SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6apj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JZS_A_MRCA1301_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 6apj ALPHA-N-ACETYLGALACT
OSAMINIDE
ALPHA-2,6-SIALYLTRAN
SFERASE 2
(Homo
sapiens) 		5 / 11 GLY A 166
PRO A 167
HIS A 172
GLN A 165
LEU A 371
 None
 1.14A 1jzsA-6apjA:
undetectable		 1jzsA-6apjA:
8.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TV8_B_SAMB2501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)		 6apj ALPHA-N-ACETYLGALACT
OSAMINIDE
ALPHA-2,6-SIALYLTRAN
SFERASE 2
(Homo
sapiens) 		4 / 7 TYR A 301
THR A 203
THR A 200
SER A 232
 None
 1.05A 1tv8B-6apjA:
undetectable		 1tv8B-6apjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA4_A_ACHA546_0
(ACETYLCHOLINESTERASE)		 6apj ALPHA-N-ACETYLGALACT
OSAMINIDE
ALPHA-2,6-SIALYLTRAN
SFERASE 2
(Homo
sapiens) 		4 / 8 TYR A 337
PHE A 338
HIS A 336
GLY A 157
 None
 1.11A 2ha4A-6apjA:
undetectable		 2ha4A-6apjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OGY_A_C2FA3000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 6apj ALPHA-N-ACETYLGALACT
OSAMINIDE
ALPHA-2,6-SIALYLTRAN
SFERASE 2
(Homo
sapiens) 		5 / 12 ASP A 278
ILE A 280
GLY A 113
SER A 106
GLN A 107
 None
 1.27A 2ogyA-6apjA:
undetectable		 2ogyA-6apjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCR_B_CHDB924_0
(FERROCHELATASE,
MITOCHONDRIAL)		 6apj ALPHA-N-ACETYLGALACT
OSAMINIDE
ALPHA-2,6-SIALYLTRAN
SFERASE 2
(Homo
sapiens) 		4 / 7 LEU A 371
ARG A 374
SER A 304
GLY A 157
 None
 1.07A 3hcrB-6apjA:
undetectable		 3hcrB-6apjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_A_RTZA1_1
(CYTOCHROME P450 2D6)		 6apj ALPHA-N-ACETYLGALACT
OSAMINIDE
ALPHA-2,6-SIALYLTRAN
SFERASE 2
(Homo
sapiens) 		5 / 12 LEU A 137
PHE A 138
GLY A 198
LEU A 178
PHE A 325
 None
 1.19A 3tbgA-6apjA:
undetectable		 3tbgA-6apjA:
11.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K7A_A_MXDA1002_1
(ANDROGEN RECEPTOR)		 6apj ALPHA-N-ACETYLGALACT
OSAMINIDE
ALPHA-2,6-SIALYLTRAN
SFERASE 2
(Homo
sapiens) 		3 / 3 GLU A 356
TRP A 360
LYS A 349
 None
 0.74A 4k7aA-6apjA:
undetectable		 4k7aA-6apjA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_D_PAUD601_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 6apj ALPHA-N-ACETYLGALACT
OSAMINIDE
ALPHA-2,6-SIALYLTRAN
SFERASE 2
(Homo
sapiens) 		4 / 8 VAL A 182
TYR A 211
GLY A 155
GLY A 158
 None
 0.88A 5e26C-6apjA:
undetectable
5e26D-6apjA:
undetectable		 5e26C-6apjA:
undetectable
5e26D-6apjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GTR_A_ESTA601_2
(ESTROGEN RECEPTOR)		 6apj ALPHA-N-ACETYLGALACT
OSAMINIDE
ALPHA-2,6-SIALYLTRAN
SFERASE 2
(Homo
sapiens) 		4 / 5 LEU A 275
PHE A 176
LEU A 137
HIS A 315
 None
 0.97A 5gtrA-6apjA:
undetectable		 5gtrA-6apjA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JMN_B_FUAB1101_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 6apj ALPHA-N-ACETYLGALACT
OSAMINIDE
ALPHA-2,6-SIALYLTRAN
SFERASE 2
(Homo
sapiens) 		4 / 5 ILE A 183
LEU A 160
HIS A 172
VAL A 175
 None
 1.22A 5jmnB-6apjA:
undetectable		 5jmnB-6apjA:
6.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKL_B_SAMB8009_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN,HISTONE H3.1
PEPTIDE,ZINC FINGER
DOMAIN-CONTAINING
PROTEIN)		 6apj ALPHA-N-ACETYLGALACT
OSAMINIDE
ALPHA-2,6-SIALYLTRAN
SFERASE 2
(Homo
sapiens) 		5 / 12 LEU A 275
GLY A 198
TYR A 197
TYR A 227
PHE A 138
 None
 1.47A 5kklB-6apjA:
undetectable		 5kklB-6apjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_A_ECLA1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 6apj ALPHA-N-ACETYLGALACT
OSAMINIDE
ALPHA-2,6-SIALYLTRAN
SFERASE 2
(Homo
sapiens) 		4 / 7 PHE A 325
ILE A 326
LEU A 353
ALA A 349
 None
 0.76A 6b5vA-6apjA:
undetectable
6b5vC-6apjA:
undetectable		 6b5vA-6apjA:
22.83
6b5vC-6apjA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_C_ECLC1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 6apj ALPHA-N-ACETYLGALACT
OSAMINIDE
ALPHA-2,6-SIALYLTRAN
SFERASE 2
(Homo
sapiens) 		4 / 7 PHE A 325
ILE A 326
LEU A 353
ALA A 349
 None
 0.76A 6b5vC-6apjA:
undetectable
6b5vD-6apjA:
undetectable		 6b5vC-6apjA:
22.83
6b5vD-6apjA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_D_ECLD1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 6apj ALPHA-N-ACETYLGALACT
OSAMINIDE
ALPHA-2,6-SIALYLTRAN
SFERASE 2
(Homo
sapiens) 		4 / 7 ALA A 349
PHE A 325
ILE A 326
LEU A 353
 None
 0.76A 6b5vB-6apjA:
undetectable
6b5vD-6apjA:
undetectable		 6b5vB-6apjA:
22.83
6b5vD-6apjA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSI_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 6apj ALPHA-N-ACETYLGALACT
OSAMINIDE
ALPHA-2,6-SIALYLTRAN
SFERASE 2
(Homo
sapiens) 		5 / 10 LEU A 371
VAL A 153
TYR A 372
TYR A 323
GLY A 155
 None
 1.46A 6bsiA-6apjA:
undetectable		 6bsiA-6apjA:
16.28