SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6ams'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMA_B_SAMB105_0
(PROTEIN (MET
REPRESSOR))		 6ams BETA SLIDING CLAMP
(Pseudomonas
aeruginosa) 		5 / 11 LEU A  53
GLU A 203
LEU A 204
ALA A 226
GLY A 216
 None
 1.21A 1cmaA-6amsA:
undetectable
1cmaB-6amsA:
undetectable		 1cmaA-6amsA:
16.76
1cmaB-6amsA:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_A_ADNA601_2
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 6ams BETA SLIDING CLAMP
(Pseudomonas
aeruginosa) 		4 / 5 THR A 232
GLU A  52
THR A 118
HIS A 223
 None
None
None
PO4  A 401 (-4.4A)
 1.16A 1d4fA-6amsA:
undetectable		 1d4fA-6amsA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_B_ADNB602_2
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 6ams BETA SLIDING CLAMP
(Pseudomonas
aeruginosa) 		4 / 5 THR A 232
GLU A  52
THR A 118
HIS A 223
 None
None
None
PO4  A 401 (-4.4A)
 1.16A 1d4fB-6amsA:
undetectable		 1d4fB-6amsA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_D_ADND604_2
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 6ams BETA SLIDING CLAMP
(Pseudomonas
aeruginosa) 		4 / 5 THR A 232
GLU A  52
THR A 118
HIS A 223
 None
None
None
PO4  A 401 (-4.4A)
 1.22A 1d4fD-6amsA:
undetectable		 1d4fD-6amsA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_A_SAMA2200_0
(PROTEIN (METHIONINE
REPRESSOR))		 6ams BETA SLIDING CLAMP
(Pseudomonas
aeruginosa) 		5 / 12 ALA A 226
GLY A 216
LEU A  53
GLU A 203
LEU A 204
 None
 1.17A 1mj2A-6amsA:
undetectable
1mj2B-6amsA:
undetectable		 1mj2A-6amsA:
16.76
1mj2B-6amsA:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_C_SAMC2199_0
(PROTEIN (METHIONINE
REPRESSOR))		 6ams BETA SLIDING CLAMP
(Pseudomonas
aeruginosa) 		5 / 12 ALA A 226
GLY A 216
LEU A  53
GLU A 203
LEU A 204
 None
 1.22A 1mj2C-6amsA:
undetectable
1mj2D-6amsA:
undetectable		 1mj2C-6amsA:
16.76
1mj2D-6amsA:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_C_SAMC200_0
(METHIONINE REPRESSOR)		 6ams BETA SLIDING CLAMP
(Pseudomonas
aeruginosa) 		5 / 12 ALA A 226
GLY A 216
LEU A  53
GLU A 203
LEU A 204
 None
 1.19A 1mjoC-6amsA:
undetectable
1mjoD-6amsA:
undetectable		 1mjoC-6amsA:
16.76
1mjoD-6amsA:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_A_SAMA200_0
(METHIONINE REPRESSOR)		 6ams BETA SLIDING CLAMP
(Pseudomonas
aeruginosa) 		5 / 11 LEU A  53
GLU A 203
LEU A 204
ALA A 226
GLY A 216
 None
 1.20A 1mjqA-6amsA:
undetectable
1mjqB-6amsA:
undetectable		 1mjqA-6amsA:
16.76
1mjqB-6amsA:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_C_SAMC199_0
(METHIONINE REPRESSOR)		 6ams BETA SLIDING CLAMP
(Pseudomonas
aeruginosa) 		5 / 10 LEU A  53
GLU A 203
LEU A 204
ALA A 226
GLY A 216
 None
 1.18A 1mjqC-6amsA:
undetectable
1mjqD-6amsA:
undetectable		 1mjqC-6amsA:
16.76
1mjqD-6amsA:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_D_SAMD200_0
(METHIONINE REPRESSOR)		 6ams BETA SLIDING CLAMP
(Pseudomonas
aeruginosa) 		5 / 12 ALA A 226
GLY A 216
LEU A  53
GLU A 203
LEU A 204
 None
 1.14A 1mjqC-6amsA:
undetectable
1mjqD-6amsA:
undetectable		 1mjqC-6amsA:
16.76
1mjqD-6amsA:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_I_SAMI199_0
(METHIONINE REPRESSOR)		 6ams BETA SLIDING CLAMP
(Pseudomonas
aeruginosa) 		5 / 11 LEU A  53
GLU A 203
LEU A 204
ALA A 226
GLY A 216
 None
 1.17A 1mjqI-6amsA:
undetectable
1mjqJ-6amsA:
undetectable		 1mjqI-6amsA:
16.76
1mjqJ-6amsA:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_J_SAMJ200_0
(METHIONINE REPRESSOR)		 6ams BETA SLIDING CLAMP
(Pseudomonas
aeruginosa) 		5 / 12 ALA A 226
GLY A 216
LEU A  53
GLU A 203
LEU A 204
 None
 1.16A 1mjqI-6amsA:
undetectable
1mjqJ-6amsA:
undetectable		 1mjqI-6amsA:
16.76
1mjqJ-6amsA:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_B_8MOB501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 6ams BETA SLIDING CLAMP
(Pseudomonas
aeruginosa) 		5 / 11 PHE A 233
VAL A 215
ILE A 224
ILE A 139
LEU A 208
 None
 1.06A 1z11B-6amsA:
undetectable		 1z11B-6amsA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_C_8MOC501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 6ams BETA SLIDING CLAMP
(Pseudomonas
aeruginosa) 		5 / 10 PHE A 233
VAL A 215
ILE A 224
ILE A 139
LEU A 208
 None
 1.04A 1z11C-6amsA:
undetectable		 1z11C-6amsA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_D_8MOD501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 6ams BETA SLIDING CLAMP
(Pseudomonas
aeruginosa) 		5 / 10 PHE A 233
VAL A 215
ILE A 224
ILE A 139
LEU A 208
 None
 1.01A 1z11D-6amsA:
undetectable		 1z11D-6amsA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXC_A_P1ZA2001_1
(SERUM ALBUMIN)		 6ams BETA SLIDING CLAMP
(Pseudomonas
aeruginosa) 		5 / 12 GLN A 262
LEU A 326
ILE A 282
ILE A 293
ALA A 267
 None
 1.00A 2bxcA-6amsA:
undetectable		 2bxcA-6amsA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H77_A_T3A1_1
(THRA PROTEIN)		 6ams BETA SLIDING CLAMP
(Pseudomonas
aeruginosa) 		5 / 12 ILE A 130
ALA A 205
LEU A 160
ILE A 201
PHE A 128
 None
 0.99A 2h77A-6amsA:
undetectable		 2h77A-6amsA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H79_A_T3A1_1
(THRA PROTEIN)		 6ams BETA SLIDING CLAMP
(Pseudomonas
aeruginosa) 		5 / 12 ILE A 130
ALA A 205
LEU A 160
ILE A 201
PHE A 128
 None
 1.05A 2h79A-6amsA:
undetectable		 2h79A-6amsA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GV1_B_BEZB303_0
(DISULFIDE
INTERCHANGE PROTEIN)		 6ams BETA SLIDING CLAMP
(Pseudomonas
aeruginosa) 		4 / 4 LEU A 284
ALA A 348
VAL A 362
PRO A 364
 None
 1.23A 3gv1B-6amsA:
undetectable		 3gv1B-6amsA:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_C_VIVC301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 6ams BETA SLIDING CLAMP
(Pseudomonas
aeruginosa) 		5 / 12 VAL A  20
LEU A  16
ALA A 226
LEU A 208
VAL A 215
 None
 1.18A 3w67C-6amsA:
undetectable		 3w67C-6amsA:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9J_A_TYLA1188_1
(BROMODOMAIN
CONTAINING 2)		 6ams BETA SLIDING CLAMP
(Pseudomonas
aeruginosa) 		4 / 5 VAL A  37
LEU A  42
LEU A  59
ILE A  90
 None
 0.93A 4a9jA-6amsA:
undetectable		 4a9jA-6amsA:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1B_A_ECNA403_1
(FLAVOHEMOGLOBIN)		 6ams BETA SLIDING CLAMP
(Pseudomonas
aeruginosa) 		5 / 12 PHE A 233
ALA A 205
LEU A 207
VAL A  51
LEU A  53
 None
 1.03A 4g1bA-6amsA:
undetectable		 4g1bA-6amsA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYK_B_IMNB300_1
(LACTOYLGLUTATHIONE
LYASE)		 6ams BETA SLIDING CLAMP
(Pseudomonas
aeruginosa) 		5 / 12 ALA A 205
LEU A 167
GLY A 157
MET A 158
LEU A 159
 None
 1.23A 4kykA-6amsA:
undetectable
4kykB-6amsA:
undetectable		 4kykA-6amsA:
20.99
4kykB-6amsA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNW_A_T3A501_1
(THYROID HORMONE
RECEPTOR ALPHA)		 6ams BETA SLIDING CLAMP
(Pseudomonas
aeruginosa) 		5 / 12 ILE A 130
ALA A 205
LEU A 160
ILE A 201
PHE A 128
 None
 1.08A 4lnwA-6amsA:
undetectable		 4lnwA-6amsA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNX_A_T3A502_1
(THYROID HORMONE
RECEPTOR ALPHA)		 6ams BETA SLIDING CLAMP
(Pseudomonas
aeruginosa) 		5 / 12 ILE A 130
ALA A 205
LEU A 160
ILE A 201
PHE A 128
 None
 1.06A 4lnxA-6amsA:
undetectable		 4lnxA-6amsA:
21.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MJQ_A_27RA401_1
(DNA POLYMERASE III
SUBUNIT BETA)		 6ams BETA SLIDING CLAMP
(Pseudomonas
aeruginosa) 		5 / 5 ARG A 152
TYR A 154
THR A 172
PRO A 243
VAL A 248
 None
 0.79A 4mjqA-6amsA:
45.8		 4mjqA-6amsA:
55.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MJR_A_0LAA404_1
(DNA POLYMERASE III
SUBUNIT BETA)		 6ams BETA SLIDING CLAMP
(Pseudomonas
aeruginosa) 		8 / 9 ARG A 152
TYR A 154
THR A 172
GLY A 174
LEU A 177
PRO A 243
VAL A 248
VAL A 361
 None
 0.64A 4mjrA-6amsA:
46.4		 4mjrA-6amsA:
55.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MJR_A_0LAA404_1
(DNA POLYMERASE III
SUBUNIT BETA)		 6ams BETA SLIDING CLAMP
(Pseudomonas
aeruginosa) 		6 / 9 THR A 172
LEU A 177
PRO A 243
VAL A 248
VAL A 361
MET A 363
 None
 0.77A 4mjrA-6amsA:
46.4		 4mjrA-6amsA:
55.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM4_B_8PRB603_2
(TRANSPORTER)		 6ams BETA SLIDING CLAMP
(Pseudomonas
aeruginosa) 		3 / 3 SER A 181
MET A 179
ASP A 354
 None
 0.80A 4mm4B-6amsA:
undetectable		 4mm4B-6amsA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_B_LOCB503_2
(TUBULIN BETA-2B
CHAIN)		 6ams BETA SLIDING CLAMP
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 135
THR A 228
ALA A 226
ILE A 224
ILE A 217
 None
 1.12A 4o2bB-6amsA:
undetectable		 4o2bB-6amsA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FXT_A_0LAA1376_1
(DNA POLYMERASE III
SUBUNIT BETA)		 6ams BETA SLIDING CLAMP
(Pseudomonas
aeruginosa) 		4 / 7 LEU A 155
THR A 172
PRO A 243
MET A 363
 None
 0.61A 5fxtA-6amsA:
39.1		 5fxtA-6amsA:
24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L0Z_B_SAMB304_0
(PROBABLE RNA
METHYLTRANSFERASE,
TRMH FAMILY)		 6ams BETA SLIDING CLAMP
(Pseudomonas
aeruginosa) 		5 / 10 LEU A 160
GLY A 157
LEU A 204
LEU A 202
ALA A 205
 None
 1.02A 5l0zB-6amsA:
undetectable		 5l0zB-6amsA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1805_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 6ams BETA SLIDING CLAMP
(Pseudomonas
aeruginosa) 		5 / 9 GLY A 157
VAL A 194
GLY A 200
PHE A 128
ILE A 130
 None
 0.96A 5vkqC-6amsA:
undetectable
5vkqD-6amsA:
undetectable		 5vkqC-6amsA:
13.14
5vkqD-6amsA:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIW_D_LOCD503_2
(TUBULIN BETA CHAIN)		 6ams BETA SLIDING CLAMP
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 135
THR A 228
ALA A 226
ILE A 224
ILE A 217
 None
 1.10A 5xiwD-6amsA:
undetectable		 5xiwD-6amsA:
12.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8P_B_ACTB804_0
(UNCHARACTERIZED
PROTEIN)		 6ams BETA SLIDING CLAMP
(Pseudomonas
aeruginosa) 		4 / 4 HIS A 351
VAL A 361
LEU A 349
ALA A 359
 None
 1.29A 6d8pB-6amsA:
undetectable		 6d8pB-6amsA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_A_AQ4A602_1
(CYTOCHROME P450 1A1)		 6ams BETA SLIDING CLAMP
(Pseudomonas
aeruginosa) 		4 / 5 ILE A 224
SER A 235
ALA A 205
LEU A 135
 None
 1.07A 6dwnA-6amsA:
undetectable		 6dwnA-6amsA:
12.26