SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6ao8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)		 6ao8 ARGININE--TRNA
LIGASE
(Neisseria
gonorrhoeae) 		4 / 5 LEU A 503
LEU A 515
LEU A 459
GLY A 560
 None
 1.03A 1a4lC-6ao8A:
undetectable		 1a4lC-6ao8A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRK_B_TFPB203_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 6ao8 ARGININE--TRNA
LIGASE
(Neisseria
gonorrhoeae) 		4 / 5 PHE A 499
LEU A 519
PHE A 148
SER A 141
 None
 1.34A 1wrkB-6ao8A:
undetectable		 1wrkB-6ao8A:
10.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_F_9CRF1600_2
(RETINOIC ACID
RECEPTOR, BETA)		 6ao8 ARGININE--TRNA
LIGASE
(Neisseria
gonorrhoeae) 		3 / 3 LEU A 173
PHE A 230
ARG A 193
 None
 0.85A 1xdkF-6ao8A:
undetectable		 1xdkF-6ao8A:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z2B_C_VLBC800_2
(TUBULIN ALPHA CHAIN)		 6ao8 ARGININE--TRNA
LIGASE
(Neisseria
gonorrhoeae) 		4 / 5 PRO A 512
VAL A 506
VAL A 145
ILE A 142
 None
 1.03A 1z2bC-6ao8A:
undetectable		 1z2bC-6ao8A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WQ5_A_MIYA1120_1
(PHOSPHOLIPASE A2,
ACIDIC)		 6ao8 ARGININE--TRNA
LIGASE
(Neisseria
gonorrhoeae) 		4 / 7 LEU A  99
ALA A 550
GLY A 554
PHE A 104
 None
 0.93A 2wq5A-6ao8A:
undetectable		 2wq5A-6ao8A:
12.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y03_A_5FWA601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 6ao8 ARGININE--TRNA
LIGASE
(Neisseria
gonorrhoeae) 		5 / 12 VAL A 336
SER A 136
SER A 135
ASN A 157
TYR A 312
 ARG  A 601 ( 4.8A)
None
None
None
ARG  A 601 (-4.4A)
 1.34A 2y03A-6ao8A:
2.2		 2y03A-6ao8A:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y03_B_5FWB601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 6ao8 ARGININE--TRNA
LIGASE
(Neisseria
gonorrhoeae) 		5 / 12 VAL A 336
SER A 136
SER A 135
ASN A 157
TYR A 312
 ARG  A 601 ( 4.8A)
None
None
None
ARG  A 601 (-4.4A)
 1.37A 2y03B-6ao8A:
undetectable		 2y03B-6ao8A:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A2Q_A_ACAA602_1
(6-AMINOHEXANOATE-CYC
LIC-DIMER HYDROLASE)		 6ao8 ARGININE--TRNA
LIGASE
(Neisseria
gonorrhoeae) 		4 / 7 ASN A  83
ALA A  58
ALA A  62
GLN A  39
 None
 0.71A 3a2qA-6ao8A:
undetectable		 3a2qA-6ao8A:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E22_B_LOCB700_2
(TUBULIN BETA-2B
CHAIN)		 6ao8 ARGININE--TRNA
LIGASE
(Neisseria
gonorrhoeae) 		5 / 11 LEU A  91
LEU A 549
ALA A 493
LEU A 497
ALA A  98
 None
 1.28A 3e22B-6ao8A:
undetectable		 3e22B-6ao8A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4POO_B_SAMB301_0
(PUTATIVE RNA
METHYLASE)		 6ao8 ARGININE--TRNA
LIGASE
(Neisseria
gonorrhoeae) 		5 / 12 GLY A 160
ASN A 123
HIS A 132
ASP A 161
ASN A 157
 ARG  A 601 ( 4.6A)
ARG  A 601 (-3.4A)
ARG  A 601 (-4.0A)
None
None
 1.36A 4pooB-6ao8A:
2.1		 4pooB-6ao8A:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOP_C_HQEC503_1
(CATALASE)		 6ao8 ARGININE--TRNA
LIGASE
(Neisseria
gonorrhoeae) 		4 / 8 PHE A 301
TYR A 312
LEU A 347
PHE A 344
 None
ARG  A 601 (-4.4A)
None
ARG  A 601 (-4.8A)
 0.92A 4qopC-6ao8A:
undetectable		 4qopC-6ao8A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_A_REAA602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 6ao8 ARGININE--TRNA
LIGASE
(Neisseria
gonorrhoeae) 		5 / 12 ILE A 566
GLY A 560
THR A 556
ASN A 454
LEU A 519
 None
 1.32A 5fhzA-6ao8A:
2.8		 5fhzA-6ao8A:
26.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_A_CELA602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 6ao8 ARGININE--TRNA
LIGASE
(Neisseria
gonorrhoeae) 		5 / 12 LEU A 288
ALA A 363
GLY A 355
ALA A 354
LEU A 276
 None
 1.05A 5jw1A-6ao8A:
3.4		 5jw1A-6ao8A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CB4_A_BEZA501_0
(CANAVALIN)		 6ao8 ARGININE--TRNA
LIGASE
(Neisseria
gonorrhoeae) 		4 / 8 LEU A 146
VAL A 335
LEU A 333
ILE A 366
 None
 0.91A 6cb4A-6ao8A:
undetectable		 6cb4A-6ao8A:
21.38