SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6aoo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CET_A_CLQA1001_0
(PROTEIN (L-LACTATE
DEHYDROGENASE))		 6aoo MALATE DEHYDROGENASE
(Haemophilus
influenzae) 		5 / 9 GLY A   7
ASP A  34
ILE A  35
ALA A  77
ILE A  97
 None
 0.63A 1cetA-6aooA:
32.7		 1cetA-6aooA:
29.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_C_ACTC3004_0
(BETA-CARBONIC
ANHYDRASE)		 6aoo MALATE DEHYDROGENASE
(Haemophilus
influenzae) 		4 / 6 TYR A 252
ASP A 301
VAL A 121
GLY A 176
 None
 1.23A 1ekjC-6aooA:
undetectable
1ekjD-6aooA:
undetectable		 1ekjC-6aooA:
22.61
1ekjD-6aooA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_C_ACTC3007_0
(BETA-CARBONIC
ANHYDRASE)		 6aoo MALATE DEHYDROGENASE
(Haemophilus
influenzae) 		4 / 6 ASP A 301
VAL A 121
GLY A 176
TYR A 252
 None
 1.23A 1ekjC-6aooA:
undetectable
1ekjD-6aooA:
undetectable		 1ekjC-6aooA:
22.61
1ekjD-6aooA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_A_RALA600_1
(ESTROGEN RECEPTOR)		 6aoo MALATE DEHYDROGENASE
(Haemophilus
influenzae) 		5 / 12 THR A 297
ALA A 300
ASP A 301
GLU A 303
LEU A 304
 None
 0.68A 1errA-6aooA:
undetectable		 1errA-6aooA:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_J_TRPJ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 6aoo MALATE DEHYDROGENASE
(Haemophilus
influenzae) 		4 / 8 ALA A 129
GLY A 145
ALA A 128
ILE A 116
 None
 0.66A 1gtnI-6aooA:
undetectable
1gtnJ-6aooA:
undetectable		 1gtnI-6aooA:
14.16
1gtnJ-6aooA:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_O_TRPO81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 6aoo MALATE DEHYDROGENASE
(Haemophilus
influenzae) 		5 / 10 GLY A 115
ALA A 235
THR A 148
HIS A 177
ALA A 232
 None
 1.47A 1gtnO-6aooA:
undetectable
1gtnP-6aooA:
undetectable		 1gtnO-6aooA:
14.16
1gtnP-6aooA:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N49_B_RITB301_1
(PROTEASE)		 6aoo MALATE DEHYDROGENASE
(Haemophilus
influenzae) 		4 / 7 ASP A 150
GLY A 145
ILE A 116
ALA A 235
 None
 0.75A 1n49A-6aooA:
undetectable		 1n49A-6aooA:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S8F_B_BEZB1503_0
(RAS-RELATED PROTEIN
RAB-9A)		 6aoo MALATE DEHYDROGENASE
(Haemophilus
influenzae) 		4 / 6 VAL A 247
THR A 246
GLU A 275
LEU A 269
 None
 1.11A 1s8fB-6aooA:
4.5		 1s8fB-6aooA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z2B_C_VLBC800_2
(TUBULIN ALPHA CHAIN)		 6aoo MALATE DEHYDROGENASE
(Haemophilus
influenzae) 		4 / 5 PRO A 184
VAL A 171
VAL A 158
ILE A 206
 None
 1.10A 1z2bC-6aooA:
5.7		 1z2bC-6aooA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VH3_A_DAHA2_1
(RANASMURFIN)		 6aoo MALATE DEHYDROGENASE
(Haemophilus
influenzae) 		5 / 9 ALA A 223
SER A  76
GLY A  13
SER A 226
ALA A 228
 SO4  A 401 (-3.4A)
None
None
None
None
 0.94A 2vh3A-6aooA:
undetectable		 2vh3A-6aooA:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VH3_B_DAHB2_1
(RANASMURFIN)		 6aoo MALATE DEHYDROGENASE
(Haemophilus
influenzae) 		4 / 8 ALA A 223
SER A  76
GLY A  13
ALA A 228
 SO4  A 401 (-3.4A)
None
None
None
 0.86A 2vh3B-6aooA:
undetectable		 2vh3B-6aooA:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CL9_A_MTXA602_2
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE (DHFR-TS))		 6aoo MALATE DEHYDROGENASE
(Haemophilus
influenzae) 		4 / 4 VAL A 171
ARG A 205
ILE A 199
THR A 169
 None
 1.29A 3cl9A-6aooA:
undetectable		 3cl9A-6aooA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 6aoo MALATE DEHYDROGENASE
(Haemophilus
influenzae) 		5 / 12 ILE A  75
GLY A 145
PHE A 144
LEU A 238
LEU A  16
 None
 1.17A 3em0B-6aooA:
undetectable		 3em0B-6aooA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP3_B_AICB2002_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 6aoo MALATE DEHYDROGENASE
(Haemophilus
influenzae) 		3 / 3 ALA A 232
ARG A 236
LYS A 240
 None
 0.80A 3kp3B-6aooA:
undetectable		 3kp3B-6aooA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_2_BO221405_1
(PROTEASOME COMPONENT
PRE3
PROTEASOME COMPONENT
PUP1)		 6aoo MALATE DEHYDROGENASE
(Haemophilus
influenzae) 		5 / 12 THR A 211
ALA A 209
GLY A 221
ALA A 223
SER A 226
 None
None
None
SO4  A 401 (-3.4A)
None
 1.20A 3mg02-6aooA:
undetectable
3mg0V-6aooA:
undetectable		 3mg02-6aooA:
23.75
3mg0V-6aooA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM2_A_SALA504_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)		 6aoo MALATE DEHYDROGENASE
(Haemophilus
influenzae) 		4 / 8 LEU A 101
ILE A 102
ILE A 116
THR A 124
 None
 0.70A 4em2A-6aooA:
undetectable		 4em2A-6aooA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_A_29SA601_1
(ESTROGEN RECEPTOR)		 6aoo MALATE DEHYDROGENASE
(Haemophilus
influenzae) 		5 / 12 THR A 297
ALA A 300
ASP A 301
GLU A 303
LEU A 304
 None
 0.63A 4xi3A-6aooA:
undetectable		 4xi3A-6aooA:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M54_B_TA1B502_1
(TUBULIN BETA-2B
CHAIN)		 6aoo MALATE DEHYDROGENASE
(Haemophilus
influenzae) 		5 / 12 VAL A  42
ASP A  45
ALA A   8
GLN A 229
LEU A  20
 None
 1.23A 5m54B-6aooA:
2.8		 5m54B-6aooA:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M54_E_TA1E502_1
(TUBULIN BETA-2B
CHAIN)		 6aoo MALATE DEHYDROGENASE
(Haemophilus
influenzae) 		5 / 12 VAL A  42
ASP A  45
ALA A   8
GLN A 229
LEU A  20
 None
 1.22A 5m54E-6aooA:
2.5		 5m54E-6aooA:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUJ_A_Z80A201_1
(BETA-LACTOGLOBULIN)		 6aoo MALATE DEHYDROGENASE
(Haemophilus
influenzae) 		4 / 8 ALA A 106
LEU A 143
ILE A  75
VAL A  98
 None
 0.85A 5nujA-6aooA:
undetectable		 5nujA-6aooA:
13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y80_A_IREA402_0
(CYCLIN-G-ASSOCIATED
KINASE)		 6aoo MALATE DEHYDROGENASE
(Haemophilus
influenzae) 		5 / 11 ALA A  36
VAL A  73
ILE A  75
THR A 118
ILE A 102
 None
 1.10A 5y80A-6aooA:
undetectable		 5y80A-6aooA:
12.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z3J_A_NCAA302_0
(ABRIN A-CHAIN)		 6aoo MALATE DEHYDROGENASE
(Haemophilus
influenzae) 		4 / 6 VAL A 125
TYR A 138
GLU A 254
ARG A 261
 None
 0.90A 5z3jA-6aooA:
undetectable		 5z3jA-6aooA:
23.55