SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6ap1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW5_A_SAMA401_0
(MODIFICATION
METHYLASE RSRI)		 6ap1 VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 4,PROTEIN
HCP1
(Pseudomonas
aeruginosa;
Saccharomyces
cerevisiae) 		5 / 12 PRO A 297
GLY A 336
SER A 337
ALA A 303
ALA A 136
 None
ADP  A 701 (-3.5A)
ADP  A 701 (-3.3A)
None
ADP  A 701 (-4.5A)
 1.09A 1nw5A-6ap1A:
undetectable		 1nw5A-6ap1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_E_FUAE706_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 6ap1 VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 4,PROTEIN
HCP1
(Pseudomonas
aeruginosa;
Saccharomyces
cerevisiae) 		5 / 10 PHE A 195
SER A 121
LEU A 202
VAL A 214
VAL A 197
 None
 1.31A 1q23E-6ap1A:
undetectable		 1q23E-6ap1A:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_I_FUAI707_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 6ap1 VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 4,PROTEIN
HCP1
(Pseudomonas
aeruginosa;
Saccharomyces
cerevisiae) 		5 / 11 PHE A 195
SER A 121
LEU A 202
VAL A 214
VAL A 197
 None
 1.34A 1q23I-6ap1A:
undetectable		 1q23I-6ap1A:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D9L_A_ACTA501_0
(CTD-PEPTIDE
RNA-BINDING PROTEIN
16)		 6ap1 VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 4,PROTEIN
HCP1
(Pseudomonas
aeruginosa;
Saccharomyces
cerevisiae) 		4 / 5 ILE A 296
PRO A 297
TYR A 295
TYR A 172
 None
 1.37A 3d9lA-6ap1A:
undetectable
3d9lY-6ap1A:
undetectable		 3d9lA-6ap1A:
undetectable
3d9lY-6ap1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SNF_A_ACTA110_0
(PROTEIN P-30)		 6ap1 VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 4,PROTEIN
HCP1
(Pseudomonas
aeruginosa;
Saccharomyces
cerevisiae) 		4 / 5 ILE A 354
THR A 389
SER A 387
PHE A 360
 None
 1.21A 3snfA-6ap1A:
undetectable		 3snfA-6ap1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZJQ_A_NCAA300_0
(PROTOGLOBIN)		 6ap1 VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 4,PROTEIN
HCP1
(Pseudomonas
aeruginosa;
Saccharomyces
cerevisiae) 		4 / 7 VAL A 272
PHE A 218
VAL A 214
ILE A 286
 None
 0.99A 3zjqA-6ap1A:
undetectable		 3zjqA-6ap1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KJJ_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 6ap1 VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 4,PROTEIN
HCP1
(Pseudomonas
aeruginosa;
Saccharomyces
cerevisiae) 		5 / 12 ILE A 229
ALA A 122
ALA A 219
LEU A 256
ILE A 231
 None
 1.05A 4kjjA-6ap1A:
undetectable		 4kjjA-6ap1A:
undetectable