SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6ap6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_C_DVAC6_0
(GRAMICIDIN A)
6ap6 PROBABLE
STRIGOLACTONE
ESTERASE DAD2

(Petunia
x
hybrida)
3 / 3 ALA A  99
VAL A  93
TRP A  34
None
0.87A 1av2C-6ap6A:
undetectable
1av2D-6ap6A:
undetectable
1av2C-6ap6A:
undetectable
1av2D-6ap6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_D_GLYD4292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)
6ap6 PROBABLE
STRIGOLACTONE
ESTERASE DAD2

(Petunia
x
hybrida)
4 / 8 PHE A 158
SER A 219
HIS A  95
SER A  96
TLF  A 300 (-4.6A)
TLF  A 300 (-2.7A)
None
TLF  A 300 (-2.6A)
1.33A 1eqbC-6ap6A:
undetectable
1eqbD-6ap6A:
undetectable
1eqbC-6ap6A:
undetectable
1eqbD-6ap6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_A_ACTA1871_0
(FPRA)
6ap6 PROBABLE
STRIGOLACTONE
ESTERASE DAD2

(Petunia
x
hybrida)
4 / 7 PHE A 174
ALA A 162
PHE A 158
SER A 219
None
None
TLF  A 300 (-4.6A)
TLF  A 300 (-2.7A)
1.20A 1lqtA-6ap6A:
undetectable
1lqtA-6ap6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_A_ACTA1428_0
(FPRA)
6ap6 PROBABLE
STRIGOLACTONE
ESTERASE DAD2

(Petunia
x
hybrida)
4 / 7 PHE A 174
ALA A 162
PHE A 158
SER A 219
None
None
TLF  A 300 (-4.6A)
TLF  A 300 (-2.7A)
1.19A 1lquA-6ap6A:
undetectable
1lquA-6ap6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_B_DVAB6_0
(GRAMICIDIN D)
6ap6 PROBABLE
STRIGOLACTONE
ESTERASE DAD2

(Petunia
x
hybrida)
3 / 3 TRP A  34
ALA A  99
VAL A  93
None
0.83A 2izqA-6ap6A:
undetectable
2izqB-6ap6A:
undetectable
2izqA-6ap6A:
undetectable
2izqB-6ap6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2M2P_B_DHIB24_0
(INSULIN B CHAIN)
6ap6 PROBABLE
STRIGOLACTONE
ESTERASE DAD2

(Petunia
x
hybrida)
3 / 3 TYR A  45
GLY A  15
PHE A  41
None
0.65A 2m2pB-6ap6A:
undetectable
2m2pB-6ap6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PRG_B_BRLB2_1
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)
6ap6 PROBABLE
STRIGOLACTONE
ESTERASE DAD2

(Petunia
x
hybrida)
5 / 12 TYR A  92
LEU A 116
VAL A 205
LEU A  52
TYR A  50
None
1.30A 2prgB-6ap6A:
undetectable
2prgB-6ap6A:
10.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_A_DIFA1373_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)
6ap6 PROBABLE
STRIGOLACTONE
ESTERASE DAD2

(Petunia
x
hybrida)
4 / 8 PHE A 158
MET A 147
VAL A 143
PHE A 125
TLF  A 300 (-4.6A)
TLF  A 300 ( 4.1A)
None
TLF  A 300 (-4.7A)
1.22A 2wekA-6ap6A:
3.3
2wekA-6ap6A:
12.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_A_SALA1302_1
(LYSR-TYPE REGULATORY
PROTEIN)
6ap6 PROBABLE
STRIGOLACTONE
ESTERASE DAD2

(Petunia
x
hybrida)
5 / 11 ILE A 119
GLY A  94
GLY A  26
HIS A 249
PRO A 248
None
1.25A 2y7kA-6ap6A:
undetectable
2y7kA-6ap6A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7P_A_SALA1000_1
(LYSR-TYPE REGULATORY
PROTEIN)
6ap6 PROBABLE
STRIGOLACTONE
ESTERASE DAD2

(Petunia
x
hybrida)
5 / 10 ILE A 119
GLY A  94
GLY A  26
HIS A 249
PRO A 248
None
1.27A 2y7pA-6ap6A:
undetectable
2y7pA-6ap6A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYX_A_ROCA201_1
(HIV-1 PROTEASE)
6ap6 PROBABLE
STRIGOLACTONE
ESTERASE DAD2

(Petunia
x
hybrida)
5 / 12 GLY A 120
ALA A 121
ILE A 103
VAL A  93
ILE A 211
None
0.89A 3cyxA-6ap6A:
undetectable
3cyxA-6ap6A:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G9E_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)
6ap6 PROBABLE
STRIGOLACTONE
ESTERASE DAD2

(Petunia
x
hybrida)
5 / 12 SER A  98
LEU A 116
VAL A 205
LEU A  52
TYR A  50
None
1.08A 3g9eA-6ap6A:
undetectable
3g9eA-6ap6A:
10.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GV1_B_BEZB303_0
(DISULFIDE
INTERCHANGE PROTEIN)
6ap6 PROBABLE
STRIGOLACTONE
ESTERASE DAD2

(Petunia
x
hybrida)
4 / 4 LEU A 178
ALA A 162
VAL A 163
PRO A 160
None
1.21A 3gv1B-6ap6A:
1.2
3gv1B-6ap6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UNI_A_SALA1344_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)
6ap6 PROBABLE
STRIGOLACTONE
ESTERASE DAD2

(Petunia
x
hybrida)
4 / 7 GLU A 259
THR A 237
VAL A 238
ALA A 263
None
0.99A 3uniA-6ap6A:
undetectable
3uniA-6ap6A:
4.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_B_ACTB701_0
(RNA (33-MER)
RNA POLYMERASE
3D-POL)
6ap6 PROBABLE
STRIGOLACTONE
ESTERASE DAD2

(Petunia
x
hybrida)
3 / 3 HIS A 249
GLY A 120
ILE A 119
None
0.60A 4k50A-6ap6A:
undetectable
4k50A-6ap6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_J_ACTJ701_0
(RNA (33-MER)
RNA POLYMERASE
3D-POL)
6ap6 PROBABLE
STRIGOLACTONE
ESTERASE DAD2

(Petunia
x
hybrida)
3 / 3 HIS A 249
GLY A 120
ILE A 119
None
0.61A 4k50I-6ap6A:
undetectable
4k50I-6ap6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_C_MXMC606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
6ap6 PROBABLE
STRIGOLACTONE
ESTERASE DAD2

(Petunia
x
hybrida)
5 / 12 MET A 198
VAL A 201
LEU A  79
LEU A 104
LEU A 116
None
1.27A 4m11C-6ap6A:
undetectable
4m11C-6ap6A:
11.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8F_B_BRLB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)
6ap6 PROBABLE
STRIGOLACTONE
ESTERASE DAD2

(Petunia
x
hybrida)
5 / 12 SER A  98
LEU A 116
VAL A 205
LEU A  52
TYR A  50
None
1.12A 4o8fB-6ap6A:
undetectable
4o8fB-6ap6A:
11.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7I_A_STIA1001_2
(MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR)
6ap6 PROBABLE
STRIGOLACTONE
ESTERASE DAD2

(Petunia
x
hybrida)
4 / 5 LEU A 112
VAL A  48
VAL A  93
ARG A  43
None
1.13A 4r7iA-6ap6A:
undetectable
4r7iA-6ap6A:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RUJ_A_VDXA501_1
(VITAMIN D3 RECEPTOR
A)
6ap6 PROBABLE
STRIGOLACTONE
ESTERASE DAD2

(Petunia
x
hybrida)
5 / 12 TYR A  92
VAL A  11
ILE A  81
SER A  98
VAL A  58
None
0.83A 4rujA-6ap6A:
undetectable
4rujA-6ap6A:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UHX_A_LZUA3008_1
(ALDEHYDE OXIDASE)
6ap6 PROBABLE
STRIGOLACTONE
ESTERASE DAD2

(Petunia
x
hybrida)
4 / 8 HIS A 132
SER A 122
ARG A 199
TRP A 240
None
0.93A 4uhxA-6ap6A:
undetectable
4uhxA-6ap6A:
4.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND7_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)
6ap6 PROBABLE
STRIGOLACTONE
ESTERASE DAD2

(Petunia
x
hybrida)
5 / 12 VAL A  75
ASP A  77
LEU A 118
ALA A 105
PHE A 113
None
1.18A 5nd7B-6ap6A:
3.2
5nd7B-6ap6A:
11.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB305_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)
6ap6 PROBABLE
STRIGOLACTONE
ESTERASE DAD2

(Petunia
x
hybrida)
3 / 3 GLU A 129
TYR A 131
ARG A 199
None
0.82A 5uunB-6ap6A:
undetectable
5uunB-6ap6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_A_8LXA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)
6ap6 PROBABLE
STRIGOLACTONE
ESTERASE DAD2

(Petunia
x
hybrida)
5 / 12 GLY A 120
TYR A  92
LEU A 116
ILE A 211
LEU A  52
None
1.22A 5y2tA-6ap6A:
undetectable
5y2tA-6ap6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZHM_B_SAMB301_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)
6ap6 PROBABLE
STRIGOLACTONE
ESTERASE DAD2

(Petunia
x
hybrida)
4 / 4 ARG A 176
SER A  57
ASP A  51
HIS A  25
None
1.37A 5zhmA-6ap6A:
1.4
5zhmA-6ap6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_A_TLFA300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)
6ap6 PROBABLE
STRIGOLACTONE
ESTERASE DAD2

(Petunia
x
hybrida)
12 / 12 PHE A  27
VAL A  97
PHE A 125
PHE A 135
ILE A 140
VAL A 143
TRP A 154
PHE A 158
SER A 190
VAL A 193
PHE A 194
HIS A 246
TLF  A 300 (-3.8A)
TLF  A 300 ( 4.4A)
TLF  A 300 (-4.7A)
TLF  A 300 ( 4.5A)
None
None
None
TLF  A 300 (-4.6A)
TLF  A 300 (-3.4A)
TLF  A 300 (-4.1A)
TLF  A 300 (-4.8A)
TLF  A 300 (-3.9A)
0.00A 6ap6A-6ap6A:
51.5
6ap6A-6ap6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_A_TLFA300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)
6ap6 PROBABLE
STRIGOLACTONE
ESTERASE DAD2

(Petunia
x
hybrida)
5 / 12 PHE A 194
VAL A 143
TRP A 154
PHE A 158
VAL A 189
TLF  A 300 (-4.8A)
None
None
TLF  A 300 (-4.6A)
None
1.11A 6ap6A-6ap6A:
51.5
6ap6A-6ap6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_B_TLFB300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)
6ap6 PROBABLE
STRIGOLACTONE
ESTERASE DAD2

(Petunia
x
hybrida)
12 / 12 PHE A  27
VAL A  97
PHE A 125
PHE A 135
ILE A 140
VAL A 143
TRP A 154
PHE A 158
SER A 190
VAL A 193
PHE A 194
HIS A 246
TLF  A 300 (-3.8A)
TLF  A 300 ( 4.4A)
TLF  A 300 (-4.7A)
TLF  A 300 ( 4.5A)
None
None
None
TLF  A 300 (-4.6A)
TLF  A 300 (-3.4A)
TLF  A 300 (-4.1A)
TLF  A 300 (-4.8A)
TLF  A 300 (-3.9A)
0.06A 6ap6B-6ap6A:
50.0
6ap6B-6ap6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_B_TLFB300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)
6ap6 PROBABLE
STRIGOLACTONE
ESTERASE DAD2

(Petunia
x
hybrida)
5 / 12 PHE A 194
VAL A 143
TRP A 154
PHE A 158
VAL A 189
TLF  A 300 (-4.8A)
None
None
TLF  A 300 (-4.6A)
None
1.11A 6ap6B-6ap6A:
50.0
6ap6B-6ap6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_A_AQ4A602_0
(CYTOCHROME P450 1A1)
6ap6 PROBABLE
STRIGOLACTONE
ESTERASE DAD2

(Petunia
x
hybrida)
5 / 12 SER A  57
ASN A 156
PHE A 174
ASP A  30
GLY A  28
None
1.26A 6dwnA-6ap6A:
undetectable
6dwnA-6ap6A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_A_AQ4A602_0
(CYTOCHROME P450 1A1)
6ap6 PROBABLE
STRIGOLACTONE
ESTERASE DAD2

(Petunia
x
hybrida)
5 / 12 SER A  57
PHE A 174
ASP A  30
GLY A  28
PHE A  27
None
None
None
None
TLF  A 300 (-3.8A)
1.18A 6dwnA-6ap6A:
undetectable
6dwnA-6ap6A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_C_AQ4C602_0
(CYTOCHROME P450 1A1)
6ap6 PROBABLE
STRIGOLACTONE
ESTERASE DAD2

(Petunia
x
hybrida)
5 / 12 SER A  57
PHE A 174
ASP A  30
GLY A  28
PHE A  27
None
None
None
None
TLF  A 300 (-3.8A)
1.15A 6dwnC-6ap6A:
undetectable
6dwnC-6ap6A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_G_TA1G501_1
(TUBULIN BETA CHAIN)
6ap6 PROBABLE
STRIGOLACTONE
ESTERASE DAD2

(Petunia
x
hybrida)
5 / 12 ASP A  77
LEU A 118
ALA A 105
PHE A 113
LEU A 116
None
1.08A 6ew0G-6ap6A:
undetectable
6ew0G-6ap6A:
18.18