SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6aqo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J96_B_TESB904_1
(3ALPHA-HYDROXYSTEROI
D DEHYDROGENASE TYPE
3)		 6aqo HYPOXANTHINE-GUANINE
PHOSPHORIBOSYLTRANSF
ERASE
(Trypanosoma
brucei) 		4 / 7 VAL A  85
ILE A  83
GLU A 191
LEU A  51
 None
 1.09A 1j96B-6aqoA:
undetectable		 1j96B-6aqoA:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		 6aqo HYPOXANTHINE-GUANINE
PHOSPHORIBOSYLTRANSF
ERASE
(Trypanosoma
brucei) 		4 / 8 LEU A 133
ASN A 132
LEU A 130
ARG A 134
 None
 0.90A 2xn3A-6aqoA:
undetectable
2xn3B-6aqoA:
undetectable		 2xn3A-6aqoA:
12.24
2xn3B-6aqoA:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_A_SAMA401_1
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 6aqo HYPOXANTHINE-GUANINE
PHOSPHORIBOSYLTRANSF
ERASE
(Trypanosoma
brucei) 		4 / 5 SER A  84
THR A  93
GLU A 147
ASP A 151
 None
None
None
45T  A 301 (-4.1A)
 1.27A 3tm4A-6aqoA:
2.0		 3tm4A-6aqoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_B_SAMB401_1
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 6aqo HYPOXANTHINE-GUANINE
PHOSPHORIBOSYLTRANSF
ERASE
(Trypanosoma
brucei) 		4 / 5 SER A  84
THR A  93
GLU A 147
ASP A 151
 None
None
None
45T  A 301 (-4.1A)
 1.24A 3tm4B-6aqoA:
undetectable		 3tm4B-6aqoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BZO_C_FI8C1201_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 6aqo HYPOXANTHINE-GUANINE
PHOSPHORIBOSYLTRANSF
ERASE
(Trypanosoma
brucei) 		5 / 12 THR A 196
VAL A 178
VAL A 193
VAL A 221
GLU A  31
 None
 1.26A 6bzoC-6aqoA:
undetectable		 6bzoC-6aqoA:
undetectable