SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6aqy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RFF_A_SPMA700_1
(TYROSYL-DNA
PHOSPHODIESTERASE 1
TOPOISOMERASE
I-DERIVED PEPTIDE)		 6aqy GDP-L-FUCOSE
SYNTHETASE
(Naegleria
fowleri) 		4 / 4 ASN A  97
TRP A  94
VAL A  91
TYR A 152
 None
 1.42A 1rffA-6aqyA:
2.0
1rffC-6aqyA:
undetectable		 1rffA-6aqyA:
22.86
1rffC-6aqyA:
3.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_A_SAMA300_0
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 6aqy GDP-L-FUCOSE
SYNTHETASE
(Naegleria
fowleri) 		5 / 12 GLY A  23
GLY A  49
GLY A  53
THR A  25
VAL A  21
 None
 0.98A 2oxtA-6aqyA:
4.4		 2oxtA-6aqyA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKW_B_P1BB1475_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 6aqy GDP-L-FUCOSE
SYNTHETASE
(Naegleria
fowleri) 		5 / 12 ILE A 271
PHE A 313
ALA A 235
LEU A  27
MET A 204
 None
 1.31A 2xkwB-6aqyA:
undetectable		 2xkwB-6aqyA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ONN_A_ACTA271_0
(PROTEIN SSM1)		 6aqy GDP-L-FUCOSE
SYNTHETASE
(Naegleria
fowleri) 		4 / 5 GLY A  29
LYS A  30
GLU A  33
GLY A  26
 None
 0.80A 3onnA-6aqyA:
2.5		 3onnA-6aqyA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_A_SAMA401_0
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 6aqy GDP-L-FUCOSE
SYNTHETASE
(Naegleria
fowleri) 		5 / 12 ALA A  77
GLY A  29
ASP A  54
ARG A  56
PHE A  79
 None
 1.36A 5zvgA-6aqyA:
5.1		 5zvgA-6aqyA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_C_FK5C201_0
(PEPTIDYLPROLYL
ISOMERASE)		 6aqy GDP-L-FUCOSE
SYNTHETASE
(Naegleria
fowleri) 		4 / 4 ASP A 158
ILE A 181
PRO A 182
LEU A 120
 None
 1.36A 6mkeB-6aqyA:
undetectable		 6mkeB-6aqyA:
14.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_D_FK5D201_0
(PEPTIDYLPROLYL
ISOMERASE)		 6aqy GDP-L-FUCOSE
SYNTHETASE
(Naegleria
fowleri) 		4 / 4 ASP A 158
ILE A 181
PRO A 182
LEU A 120
 None
 1.37A 6mkeA-6aqyA:
undetectable		 6mkeA-6aqyA:
14.37