SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6anv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E06_A_IPBA600_0
(ODORANT-BINDING
PROTEIN)
6anv ANTI-CRISPR PROTEIN
ACRF1 FUSED WITH
C-TERMINAL MBP TAG

(Escherichia
coli;
Pseudomonas
phage
JBD30)
4 / 6 VAL A  88
VAL A 130
ILE A 140
ASN A 347
None
0.93A 1e06A-6anvA:
undetectable
1e06A-6anvA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_D_ESTD352_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)
6anv ANTI-CRISPR PROTEIN
ACRF1 FUSED WITH
C-TERMINAL MBP TAG

(Escherichia
coli;
Pseudomonas
phage
JBD30)
4 / 6 SER A  38
VAL A  39
GLY A  40
GLU A  66
None
None
MES  A 502 (-3.4A)
None
0.86A 1fduD-6anvA:
undetectable
1fduD-6anvA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KGL_A_RTLA175_1
(CELLULAR
RETINOL-BINDING
PROTEIN TYPE I)
6anv ANTI-CRISPR PROTEIN
ACRF1 FUSED WITH
C-TERMINAL MBP TAG

(Escherichia
coli;
Pseudomonas
phage
JBD30)
4 / 7 LEU A 384
ILE A 409
THR A 173
MET A 401
None
1.16A 1kglA-6anvA:
undetectable
1kglA-6anvA:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VE3_A_REAA1445_1
(PUTATIVE CYTOCHROME
P450 120)
6anv ANTI-CRISPR PROTEIN
ACRF1 FUSED WITH
C-TERMINAL MBP TAG

(Escherichia
coli;
Pseudomonas
phage
JBD30)
5 / 12 ALA A 344
LEU A 360
PHE A 359
VAL A 373
GLY A  96
None
1.08A 2ve3A-6anvA:
undetectable
2ve3A-6anvA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_A_P1ZA1352_1
(PROSTAGLANDIN
REDUCTASE 2)
6anv ANTI-CRISPR PROTEIN
ACRF1 FUSED WITH
C-TERMINAL MBP TAG

(Escherichia
coli;
Pseudomonas
phage
JBD30)
4 / 7 TYR A  55
LEU A   7
ASN A  16
LYS A   5
None
1.44A 2w98A-6anvA:
undetectable
2w98B-6anvA:
undetectable
2w98A-6anvA:
20.52
2w98B-6anvA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_A_SAMA801_1
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)
6anv ANTI-CRISPR PROTEIN
ACRF1 FUSED WITH
C-TERMINAL MBP TAG

(Escherichia
coli;
Pseudomonas
phage
JBD30)
4 / 8 THR A 173
LEU A 365
ASP A 367
GLU A 191
None
None
None
MTT  A 501 (-2.7A)
1.04A 2zw9A-6anvA:
undetectable
2zw9A-6anvA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A301_1
(THIOPURINE
S-METHYLTRANSFERASE)
6anv ANTI-CRISPR PROTEIN
ACRF1 FUSED WITH
C-TERMINAL MBP TAG

(Escherichia
coli;
Pseudomonas
phage
JBD30)
4 / 6 PHE A 338
ALA A 242
LEU A 327
PRO A 239
None
1.00A 3bgdA-6anvA:
undetectable
3bgdA-6anvA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_C_SVRC507_1
(PHOSPHOLIPASE A2)
6anv ANTI-CRISPR PROTEIN
ACRF1 FUSED WITH
C-TERMINAL MBP TAG

(Escherichia
coli;
Pseudomonas
phage
JBD30)
4 / 7 VAL A 190
GLY A 380
PRO A 309
LYS A 385
None
0.77A 3bjwC-6anvA:
undetectable
3bjwC-6anvA:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_G_SVRG506_1
(PHOSPHOLIPASE A2)
6anv ANTI-CRISPR PROTEIN
ACRF1 FUSED WITH
C-TERMINAL MBP TAG

(Escherichia
coli;
Pseudomonas
phage
JBD30)
4 / 8 VAL A 190
GLY A 380
PRO A 309
LYS A 385
None
0.92A 3bjwA-6anvA:
undetectable
3bjwA-6anvA:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G2O_A_SAMA500_1
(PCZA361.24)
6anv ANTI-CRISPR PROTEIN
ACRF1 FUSED WITH
C-TERMINAL MBP TAG

(Escherichia
coli;
Pseudomonas
phage
JBD30)
3 / 3 ARG A  75
GLU A 118
ASP A 138
None
0.90A 3g2oA-6anvA:
undetectable
3g2oA-6anvA:
21.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JYR_A_ACRA371_1
(MALTOSE-BINDING
PERIPLASMIC PROTEIN)
6anv ANTI-CRISPR PROTEIN
ACRF1 FUSED WITH
C-TERMINAL MBP TAG

(Escherichia
coli;
Pseudomonas
phage
JBD30)
12 / 12 ASP A  94
LYS A  95
LYS A 122
GLU A 124
GLU A 125
ALA A 143
ASP A 145
ARG A 146
GLU A 191
PRO A 234
TRP A 310
TYR A 421
MTT  A 501 ( 3.0A)
MTT  A 501 (-2.7A)
MES  A 502 (-3.7A)
MTT  A 501 (-3.1A)
MTT  A 501 (-3.5A)
MTT  A 501 (-3.2A)
MTT  A 501 (-2.9A)
MTT  A 501 (-4.0A)
MTT  A 501 (-2.7A)
MTT  A 501 (-3.4A)
MTT  A 501 (-4.3A)
MTT  A 501 (-4.5A)
0.23A 3jyrA-6anvA:
62.4
3jyrA-6anvA:
80.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JYR_A_ACRA371_2
(MALTOSE-BINDING
PERIPLASMIC PROTEIN)
6anv ANTI-CRISPR PROTEIN
ACRF1 FUSED WITH
C-TERMINAL MBP TAG

(Escherichia
coli;
Pseudomonas
phage
JBD30)
7 / 7 ASN A  92
TRP A 142
GLU A 233
TYR A 235
MET A 410
TRP A 420
ARG A 424
MTT  A 501 (-4.6A)
MTT  A 501 (-4.1A)
MTT  A 501 (-3.2A)
MTT  A 501 (-3.8A)
MTT  A 501 ( 4.1A)
MTT  A 501 (-3.8A)
MTT  A 501 (-4.1A)
0.45A 3jyrA-6anvA:
62.4
3jyrA-6anvA:
80.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_V_BO2V1401_1
(PROTEASOME COMPONENT
PUP1
PROTEASOME COMPONENT
PUP3)
6anv ANTI-CRISPR PROTEIN
ACRF1 FUSED WITH
C-TERMINAL MBP TAG

(Escherichia
coli;
Pseudomonas
phage
JBD30)
5 / 11 GLN A 445
ALA A 444
ALA A 242
GLY A 246
ALA A 268
None
0.99A 3mg0V-6anvA:
undetectable
3mg0W-6anvA:
undetectable
3mg0V-6anvA:
21.68
3mg0W-6anvA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Y_B_DIFB585_1
(PROSTAGLANDIN G/H
SYNTHASE 1)
6anv ANTI-CRISPR PROTEIN
ACRF1 FUSED WITH
C-TERMINAL MBP TAG

(Escherichia
coli;
Pseudomonas
phage
JBD30)
5 / 12 VAL A 276
LEU A 240
GLY A 267
ALA A 268
LEU A 441
None
0.99A 3n8yB-6anvA:
undetectable
3n8yB-6anvA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9T_C_BEZC264_0
(ECHA1_1)
6anv ANTI-CRISPR PROTEIN
ACRF1 FUSED WITH
C-TERMINAL MBP TAG

(Escherichia
coli;
Pseudomonas
phage
JBD30)
4 / 5 ALA A  41
GLU A  31
ALA A  18
MET A   1
MES  A 502 (-4.6A)
None
None
PEG  A 509 ( 4.2A)
1.29A 3r9tC-6anvA:
undetectable
3r9tC-6anvA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SJ4_X_DXCX75_0
(CYTOCHROME C7)
6anv ANTI-CRISPR PROTEIN
ACRF1 FUSED WITH
C-TERMINAL MBP TAG

(Escherichia
coli;
Pseudomonas
phage
JBD30)
5 / 9 ILE A 212
LEU A 278
LYS A 336
ILE A 306
GLY A 271
None
1.26A 3sj4X-6anvA:
undetectable
3sj4X-6anvA:
10.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_B_RTZB1_1
(CYTOCHROME P450 2D6)
6anv ANTI-CRISPR PROTEIN
ACRF1 FUSED WITH
C-TERMINAL MBP TAG

(Escherichia
coli;
Pseudomonas
phage
JBD30)
5 / 12 PHE A 236
GLY A 380
LEU A 379
GLU A 191
ALA A 311
MTT  A 501 (-4.8A)
None
None
MTT  A 501 (-2.7A)
None
0.82A 3tbgB-6anvA:
undetectable
3tbgB-6anvA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_D_RTZD1_1
(CYTOCHROME P450 2D6)
6anv ANTI-CRISPR PROTEIN
ACRF1 FUSED WITH
C-TERMINAL MBP TAG

(Escherichia
coli;
Pseudomonas
phage
JBD30)
5 / 12 PHE A 236
GLY A 380
LEU A 379
GLU A 191
ALA A 311
MTT  A 501 (-4.8A)
None
None
MTT  A 501 (-2.7A)
None
0.80A 3tbgD-6anvA:
undetectable
3tbgD-6anvA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VWQ_A_ACAA601_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)
6anv ANTI-CRISPR PROTEIN
ACRF1 FUSED WITH
C-TERMINAL MBP TAG

(Escherichia
coli;
Pseudomonas
phage
JBD30)
5 / 12 ALA A 311
TYR A  97
TYR A 290
ASN A 314
GLY A 308
None
None
PEG  A 509 (-3.6A)
PEG  A 509 (-4.0A)
None
1.35A 3vwqA-6anvA:
undetectable
3vwqA-6anvA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_A_SAMA501_1
(MNMC2)
6anv ANTI-CRISPR PROTEIN
ACRF1 FUSED WITH
C-TERMINAL MBP TAG

(Escherichia
coli;
Pseudomonas
phage
JBD30)
4 / 6 GLU A 388
ASP A 394
ASP A 367
ASN A 374
None
1.34A 3vywA-6anvA:
undetectable
3vywA-6anvA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_D_SAMD401_1
(MNMC2)
6anv ANTI-CRISPR PROTEIN
ACRF1 FUSED WITH
C-TERMINAL MBP TAG

(Escherichia
coli;
Pseudomonas
phage
JBD30)
4 / 5 GLU A 388
ASP A 394
ASP A 367
ASN A 374
None
1.34A 3vywD-6anvA:
undetectable
3vywD-6anvA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_G_TMQG202_1
(DIHYDROFOLATE
REDUCTASE)
6anv ANTI-CRISPR PROTEIN
ACRF1 FUSED WITH
C-TERMINAL MBP TAG

(Escherichia
coli;
Pseudomonas
phage
JBD30)
5 / 12 ILE A 346
ALA A 185
LEU A 100
VAL A 103
ILE A 139
None
1.08A 4m2xG-6anvA:
undetectable
4m2xG-6anvA:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_A_SAMA601_1
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)
6anv ANTI-CRISPR PROTEIN
ACRF1 FUSED WITH
C-TERMINAL MBP TAG

(Escherichia
coli;
Pseudomonas
phage
JBD30)
4 / 5 ASN A 347
ALA A 131
GLY A 136
ASP A  94
None
None
None
MTT  A 501 ( 3.0A)
1.00A 4n48A-6anvA:
undetectable
4n48A-6anvA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_B_NPSB602_1
(SERUM ALBUMIN)
6anv ANTI-CRISPR PROTEIN
ACRF1 FUSED WITH
C-TERMINAL MBP TAG

(Escherichia
coli;
Pseudomonas
phage
JBD30)
5 / 9 ALA A 344
ALA A 185
LEU A 183
LEU A 342
VAL A 341
None
1.17A 4or0B-6anvA:
undetectable
4or0B-6anvA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJE_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)
6anv ANTI-CRISPR PROTEIN
ACRF1 FUSED WITH
C-TERMINAL MBP TAG

(Escherichia
coli;
Pseudomonas
phage
JBD30)
4 / 6 LEU A 384
ILE A 409
THR A 173
MET A 401
None
1.19A 5ljeA-6anvA:
undetectable
5ljeA-6anvA:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_B_C2FB3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)
6anv ANTI-CRISPR PROTEIN
ACRF1 FUSED WITH
C-TERMINAL MBP TAG

(Escherichia
coli;
Pseudomonas
phage
JBD30)
3 / 3 ASP A 376
ASN A  98
ASP A  43
None
PGE  A 503 (-4.3A)
PGE  A 503 ( 4.4A)
0.90A 5vopB-6anvA:
undetectable
5vopB-6anvA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W4Z_A_RBFA502_1
(RIBOFLAVIN LYASE)
6anv ANTI-CRISPR PROTEIN
ACRF1 FUSED WITH
C-TERMINAL MBP TAG

(Escherichia
coli;
Pseudomonas
phage
JBD30)
6 / 12 ALA A 422
ALA A 418
GLY A 246
ALA A 268
PHE A 249
VAL A 261
None
1.44A 5w4zA-6anvA:
undetectable
5w4zA-6anvA:
11.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W4Z_B_RBFB502_1
(RIBOFLAVIN LYASE)
6anv ANTI-CRISPR PROTEIN
ACRF1 FUSED WITH
C-TERMINAL MBP TAG

(Escherichia
coli;
Pseudomonas
phage
JBD30)
6 / 12 ALA A 422
ALA A 418
GLY A 246
ALA A 268
PHE A 249
VAL A 261
None
1.46A 5w4zB-6anvA:
undetectable
5w4zB-6anvA:
11.82