SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6aoj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XL6_B_SPMB3001_1 (INWARD RECTIFIER POTASSIUM CHANNEL)	6aoj	CEG4 (Legionella pneumophila)	4 / 5	ALA A 60 TYR A 62 ALA A 56 TYR A 116	None	1.15A	1xl6A-6aojA: undetectable 1xl6B-6aojA: undetectable	1xl6A-6aojA: 14.43 1xl6B-6aojA: 14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2V0M_A_KLNA1500_1 (CYTOCHROME P450 3A4)	6aoj	CEG4 (Legionella pneumophila)	5 / 11	SER A 81 LEU A 196 PHE A 87 ARG A 184 LEU A 156	None	1.33A	2v0mA-6aojA: undetectable	2v0mA-6aojA: 10.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2V0M_D_KLND1498_1 (CYTOCHROME P450 3A4)	6aoj	CEG4 (Legionella pneumophila)	5 / 11	SER A 81 LEU A 196 PHE A 87 ARG A 184 LEU A 156	None	1.28A	2v0mD-6aojA: undetectable	2v0mD-6aojA: 10.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2WLK_B_SPMB1302_1 (ATP-SENSITIVE INWARD RECTIFIER POTASSIUM CHANNEL 10)	6aoj	CEG4 (Legionella pneumophila)	4 / 4	ALA A 60 TYR A 62 ALA A 56 TYR A 116	None	1.19A	2wlkA-6aojA: undetectable 2wlkB-6aojA: undetectable	2wlkA-6aojA: 14.43 2wlkB-6aojA: 14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3W9T_D_W9TD507_1 (HEMOLYTIC LECTIN CEL-III)	6aoj	CEG4 (Legionella pneumophila)	4 / 5	ASP A 158 GLU A 21 GLY A 19 ASP A 162	MG A 301 (-2.4A) None None None	1.30A	3w9tD-6aojA: undetectable	3w9tD-6aojA: 10.16

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1XL6_B_SPMB3001_1","INWARD RECTIFIER POTASSIUM CHANNEL;INWARD RECTIFIER POTASSIUM CHANNEL","6aoj","CEG4","Legionella pneumophila",4,"ALA A  60;TYR A  62;ALA A  56;TYR A 116","None","1.15A","1xl6A-6aojA:undetectable;1xl6B-6aojA:undetectable","1xl6A-6aojA:14.43;1xl6B-6aojA:14.43"],["2V0M_A_KLNA1500_1","CYTOCHROME P450 3A4","6aoj","CEG4","Legionella pneumophila",5,"SER A  81;LEU A 196;PHE A  87;ARG A 184;LEU A 156","None","1.33A","2v0mA-6aojA:undetectable","2v0mA-6aojA:10.72"],["2V0M_D_KLND1498_1","CYTOCHROME P450 3A4","6aoj","CEG4","Legionella pneumophila",5,"SER A  81;LEU A 196;PHE A  87;ARG A 184;LEU A 156","None","1.28A","2v0mD-6aojA:undetectable","2v0mD-6aojA:10.72"],["2WLK_B_SPMB1302_1","ATP-SENSITIVE INWARD RECTIFIER POTASSIUM CHANNEL 10;ATP-SENSITIVE INWARD RECTIFIER POTASSIUM CHANNEL 10","6aoj","CEG4","Legionella pneumophila",4,"ALA A  60;TYR A  62;ALA A  56;TYR A 116","None","1.19A","2wlkA-6aojA:undetectable;2wlkB-6aojA:undetectable","2wlkA-6aojA:14.43;2wlkB-6aojA:14.43"],["3W9T_D_W9TD507_1","HEMOLYTIC LECTIN CEL-III","6aoj","CEG4","Legionella pneumophila",4,"ASP A 158;GLU A  21;GLY A  19;ASP A 162"," MG A 301 (-2.4A);None;None;None","1.30A","3w9tD-6aojA:undetectable","3w9tD-6aojA:10.16"]]