SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6ap4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
11GS_A_EAAA211_1
(GLUTATHIONE
S-TRANSFERASE)		 6ap4 DNA POLYMERASE III
SUBUNIT BETA
(Acinetobacter
baumannii) 		4 / 7 VAL A  21
ILE A  29
TYR A 119
GLY A  46
 None
 0.89A 11gsA-6ap4A:
undetectable		 11gsA-6ap4A:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RMT_D_ADND1504_1
(CLASS B ACID
PHOSPHATASE)		 6ap4 DNA POLYMERASE III
SUBUNIT BETA
(Acinetobacter
baumannii) 		4 / 8 PHE A 257
TYR A 158
LEU A 159
ASP A 177
 None
 1.07A 1rmtD-6ap4A:
undetectable		 1rmtD-6ap4A:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GSS_A_EAAA0_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 6ap4 DNA POLYMERASE III
SUBUNIT BETA
(Acinetobacter
baumannii) 		4 / 8 VAL A  21
ILE A  29
TYR A 119
GLY A  46
 None
 0.93A 2gssA-6ap4A:
undetectable		 2gssA-6ap4A:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GSS_B_EAAB0_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 6ap4 DNA POLYMERASE III
SUBUNIT BETA
(Acinetobacter
baumannii) 		4 / 8 VAL A  21
ILE A  29
TYR A 119
GLY A  46
 None
 0.93A 2gssB-6ap4A:
undetectable		 2gssB-6ap4A:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_A_SNLA1001_1
(MINERALOCORTICOID
RECEPTOR)		 6ap4 DNA POLYMERASE III
SUBUNIT BETA
(Acinetobacter
baumannii) 		5 / 12 LEU A 227
ASN A 229
LEU A 221
LEU A  53
THR A 123
 None
 1.40A 2oaxA-6ap4A:
undetectable		 2oaxA-6ap4A:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_A_SNLA1001_1
(MINERALOCORTICOID
RECEPTOR)		 6ap4 DNA POLYMERASE III
SUBUNIT BETA
(Acinetobacter
baumannii) 		5 / 12 LEU A 227
LEU A 221
LEU A 208
LEU A  53
THR A 123
 None
 1.46A 2oaxA-6ap4A:
undetectable		 2oaxA-6ap4A:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEB_A_HSMA145_1
(D7R4 PROTEIN)		 6ap4 DNA POLYMERASE III
SUBUNIT BETA
(Acinetobacter
baumannii) 		4 / 7 ILE A 264
ARG A 261
ASP A 167
GLU A 165
 None
 1.15A 2qebA-6ap4A:
undetectable		 2qebA-6ap4A:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEB_B_HSMB145_1
(D7R4 PROTEIN)		 6ap4 DNA POLYMERASE III
SUBUNIT BETA
(Acinetobacter
baumannii) 		4 / 7 ILE A 264
ARG A 261
ASP A 167
GLU A 165
 None
 1.14A 2qebB-6ap4A:
undetectable		 2qebB-6ap4A:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_B_CHDB6_0
(FERROCHELATASE)		 6ap4 DNA POLYMERASE III
SUBUNIT BETA
(Acinetobacter
baumannii) 		5 / 12 LEU A 299
PHE A 301
LEU A 308
SER A 282
VAL A 352
 None
 1.28A 3aqiB-6ap4A:
undetectable		 3aqiB-6ap4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_B_TOPB200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 6ap4 DNA POLYMERASE III
SUBUNIT BETA
(Acinetobacter
baumannii) 		5 / 12 ALA A 173
LEU A 171
LEU A 139
ILE A 223
LEU A 228
 None
 1.13A 3fl9B-6ap4A:
undetectable		 3fl9B-6ap4A:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N9J_A_EAAA210_1
(GLUTATHIONE
S-TRANSFERASE P)		 6ap4 DNA POLYMERASE III
SUBUNIT BETA
(Acinetobacter
baumannii) 		4 / 8 VAL A  21
ILE A  29
TYR A 119
GLY A  46
 None
 0.95A 3n9jA-6ap4A:
undetectable		 3n9jA-6ap4A:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SU9_A_ACTA426_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 6ap4 DNA POLYMERASE III
SUBUNIT BETA
(Acinetobacter
baumannii) 		3 / 3 GLN A 241
GLU A 240
LYS A 240
 None
 0.77A 3su9A-6ap4A:
undetectable		 3su9A-6ap4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_CHDA1502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 6ap4 DNA POLYMERASE III
SUBUNIT BETA
(Acinetobacter
baumannii) 		5 / 12 LEU A 299
PHE A 301
LEU A 308
SER A 282
VAL A 352
 None
 1.30A 3w1wA-6ap4A:
undetectable		 3w1wA-6ap4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C66_A_H4CA1168_0
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 6ap4 DNA POLYMERASE III
SUBUNIT BETA
(Acinetobacter
baumannii) 		5 / 9 PRO A 368
GLN A 366
VAL A 365
LEU A 347
LEU A 344
 None
 1.41A 4c66A-6ap4A:
undetectable		 4c66A-6ap4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1B_A_ECNA403_1
(FLAVOHEMOGLOBIN)		 6ap4 DNA POLYMERASE III
SUBUNIT BETA
(Acinetobacter
baumannii) 		5 / 12 PHE A 248
GLN A 209
LEU A 211
VAL A  51
LEU A  53
 None
 0.99A 4g1bA-6ap4A:
undetectable		 4g1bA-6ap4A:
10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJQ_A_27RA401_1
(DNA POLYMERASE III
SUBUNIT BETA)		 6ap4 DNA POLYMERASE III
SUBUNIT BETA
(Acinetobacter
baumannii) 		5 / 5 ARG A 156
TYR A 158
THR A 176
PRO A 258
VAL A 263
 None
 0.65A 4mjqA-6ap4A:
43.5		 4mjqA-6ap4A:
11.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJR_A_0LAA404_1
(DNA POLYMERASE III
SUBUNIT BETA)		 6ap4 DNA POLYMERASE III
SUBUNIT BETA
(Acinetobacter
baumannii) 		8 / 9 ARG A 156
TYR A 158
THR A 176
GLY A 178
LEU A 181
PRO A 258
VAL A 263
VAL A 376
 None
 0.55A 4mjrA-6ap4A:
43.4		 4mjrA-6ap4A:
11.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJR_A_0LAA404_1
(DNA POLYMERASE III
SUBUNIT BETA)		 6ap4 DNA POLYMERASE III
SUBUNIT BETA
(Acinetobacter
baumannii) 		8 / 9 ARG A 156
TYR A 158
THR A 176
LEU A 181
PRO A 258
VAL A 263
VAL A 376
MET A 378
 None
 0.91A 4mjrA-6ap4A:
43.4		 4mjrA-6ap4A:
11.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X30_A_T44A401_1
(THYROXINE-BINDING
GLOBULIN)		 6ap4 DNA POLYMERASE III
SUBUNIT BETA
(Acinetobacter
baumannii) 		5 / 9 ALA A 287
LEU A 306
LEU A 283
LEU A 308
ARG A 285
 None
 1.37A 4x30A-6ap4A:
undetectable		 4x30A-6ap4A:
11.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FXT_A_0LAA1376_1
(DNA POLYMERASE III
SUBUNIT BETA)		 6ap4 DNA POLYMERASE III
SUBUNIT BETA
(Acinetobacter
baumannii) 		4 / 7 LEU A 159
THR A 176
PRO A 258
MET A 378
 None
 0.55A 5fxtA-6ap4A:
37.7		 5fxtA-6ap4A:
10.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VW5_A_NCAA403_0
(FERREDOXIN--NADP
REDUCTASE)		 6ap4 DNA POLYMERASE III
SUBUNIT BETA
(Acinetobacter
baumannii) 		4 / 8 THR A 130
GLY A 129
GLY A 224
ALA A 198
 None
 0.67A 5vw5A-6ap4A:
undetectable		 5vw5A-6ap4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AJI_A_AY6A1001_0
(DRUG EXPORTERS OF
THE RND
SUPERFAMILY-LIKE
PROTEIN,ENDOLYSIN)		 6ap4 DNA POLYMERASE III
SUBUNIT BETA
(Acinetobacter
baumannii) 		5 / 12 ILE A  44
ILE A 244
VAL A 246
VAL A  21
ALA A  20
 None
 1.18A 6ajiA-6ap4A:
undetectable		 6ajiA-6ap4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G9B_A_IXXA609_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN
ENVELOPE
GLYCOPROTEIN)		 6ap4 DNA POLYMERASE III
SUBUNIT BETA
(Acinetobacter
baumannii) 		4 / 7 LEU A 208
LEU A 228
LEU A 252
LEU A 171
 None
 0.74A 6g9bA-6ap4A:
undetectable
6g9bB-6ap4A:
undetectable		 6g9bA-6ap4A:
27.17
6g9bB-6ap4A:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 6ap4 DNA POLYMERASE III
SUBUNIT BETA
(Acinetobacter
baumannii) 		4 / 7 ILE A 186
LEU A 142
THR A 220
LEU A 221
 None
 0.88A 6nmfA-6ap4A:
undetectable
6nmfJ-6ap4A:
undetectable		 6nmfA-6ap4A:
undetectable
6nmfJ-6ap4A:
undetectable