SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6al7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FAP_A_RAPA108_2
(FK506-BINDING
PROTEIN
FRAP)		 6al7 12-EPI-HAPALINDOLE
C/U SYNTHASE
(Fischerella
sp.
ATCC
43239) 		4 / 8 LEU A 213
SER A 138
GLY A 140
TYR A 101
 None
CA  A 301 (-4.3A)
None
None
 1.02A 1fapB-6al7A:
undetectable		 1fapB-6al7A:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOI_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 6al7 12-EPI-HAPALINDOLE
C/U SYNTHASE
(Fischerella
sp.
ATCC
43239) 		4 / 5 ASP A 216
GLY A  83
VAL A  79
ILE A  99
 CA  A 302 (-2.4A)
None
None
None
 1.01A 2aoiA-6al7A:
undetectable		 2aoiA-6al7A:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FQY_A_ADNA400_1
(MEMBRANE LIPOPROTEIN
TMPC)		 6al7 12-EPI-HAPALINDOLE
C/U SYNTHASE
(Fischerella
sp.
ATCC
43239) 		5 / 12 ASN A 137
GLY A 140
PHE A 210
GLY A 212
ASP A 214
 CA  A 301 (-3.1A)
None
None
None
None
 1.02A 2fqyA-6al7A:
undetectable		 2fqyA-6al7A:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_A_DIFA1373_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 6al7 12-EPI-HAPALINDOLE
C/U SYNTHASE
(Fischerella
sp.
ATCC
43239) 		4 / 8 SER A 138
PHE A 210
TYR A  89
ASN A 204
 CA  A 301 (-4.3A)
None
None
None
 1.27A 2wekA-6al7A:
undetectable		 2wekA-6al7A:
12.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J4V_D_SVRD301_1
(NUCLEOCAPSID PROTEIN)		 6al7 12-EPI-HAPALINDOLE
C/U SYNTHASE
(Fischerella
sp.
ATCC
43239) 		5 / 11 GLY A 136
ASN A 137
ALA A 148
PRO A  94
ILE A  99
 None
CA  A 301 (-3.1A)
None
None
None
 1.36A 4j4vD-6al7A:
undetectable
4j4vE-6al7A:
undetectable		 4j4vD-6al7A:
13.33
4j4vE-6al7A:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_A_NPSA601_1
(SERUM ALBUMIN)		 6al7 12-EPI-HAPALINDOLE
C/U SYNTHASE
(Fischerella
sp.
ATCC
43239) 		5 / 11 ASN A  77
PHE A 115
VAL A  79
GLY A 100
THR A  50
 None
 1.49A 4or0A-6al7A:
undetectable		 4or0A-6al7A:
9.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_B_ADNB501_1
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 6al7 12-EPI-HAPALINDOLE
C/U SYNTHASE
(Fischerella
sp.
ATCC
43239) 		5 / 12 ASN A 137
GLY A 140
PHE A 210
GLY A 212
ASP A 214
 CA  A 301 (-3.1A)
None
None
None
None
 1.10A 4pevB-6al7A:
undetectable		 4pevB-6al7A:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7I_A_STIA1001_2
(MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR)		 6al7 12-EPI-HAPALINDOLE
C/U SYNTHASE
(Fischerella
sp.
ATCC
43239) 		4 / 5 LEU A 198
VAL A 183
VAL A 218
TYR A 129
 None
 0.94A 4r7iA-6al7A:
undetectable		 4r7iA-6al7A:
12.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_P_CHDP304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 6al7 12-EPI-HAPALINDOLE
C/U SYNTHASE
(Fischerella
sp.
ATCC
43239) 		4 / 7 LYS A 144
PHE A  88
LEU A 147
PHE A 210
 None
 0.99A 5x1fP-6al7A:
undetectable
5x1fW-6al7A:
undetectable		 5x1fP-6al7A:
undetectable
5x1fW-6al7A:
undetectable