SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6an0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)		 6an0 HISTIDINOL
DEHYDROGENASE
(Elizabethkingia
anophelis) 		4 / 5 LEU A 278
LEU A 274
LEU A 306
GLY A 303
 None
None
IOD  A 509 ( 4.6A)
None
 0.99A 1a4lC-6an0A:
undetectable		 1a4lC-6an0A:
22.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1KAR_A_HSMA502_1
(HISTIDINOL
DEHYDROGENASE)		 6an0 HISTIDINOL
DEHYDROGENASE
(Elizabethkingia
anophelis) 		6 / 9 LEU A 132
SER A 134
HIS A 258
ASP A 356
TYR A 357
HIS A 363
 None
None
ZN  A 501 (-3.3A)
ZN  A 501 (-2.7A)
None
None
 0.27A 1karA-6an0A:
51.7
1karB-6an0A:
51.0		 1karA-6an0A:
49.67
1karB-6an0A:
49.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1KAR_B_HSMB503_1
(HISTIDINOL
DEHYDROGENASE)		 6an0 HISTIDINOL
DEHYDROGENASE
(Elizabethkingia
anophelis) 		6 / 9 LEU A 132
SER A 134
HIS A 258
ASP A 356
TYR A 357
HIS A 363
 None
None
ZN  A 501 (-3.3A)
ZN  A 501 (-2.7A)
None
None
 0.24A 1karA-6an0A:
51.7
1karB-6an0A:
51.0		 1karA-6an0A:
49.67
1karB-6an0A:
49.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SGU_B_MK1B2632_2
(POL POLYPROTEIN)		 6an0 HISTIDINOL
DEHYDROGENASE
(Elizabethkingia
anophelis) 		5 / 12 ALA A 171
ILE A 125
ILE A 123
GLY A 140
ILE A 141
 None
None
None
None
EDO  A 502 ( 4.6A)
 0.87A 1sguB-6an0A:
undetectable		 1sguB-6an0A:
12.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN0_C_T44C601_1
(TRANSTHYRETIN)		 6an0 HISTIDINOL
DEHYDROGENASE
(Elizabethkingia
anophelis) 		5 / 9 LEU A 288
LEU A 285
LEU A 252
GLU A 352
ALA A 256
 None
 1.42A 1sn0A-6an0A:
undetectable
1sn0C-6an0A:
undetectable		 1sn0A-6an0A:
14.83
1sn0C-6an0A:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B60_B_RITB100_2
(GAG-POL POLYPROTEIN)		 6an0 HISTIDINOL
DEHYDROGENASE
(Elizabethkingia
anophelis) 		5 / 11 GLY A 140
ALA A 143
ILE A 118
ALA A 201
ILE A 121
 None
 0.97A 2b60B-6an0A:
undetectable		 2b60B-6an0A:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FT9_A_CHDA131_0
(FATTY ACID-BINDING
PROTEIN 2, LIVER)		 6an0 HISTIDINOL
DEHYDROGENASE
(Elizabethkingia
anophelis) 		5 / 11 LEU A 278
ILE A 304
PRO A   7
ASN A   6
LEU A 299
 None
None
None
IOD  A 509 (-4.1A)
None
 1.29A 2ft9A-6an0A:
undetectable		 2ft9A-6an0A:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1499_1
(CYTOCHROME P450 3A4)		 6an0 HISTIDINOL
DEHYDROGENASE
(Elizabethkingia
anophelis) 		4 / 7 PHE A  34
ILE A  37
ILE A 198
GLY A 223
 None
 0.91A 2v0mB-6an0A:
undetectable		 2v0mB-6an0A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_A_P1ZA1353_1
(PROSTAGLANDIN
REDUCTASE 2)		 6an0 HISTIDINOL
DEHYDROGENASE
(Elizabethkingia
anophelis) 		5 / 9 THR A 106
GLU A 107
VAL A 109
GLY A 400
ILE A 396
 None
 1.11A 2w98A-6an0A:
3.6		 2w98A-6an0A:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRZ_A_ACTA1470_0
(DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE)		 6an0 HISTIDINOL
DEHYDROGENASE
(Elizabethkingia
anophelis) 		4 / 5 ARG A 116
ALA A 115
GLU A 114
TRP A 112
 None
HIS  A 520 (-3.5A)
HIS  A 520 (-4.4A)
None
 1.50A 2xrzA-6an0A:
2.7		 2xrzA-6an0A:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_B_CHDB505_0
(FERROCHELATASE,
MITOCHONDRIAL)		 6an0 HISTIDINOL
DEHYDROGENASE
(Elizabethkingia
anophelis) 		5 / 12 LEU A 236
ARG A 302
ILE A 304
SER A 340
THR A 339
 None
 1.12A 4f4dB-6an0A:
3.1		 4f4dB-6an0A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_A_MXMA606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 6an0 HISTIDINOL
DEHYDROGENASE
(Elizabethkingia
anophelis) 		5 / 12 MET A   1
LEU A 298
ALA A 250
SER A 254
LEU A 253
 None
 1.50A 4m11A-6an0A:
undetectable		 4m11A-6an0A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_A_HCYA900_1
(GLUCOCORTICOID
RECEPTOR)		 6an0 HISTIDINOL
DEHYDROGENASE
(Elizabethkingia
anophelis) 		5 / 12 LEU A 173
ASN A 172
GLY A 175
LEU A 137
ILE A  71
 None
 1.37A 4p6xA-6an0A:
undetectable		 4p6xA-6an0A:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_E_HCYE900_1
(GLUCOCORTICOID
RECEPTOR)		 6an0 HISTIDINOL
DEHYDROGENASE
(Elizabethkingia
anophelis) 		5 / 12 LEU A 173
ASN A 172
GLY A 175
LEU A 137
ILE A  71
 None
 1.42A 4p6xE-6an0A:
undetectable		 4p6xE-6an0A:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_I_HCYI900_1
(GLUCOCORTICOID
RECEPTOR)		 6an0 HISTIDINOL
DEHYDROGENASE
(Elizabethkingia
anophelis) 		5 / 12 LEU A 173
ASN A 172
GLY A 175
LEU A 137
ILE A  71
 None
 1.37A 4p6xI-6an0A:
undetectable		 4p6xI-6an0A:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVG_A_SAMA503_0
(D-MYCAROSE
3-C-METHYLTRANSFERAS
E)		 6an0 HISTIDINOL
DEHYDROGENASE
(Elizabethkingia
anophelis) 		5 / 12 TYR A 180
THR A 192
ILE A 123
ALA A 182
ILE A 176
 None
 1.07A 4rvgA-6an0A:
3.5		 4rvgA-6an0A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZXI_A_GLYA1402_0
(TYROCIDINE
SYNTHETASE 3)		 6an0 HISTIDINOL
DEHYDROGENASE
(Elizabethkingia
anophelis) 		4 / 7 ASP A 240
ILE A 328
GLY A 347
THR A 242
 None
 1.17A 4zxiA-6an0A:
3.6		 4zxiA-6an0A:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1N_G_DVAG9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 6an0 HISTIDINOL
DEHYDROGENASE
(Elizabethkingia
anophelis) 		3 / 3 ALA A 314
ASN A 317
LEU A 318
 None
 0.38A 5i1nB-6an0A:
undetectable		 5i1nB-6an0A:
6.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1P_F_DVAF9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 6an0 HISTIDINOL
DEHYDROGENASE
(Elizabethkingia
anophelis) 		3 / 3 ALA A 314
ASN A 317
LEU A 318
 None
 0.39A 5i1pA-6an0A:
undetectable		 5i1pA-6an0A:
6.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_B_MMSB514_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 6an0 HISTIDINOL
DEHYDROGENASE
(Elizabethkingia
anophelis) 		4 / 8 HIS A 258
SER A 343
HIS A 363
SER A 134
 ZN  A 501 (-3.3A)
None
None
None
 1.01A 5m8rB-6an0A:
undetectable		 5m8rB-6an0A:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_A_ZOTA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 6an0 HISTIDINOL
DEHYDROGENASE
(Elizabethkingia
anophelis) 		5 / 12 VAL A 224
GLY A 223
PHE A  34
PHE A 193
VAL A  30
 None
 1.16A 6a94A-6an0A:
undetectable		 6a94A-6an0A:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_B_ZOTB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 6an0 HISTIDINOL
DEHYDROGENASE
(Elizabethkingia
anophelis) 		5 / 12 VAL A 224
GLY A 223
PHE A  34
PHE A 193
VAL A  30
 None
 1.14A 6a94B-6an0A:
undetectable		 6a94B-6an0A:
23.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6AN0_A_HISA520_0
(HISTIDINOL
DEHYDROGENASE)		 6an0 HISTIDINOL
DEHYDROGENASE
(Elizabethkingia
anophelis) 		6 / 6 GLU A  98
LYS A 100
ARG A 113
GLU A 114
ALA A 115
LYS A 385
 HIS  A 520 (-3.5A)
None
HIS  A 520 (-4.9A)
HIS  A 520 (-4.4A)
HIS  A 520 (-3.5A)
HIS  A 520 (-3.7A)
 0.00A 6an0A-6an0A:
60.4		 6an0A-6an0A:
100.00