SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6aon'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D1G_A_MTXA171_1
(DIHYDROFOLATE
REDUCTASE)		 6aon DIHYDROLIPOYL
DEHYDROGENASE
(Bordetella
pertussis) 		5 / 12 ALA A 444
ASP A 415
LYS A 413
LEU A 376
ILE A 409
 None
 1.12A 1d1gA-6aonA:
undetectable		 1d1gA-6aonA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHF_A_FOLA187_0
(DIHYDROFOLATE
REDUCTASE)		 6aon DIHYDROLIPOYL
DEHYDROGENASE
(Bordetella
pertussis) 		5 / 12 ILE A 241
ALA A 235
PHE A 218
THR A 362
ILE A 366
 None
 1.10A 1dhfA-6aonA:
undetectable		 1dhfA-6aonA:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHF_B_FOLB187_0
(DIHYDROFOLATE
REDUCTASE)		 6aon DIHYDROLIPOYL
DEHYDROGENASE
(Bordetella
pertussis) 		5 / 12 ILE A 241
ALA A 235
PHE A 218
THR A 362
ILE A 366
 None
 1.07A 1dhfB-6aonA:
undetectable		 1dhfB-6aonA:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DYI_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 6aon DIHYDROLIPOYL
DEHYDROGENASE
(Bordetella
pertussis) 		5 / 12 ILE A 241
ALA A 235
PHE A 218
THR A 362
ILE A 366
 None
 1.13A 1dyiA-6aonA:
undetectable		 1dyiA-6aonA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DYI_B_FOLB161_0
(DIHYDROFOLATE
REDUCTASE)		 6aon DIHYDROLIPOYL
DEHYDROGENASE
(Bordetella
pertussis) 		5 / 12 ILE A 241
ALA A 235
PHE A 218
THR A 362
ILE A 366
 None
 1.06A 1dyiB-6aonA:
undetectable		 1dyiB-6aonA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_I_FUAI707_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 6aon DIHYDROLIPOYL
DEHYDROGENASE
(Bordetella
pertussis) 		3 / 3 VAL A 340
ALA A 339
HIS A 350
 None
 0.57A 1q23G-6aonA:
undetectable		 1q23G-6aonA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_K_FUAK712_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 6aon DIHYDROLIPOYL
DEHYDROGENASE
(Bordetella
pertussis) 		3 / 3 VAL A 340
ALA A 339
HIS A 350
 None
 0.61A 1q23L-6aonA:
undetectable		 1q23L-6aonA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_L_FUAL710_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 6aon DIHYDROLIPOYL
DEHYDROGENASE
(Bordetella
pertussis) 		3 / 3 VAL A 340
ALA A 339
HIS A 350
 None
 0.47A 1q23J-6aonA:
undetectable		 1q23J-6aonA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RE7_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 6aon DIHYDROLIPOYL
DEHYDROGENASE
(Bordetella
pertussis) 		5 / 12 ILE A 241
ALA A 235
PHE A 218
THR A 362
ILE A 366
 None
 1.04A 1re7A-6aonA:
undetectable		 1re7A-6aonA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TKQ_B_DVAB6_0
(GRAMICIDIN A)		 6aon DIHYDROLIPOYL
DEHYDROGENASE
(Bordetella
pertussis) 		3 / 3 ALA A 319
VAL A 149
TRP A 132
 None
 0.88A 1tkqB-6aonA:
undetectable		 1tkqB-6aonA:
3.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3A_A_TOPA1190_1
(DIHYDROFOLATE
REDUCTASE)		 6aon DIHYDROLIPOYL
DEHYDROGENASE
(Bordetella
pertussis) 		5 / 11 ILE A 241
ALA A 235
PHE A 218
THR A 362
ILE A 366
 None
 1.06A 2w3aA-6aonA:
undetectable		 2w3aA-6aonA:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3A_B_TOPB1189_1
(DIHYDROFOLATE
REDUCTASE)		 6aon DIHYDROLIPOYL
DEHYDROGENASE
(Bordetella
pertussis) 		5 / 10 ILE A 241
ALA A 235
PHE A 218
THR A 362
ILE A 366
 None
 1.07A 2w3aB-6aonA:
undetectable		 2w3aB-6aonA:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3B_A_FOLA401_0
(DIHYDROFOLATE
REDUCTASE)		 6aon DIHYDROLIPOYL
DEHYDROGENASE
(Bordetella
pertussis) 		5 / 12 ILE A 241
ALA A 235
PHE A 218
THR A 362
ILE A 366
 None
 1.08A 2w3bA-6aonA:
undetectable		 2w3bA-6aonA:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCM_X_SAMX5452_0
(UNCHARACTERIZED
PROTEIN TM_1570)		 6aon DIHYDROLIPOYL
DEHYDROGENASE
(Bordetella
pertussis) 		5 / 11 GLY A 195
GLY A 190
LEU A 171
SER A 172
ALA A 176
 None
 0.97A 3dcmX-6aonA:
undetectable		 3dcmX-6aonA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCM_X_SAMX5452_0
(UNCHARACTERIZED
PROTEIN TM_1570)		 6aon DIHYDROLIPOYL
DEHYDROGENASE
(Bordetella
pertussis) 		5 / 11 GLY A 195
ILE A 179
LEU A 171
SER A 172
ALA A 176
 None
 0.93A 3dcmX-6aonA:
undetectable		 3dcmX-6aonA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM4_A_DR7A100_1
(PROTEASE)		 6aon DIHYDROLIPOYL
DEHYDROGENASE
(Bordetella
pertussis) 		5 / 11 GLY A 190
ALA A 191
GLY A 199
LEU A 186
ILE A 241
 None
 0.95A 3em4A-6aonA:
undetectable		 3em4A-6aonA:
11.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJO_B_EAAB211_1
(GLUTATHIONE
S-TRANSFERASE P)		 6aon DIHYDROLIPOYL
DEHYDROGENASE
(Bordetella
pertussis) 		4 / 8 VAL A 273
ILE A 170
VAL A 278
GLY A 187
 None
 0.71A 3hjoB-6aonA:
undetectable		 3hjoB-6aonA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_A_CELA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 6aon DIHYDROLIPOYL
DEHYDROGENASE
(Bordetella
pertussis) 		5 / 12 GLN A 237
SER A 233
ILE A 423
ALA A 427
SER A 428
 None
 1.13A 3kk6A-6aonA:
0.7		 3kk6A-6aonA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N0H_A_TOPA187_1
(DIHYDROFOLATE
REDUCTASE)		 6aon DIHYDROLIPOYL
DEHYDROGENASE
(Bordetella
pertussis) 		5 / 11 ILE A 241
ALA A 235
PHE A 218
THR A 362
ILE A 366
 None
 1.07A 3n0hA-6aonA:
undetectable		 3n0hA-6aonA:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QG2_B_CP6B709_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 6aon DIHYDROLIPOYL
DEHYDROGENASE
(Bordetella
pertussis) 		5 / 11 ILE A 241
ALA A 235
PHE A 218
ILE A 366
LEU A 196
 None
 1.09A 3qg2B-6aonA:
undetectable		 3qg2B-6aonA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3V_A_TOPA187_1
(DIHYDROFOLATE
REDUCTASE)		 6aon DIHYDROLIPOYL
DEHYDROGENASE
(Bordetella
pertussis) 		5 / 12 ILE A 241
ALA A 235
PHE A 218
THR A 362
ILE A 366
 None
 1.05A 3s3vA-6aonA:
undetectable		 3s3vA-6aonA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A3U_A_ACTA1358_0
(NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE)		 6aon DIHYDROLIPOYL
DEHYDROGENASE
(Bordetella
pertussis) 		5 / 9 ALA A 123
ILE A 134
GLY A 126
VAL A 294
ASN A 290
 None
 1.21A 4a3uA-6aonA:
undetectable		 4a3uA-6aonA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZV_A_SAMA1474_1
(WBDD)		 6aon DIHYDROLIPOYL
DEHYDROGENASE
(Bordetella
pertussis) 		4 / 6 TYR A 383
ASP A 223
GLN A 225
GLU A 217
 None
None
None
CA  A 502 ( 4.8A)
 1.37A 4azvA-6aonA:
4.0		 4azvA-6aonA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJ1_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 6aon DIHYDROLIPOYL
DEHYDROGENASE
(Bordetella
pertussis) 		5 / 12 ILE A 241
ALA A 235
PHE A 218
THR A 362
ILE A 366
 None
 1.12A 4ej1B-6aonA:
undetectable		 4ej1B-6aonA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FE1_A_PQNA846_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 6aon DIHYDROLIPOYL
DEHYDROGENASE
(Bordetella
pertussis) 		5 / 10 ALA A 291
LEU A 289
GLY A 288
ALA A  23
MET A  28
 None
FAD  A 501 ( 4.8A)
None
None
None
 1.48A 4fe1A-6aonA:
undetectable
4fe1J-6aonA:
undetectable		 4fe1A-6aonA:
21.08
4fe1J-6aonA:
6.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGJ_A_1PQA304_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 6aon DIHYDROLIPOYL
DEHYDROGENASE
(Bordetella
pertussis) 		4 / 8 PHE A 110
ILE A  18
GLY A  47
ASN A 102
 None
None
FAD  A 501 (-3.2A)
None
 1.03A 4fgjA-6aonA:
3.1
4fgjB-6aonA:
undetectable		 4fgjA-6aonA:
16.80
4fgjB-6aonA:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KEB_B_FOLB202_0
(DIHYDROFOLATE
REDUCTASE)		 6aon DIHYDROLIPOYL
DEHYDROGENASE
(Bordetella
pertussis) 		5 / 12 ILE A 241
ALA A 235
PHE A 218
THR A 362
ILE A 366
 None
 1.09A 4kebB-6aonA:
undetectable		 4kebB-6aonA:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KJK_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 6aon DIHYDROLIPOYL
DEHYDROGENASE
(Bordetella
pertussis) 		5 / 12 ILE A 241
ALA A 235
PHE A 218
THR A 362
ILE A 366
 None
 1.06A 4kjkA-6aonA:
undetectable		 4kjkA-6aonA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KR4_C_AICC401_1
(OUTER MEMBRANE
PROTEIN F)		 6aon DIHYDROLIPOYL
DEHYDROGENASE
(Bordetella
pertussis) 		4 / 8 ARG A 204
ARG A 203
ASP A 401
GLU A 365
 None
 1.12A 4kr4C-6aonA:
undetectable		 4kr4C-6aonA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KSZ_A_CYSA620_0
(LACTOPEROXIDASE)		 6aon DIHYDROLIPOYL
DEHYDROGENASE
(Bordetella
pertussis) 		3 / 3 ARG A 158
GLU A 159
PHE A 165
 None
 0.87A 4kszA-6aonA:
0.0		 4kszA-6aonA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M6K_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 6aon DIHYDROLIPOYL
DEHYDROGENASE
(Bordetella
pertussis) 		5 / 12 ILE A 241
ALA A 235
PHE A 218
THR A 362
ILE A 366
 None
 1.07A 4m6kA-6aonA:
undetectable		 4m6kA-6aonA:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTJ_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 6aon DIHYDROLIPOYL
DEHYDROGENASE
(Bordetella
pertussis) 		5 / 12 ILE A 241
ALA A 235
PHE A 218
THR A 362
ILE A 366
 None
 1.11A 4ptjA-6aonA:
undetectable		 4ptjA-6aonA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLE_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 6aon DIHYDROLIPOYL
DEHYDROGENASE
(Bordetella
pertussis) 		5 / 12 ILE A 241
ALA A 235
PHE A 218
THR A 362
ILE A 366
 None
 1.15A 4qleA-6aonA:
undetectable		 4qleA-6aonA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5F_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 6aon DIHYDROLIPOYL
DEHYDROGENASE
(Bordetella
pertussis) 		5 / 12 ILE A 241
ALA A 235
PHE A 218
THR A 362
ILE A 366
 None
 1.10A 4x5fA-6aonA:
undetectable		 4x5fA-6aonA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5F_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 6aon DIHYDROLIPOYL
DEHYDROGENASE
(Bordetella
pertussis) 		5 / 12 ILE A 241
ALA A 235
PHE A 218
THR A 362
ILE A 366
 None
 1.07A 4x5fB-6aonA:
undetectable		 4x5fB-6aonA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5G_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 6aon DIHYDROLIPOYL
DEHYDROGENASE
(Bordetella
pertussis) 		5 / 12 ILE A 241
ALA A 235
PHE A 218
THR A 362
ILE A 366
 None
 1.13A 4x5gA-6aonA:
undetectable		 4x5gA-6aonA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR2_A_ROCA101_1
(PROTEASE PR5-SQV)		 6aon DIHYDROLIPOYL
DEHYDROGENASE
(Bordetella
pertussis) 		5 / 9 ALA A 222
ASP A 223
ILE A 423
ILE A 431
THR A 362
 None
 1.20A 5kr2A-6aonA:
undetectable		 5kr2A-6aonA:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR2_C_ROCC101_1
(PROTEASE PR5-SQV)		 6aon DIHYDROLIPOYL
DEHYDROGENASE
(Bordetella
pertussis) 		5 / 9 ALA A 222
ASP A 223
ILE A 423
ILE A 431
THR A 362
 None
 1.20A 5kr2C-6aonA:
undetectable		 5kr2C-6aonA:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_H_BO2H306_1
(PROTEASOME SUBUNIT
BETA TYPE-7
PROTEASOME SUBUNIT
BETA TYPE-3)		 6aon DIHYDROLIPOYL
DEHYDROGENASE
(Bordetella
pertussis) 		5 / 10 ALA A  19
GLU A 336
ALA A  12
GLY A  13
ALA A 152
 None
None
None
FAD  A 501 (-3.4A)
FAD  A 501 (-4.8A)
 1.13A 5lf3H-6aonA:
undetectable
5lf3I-6aonA:
undetectable		 5lf3H-6aonA:
20.95
5lf3I-6aonA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_V_BO2V303_1
(PROTEASOME SUBUNIT
BETA TYPE-7
PROTEASOME SUBUNIT
BETA TYPE-3)		 6aon DIHYDROLIPOYL
DEHYDROGENASE
(Bordetella
pertussis) 		5 / 10 ALA A  19
GLU A 336
ALA A  12
GLY A  13
ALA A 152
 None
None
None
FAD  A 501 (-3.4A)
FAD  A 501 (-4.8A)
 1.15A 5lf3V-6aonA:
undetectable
5lf3W-6aonA:
undetectable		 5lf3V-6aonA:
20.95
5lf3W-6aonA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_E_PFLE409_1
(PROTON-GATED ION
CHANNEL)		 6aon DIHYDROLIPOYL
DEHYDROGENASE
(Bordetella
pertussis) 		5 / 10 ALA A 444
ALA A 434
ILE A 437
GLU A 433
ILE A 431
 None
 0.93A 5mvmD-6aonA:
undetectable
5mvmE-6aonA:
undetectable		 5mvmD-6aonA:
10.48
5mvmE-6aonA:
10.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OG9_A_TESA504_1
(-)		 6aon DIHYDROLIPOYL
DEHYDROGENASE
(Bordetella
pertussis) 		4 / 8 ILE A  10
VAL A 317
ALA A 293
LEU A 296
 FAD  A 501 (-4.7A)
None
None
None
 0.69A 5og9A-6aonA:
undetectable		 5og9A-6aonA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W4Z_B_RBFB502_1
(RIBOFLAVIN LYASE)		 6aon DIHYDROLIPOYL
DEHYDROGENASE
(Bordetella
pertussis) 		5 / 12 ALA A 396
GLY A 424
GLY A 386
ALA A 467
THR A 472
 None
 0.99A 5w4zB-6aonA:
undetectable		 5w4zB-6aonA:
10.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YSI_A_NCAA1001_0
(UBIQUITINATING/DEUBI
QUITINATING ENZYME
SDEA)		 6aon DIHYDROLIPOYL
DEHYDROGENASE
(Bordetella
pertussis) 		4 / 6 GLY A 206
SER A  64
VAL A 182
TRP A 202
 None
 1.10A 5ysiA-6aonA:
undetectable		 5ysiA-6aonA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6F_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 6aon DIHYDROLIPOYL
DEHYDROGENASE
(Bordetella
pertussis) 		5 / 12 ILE A 241
ALA A 235
PHE A 218
THR A 362
ILE A 366
 None
 1.09A 5z6fA-6aonA:
undetectable		 5z6fA-6aonA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C06_D_FI8D1404_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 6aon DIHYDROLIPOYL
DEHYDROGENASE
(Bordetella
pertussis) 		3 / 3 ARG A 449
LYS A 462
ARG A 397
 None
 1.18A 6c06D-6aonA:
undetectable		 6c06D-6aonA:
undetectable