SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6aq7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H8S_A_AICA1000_1
(MUTANT AL2 6E7P9G)		 6aq7 POM6 FAB HEAVY CHAIN
POM6 FAB LIGHT CHAIN
(Mus
musculus) 		7 / 12 TYR L  40
GLN L  93
LEU L 100
PHE L 102
VAL H  36
ALA H  96
TRP H 105
 None
 0.99A 1h8sA-6aq7L:
21.6		 1h8sA-6aq7L:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LBC_A_CYZA330_1
(GLUTAMINE RECEPTOR 2)		 6aq7 POM6 FAB HEAVY CHAIN
POM6 FAB LIGHT CHAIN
(Mus
musculus) 		5 / 12 MET L 179
SER L 178
LEU H 178
SER H 179
SER H 181
 None
 1.43A 1lbcA-6aq7L:
undetectable
1lbcC-6aq7L:
undetectable		 1lbcA-6aq7L:
15.59
1lbcC-6aq7L:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP2_A_PNNA5001_0
(TRANSCRIPTIONAL
REGULATOR TCAR)		 6aq7 POM6 FAB HEAVY CHAIN
POM6 FAB LIGHT CHAIN
(Mus
musculus;
Mus
musculus) 		4 / 8 ASN H  58
THR L  98
LEU L 100
SER H  98
 None
 0.70A 3kp2A-6aq7H:
undetectable
3kp2B-6aq7H:
undetectable		 3kp2A-6aq7H:
undetectable
3kp2B-6aq7H:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP2_A_PNNA5001_0
(TRANSCRIPTIONAL
REGULATOR TCAR)		 6aq7 POM6 FAB HEAVY CHAIN
POM6 FAB LIGHT CHAIN
(Mus
musculus;
Mus
musculus) 		4 / 8 THR L  98
LEU L 100
SER H  98
ASN H  56
 None
 1.14A 3kp2A-6aq7L:
undetectable
3kp2B-6aq7L:
undetectable		 3kp2A-6aq7L:
undetectable
3kp2B-6aq7L:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_A_SALA3005_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 6aq7 POM6 FAB HEAVY CHAIN
POM6 FAB LIGHT CHAIN
(Mus
musculus) 		4 / 8 ASN H  58
THR L  98
LEU L 100
SER H  98
 None
 0.71A 3kp6A-6aq7H:
undetectable		 3kp6A-6aq7H:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LS4_H_TCIH220_2
(HEAVY CHAIN OF
ANTIBODY FAB
FRAGMENT
LIGHT CHAIN OF
ANTIBODY FAB
FRAGMENT)		 6aq7 POM6 FAB LIGHT CHAIN
(Mus
musculus) 		4 / 5 TYR L  40
GLN L  93
LEU L 100
PHE L 102
 None
 1.03A 3ls4L-6aq7L:
26.6		 3ls4L-6aq7L:
25.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PMZ_E_TUBE220_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 6aq7 POM6 FAB LIGHT CHAIN
(Mus
musculus) 		4 / 6 TYR L  90
GLN L   6
ILE L  21
SER L  88
 None
 1.30A 3pmzD-6aq7L:
undetectable		 3pmzD-6aq7L:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M7K_H_ACTH302_0
(10H10 HEAVY CHAIN)		 6aq7 POM6 FAB HEAVY CHAIN
(Mus
musculus) 		4 / 5 VAL H   1
TYR H  26
ARG H  97
TYR H 104
 None
 0.21A 4m7kH-6aq7H:
27.7		 4m7kH-6aq7H:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2G_B_CTCB222_0
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 6aq7 POM6 FAB HEAVY CHAIN
POM6 FAB LIGHT CHAIN
(Mus
musculus;
Mus
musculus) 		5 / 12 ARG L 215
THR L 182
VAL L 136
ILE L 121
SER H 129
 None
 1.50A 4v2gB-6aq7L:
undetectable		 4v2gB-6aq7L:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1I_B_LOCB502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 6aq7 POM6 FAB HEAVY CHAIN
(Mus
musculus) 		3 / 3 SER H 204
ALA H 199
VAL H 198
 None
 0.60A 4x1iA-6aq7H:
undetectable		 4x1iA-6aq7H:
11.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_P_BEZP801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 6aq7 POM6 FAB HEAVY CHAIN
POM6 FAB LIGHT CHAIN
(Mus
musculus;
Mus
musculus) 		4 / 5 SER H  98
ALA H 101
HIS H  34
LEU L 100
 None
 1.12A 5dzkb-6aq7H:
undetectable
5dzkp-6aq7H:
undetectable		 5dzkb-6aq7H:
undetectable
5dzkp-6aq7H:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_Q_BEZQ801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 6aq7 POM6 FAB HEAVY CHAIN
POM6 FAB LIGHT CHAIN
(Mus
musculus;
Mus
musculus) 		4 / 5 SER H  98
ALA H 101
HIS H  34
LEU L 100
 None
 1.20A 5dzkc-6aq7H:
undetectable
5dzkq-6aq7H:
undetectable		 5dzkc-6aq7H:
undetectable
5dzkq-6aq7H:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_U_BEZU801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 6aq7 POM6 FAB HEAVY CHAIN
POM6 FAB LIGHT CHAIN
(Mus
musculus;
Mus
musculus) 		4 / 6 SER H  98
ALA H 101
HIS H  34
LEU L 100
 None
 1.19A 5dzkg-6aq7H:
undetectable
5dzku-6aq7H:
undetectable		 5dzkg-6aq7H:
undetectable
5dzku-6aq7H:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EYP_B_LOCB502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 6aq7 POM6 FAB HEAVY CHAIN
(Mus
musculus) 		3 / 3 SER H 204
ALA H 199
VAL H 198
 None
 0.57A 5eypA-6aq7H:
undetectable		 5eypA-6aq7H:
11.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4E_D_EDPD402_1
(PROTON-GATED ION
CHANNEL)		 6aq7 POM6 FAB LIGHT CHAIN
(Mus
musculus) 		4 / 8 THR L  78
SER L  67
THR L  76
SER L  69
 None
 1.00A 5l4eA-6aq7L:
3.3
5l4eB-6aq7L:
undetectable
5l4eC-6aq7L:
undetectable
5l4eD-6aq7L:
3.3
5l4eE-6aq7L:
3.3		 5l4eA-6aq7L:
11.73
5l4eB-6aq7L:
11.73
5l4eC-6aq7L:
11.73
5l4eD-6aq7L:
11.73
5l4eE-6aq7L:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MTH_A_ACTA302_0
(ANTIBODY FAB HEAVY
CHAIN)		 6aq7 POM6 FAB HEAVY CHAIN
(Mus
musculus) 		5 / 5 SER H 114
ALA H 116
PHE H 147
LEU H 171
ASP H 174
 None
 0.28A 5mthA-6aq7H:
29.3		 5mthA-6aq7H:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIW_D_LOCD503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA CHAIN)		 6aq7 POM6 FAB HEAVY CHAIN
(Mus
musculus) 		3 / 3 SER H 204
ALA H 199
VAL H 198
 None
 0.52A 5xiwC-6aq7H:
undetectable		 5xiwC-6aq7H:
20.22