SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6ao3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_A_STRA1001_2
(MINERALOCORTICOID
RECEPTOR)		 6ao3 GASDERMIN-D
(Mus
musculus) 		4 / 4 LEU A 315
LEU A 478
SER A 475
LEU A 381
 None
 1.02A 1ya3A-6ao3A:
undetectable		 1ya3A-6ao3A:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZG_A_NCAA302_0
(ADP-RIBOSYL CYCLASE
1)		 6ao3 GASDERMIN-D
(Mus
musculus) 		4 / 7 LEU A 292
ASP A 288
TRP A 418
SER A 470
 None
 1.10A 3dzgA-6ao3A:
undetectable		 3dzgA-6ao3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZG_B_NCAB302_0
(ADP-RIBOSYL CYCLASE
1)		 6ao3 GASDERMIN-D
(Mus
musculus) 		4 / 7 LEU A 292
ASP A 288
TRP A 418
SER A 470
 None
 1.07A 3dzgB-6ao3A:
undetectable		 3dzgB-6ao3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJD_B_C2FB314_0
(UNCHARACTERIZED
PROTEIN)		 6ao3 GASDERMIN-D
(Mus
musculus) 		5 / 12 LEU A 384
CYH A 448
LEU A 452
GLN A 404
LEU A 392
 None
 1.12A 3ijdB-6ao3A:
undetectable		 3ijdB-6ao3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVC_A_BEZA301_0
(DIGUANYLATE CYCLASE
DOSC)		 6ao3 GASDERMIN-D
(Mus
musculus) 		4 / 8 ILE A 314
LEU A 306
ILE A 374
LEU A 370
 None
 0.81A 4zvcA-6ao3A:
2.1
4zvcB-6ao3A:
2.1		 4zvcA-6ao3A:
undetectable
4zvcB-6ao3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVC_A_BEZA301_0
(DIGUANYLATE CYCLASE
DOSC)		 6ao3 GASDERMIN-D
(Mus
musculus) 		4 / 8 ILE A 374
LEU A 370
ILE A 314
LEU A 306
 None
 0.80A 4zvcA-6ao3A:
2.1
4zvcB-6ao3A:
2.1		 4zvcA-6ao3A:
undetectable
4zvcB-6ao3A:
undetectable