SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6ans'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_D_TRPD81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 6ans UNCHARACTERIZED
PROTEIN
(Burkholderia
cenocepacia) 		5 / 9 THR A 341
ALA A  35
THR A  41
HIS A 337
ILE A  30
 None
 1.47A 1c9sC-6ansA:
0.9
1c9sD-6ansA:
0.9		 1c9sC-6ansA:
11.37
1c9sD-6ansA:
11.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IEP_B_STIB202_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 6ans UNCHARACTERIZED
PROTEIN
(Burkholderia
cenocepacia) 		4 / 7 VAL A 172
ILE A 189
ARG A 162
LEU A 113
 None
 1.02A 1iepB-6ansA:
undetectable		 1iepB-6ansA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXK_A_IMNA2001_1
(SERUM ALBUMIN)		 6ans UNCHARACTERIZED
PROTEIN
(Burkholderia
cenocepacia) 		4 / 8 ALA A 185
ARG A 106
LEU A 187
ASP A 144
 None
 1.15A 2bxkA-6ansA:
undetectable		 2bxkA-6ansA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YLO_A_TESA1920_1
(ANDROGEN RECEPTOR)		 6ans UNCHARACTERIZED
PROTEIN
(Burkholderia
cenocepacia) 		5 / 12 LEU A 171
GLN A 118
MET A 128
VAL A 249
MET A  59
 None
None
GOL  A 403 ( 4.6A)
None
None
 1.49A 2yloA-6ansA:
undetectable		 2yloA-6ansA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_C_VIVC301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 6ans UNCHARACTERIZED
PROTEIN
(Burkholderia
cenocepacia) 		5 / 12 ALA A  93
PHE A  71
ILE A 149
LEU A 151
VAL A  95
 None
 1.15A 3w67C-6ansA:
undetectable		 3w67C-6ansA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A79_A_P1BA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 6ans UNCHARACTERIZED
PROTEIN
(Burkholderia
cenocepacia) 		5 / 12 PRO A 355
LEU A 238
LEU A 332
CYH A 303
ILE A 272
 None
 1.47A 4a79A-6ansA:
undetectable		 4a79A-6ansA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A79_B_P1BB601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 6ans UNCHARACTERIZED
PROTEIN
(Burkholderia
cenocepacia) 		5 / 12 PRO A 355
LEU A 238
LEU A 332
CYH A 303
ILE A 272
 None
 1.45A 4a79B-6ansA:
undetectable		 4a79B-6ansA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_A_SAMA301_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 6ans UNCHARACTERIZED
PROTEIN
(Burkholderia
cenocepacia) 		3 / 3 SER A 294
ASP A  87
ASP A 178
 None
 0.85A 4mwzA-6ansA:
undetectable		 4mwzA-6ansA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B0L_B_TA1B502_1
(TUBULIN BETA CHAIN)		 6ans UNCHARACTERIZED
PROTEIN
(Burkholderia
cenocepacia) 		5 / 12 LEU A 187
LEU A 113
THR A 104
ARG A 102
GLY A 158
 None
 0.99A 6b0lB-6ansA:
undetectable		 6b0lB-6ansA:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FTP_B_DM2B501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		 6ans UNCHARACTERIZED
PROTEIN
(Burkholderia
cenocepacia) 		5 / 9 LEU A 113
SER A 114
PHE A 115
LEU A 170
VAL A 147
 None
 1.24A 6ftpA-6ansA:
undetectable
6ftpB-6ansA:
undetectable		 6ftpA-6ansA:
13.06
6ftpB-6ansA:
6.93