SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6amz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_J_FUAJ711_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 6amz 2,3,4,5-TETRAHYDROPY
RIDINE-2,6-DICARBOXY
LATE
N-SUCCINYLTRANSFERAS
E
(Acinetobacter
baumannii) 		5 / 11 SER A 115
PHE A  90
LEU A 123
VAL A 140
VAL A 128
 None
 1.41A 1q23J-6amzA:
undetectable		 1q23J-6amzA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_D_KLND1498_1
(CYTOCHROME P450 3A4)		 6amz 2,3,4,5-TETRAHYDROPY
RIDINE-2,6-DICARBOXY
LATE
N-SUCCINYLTRANSFERAS
E
(Acinetobacter
baumannii) 		5 / 11 SER A 231
ILE A 252
ALA A 250
THR A 212
GLU A 179
 None
None
None
MRD  A 301 (-3.1A)
None
 1.32A 2v0mD-6amzA:
undetectable		 2v0mD-6amzA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJO_B_EAAB211_1
(GLUTATHIONE
S-TRANSFERASE P)		 6amz 2,3,4,5-TETRAHYDROPY
RIDINE-2,6-DICARBOXY
LATE
N-SUCCINYLTRANSFERAS
E
(Acinetobacter
baumannii) 		4 / 8 VAL A 227
VAL A 156
ASN A 181
GLY A 199
 None
 0.73A 3hjoB-6amzA:
undetectable		 3hjoB-6amzA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILT_H_TRUH800_1
(GLUTAMATE RECEPTOR 2)		 6amz 2,3,4,5-TETRAHYDROPY
RIDINE-2,6-DICARBOXY
LATE
N-SUCCINYLTRANSFERAS
E
(Acinetobacter
baumannii) 		3 / 3 ILE A 164
SER A 188
SER A 159
 None
 0.64A 3iltH-6amzA:
undetectable		 3iltH-6amzA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SM2_A_478A126_2
(GAG-PRO-POL
POLYPROTEIN)		 6amz 2,3,4,5-TETRAHYDROPY
RIDINE-2,6-DICARBOXY
LATE
N-SUCCINYLTRANSFERAS
E
(Acinetobacter
baumannii) 		5 / 11 ALA A 144
VAL A 128
GLY A 147
LEU A 123
LEU A 158
 None
 1.03A 3sm2B-6amzA:
undetectable		 3sm2B-6amzA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DT8_A_ADNA401_1
(APH(2'')-ID)		 6amz 2,3,4,5-TETRAHYDROPY
RIDINE-2,6-DICARBOXY
LATE
N-SUCCINYLTRANSFERAS
E
(Acinetobacter
baumannii) 		5 / 11 SER A 200
GLY A 230
ILE A 208
HIS A 223
ILE A 214
 None
 0.98A 4dt8A-6amzA:
undetectable		 4dt8A-6amzA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNX_A_T44A501_1
(THYROID HORMONE
RECEPTOR ALPHA)		 6amz 2,3,4,5-TETRAHYDROPY
RIDINE-2,6-DICARBOXY
LATE
N-SUCCINYLTRANSFERAS
E
(Acinetobacter
baumannii) 		4 / 6 SER A 115
GLN A 117
VAL A 146
THR A 145
 None
 1.35A 4lnxA-6amzA:
undetectable		 4lnxA-6amzA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W9N_C_CCSC1548_0
(ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE)		 6amz 2,3,4,5-TETRAHYDROPY
RIDINE-2,6-DICARBOXY
LATE
N-SUCCINYLTRANSFERAS
E
(Acinetobacter
baumannii) 		3 / 3 ALA A  46
TRP A  53
VAL A  54
 None
 0.20A 4w9nC-6amzA:
undetectable		 4w9nC-6amzA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y1D_D_DVAD5_0
(CYCLIC HEXAPEPTIDE
CYC[NDPOPPKID]
INTEGRASE)		 6amz 2,3,4,5-TETRAHYDROPY
RIDINE-2,6-DICARBOXY
LATE
N-SUCCINYLTRANSFERAS
E
(Acinetobacter
baumannii) 		3 / 3 GLU A 136
LYS A 154
ASN A 120
 None
 1.08A 4y1dA-6amzA:
undetectable
4y1dD-6amzA:
undetectable		 4y1dA-6amzA:
22.83
4y1dD-6amzA:
4.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGJ_A_CTYA402_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 6amz 2,3,4,5-TETRAHYDROPY
RIDINE-2,6-DICARBOXY
LATE
N-SUCCINYLTRANSFERAS
E
(Acinetobacter
baumannii) 		5 / 12 ILE A 178
VAL A 227
ALA A 249
ALA A 250
VAL A 233
 None
 1.08A 5igjA-6amzA:
undetectable		 5igjA-6amzA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR0_A_478A101_1
(PROTEASE E35D-APV)		 6amz 2,3,4,5-TETRAHYDROPY
RIDINE-2,6-DICARBOXY
LATE
N-SUCCINYLTRANSFERAS
E
(Acinetobacter
baumannii) 		5 / 9 ALA A 250
ILE A 202
GLY A 205
VAL A 191
ILE A 208
 None
 1.12A 5kr0A-6amzA:
undetectable		 5kr0A-6amzA:
18.48