SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6amw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DVX_B_DIFB125_2
(TRANSTHYRETIN)		 6amw TYROSINE-PROTEIN
KINASE ABL1
(Homo
sapiens) 		4 / 7 LEU A 214
LEU A 141
SER A 140
VAL A 151
 None
 1.02A 1dvxB-6amwA:
undetectable		 1dvxB-6amwA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A2Q_A_ACAA601_1
(6-AMINOHEXANOATE-CYC
LIC-DIMER HYDROLASE)		 6amw TYROSINE-PROTEIN
KINASE ABL1
(Homo
sapiens) 		4 / 7 GLY A 126
ASN A 125
ALA A 121
VAL A 130
 None
 0.74A 3a2qA-6amwA:
undetectable		 3a2qA-6amwA:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7B_B_HAEB1270_1
(COLLAGENASE 3)		 6amw TYROSINE-PROTEIN
KINASE ABL1
(Homo
sapiens) 		4 / 5 LEU A  61
HIS A 114
GLU A 117
HIS A  21
 None
 1.25A 4a7bB-6amwA:
undetectable		 4a7bB-6amwA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UIN_H_QI9H1226_0
(FAB 314.3)		 6amw TYROSINE-PROTEIN
KINASE ABL1
(Homo
sapiens) 		5 / 12 TRP A 118
THR A  98
SER A  94
LEU A  17
PRO A  18
 None
 1.34A 4uinH-6amwA:
undetectable
4uinL-6amwA:
undetectable		 4uinH-6amwA:
23.81
4uinL-6amwA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		 6amw TYROSINE-PROTEIN
KINASE ABL1
(Homo
sapiens) 		4 / 6 LEU A 214
LEU A 141
SER A 140
VAL A 151
 None
 1.06A 5a6iA-6amwA:
undetectable		 5a6iA-6amwA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA607_0
(ALPHA-AMYLASE)		 6amw TYROSINE-PROTEIN
KINASE ABL1
(Homo
sapiens) 		4 / 4 ARG A  50
SER A  54
ASP A  55
ASN A  83
 None
 1.25A 6ag0A-6amwA:
undetectable		 6ag0A-6amwA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FHW_A_ACRA801_2
(GLUCOAMYLASE P)		 6amw TYROSINE-PROTEIN
KINASE ABL1
(Homo
sapiens) 		3 / 3 TRP A 129
GLU A 117
GLU A  57
 None
 0.97A 6fhwA-6amwA:
undetectable		 6fhwA-6amwA:
17.25