SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6ape'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_B_ACTB1873_0
(FPRA)		 6ape BIFUNCTIONAL PROTEIN
FOLD
(Helicobacter
pylori) 		3 / 3 ASP A  92
ASP A  88
LYS A 121
 None
 1.16A 1lqtB-6apeA:
2.6		 1lqtB-6apeA:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OSV_B_CHCB201_1
(BILE ACID RECEPTOR)		 6ape BIFUNCTIONAL PROTEIN
FOLD
(Helicobacter
pylori) 		5 / 12 LEU A 275
MET A  66
ILE A  58
ILE A 271
TYR A  16
 None
 1.45A 1osvB-6apeA:
undetectable		 1osvB-6apeA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7L_C_SAMC685_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 6ape BIFUNCTIONAL PROTEIN
FOLD
(Helicobacter
pylori) 		4 / 8 ALA A 228
ASP A 246
ILE A 219
ILE A 199
 None
GOL  A 303 ( 4.8A)
None
None
 0.89A 1p7lD-6apeA:
undetectable		 1p7lD-6apeA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7L_C_SAMC885_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 6ape BIFUNCTIONAL PROTEIN
FOLD
(Helicobacter
pylori) 		4 / 8 ALA A 228
ASP A 246
ILE A 219
ILE A 199
 None
GOL  A 303 ( 4.8A)
None
None
 0.91A 1p7lC-6apeA:
undetectable		 1p7lC-6apeA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_B_DIFB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 6ape BIFUNCTIONAL PROTEIN
FOLD
(Helicobacter
pylori) 		5 / 9 LEU A 178
VAL A 191
GLY A 169
ALA A 170
SER A 171
 None
 1.30A 1pxxB-6apeA:
undetectable		 1pxxB-6apeA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_A_SAMA385_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 6ape BIFUNCTIONAL PROTEIN
FOLD
(Helicobacter
pylori) 		4 / 8 ALA A 228
ASP A 246
ILE A 219
ILE A 199
 None
GOL  A 303 ( 4.8A)
None
None
 0.87A 1rg9B-6apeA:
undetectable		 1rg9B-6apeA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_B_SAMB485_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 6ape BIFUNCTIONAL PROTEIN
FOLD
(Helicobacter
pylori) 		4 / 8 ALA A 228
ASP A 246
ILE A 219
ILE A 199
 None
GOL  A 303 ( 4.8A)
None
None
 0.88A 1rg9A-6apeA:
undetectable		 1rg9A-6apeA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_C_SAMC585_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 6ape BIFUNCTIONAL PROTEIN
FOLD
(Helicobacter
pylori) 		4 / 8 ALA A 228
ASP A 246
ILE A 219
ILE A 199
 None
GOL  A 303 ( 4.8A)
None
None
 0.88A 1rg9D-6apeA:
undetectable		 1rg9D-6apeA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_C_SAMC685_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 6ape BIFUNCTIONAL PROTEIN
FOLD
(Helicobacter
pylori) 		4 / 8 ALA A 228
ASP A 246
ILE A 219
ILE A 199
 None
GOL  A 303 ( 4.8A)
None
None
 0.89A 1rg9C-6apeA:
undetectable		 1rg9C-6apeA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1O_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 6ape BIFUNCTIONAL PROTEIN
FOLD
(Helicobacter
pylori) 		5 / 9 THR A 196
VAL A 213
GLY A 169
VAL A 209
ILE A 219
 None
 1.33A 2a1oB-6apeA:
undetectable		 2a1oB-6apeA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NPN_A_SAMA4633_0
(PUTATIVE COBALAMIN
SYNTHESIS RELATED
PROTEIN)		 6ape BIFUNCTIONAL PROTEIN
FOLD
(Helicobacter
pylori) 		5 / 9 GLY A 148
THR A 145
ALA A 144
LEU A 134
LEU A 274
 None
None
GOL  A 305 ( 4.5A)
None
GOL  A 305 (-4.3A)
 1.28A 2npnA-6apeA:
2.1		 2npnA-6apeA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTH_A_IMNA301_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 6ape BIFUNCTIONAL PROTEIN
FOLD
(Helicobacter
pylori) 		3 / 3 ASP A  88
TYR A  89
LYS A  71
 None
 1.18A 2othA-6apeA:
undetectable		 2othA-6apeA:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_A_SVRA508_2
(PHOSPHOLIPASE A2)		 6ape BIFUNCTIONAL PROTEIN
FOLD
(Helicobacter
pylori) 		5 / 9 VAL A 262
GLY A 265
PRO A 268
THR A 270
GLY A 148
 None
None
None
GOL  A 305 (-4.7A)
None
 1.40A 3bjwG-6apeA:
undetectable		 3bjwG-6apeA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCR_A_CHDA424_0
(FERROCHELATASE,
MITOCHONDRIAL)		 6ape BIFUNCTIONAL PROTEIN
FOLD
(Helicobacter
pylori) 		4 / 8 LEU A   8
GLY A 267
PRO A 268
MET A 269
 None
 0.99A 3hcrA-6apeA:
3.0		 3hcrA-6apeA:
24.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJX_B_HCZB800_1
(GLUTAMATE RECEPTOR 2)		 6ape BIFUNCTIONAL PROTEIN
FOLD
(Helicobacter
pylori) 		5 / 10 PRO A 143
ILE A 174
PRO A 146
SER A 179
GLY A 175
 None
 1.32A 3ijxB-6apeA:
undetectable
3ijxD-6apeA:
undetectable		 3ijxB-6apeA:
22.96
3ijxD-6apeA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_B_HFZB800_1
(GLUTAMATE RECEPTOR 2)		 6ape BIFUNCTIONAL PROTEIN
FOLD
(Helicobacter
pylori) 		5 / 10 PRO A 143
ILE A 174
PRO A 146
SER A 179
GLY A 175
 None
 1.34A 3iluB-6apeA:
undetectable
3iluE-6apeA:
undetectable		 3iluB-6apeA:
22.96
3iluE-6apeA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_E_PZIE800_0
(GLUTAMATE RECEPTOR 2)		 6ape BIFUNCTIONAL PROTEIN
FOLD
(Helicobacter
pylori) 		5 / 10 PRO A 177
SER A 171
GLY A 175
PRO A 146
ASP A 246
 None
None
None
None
GOL  A 303 ( 4.8A)
 1.31A 3lsfB-6apeA:
undetectable
3lsfE-6apeA:
undetectable		 3lsfB-6apeA:
22.96
3lsfE-6apeA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ONN_A_ACTA270_0
(PROTEIN SSM1)		 6ape BIFUNCTIONAL PROTEIN
FOLD
(Helicobacter
pylori) 		4 / 5 LEU A 134
SER A 140
LEU A 142
PRO A 143
 None
 1.16A 3onnA-6apeA:
undetectable		 3onnA-6apeA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_1
(ADENOSINE KINASE)		 6ape BIFUNCTIONAL PROTEIN
FOLD
(Helicobacter
pylori) 		5 / 12 LEU A 224
GLY A 234
GLY A 245
ASN A 236
VAL A 211
 None
GOL  A 303 (-3.6A)
None
GOL  A 303 ( 4.6A)
None
 0.92A 4dc3B-6apeA:
undetectable		 4dc3B-6apeA:
27.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQ4_A_SALA601_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 6ape BIFUNCTIONAL PROTEIN
FOLD
(Helicobacter
pylori) 		4 / 7 THR A 145
ILE A 233
THR A 260
GLY A 265
 None
 0.92A 4eq4A-6apeA:
undetectable		 4eq4A-6apeA:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQL_B_SALB602_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 6ape BIFUNCTIONAL PROTEIN
FOLD
(Helicobacter
pylori) 		4 / 7 THR A 145
ILE A 233
THR A 260
GLY A 265
 None
 0.96A 4eqlB-6apeA:
undetectable		 4eqlB-6apeA:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L39_B_SALB601_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 6ape BIFUNCTIONAL PROTEIN
FOLD
(Helicobacter
pylori) 		4 / 7 THR A 145
ILE A 233
THR A 260
GLY A 265
 None
 0.92A 4l39B-6apeA:
undetectable		 4l39B-6apeA:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N49_A_SAMA601_1
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 6ape BIFUNCTIONAL PROTEIN
FOLD
(Helicobacter
pylori) 		4 / 4 ASN A 236
GLY A 245
ASP A 198
ASP A 217
 GOL  A 303 ( 4.6A)
None
None
None
 1.26A 4n49A-6apeA:
undetectable		 4n49A-6apeA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_A_SAMA407_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 6ape BIFUNCTIONAL PROTEIN
FOLD
(Helicobacter
pylori) 		4 / 8 ALA A 228
ASP A 246
ILE A 219
ILE A 199
 None
GOL  A 303 ( 4.8A)
None
None
 0.85A 4ndnB-6apeA:
undetectable		 4ndnB-6apeA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_C_SAMC405_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 6ape BIFUNCTIONAL PROTEIN
FOLD
(Helicobacter
pylori) 		4 / 8 ALA A 228
ASP A 246
ILE A 219
ILE A 199
 None
GOL  A 303 ( 4.8A)
None
None
 0.84A 4ndnD-6apeA:
undetectable		 4ndnD-6apeA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QC6_B_KANB201_2
(BIFUNCTIONAL AAC/APH)		 6ape BIFUNCTIONAL PROTEIN
FOLD
(Helicobacter
pylori) 		3 / 3 LEU A  85
ASP A  88
TYR A  89
 None
 0.66A 4qc6B-6apeA:
undetectable		 4qc6B-6apeA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDT_A_ACTA409_0
(FAD:PROTEIN FMN
TRANSFERASE)		 6ape BIFUNCTIONAL PROTEIN
FOLD
(Helicobacter
pylori) 		4 / 5 VAL A 231
ILE A 233
VAL A 149
THR A 145
 None
 0.75A 4xdtA-6apeA:
undetectable		 4xdtA-6apeA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YVP_B_GBMB402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C1)		 6ape BIFUNCTIONAL PROTEIN
FOLD
(Helicobacter
pylori) 		5 / 12 VAL A 191
ILE A 167
ASN A 184
LEU A 134
LEU A 181
 None
 1.34A 4yvpB-6apeA:
undetectable		 4yvpB-6apeA:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T8S_B_SAMB402_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 6ape BIFUNCTIONAL PROTEIN
FOLD
(Helicobacter
pylori) 		4 / 8 ALA A 228
ASP A 246
ILE A 219
ILE A 199
 None
GOL  A 303 ( 4.8A)
None
None
 0.92A 5t8sA-6apeA:
undetectable		 5t8sA-6apeA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DEB_B_MTXB302_1
(BIFUNCTIONAL PROTEIN
FOLD)		 6ape BIFUNCTIONAL PROTEIN
FOLD
(Helicobacter
pylori) 		10 / 12 LEU A  99
GLN A 101
LEU A 102
PRO A 103
ASP A 124
PHE A 126
THR A 145
SER A 171
ILE A 173
THR A 270
 None
None
None
None
GOL  A 305 (-2.9A)
None
None
None
None
GOL  A 305 (-4.7A)
 0.51A 6debB-6apeA:
44.0		 6debB-6apeA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DEB_B_MTXB302_1
(BIFUNCTIONAL PROTEIN
FOLD)		 6ape BIFUNCTIONAL PROTEIN
FOLD
(Helicobacter
pylori) 		6 / 12 LEU A  99
GLN A 101
LEU A 102
PRO A 103
ASP A 124
THR A 270
 None
None
None
None
GOL  A 305 (-2.9A)
GOL  A 305 (-4.7A)
 0.91A 6debB-6apeA:
44.0		 6debB-6apeA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DEB_B_MTXB303_1
(BIFUNCTIONAL PROTEIN
FOLD)		 6ape BIFUNCTIONAL PROTEIN
FOLD
(Helicobacter
pylori) 		5 / 5 TYR A  53
LYS A  57
GLN A 101
GLY A 212
ILE A 235
 None
GOL  A 305 (-2.7A)
None
GOL  A 303 (-3.6A)
GOL  A 303 (-4.7A)
 1.22A 6debB-6apeA:
44.0		 6debB-6apeA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DEB_B_MTXB303_1
(BIFUNCTIONAL PROTEIN
FOLD)		 6ape BIFUNCTIONAL PROTEIN
FOLD
(Helicobacter
pylori) 		5 / 5 TYR A  53
LYS A  57
GLN A 101
GLY A 214
ILE A 235
 None
GOL  A 305 (-2.7A)
None
GOL  A 303 (-3.5A)
GOL  A 303 (-4.7A)
 0.77A 6debB-6apeA:
44.0		 6debB-6apeA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBN_B_SAMB401_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 6ape BIFUNCTIONAL PROTEIN
FOLD
(Helicobacter
pylori) 		4 / 7 ALA A 228
ASP A 246
ILE A 219
ILE A 199
 None
GOL  A 303 ( 4.8A)
None
None
 0.78A 6fbnA-6apeA:
undetectable		 6fbnA-6apeA:
21.97