
(CARBONIC ANHYDRASE
13)		 6acd -
(-) 		5 / 12 VAL A 562
PHE A 529
LEU A 538
THR A 539
VAL A 313
 None
 1.20A 3czvA-6acdA:
undetectable
3czvB-6acdA:
undetectable		 3czvA-6acdA:
undetectable
3czvB-6acdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS4_A_AZMA702_1
(CARBONIC ANHYDRASE 2)		 6acd -
(-) 		4 / 7 VAL A 420
LYS A 365
TYR A 367
PRO A 399
 None
 1.23A 3hs4A-6acdA:
undetectable		 3hs4A-6acdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I45_A_NIOA500_1
(TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
PROTEIN)		 6acd -
(-) 		4 / 8 LEU A 377
TYR A 352
PHE A 501
LEU A 503
 None
 0.97A 3i45A-6acdA:
undetectable		 3i45A-6acdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_B_TFPB201_1
(PROTEIN S100-A4)		 6acd -
(-) 		4 / 8 GLY A1026
PHE A 782
PHE A 784
PHE A1034
 None
 1.02A 3ko0B-6acdA:
1.2
3ko0J-6acdA:
1.2		 3ko0B-6acdA:
undetectable
3ko0J-6acdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_J_TFPJ201_1
(PROTEIN S100-A4)		 6acd -
(-) 		4 / 8 PHE A1034
GLY A1026
PHE A 782
PHE A 784
 None
 1.08A 3ko0B-6acdA:
1.2
3ko0J-6acdA:
1.2		 3ko0B-6acdA:
undetectable
3ko0J-6acdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_K_TFPK201_1
(PROTEIN S100-A4)		 6acd -
(-) 		4 / 8 GLY A1026
PHE A 782
PHE A 784
PHE A1034
 None
 1.04A 3ko0K-6acdA:
1.2
3ko0S-6acdA:
1.2		 3ko0K-6acdA:
undetectable
3ko0S-6acdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_L_TFPL201_1
(PROTEIN S100-A4)		 6acd -
(-) 		4 / 7 GLY A1026
PHE A 782
PHE A 784
PHE A1034
 None
 1.11A 3ko0L-6acdA:
1.2
3ko0N-6acdA:
1.2		 3ko0L-6acdA:
undetectable
3ko0N-6acdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_S_TFPS201_1
(PROTEIN S100-A4)		 6acd -
(-) 		4 / 7 PHE A1034
GLY A1026
PHE A 782
PHE A 784
 None
 1.09A 3ko0K-6acdA:
1.2
3ko0S-6acdA:
1.2		 3ko0K-6acdA:
undetectable
3ko0S-6acdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_C_PM6C1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 6acd -
(-) 		4 / 6 PHE A 870
THR A 865
ALA A 874
ALA A 875
 None
 1.25A 3ns1C-6acdA:
undetectable		 3ns1C-6acdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_B_NCTB501_1
(CYTOCHROME P450 2A13)		 6acd -
(-) 		4 / 8 PHE A 325
PHE A 329
LEU A 374
LEU A 355
 None
 0.87A 4ejgB-6acdA:
undetectable		 4ejgB-6acdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_C_NCTC501_1
(CYTOCHROME P450 2A13)		 6acd -
(-) 		4 / 7 PHE A 325
PHE A 329
LEU A 374
LEU A 355
 None
 0.92A 4ejgC-6acdA:
undetectable		 4ejgC-6acdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KMM_A_CHDA503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 6acd -
(-) 		4 / 7 PRO A 710
SER A1003
VAL A 934
MET A 713
 None
 1.37A 4kmmA-6acdA:
undetectable		 4kmmA-6acdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVV_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 6acd -
(-) 		4 / 8 THR A 616
GLY A 579
GLY A 580
VAL A 581
 None
 0.72A 4qvvK-6acdA:
undetectable
4qvvL-6acdA:
undetectable		 4qvvK-6acdA:
undetectable
4qvvL-6acdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVV_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 6acd -
(-) 		4 / 8 THR A 616
GLY A 579
GLY A 580
VAL A 581
 None
 0.72A 4qvvY-6acdA:
undetectable
4qvvZ-6acdA:
undetectable		 4qvvY-6acdA:
undetectable
4qvvZ-6acdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUC_A_SAMA303_0
(CATECHOL
O-METHYLTRANSFERASE)		 6acd -
(-) 		5 / 12 ASN A  96
VAL A  97
GLY A 100
ILE A 115
ILE A 125
 None
 1.46A 4xucA-6acdA:
undetectable		 4xucA-6acdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C6P_A_4YHA601_1
(PROTEIN C)		 6acd -
(-) 		4 / 6 ALA A 857
SER A 861
ASP A 790
PRO A 791
 None
 1.18A 5c6pA-6acdA:
undetectable		 5c6pA-6acdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1N_G_DVAG9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 6acd -
(-) 		3 / 3 ALA A1002
ASN A1005
LEU A1006
 None
 0.39A 5i1nB-6acdA:
undetectable		 5i1nB-6acdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1P_F_DVAF9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 6acd -
(-) 		3 / 3 ALA A1002
ASN A1005
LEU A1006
 None
 0.39A 5i1pA-6acdA:
undetectable		 5i1pA-6acdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JI0_A_9CRA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 6acd -
(-) 		5 / 11 ILE A 724
LEU A 959
LEU A 735
VAL A 718
LEU A 948
 None
 1.10A 5ji0A-6acdA:
undetectable		 5ji0A-6acdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR1_B_017B101_1
(PROTEASE PR5-DRV)		 6acd -
(-) 		5 / 10 ALA A 676
ILE A 674
GLY A 638
ILE A 637
ILE A 652
 None
 1.03A 5kr1A-6acdA:
undetectable		 5kr1A-6acdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M78_A_SALA304_1
(CARBONIC ANHYDRASE 2)		 6acd -
(-) 		4 / 7 VAL A 562
PHE A 529
LEU A 538
THR A 539
 None
 0.91A 5m78A-6acdA:
undetectable		 5m78A-6acdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGT_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 6acd -
(-) 		3 / 3 VAL A 601
TYR A 598
GLN A 599
 None
 0.72A 5qgtA-6acdA:
undetectable		 5qgtA-6acdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QXS_D_FOZD403_0
(THYMIDYLATE SYNTHASE)		 6acd -
(-) 		5 / 12 PRO A1035
LEU A 876
LEU A1016
GLY A1017
ALA A 872
 None
 0.86A 6qxsD-6acdA:
undetectable		 6qxsD-6acdA:
undetectable