SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6aqh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_A_ESTA351_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 6aqh LYSINE--TRNA LIGASE
(Mycolicibacteriu
m
thermoresistibil
e) 		5 / 12 VAL A 377
GLY A 378
LEU A 381
PHE A 390
SER A 322
 None
 1.12A 1fduA-6aqhA:
undetectable		 1fduA-6aqhA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_C_ADNC2502_2
(ADENOSYLHOMOCYSTEINA
SE)		 6aqh LYSINE--TRNA LIGASE
(Mycolicibacteriu
m
thermoresistibil
e) 		3 / 3 GLU A 274
THR A 472
LEU A 193
 LYS  A 601 (-3.5A)
None
None
 0.61A 1v8bC-6aqhA:
undetectable		 1v8bC-6aqhA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS1_B_017B203_1
(HIV-1 PROTEASE)		 6aqh LYSINE--TRNA LIGASE
(Mycolicibacteriu
m
thermoresistibil
e) 		4 / 7 GLU A  85
PRO A  38
ARG A  39
GLY A  67
 None
 1.26A 2hs1B-6aqhA:
undetectable		 2hs1B-6aqhA:
12.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NV4_A_SAMA201_0
(UPF0066 PROTEIN
AF_0241)		 6aqh LYSINE--TRNA LIGASE
(Mycolicibacteriu
m
thermoresistibil
e) 		5 / 12 ALA A 297
GLN A 181
PRO A 307
GLY A 485
LEU A 316
 None
 1.30A 2nv4A-6aqhA:
undetectable		 2nv4A-6aqhA:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NV4_B_SAMB202_0
(UPF0066 PROTEIN
AF_0241)		 6aqh LYSINE--TRNA LIGASE
(Mycolicibacteriu
m
thermoresistibil
e) 		5 / 12 ALA A 297
GLN A 181
PRO A 307
GLY A 485
LEU A 316
 None
 1.31A 2nv4B-6aqhA:
undetectable		 2nv4B-6aqhA:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_B_CHDB501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 6aqh LYSINE--TRNA LIGASE
(Mycolicibacteriu
m
thermoresistibil
e) 		5 / 11 LEU A 193
PHE A 198
LEU A 292
LEU A 413
TRP A 411
 None
 1.26A 2po5B-6aqhA:
undetectable		 2po5B-6aqhA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO7_B_CHDB501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 6aqh LYSINE--TRNA LIGASE
(Mycolicibacteriu
m
thermoresistibil
e) 		5 / 12 LEU A 193
PHE A 198
LEU A 292
LEU A 413
TRP A 411
 None
 1.26A 2po7B-6aqhA:
undetectable		 2po7B-6aqhA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_B_CHDB928_0
(FERROCHELATASE)		 6aqh LYSINE--TRNA LIGASE
(Mycolicibacteriu
m
thermoresistibil
e) 		5 / 12 LEU A 193
PHE A 198
LEU A 292
LEU A 413
TRP A 411
 None
 1.27A 2qd4B-6aqhA:
undetectable		 2qd4B-6aqhA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA504_1
(CYTOCHROME P450 2B4)		 6aqh LYSINE--TRNA LIGASE
(Mycolicibacteriu
m
thermoresistibil
e) 		5 / 9 LEU A 193
LEU A 273
GLU A 252
PHE A 198
VAL A 250
 None
 1.44A 3tmzA-6aqhA:
undetectable		 3tmzA-6aqhA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DO3_B_0LAB602_1
(FATTY-ACID AMIDE
HYDROLASE 1)		 6aqh LYSINE--TRNA LIGASE
(Mycolicibacteriu
m
thermoresistibil
e) 		4 / 6 LEU A 193
LEU A 292
ILE A 293
MET A 474
 None
 0.99A 4do3B-6aqhA:
undetectable		 4do3B-6aqhA:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K87_A_ADNA602_1
(PROLINE--TRNA LIGASE)		 6aqh LYSINE--TRNA LIGASE
(Mycolicibacteriu
m
thermoresistibil
e) 		4 / 8 ARG A 258
PHE A 270
THR A 422
ARG A 478
 LYS  A 601 ( 3.4A)
KRS  A 602 (-3.5A)
LYS  A 601 ( 4.3A)
KRS  A 602 (-3.5A)
 0.75A 4k87A-6aqhA:
11.3		 4k87A-6aqhA:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_B_29SB601_2
(ESTROGEN RECEPTOR)		 6aqh LYSINE--TRNA LIGASE
(Mycolicibacteriu
m
thermoresistibil
e) 		4 / 5 LEU A 292
GLU A 299
MET A 186
LEU A 253
 None
 1.03A 4xi3B-6aqhA:
undetectable		 4xi3B-6aqhA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KMF_A_6U9A1301_1
(ION TRANSPORT
PROTEIN)		 6aqh LYSINE--TRNA LIGASE
(Mycolicibacteriu
m
thermoresistibil
e) 		5 / 6 THR A 394
GLY A 366
GLU A 370
TYR A 326
ILE A 337
 None
 1.29A 5kmfA-6aqhA:
undetectable
5kmfC-6aqhA:
undetectable		 5kmfA-6aqhA:
20.08
5kmfC-6aqhA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BNI_A_ADNA602_1
(LYSINE--TRNA LIGASE)		 6aqh LYSINE--TRNA LIGASE
(Mycolicibacteriu
m
thermoresistibil
e) 		7 / 10 ARG A 258
HIS A 266
PHE A 270
GLU A 419
GLY A 475
ARG A 478
ILE A 488
 LYS  A 601 ( 3.4A)
KRS  A 602 (-4.5A)
KRS  A 602 (-3.5A)
KRS  A 602 (-3.8A)
KRS  A 602 (-3.8A)
KRS  A 602 (-3.5A)
None
 0.53A 6bniA-6aqhA:
43.9		 6bniA-6aqhA:
10.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BNI_B_ADNB602_1
(LYSINE--TRNA LIGASE)		 6aqh LYSINE--TRNA LIGASE
(Mycolicibacteriu
m
thermoresistibil
e) 		7 / 10 ARG A 258
HIS A 266
PHE A 270
GLU A 419
GLY A 475
ARG A 478
ILE A 488
 LYS  A 601 ( 3.4A)
KRS  A 602 (-4.5A)
KRS  A 602 (-3.5A)
KRS  A 602 (-3.8A)
KRS  A 602 (-3.8A)
KRS  A 602 (-3.5A)
None
 0.53A 6bniB-6aqhA:
44.0		 6bniB-6aqhA:
10.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_B_GMJB301_1
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 6aqh LYSINE--TRNA LIGASE
(Mycolicibacteriu
m
thermoresistibil
e) 		4 / 6 ASP A 412
VAL A 387
GLU A 419
ALA A 213
 None
None
KRS  A 602 (-3.8A)
LYS  A 601 (-3.4A)
 1.18A 6djzB-6aqhA:
undetectable		 6djzB-6aqhA:
19.22