SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6am0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_A_CIAA1003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 6am0 KLLA0F23980P
(Kluyveromyces
lactis) 		5 / 11 ALA A 107
PHE A 130
LEU A 119
ILE A 109
PHE A 206
 None
 1.07A 1uduA-6am0A:
undetectable		 1uduA-6am0A:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_F_9CRF1600_2
(RETINOIC ACID
RECEPTOR, BETA)		 6am0 KLLA0F23980P
(Kluyveromyces
lactis) 		3 / 3 LEU A 114
PHE A 110
ARG A 230
 None
 0.63A 1xdkF-6am0A:
undetectable		 1xdkF-6am0A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_B_TACB1888_1
(ELONGATION FACTOR
EF-TU)		 6am0 KLLA0A01474P
KLLA0F23980P
(Kluyveromyces
lactis) 		4 / 5 THR C 363
SER A  35
ASP A  33
PRO A  31
 None
 1.10A 2hdnA-6am0C:
undetectable
2hdnB-6am0C:
undetectable
2hdnD-6am0C:
undetectable		 2hdnA-6am0C:
25.00
2hdnB-6am0C:
8.23
2hdnD-6am0C:
8.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_D_TACD2888_1
(ELONGATION FACTOR
EF-TU)		 6am0 KLLA0A01474P
KLLA0F23980P
(Kluyveromyces
lactis) 		4 / 5 SER A  35
THR C 363
ASP A  33
PRO A  31
 None
 1.03A 2hdnB-6am0A:
undetectable
2hdnC-6am0A:
undetectable
2hdnD-6am0A:
undetectable		 2hdnB-6am0A:
14.83
2hdnC-6am0A:
14.29
2hdnD-6am0A:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_F_TACF3888_1
(ELONGATION FACTOR
EF-TU)		 6am0 KLLA0A01474P
KLLA0F23980P
(Kluyveromyces
lactis) 		4 / 7 THR C 363
ASP A  33
PRO A  31
SER A  35
 None
 1.01A 2hdnE-6am0C:
undetectable
2hdnF-6am0C:
undetectable
2hdnH-6am0C:
undetectable		 2hdnE-6am0C:
25.00
2hdnF-6am0C:
8.23
2hdnH-6am0C:
8.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_H_TACH4888_1
(ELONGATION FACTOR
EF-TU)		 6am0 KLLA0A01474P
KLLA0F23980P
(Kluyveromyces
lactis) 		4 / 7 SER A  35
THR C 363
ASP A  33
PRO A  31
 None
 1.01A 2hdnF-6am0A:
undetectable
2hdnG-6am0A:
undetectable
2hdnH-6am0A:
undetectable		 2hdnF-6am0A:
14.83
2hdnG-6am0A:
14.29
2hdnH-6am0A:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_J_TACJ5888_1
(ELONGATION FACTOR
EF-TU)		 6am0 KLLA0A01474P
KLLA0F23980P
(Kluyveromyces
lactis) 		4 / 6 THR C 363
ASP A  33
PRO A  31
SER A  35
 None
 1.06A 2hdnI-6am0C:
undetectable
2hdnJ-6am0C:
undetectable
2hdnL-6am0C:
undetectable		 2hdnI-6am0C:
25.00
2hdnJ-6am0C:
8.23
2hdnL-6am0C:
8.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_L_TACL6888_1
(ELONGATION FACTOR
EF-TU)		 6am0 KLLA0A01474P
KLLA0F23980P
(Kluyveromyces
lactis) 		4 / 6 SER A  35
THR C 363
ASP A  33
PRO A  31
 None
 1.00A 2hdnJ-6am0A:
undetectable
2hdnK-6am0A:
undetectable
2hdnL-6am0A:
undetectable		 2hdnJ-6am0A:
14.83
2hdnK-6am0A:
14.29
2hdnL-6am0A:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VXI_A_ASCA502_0
(DYP)		 6am0 KLLA0F23980P
KLLA0A01474P
(Kluyveromyces
lactis;
Kluyveromyces
lactis) 		4 / 5 ALA C 362
ARG A  39
PRO A  30
HIS A  43
 None
 0.93A 3vxiA-6am0C:
undetectable		 3vxiA-6am0C:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_A_715A801_2
(DIPEPTIDYL PEPTIDASE
4)		 6am0 KLLA0A01474P
KLLA0F23980P
(Kluyveromyces
lactis) 		3 / 3 PHE A  95
TYR C 359
TYR A  98
 None
 0.96A 4ffwA-6am0A:
undetectable		 4ffwA-6am0A:
11.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_A_SAMA407_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 6am0 KLLA0F23980P
(Kluyveromyces
lactis) 		4 / 8 ALA A  91
ASP A  76
ILE A  75
ILE A  81
 None
 0.92A 4ndnB-6am0A:
undetectable		 4ndnB-6am0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_C_SAMC405_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 6am0 KLLA0F23980P
(Kluyveromyces
lactis) 		4 / 8 ALA A  91
ASP A  76
ILE A  75
ILE A  81
 None
 0.95A 4ndnD-6am0A:
undetectable		 4ndnD-6am0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PBH_A_BEZA401_0
(TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT, PUTATIVE)		 6am0 KLLA0F23980P
(Kluyveromyces
lactis) 		5 / 12 ILE A 229
ALA A 108
LEU A 209
LEU A 119
PHE A 110
 None
 1.33A 4pbhA-6am0A:
undetectable		 4pbhA-6am0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_H_SAMH301_1
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 6am0 KLLA0F23980P
KLLA0A01474P
(Kluyveromyces
lactis;
Kluyveromyces
lactis) 		4 / 5 THR C 366
GLY A 136
GLU A  46
HIS A  43
 None
 1.22A 5c0oH-6am0C:
undetectable		 5c0oH-6am0C:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KBW_A_RBFA201_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 6am0 KLLA0F23980P
(Kluyveromyces
lactis) 		5 / 12 GLU A 186
ASP A 112
GLY A 183
LEU A 157
ALA A 107
 None
 1.42A 5kbwA-6am0A:
undetectable		 5kbwA-6am0A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_A_ACRA1481_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 6am0 KLLA0F23980P
(Kluyveromyces
lactis) 		4 / 6 TRP A  49
HIS A 194
ARG A 147
GLU A 151
 6VQ  A 302 (-3.4A)
6VQ  A 302 (-4.0A)
None
None
 1.37A 5x7pA-6am0A:
undetectable		 5x7pA-6am0A:
5.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_B_ACRB1481_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 6am0 KLLA0F23980P
(Kluyveromyces
lactis) 		4 / 6 TRP A  49
HIS A 194
ARG A 147
GLU A 151
 6VQ  A 302 (-3.4A)
6VQ  A 302 (-4.0A)
None
None
 1.38A 5x7pB-6am0A:
undetectable		 5x7pB-6am0A:
5.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Q_A_ACRA1481_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 6am0 KLLA0F23980P
(Kluyveromyces
lactis) 		4 / 6 TRP A  49
HIS A 194
ARG A 147
GLU A 151
 6VQ  A 302 (-3.4A)
6VQ  A 302 (-4.0A)
None
None
 1.38A 5x7qA-6am0A:
undetectable		 5x7qA-6am0A:
5.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Q_B_ACRB1481_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 6am0 KLLA0F23980P
(Kluyveromyces
lactis) 		4 / 6 TRP A  49
HIS A 194
ARG A 147
GLU A 151
 6VQ  A 302 (-3.4A)
6VQ  A 302 (-4.0A)
None
None
 1.34A 5x7qB-6am0A:
undetectable		 5x7qB-6am0A:
5.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7R_A_ACRA1481_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 6am0 KLLA0F23980P
(Kluyveromyces
lactis) 		4 / 6 TRP A  49
HIS A 194
ARG A 147
GLU A 151
 6VQ  A 302 (-3.4A)
6VQ  A 302 (-4.0A)
None
None
 1.37A 5x7rA-6am0A:
undetectable		 5x7rA-6am0A:
5.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7R_B_ACRB1481_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 6am0 KLLA0F23980P
(Kluyveromyces
lactis) 		4 / 6 TRP A  49
HIS A 194
ARG A 147
GLU A 151
 6VQ  A 302 (-3.4A)
6VQ  A 302 (-4.0A)
None
None
 1.37A 5x7rB-6am0A:
undetectable		 5x7rB-6am0A:
5.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBN_B_SAMB401_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 6am0 KLLA0F23980P
(Kluyveromyces
lactis) 		4 / 7 ALA A  91
ASP A  76
ILE A  75
ILE A  81
 None
 0.93A 6fbnA-6am0A:
undetectable		 6fbnA-6am0A:
undetectable