SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6ao1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
13GS_A_SASA211_1
(GLUTATHIONE
S-TRANSFERASE)		 6ao1 BETA-LACTAMASE
DOMAIN PROTEIN
(Paraburkholderia
phymatum) 		5 / 10 TYR A  10
PRO A  11
ARG A 229
VAL A  25
GLY A  15
 None
 1.46A 13gsA-6ao1A:
undetectable		 13gsA-6ao1A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQ5_B_PAUB6003_0
(PANTOTHENATE KINASE)		 6ao1 BETA-LACTAMASE
DOMAIN PROTEIN
(Paraburkholderia
phymatum) 		5 / 10 ASP A 224
LEU A 227
HIS A 205
TYR A 249
LEU A  40
 CA  A 403 ( 2.2A)
None
CA  A 404 (-3.3A)
None
None
 1.48A 1sq5B-6ao1A:
undetectable		 1sq5B-6ao1A:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_B_STRB2001_2
(MINERALOCORTICOID
RECEPTOR)		 6ao1 BETA-LACTAMASE
DOMAIN PROTEIN
(Paraburkholderia
phymatum) 		3 / 3 LEU A 246
LEU A 330
MET A 312
 None
 0.63A 1ya3B-6ao1A:
undetectable		 1ya3B-6ao1A:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_2
(CES1 PROTEIN)		 6ao1 BETA-LACTAMASE
DOMAIN PROTEIN
(Paraburkholderia
phymatum) 		4 / 4 LEU A 212
PRO A 207
ILE A 121
LEU A 184
 None
 1.08A 1ya4B-6ao1A:
undetectable		 1ya4B-6ao1A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HC4_A_VDXA525_1
(VITAMIN D RECEPTOR)		 6ao1 BETA-LACTAMASE
DOMAIN PROTEIN
(Paraburkholderia
phymatum) 		5 / 12 LEU A 248
SER A 252
HIS A 332
HIS A 287
LEU A 291
 None
 1.38A 2hc4A-6ao1A:
undetectable		 2hc4A-6ao1A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_D_SNLD4001_1
(MINERALOCORTICOID
RECEPTOR)		 6ao1 BETA-LACTAMASE
DOMAIN PROTEIN
(Paraburkholderia
phymatum) 		5 / 12 LEU A 100
LEU A 173
ALA A  66
LEU A  36
LEU A  45
 None
 1.42A 2oaxD-6ao1A:
undetectable		 2oaxD-6ao1A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIQ_A_STIA1001_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 6ao1 BETA-LACTAMASE
DOMAIN PROTEIN
(Paraburkholderia
phymatum) 		4 / 5 LEU A 102
VAL A 199
LEU A 190
ARG A 183
 None
 1.09A 2oiqA-6ao1A:
undetectable		 2oiqA-6ao1A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q0J_B_BEZB500_0
(QUINOLONE SIGNAL
RESPONSE PROTEIN)		 6ao1 BETA-LACTAMASE
DOMAIN PROTEIN
(Paraburkholderia
phymatum) 		5 / 11 ASP A  98
HIS A  99
HIS A 205
ASP A 224
HIS A 269
 CA  A 403 (-3.0A)
CA  A 403 (-3.7A)
CA  A 404 (-3.3A)
CA  A 403 ( 2.2A)
CA  A 403 (-3.7A)
 0.53A 2q0jB-6ao1A:
22.4		 2q0jB-6ao1A:
27.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q0J_B_BEZB500_0
(QUINOLONE SIGNAL
RESPONSE PROTEIN)		 6ao1 BETA-LACTAMASE
DOMAIN PROTEIN
(Paraburkholderia
phymatum) 		5 / 11 ASP A  98
HIS A  99
HIS A 205
ASP A 224
LEU A  40
 CA  A 403 (-3.0A)
CA  A 403 (-3.7A)
CA  A 404 (-3.3A)
CA  A 403 ( 2.2A)
None
 1.14A 2q0jB-6ao1A:
22.4		 2q0jB-6ao1A:
27.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5P_B_MK1B902_1
(PROTEASE)		 6ao1 BETA-LACTAMASE
DOMAIN PROTEIN
(Paraburkholderia
phymatum) 		5 / 12 LEU A  47
VAL A  90
GLY A 101
ILE A  70
ILE A  60
 None
 0.97A 2r5pA-6ao1A:
undetectable		 2r5pA-6ao1A:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5P_D_MK1D902_1
(PROTEASE)		 6ao1 BETA-LACTAMASE
DOMAIN PROTEIN
(Paraburkholderia
phymatum) 		5 / 12 LEU A  47
VAL A  90
GLY A 101
ILE A  70
ILE A  60
 None
 0.97A 2r5pC-6ao1A:
undetectable		 2r5pC-6ao1A:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A25_A_SAMA279_1
(UNCHARACTERIZED
PROTEIN PH0793)		 6ao1 BETA-LACTAMASE
DOMAIN PROTEIN
(Paraburkholderia
phymatum) 		3 / 3 MET A 127
GLU A 208
ASP A 188
 None
 1.06A 3a25A-6ao1A:
undetectable		 3a25A-6ao1A:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_B_TOPB200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 6ao1 BETA-LACTAMASE
DOMAIN PROTEIN
(Paraburkholderia
phymatum) 		5 / 12 ALA A  81
LEU A  32
ILE A  60
LEU A 106
THR A  80
 EDO  A 402 (-3.7A)
None
None
None
None
 1.13A 3fl9B-6ao1A:
undetectable		 3fl9B-6ao1A:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NNE_G_ACTG601_0
(CHOLINE OXIDASE)		 6ao1 BETA-LACTAMASE
DOMAIN PROTEIN
(Paraburkholderia
phymatum) 		4 / 6 ALA A 305
HIS A 148
VAL A 236
HIS A 334
 None
 1.16A 3nneG-6ao1A:
undetectable		 3nneG-6ao1A:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C1D_B_X8ZB350_1
(BETA-LACTAMASE CLASS
B VIM-2)		 6ao1 BETA-LACTAMASE
DOMAIN PROTEIN
(Paraburkholderia
phymatum) 		5 / 10 HIS A  94
HIS A  96
ASP A  98
HIS A 205
ASN A 233
 CA  A 404 (-3.4A)
CA  A 404 (-3.2A)
CA  A 403 (-3.0A)
CA  A 404 (-3.3A)
None
 1.05A 4c1dB-6ao1A:
18.9		 4c1dB-6ao1A:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C1D_B_X8ZB350_1
(BETA-LACTAMASE CLASS
B VIM-2)		 6ao1 BETA-LACTAMASE
DOMAIN PROTEIN
(Paraburkholderia
phymatum) 		5 / 10 HIS A  94
HIS A  96
ASP A  98
HIS A 205
HIS A 269
 CA  A 404 (-3.4A)
CA  A 404 (-3.2A)
CA  A 403 (-3.0A)
CA  A 404 (-3.3A)
CA  A 403 (-3.7A)
 0.90A 4c1dB-6ao1A:
18.9		 4c1dB-6ao1A:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C1F_A_X8ZA300_1
(BETA-LACTAMASE IMP-1)		 6ao1 BETA-LACTAMASE
DOMAIN PROTEIN
(Paraburkholderia
phymatum) 		5 / 11 HIS A  94
HIS A  96
ASP A  98
ASN A 233
HIS A 269
 CA  A 404 (-3.4A)
CA  A 404 (-3.2A)
CA  A 403 (-3.0A)
None
CA  A 403 (-3.7A)
 0.76A 4c1fA-6ao1A:
18.6
4c1fB-6ao1A:
18.4		 4c1fA-6ao1A:
19.73
4c1fB-6ao1A:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C1F_A_X8ZA300_1
(BETA-LACTAMASE IMP-1)		 6ao1 BETA-LACTAMASE
DOMAIN PROTEIN
(Paraburkholderia
phymatum) 		5 / 11 HIS A  94
HIS A  96
ASP A  98
HIS A 205
ASN A 233
 CA  A 404 (-3.4A)
CA  A 404 (-3.2A)
CA  A 403 (-3.0A)
CA  A 404 (-3.3A)
None
 0.97A 4c1fA-6ao1A:
18.6
4c1fB-6ao1A:
18.4		 4c1fA-6ao1A:
19.73
4c1fB-6ao1A:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C1H_A_X8ZA305_1
(BETA-LACTAMASE 2)		 6ao1 BETA-LACTAMASE
DOMAIN PROTEIN
(Paraburkholderia
phymatum) 		5 / 9 HIS A  94
HIS A  96
ASP A  98
ASN A 233
HIS A 269
 CA  A 404 (-3.4A)
CA  A 404 (-3.2A)
CA  A 403 (-3.0A)
None
CA  A 403 (-3.7A)
 0.72A 4c1hA-6ao1A:
19.1		 4c1hA-6ao1A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C1H_A_X8ZA305_1
(BETA-LACTAMASE 2)		 6ao1 BETA-LACTAMASE
DOMAIN PROTEIN
(Paraburkholderia
phymatum) 		5 / 9 HIS A  94
HIS A  96
ASP A  98
HIS A 205
HIS A 269
 CA  A 404 (-3.4A)
CA  A 404 (-3.2A)
CA  A 403 (-3.0A)
CA  A 404 (-3.3A)
CA  A 403 (-3.7A)
 0.91A 4c1hA-6ao1A:
19.1		 4c1hA-6ao1A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_B_PXLB300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 6ao1 BETA-LACTAMASE
DOMAIN PROTEIN
(Paraburkholderia
phymatum) 		5 / 10 GLY A 101
ASP A  98
GLY A  64
HIS A  94
HIS A 269
 None
CA  A 403 (-3.0A)
None
CA  A 404 (-3.4A)
CA  A 403 (-3.7A)
 1.11A 4c5nB-6ao1A:
undetectable		 4c5nB-6ao1A:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HVR_A_SALA203_1
(3-HYDROXYANTHRANILAT
E 3,4-DIOXYGENASE)		 6ao1 BETA-LACTAMASE
DOMAIN PROTEIN
(Paraburkholderia
phymatum) 		4 / 7 HIS A   0
HIS A 286
VAL A 234
GLU A 328
 None
EDO  A 401 ( 4.2A)
None
None
 0.99A 4hvrA-6ao1A:
undetectable		 4hvrA-6ao1A:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MA3_L_ACTL301_0
(C2095 HEAVY CHAIN
C2095 LIGHT CHAIN)		 6ao1 BETA-LACTAMASE
DOMAIN PROTEIN
(Paraburkholderia
phymatum) 		3 / 3 PRO A 267
ASN A  44
HIS A  42
 None
 0.88A 4ma3H-6ao1A:
undetectable
4ma3L-6ao1A:
undetectable		 4ma3H-6ao1A:
18.75
4ma3L-6ao1A:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYA_A_X8ZA307_1
(METALLO-BETA-LACTAMA
SE)		 6ao1 BETA-LACTAMASE
DOMAIN PROTEIN
(Paraburkholderia
phymatum) 		6 / 11 HIS A  94
HIS A  96
ASP A  98
HIS A  99
HIS A 205
HIS A 269
 CA  A 404 (-3.4A)
CA  A 404 (-3.2A)
CA  A 403 (-3.0A)
CA  A 403 (-3.7A)
CA  A 404 (-3.3A)
CA  A 403 (-3.7A)
 0.58A 5ayaA-6ao1A:
16.3		 5ayaA-6ao1A:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYA_A_X8ZA307_1
(METALLO-BETA-LACTAMA
SE)		 6ao1 BETA-LACTAMASE
DOMAIN PROTEIN
(Paraburkholderia
phymatum) 		6 / 11 HIS A  94
HIS A  96
ASP A  98
HIS A  99
HIS A 205
THR A 232
 CA  A 404 (-3.4A)
CA  A 404 (-3.2A)
CA  A 403 (-3.0A)
CA  A 403 (-3.7A)
CA  A 404 (-3.3A)
None
 0.81A 5ayaA-6ao1A:
16.3		 5ayaA-6ao1A:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HPU_C_IPHC101_0
(INSULIN, CHAIN A
INSULIN, CHAIN B)		 6ao1 BETA-LACTAMASE
DOMAIN PROTEIN
(Paraburkholderia
phymatum) 		4 / 6 CYH A 298
LEU A 342
HIS A 332
LEU A 333
 None
 0.99A 5hpuC-6ao1A:
undetectable
5hpuD-6ao1A:
undetectable		 5hpuC-6ao1A:
5.61
5hpuD-6ao1A:
5.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HPU_C_IPHC101_0
(INSULIN, CHAIN A
INSULIN, CHAIN B)		 6ao1 BETA-LACTAMASE
DOMAIN PROTEIN
(Paraburkholderia
phymatum) 		4 / 6 CYH A 298
LEU A 342
HIS A 332
LEU A 333
 None
 1.16A 5hpuC-6ao1A:
undetectable
5hpuD-6ao1A:
undetectable		 5hpuC-6ao1A:
5.61
5hpuD-6ao1A:
5.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZW_A_9F2A1102_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 6ao1 BETA-LACTAMASE
DOMAIN PROTEIN
(Paraburkholderia
phymatum) 		5 / 10 HIS A  94
HIS A  96
HIS A  99
HIS A 205
ASP A 224
 CA  A 404 (-3.4A)
CA  A 404 (-3.2A)
CA  A 403 (-3.7A)
CA  A 404 (-3.3A)
CA  A 403 ( 2.2A)
 0.46A 5nzwA-6ao1A:
5.5		 5nzwA-6ao1A:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_A_CUA602_0
(THIOCYANATE
DEHYDROGENASE)		 6ao1 BETA-LACTAMASE
DOMAIN PROTEIN
(Paraburkholderia
phymatum) 		3 / 3 LYS A  -6
HIS A  -3
HIS A  -4
 None
 1.24A 5oexA-6ao1A:
undetectable		 5oexA-6ao1A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_C_CUC603_0
(THIOCYANATE
DEHYDROGENASE)		 6ao1 BETA-LACTAMASE
DOMAIN PROTEIN
(Paraburkholderia
phymatum) 		3 / 3 LYS A  -6
HIS A  -3
HIS A  -4
 None
 1.26A 5oexC-6ao1A:
undetectable		 5oexC-6ao1A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_D_CUD603_0
(THIOCYANATE
DEHYDROGENASE)		 6ao1 BETA-LACTAMASE
DOMAIN PROTEIN
(Paraburkholderia
phymatum) 		3 / 3 LYS A  -6
HIS A  -3
HIS A  -4
 None
 1.23A 5oexD-6ao1A:
undetectable		 5oexD-6ao1A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5P9I_A_1E8A701_2
(TYROSINE-PROTEIN
KINASE BTK)		 6ao1 BETA-LACTAMASE
DOMAIN PROTEIN
(Paraburkholderia
phymatum) 		4 / 5 LEU A 220
MET A 225
CYH A 210
ASP A  62
 None
 1.46A 5p9iA-6ao1A:
undetectable		 5p9iA-6ao1A:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		 6ao1 BETA-LACTAMASE
DOMAIN PROTEIN
(Paraburkholderia
phymatum) 		5 / 12 ILE A 221
ASP A 224
LEU A 190
ALA A 103
GLY A 101
 None
CA  A 403 ( 2.2A)
None
None
None
 0.94A 5uxdB-6ao1A:
undetectable		 5uxdB-6ao1A:
24.36