SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6apx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4007_1
(SERUM ALBUMIN)		 6apx MALTOSE-BINDING
PERIPLASMIC
PROTEIN,DUAL
SPECIFICITY PROTEIN
PHOSPHATASE 1
(Escherichia
coli;
Homo
sapiens) 		4 / 8 HIS A1217
PHE A1214
ASP A1196
LEU A1195
 None
 0.65A 1e7cA-6apxA:
2.6		 1e7cA-6apxA:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R5L_A_VIVA301_0
(PROTEIN
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN))		 6apx MONOBODY YSX1
(synthetic
construct) 		5 / 12 VAL B  45
ILE B  59
ILE B  70
ILE B  86
ILE B  18
 None
 1.33A 1r5lA-6apxB:
undetectable		 1r5lA-6apxB:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RMT_C_ADNC1503_1
(CLASS B ACID
PHOSPHATASE)		 6apx MALTOSE-BINDING
PERIPLASMIC
PROTEIN,DUAL
SPECIFICITY PROTEIN
PHOSPHATASE 1
(Escherichia
coli;
Homo
sapiens) 		4 / 8 ASP A1196
TYR A1220
LEU A1203
GLY A1199
 None
 0.94A 1rmtC-6apxA:
undetectable		 1rmtC-6apxA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2M2P_B_DHIB24_0
(INSULIN B CHAIN)		 6apx MALTOSE-BINDING
PERIPLASMIC
PROTEIN,DUAL
SPECIFICITY PROTEIN
PHOSPHATASE 1
(Escherichia
coli;
Homo
sapiens) 		3 / 3 TYR A1218
GLY A1216
PHE A1214
 None
 0.65A 2m2pB-6apxA:
undetectable		 2m2pB-6apxA:
4.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7B_A_BEZA1529_0
(BENZOATE-COENZYME A
LIGASE)		 6apx MALTOSE-BINDING
PERIPLASMIC
PROTEIN,DUAL
SPECIFICITY PROTEIN
PHOSPHATASE 1
(Escherichia
coli;
Homo
sapiens) 		5 / 9 ALA A1186
TYR A1187
ALA A 370
GLY A1172
ILE A 178
 None
None
SO4  A1401 ( 3.9A)
SO4  A1401 (-3.3A)
None
 1.21A 2v7bA-6apxA:
2.5		 2v7bA-6apxA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7B_B_BEZB1529_0
(BENZOATE-COENZYME A
LIGASE)		 6apx MALTOSE-BINDING
PERIPLASMIC
PROTEIN,DUAL
SPECIFICITY PROTEIN
PHOSPHATASE 1
(Escherichia
coli;
Homo
sapiens) 		5 / 9 ALA A1186
TYR A1187
ALA A 370
GLY A1172
ILE A 178
 None
None
SO4  A1401 ( 3.9A)
SO4  A1401 (-3.3A)
None
 1.22A 2v7bB-6apxA:
undetectable		 2v7bB-6apxA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VE3_A_REAA1445_1
(PUTATIVE CYTOCHROME
P450 120)		 6apx MALTOSE-BINDING
PERIPLASMIC
PROTEIN,DUAL
SPECIFICITY PROTEIN
PHOSPHATASE 1
(Escherichia
coli;
Homo
sapiens) 		5 / 12 ALA A 264
LEU A 280
PHE A 279
VAL A 293
GLY A  16
 None
 1.08A 2ve3A-6apxA:
undetectable		 2ve3A-6apxA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_C_VDYC6178_1
(VITAMIN D
HYDROXYLASE)		 6apx MALTOSE-BINDING
PERIPLASMIC
PROTEIN,DUAL
SPECIFICITY PROTEIN
PHOSPHATASE 1
(Escherichia
coli;
Homo
sapiens) 		5 / 12 ILE A 108
LEU A 262
ILE A  59
VAL A  23
LEU A  20
 None
 1.08A 3a51C-6apxA:
undetectable		 3a51C-6apxA:
24.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_A_SAMA238_1
(N,N-DIMETHYLTRANSFER
ASE)		 6apx MALTOSE-BINDING
PERIPLASMIC
PROTEIN,DUAL
SPECIFICITY PROTEIN
PHOSPHATASE 1
MONOBODY YSX1
(Escherichia
coli;
Homo
sapiens;
synthetic
construct) 		3 / 3 TYR B  77
GLU A  44
ASP A  41
 None
 0.86A 3bxoA-6apxB:
undetectable		 3bxoA-6apxB:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DFR_A_MTXA164_1
(DIHYDROFOLATE
REDUCTASE)		 6apx MALTOSE-BINDING
PERIPLASMIC
PROTEIN,DUAL
SPECIFICITY PROTEIN
PHOSPHATASE 1
(Escherichia
coli;
Homo
sapiens) 		5 / 12 LEU A 262
ALA A 264
LEU A 284
LEU A  20
ALA A 109
 None
 1.12A 3dfrA-6apxA:
undetectable		 3dfrA-6apxA:
14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GAN_A_SVRA158_1
(UNCHARACTERIZED
PROTEIN AT3G22680)		 6apx MONOBODY YSX1
(synthetic
construct) 		5 / 11 GLN B  46
VAL B  45
PRO B  44
ILE B  88
PRO B  85
 None
 1.12A 3ganA-6apxB:
undetectable		 3ganA-6apxB:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GV1_A_BEZA302_0
(DISULFIDE
INTERCHANGE PROTEIN)		 6apx MALTOSE-BINDING
PERIPLASMIC
PROTEIN,DUAL
SPECIFICITY PROTEIN
PHOSPHATASE 1
(Escherichia
coli;
Homo
sapiens) 		4 / 6 PRO A 126
LEU A 147
ALA A 223
PRO A 125
 None
 1.30A 3gv1A-6apxA:
undetectable
3gv1C-6apxA:
undetectable		 3gv1A-6apxA:
16.35
3gv1C-6apxA:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GV1_B_BEZB301_0
(DISULFIDE
INTERCHANGE PROTEIN)		 6apx MALTOSE-BINDING
PERIPLASMIC
PROTEIN,DUAL
SPECIFICITY PROTEIN
PHOSPHATASE 1
(Escherichia
coli;
Homo
sapiens) 		4 / 6 LEU A 147
ALA A 223
PRO A 125
PRO A 126
 None
 1.29A 3gv1A-6apxA:
undetectable
3gv1B-6apxA:
undetectable		 3gv1A-6apxA:
16.35
3gv1B-6apxA:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS6_A_EPAA1_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 6apx MALTOSE-BINDING
PERIPLASMIC
PROTEIN,DUAL
SPECIFICITY PROTEIN
PHOSPHATASE 1
(Escherichia
coli;
Homo
sapiens) 		5 / 12 VAL A 343
GLY A 187
ALA A 188
LEU A 192
LEU A 160
 None
 1.03A 3hs6A-6apxA:
undetectable		 3hs6A-6apxA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JAY_A_SAMA1102_0
(STRUCTURAL PROTEIN
VP3)		 6apx MALTOSE-BINDING
PERIPLASMIC
PROTEIN,DUAL
SPECIFICITY PROTEIN
PHOSPHATASE 1
MONOBODY YSX1
(Escherichia
coli;
Homo
sapiens;
synthetic
construct) 		5 / 12 TYR B  77
ILE A 329
GLY A 260
ALA A 109
PRO A 107
 None
 0.88A 3jayA-6apxB:
undetectable		 3jayA-6apxB:
7.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1102_0
(STRUCTURAL PROTEIN
VP3)		 6apx MALTOSE-BINDING
PERIPLASMIC
PROTEIN,DUAL
SPECIFICITY PROTEIN
PHOSPHATASE 1
MONOBODY YSX1
(Escherichia
coli;
Homo
sapiens;
synthetic
construct) 		5 / 12 TYR B  77
ILE A 329
GLY A 260
ALA A 109
PRO A 107
 None
 0.96A 3jb2A-6apxB:
undetectable		 3jb2A-6apxB:
7.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_B_ROCB201_4
(HIV-1 PROTEASE)		 6apx MALTOSE-BINDING
PERIPLASMIC
PROTEIN,DUAL
SPECIFICITY PROTEIN
PHOSPHATASE 1
(Escherichia
coli;
Homo
sapiens) 		4 / 4 ARG A 344
ASP A 197
GLY A 191
THR A 157
 None
 1.44A 3k4vB-6apxA:
undetectable		 3k4vB-6apxA:
11.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Y_B_DIFB585_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 6apx MALTOSE-BINDING
PERIPLASMIC
PROTEIN,DUAL
SPECIFICITY PROTEIN
PHOSPHATASE 1
(Escherichia
coli;
Homo
sapiens) 		5 / 12 VAL A 196
LEU A 160
GLY A 187
ALA A 188
LEU A 361
 None
 0.97A 3n8yB-6apxA:
undetectable		 3n8yB-6apxA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PMZ_E_TUBE220_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 6apx MALTOSE-BINDING
PERIPLASMIC
PROTEIN,DUAL
SPECIFICITY PROTEIN
PHOSPHATASE 1
(Escherichia
coli;
Homo
sapiens) 		4 / 6 TYR A1187
GLN A 335
ILE A 178
SER A1190
 None
 1.19A 3pmzD-6apxA:
undetectable		 3pmzD-6apxA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFN_A_ROCA401_1
(HIV-1 PROTEASE)		 6apx MALTOSE-BINDING
PERIPLASMIC
PROTEIN,DUAL
SPECIFICITY PROTEIN
PHOSPHATASE 1
(Escherichia
coli;
Homo
sapiens) 		6 / 11 GLY A 300
ALA A 301
VAL A 259
GLY A 260
THR A  93
PRO A 107
 None
 1.28A 3ufnA-6apxA:
undetectable		 3ufnA-6apxA:
12.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UT5_B_LOCB502_1
(TUBULIN BETA CHAIN)		 6apx MALTOSE-BINDING
PERIPLASMIC
PROTEIN,DUAL
SPECIFICITY PROTEIN
PHOSPHATASE 1
(Escherichia
coli;
Homo
sapiens) 		5 / 12 LEU A 139
LEU A 122
ASN A 124
ILE A 132
LYS A 127
 None
 1.12A 3ut5B-6apxA:
undetectable		 3ut5B-6apxA:
21.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3VFJ_A_ACTA410_0
(MALTOSE-BINDING
PERIPLASMIC PROTEIN,
C-TERMINAL FUSED BY
CYS-LYS-D-ALA-D-ALA)		 6apx MALTOSE-BINDING
PERIPLASMIC
PROTEIN,DUAL
SPECIFICITY PROTEIN
PHOSPHATASE 1
(Escherichia
coli;
Homo
sapiens) 		4 / 4 LYS A  15
ALA A  63
GLU A 111
LEU A 262
 None
 0.72A 3vfjA-6apxA:
57.5		 3vfjA-6apxA:
83.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VRJ_A_1KXA301_1
(HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-57 ALPHA
CHAIN
10-MER PEPTIDE)		 6apx MONOBODY YSX1
(synthetic
construct) 		5 / 12 ILE B  70
VAL B  72
TYR B  32
TYR B  36
ILE B  59
 None
 1.15A 3vrjA-6apxB:
5.0
3vrjC-6apxB:
undetectable		 3vrjA-6apxB:
14.49
3vrjC-6apxB:
8.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_D_SAMD401_1
(MNMC2)		 6apx MALTOSE-BINDING
PERIPLASMIC
PROTEIN,DUAL
SPECIFICITY PROTEIN
PHOSPHATASE 1
(Escherichia
coli;
Homo
sapiens) 		4 / 5 GLU A 308
ASP A 314
ASP A 287
ASN A 294
 None
 1.39A 3vywD-6apxA:
undetectable		 3vywD-6apxA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F84_A_SAMA501_0
(GERANYL DIPHOSPHATE
2-C-METHYLTRANSFERAS
E)		 6apx MONOBODY YSX1
(synthetic
construct) 		5 / 12 GLY B  75
GLY B  80
VAL B  29
TYR B  73
VAL B  72
 None
 1.23A 4f84A-6apxB:
undetectable		 4f84A-6apxB:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GBO_B_CUB301_0
(E7)		 6apx MALTOSE-BINDING
PERIPLASMIC
PROTEIN,DUAL
SPECIFICITY PROTEIN
PHOSPHATASE 1
(Escherichia
coli;
Homo
sapiens) 		4 / 5 HIS A1213
ALA A1189
HIS A1257
TYR A1220
 None
 1.37A 4gboB-6apxA:
undetectable		 4gboB-6apxA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_G_TMQG202_1
(DIHYDROFOLATE
REDUCTASE)		 6apx MALTOSE-BINDING
PERIPLASMIC
PROTEIN,DUAL
SPECIFICITY PROTEIN
PHOSPHATASE 1
(Escherichia
coli;
Homo
sapiens) 		5 / 12 ILE A 266
ILE A 108
LEU A  20
VAL A  23
ILE A  59
 None
 0.91A 4m2xG-6apxA:
undetectable		 4m2xG-6apxA:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_A_DGXA1107_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 6apx MALTOSE-BINDING
PERIPLASMIC
PROTEIN,DUAL
SPECIFICITY PROTEIN
PHOSPHATASE 1
(Escherichia
coli;
Homo
sapiens) 		4 / 4 ASN A1298
VAL A1225
THR A1267
ILE A1268
 None
 1.23A 4retA-6apxA:
4.5		 4retA-6apxA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_C_DGXC2005_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 6apx MALTOSE-BINDING
PERIPLASMIC
PROTEIN,DUAL
SPECIFICITY PROTEIN
PHOSPHATASE 1
(Escherichia
coli;
Homo
sapiens) 		4 / 4 ASN A1298
VAL A1225
THR A1267
ILE A1268
 None
 1.23A 4retC-6apxA:
4.5		 4retC-6apxA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EYP_B_LOCB502_2
(TUBULIN BETA CHAIN)		 6apx MALTOSE-BINDING
PERIPLASMIC
PROTEIN,DUAL
SPECIFICITY PROTEIN
PHOSPHATASE 1
(Escherichia
coli;
Homo
sapiens) 		5 / 12 LEU A 139
LEU A 122
ASN A 124
ILE A 132
LYS A 127
 None
 1.12A 5eypB-6apxA:
undetectable		 5eypB-6apxA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EYP_B_LOCB502_2
(TUBULIN BETA CHAIN)		 6apx MALTOSE-BINDING
PERIPLASMIC
PROTEIN,DUAL
SPECIFICITY PROTEIN
PHOSPHATASE 1
(Escherichia
coli;
Homo
sapiens) 		5 / 12 LEU A 139
LEU A 122
THR A 245
ILE A 132
LYS A 127
 None
 1.12A 5eypB-6apxA:
undetectable		 5eypB-6apxA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F1A_B_SALB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 6apx MALTOSE-BINDING
PERIPLASMIC
PROTEIN,DUAL
SPECIFICITY PROTEIN
PHOSPHATASE 1
(Escherichia
coli;
Homo
sapiens) 		4 / 7 LEU A  76
GLY A 265
ALA A 264
SER A 263
 None
 0.89A 5f1aB-6apxA:
undetectable		 5f1aB-6apxA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODC_A_ACTA703_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 6apx MALTOSE-BINDING
PERIPLASMIC
PROTEIN,DUAL
SPECIFICITY PROTEIN
PHOSPHATASE 1
(Escherichia
coli;
Homo
sapiens) 		4 / 4 GLN A  72
GLN A1259
PRO A1211
ALA A1186
 SO4  A1403 (-3.1A)
None
None
None
 1.49A 5odcA-6apxA:
undetectable
5odcG-6apxA:
2.1		 5odcA-6apxA:
22.79
5odcG-6apxA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODC_G_ACTG704_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 6apx MALTOSE-BINDING
PERIPLASMIC
PROTEIN,DUAL
SPECIFICITY PROTEIN
PHOSPHATASE 1
(Escherichia
coli;
Homo
sapiens) 		4 / 5 PRO A1211
ALA A1186
GLN A  72
GLN A1259
 None
None
SO4  A1403 (-3.1A)
None
 1.49A 5odcA-6apxA:
undetectable
5odcG-6apxA:
2.2		 5odcA-6apxA:
22.79
5odcG-6apxA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_D_ERMD1201_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 6apx MALTOSE-BINDING
PERIPLASMIC
PROTEIN,DUAL
SPECIFICITY PROTEIN
PHOSPHATASE 1
MONOBODY YSX1
(Escherichia
coli;
Homo
sapiens;
synthetic
construct) 		5 / 12 MET A1274
VAL A1312
GLN A1307
LEU A1306
VAL B   9
 None
 1.30A 5tudD-6apxA:
undetectable		 5tudD-6apxA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W4Z_A_RBFA502_1
(RIBOFLAVIN LYASE)		 6apx MALTOSE-BINDING
PERIPLASMIC
PROTEIN,DUAL
SPECIFICITY PROTEIN
PHOSPHATASE 1
(Escherichia
coli;
Homo
sapiens) 		6 / 12 ALA A 342
ALA A 338
GLY A 166
ALA A 188
PHE A 169
VAL A 181
 None
 1.39A 5w4zA-6apxA:
undetectable		 5w4zA-6apxA:
9.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W4Z_B_RBFB502_1
(RIBOFLAVIN LYASE)		 6apx MALTOSE-BINDING
PERIPLASMIC
PROTEIN,DUAL
SPECIFICITY PROTEIN
PHOSPHATASE 1
(Escherichia
coli;
Homo
sapiens) 		6 / 12 ALA A 342
ALA A 338
GLY A 166
ALA A 188
PHE A 169
VAL A 181
 None
 1.41A 5w4zB-6apxA:
undetectable		 5w4zB-6apxA:
9.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIW_D_LOCD503_2
(TUBULIN BETA CHAIN)		 6apx MALTOSE-BINDING
PERIPLASMIC
PROTEIN,DUAL
SPECIFICITY PROTEIN
PHOSPHATASE 1
(Escherichia
coli;
Homo
sapiens) 		5 / 12 LEU A 139
LEU A 122
ASN A 124
ILE A 132
LYS A 127
 None
 1.06A 5xiwD-6apxA:
undetectable		 5xiwD-6apxA:
9.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA603_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 6apx MALTOSE-BINDING
PERIPLASMIC
PROTEIN,DUAL
SPECIFICITY PROTEIN
PHOSPHATASE 1
(Escherichia
coli;
Homo
sapiens) 		3 / 3 TYR A 155
ASN A 227
LEU A 113
 None
 0.83A 6b58A-6apxA:
2.3		 6b58A-6apxA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BM5_A_SAMA1301_0
(METHIONINE SYNTHASE)		 6apx MALTOSE-BINDING
PERIPLASMIC
PROTEIN,DUAL
SPECIFICITY PROTEIN
PHOSPHATASE 1
(Escherichia
coli;
Homo
sapiens) 		5 / 11 PRO A 133
GLU A 130
PRO A 254
ALA A 163
PRO A 159
 None
 1.40A 6bm5A-6apxA:
undetectable		 6bm5A-6apxA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_D_EY4D500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 6apx MONOBODY YSX1
(synthetic
construct) 		4 / 7 ILE B  70
VAL B   8
ALA B  11
THR B  12
 None
 0.92A 6cduC-6apxB:
undetectable
6cduD-6apxB:
undetectable		 6cduC-6apxB:
16.92
6cduD-6apxB:
16.92